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Tissue Extracts (6):
Recent article
Tissue Extracts
Abstract
Mammalian sPLA2-IB localization cell are well characterized. In contrast, much less is known about aquatic primitive ones. The aquatic world contains a wide variety of living species and, hence represents a great potential for discovering new lipolytic enzymes and the mode of digestion of lipid food....
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PMID: 21631952
PDF is available here.
PDF is available here.
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Abstract
We investigated expressional changes in the hippocampus and cortex at 72 h after infection when dexamethasone was given to infant rats with pneumococcal meningitis. Nursing Wistar rats were intracisternally infected with Streptococcus pneumoniae to induce experimental meningitis or were sham-infecte...
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PMID: 21412436
PDF is available here.
PDF is available here.
Abstract
We showed that extracts of aortic tissues from the mgR mouse model of Marfan syndrome showed increased chemotactic stimulatory activity related to the elastin-binding protein. Aortic samples were collected from 6 patients with Marfan syndrome and 8 with isolated aneurysms of the ascending aorta. Con...
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PMID: 21647416
PDF is available here.
PDF is available here.
Abstract
This section of the Journal of Drugs in Dermatology (JDD) is dedicated to Dendreon's Provenge (Sipuleucel-T), the first therapeutic DC vaccine proven effective and approved by the United States (U.S.) Food and Drug Administration (FDA) for advanced cancer. This editorial will discuss...
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PMID: 21061758
PDF is available here.
PDF is available here.
Abstract
The FDA has approved 2 new treatments for castration-resistant (formerly called hormone-refractory) prostate cancer. Sipuleucel-T (Provenge - Dendreon) s the first immunotherapy approved for treatment of prostate cancer. Cabazitaxel (Jevtana - Sanofi-Aventis) is approved for second-line treatment of...
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PMID: 20814400
PDF is available here.
PDF is available here.
Abstract
Abstract
Journal of Immunological Methods (359)1-2 2010
Abstract
We describe the optimization of a protocol for extracting proteins from human tissues in a format that is compatible with the functional analysis of human T cells. The tissue was homogenized in a mixture of butan-1-ol, acetonitrile and water and then lyophilized. Lyophilized protein extracts were di...
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PMID: 20470778
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We recently developed activatable cell-penetrating peptides (ACPPs) that target contrast agents to in vivo sites of matrix metalloproteinase activity, such as tumors. Here we use parallel in vivo and in vitro selection with phage display to identify novel tumor-homing ACPPs with no bias for primary...
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PMID: 20460372
PDF is available here.
PDF is available here.
Abstract
We show that the BBSome constitutes a coat complex that sorts membrane proteins to primary cilia. The BBSome is the major effector of the Arf-like GTPase Arl6/BBS3, and the BBSome and GTP-bound Arl6 colocalize at ciliary punctae in an interdependent manner. Strikingly, Arl6(GTP)-mediated recruitment...
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PMID: 20603001
PDF is available here.
PDF is available here.
Abstract
I and II clinical trials. Our objective was to determine the effect of adding AE-941 to chemoradiotherapy on overall survival of patients with unresectable stage III non-small cell lung cancer (NSCLC). METHODS A randomized, double-blinded, placebo-controlled, phase III clinical trial was designed to...
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PMID: 20505152
PDF is available here.
PDF is available here.
Abstract
We show that MSC from seven donors secrete chemokines and cytokines in variable ranges, with some factors showing high variability. Treatment of cultured MSC with pro-inflammatory cytokines or tissue extracts from injured spinal cord resulted in up-regulation of selected cytokines, whereas treatment...
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PMID: 20185331
PDF is available here.
PDF is available here.
Abstract
To search for novel transcripts encoding biologically active venom components, a subtractive cDNA library specific to the venom gland and sac (gland/sac) of a solitary hunting wasp species, Eumenes pomiformis Fabricius (1781), was constructed by suppression subtractive hybridization. A total of 541...
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PMID: 20096300
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)5 2010
Abstract
Proteins and peptides of Amydae Carapax with molecular weight less than 6000 were proved to have biological activity. 8 components (Bj1-Bj8) were isolated from the active fraction. Bj4, Bj6 and Bj7 were screened as active components. Bj7 was further purified, resulting in 7 components (Bj701-Bj707)....
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PMID: 20509999
PDF is available here.
PDF is available here.
Abstract
A pivotal phase III study using Sipuleucel-T, an autologous prostatic acid phosphatase (PAP)-loaded dendritic cell immunotherapy, in men with metastatic castration-resistant prostate cancer (CRPC) demonstrated a survival advantage over placebo. By contrast, two phase III studies of GVAX, an allogene...
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PMID: 20179598
PDF is available here.
PDF is available here.
Abstract
Abstract
Since deer velvet (DV) extract promotes angiogenesis, its ability to modulate the growth and invasiveness of colon tumours was investigated. Male Wistar rats were each given a subcutaneous injection of azoxymethane (AOM) at 15 mg/kg once a week for 3 weeks. One week following the last dose of AOM th...
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PMID: 20176070
PDF is available here.
PDF is available here.
Abstract
Genetically modified (GM) foods must be tested for safety, including by allergenicity tests to ensure that they do not contain new allergens or higher concentrations of known allergens than the same non-GM foods. In this study experimentally developed EGFP-transgenic chickens were used and evaluated...
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PMID: 20188780
PDF is available here.
PDF is available here.
Abstract
The essential elements and contaminants (Pb and Cd) were determined seasonally in the muscle and liver of six demersal fish species Sparus aurata, Chelidonichthys lucernus, Upeneus molluccensis, Solea solea, Merluccius merluccius and Saurida undosquamis from the Iskenderun Bay, Eastern Mediterranean...
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PMID: 20214948
PDF is available here.
PDF is available here.
Abstract
We investigated cyanobacterial toxins, specifically cylindrospermopsin (CYN), the microcystins (MCYST) and the "paralytic shellfish toxins" (PST), in Lago Catemaco (Veracruz, Mexico). Lago Catemaco is a tropical lake dominated by Cylindrospermopsis, specifically identified as Cylindrospermopsis cate...
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PMID: 19651152
PDF is available here.
PDF is available here.
Journal of Experimental Biology (213)Pt 10 2010
Abstract
In the developing frog brain, the majority of mast cells (MC) are distributed in the pia mater, and some immature MC are located adjacent to the blood capillaries in and around the neuropil. In the adult brain, MC are more numerous than in pre- and pro-metamorphic tadpoles; they are mainly located w...
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PMID: 20435827
PDF is available here.
PDF is available here.
Methods in Molecular Biology (616)616 2010
Abstract
We discuss expertise developed in our laboratory for the isolation of specific lymphocyte and endothelial populations from explanted human liver tissue specimens. We then move on to provide specific examples of assays such as the Stamper-Woodruff assay, the transmigration assay and the tissue-specif...
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PMID: 20379879
PDF is available here.
PDF is available here.
Methods in Molecular Biology (630)630 2010
Abstract
We have piloted the use of real-time PCR measurement of specific prognostic genes, so called "Indicator" genes, in globally amplified polyA cDNA for this purpose. Poly(A) PCR coordinately amplifies cDNA copies of all polyadenylated mRNAs, thereby generating a PCR product (polyA cDNA) whose compositi...
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PMID: 20300988
PDF is available here.
PDF is available here.
Biochemical Journal (426)3 2010
Abstract
We have investigated the expression of beta-F1-ATPase mRNA (termed beta-mRNA) in breast, colon and lung adenocarcinomas and squamous carcinomas of the lung. Despite the down-regulation of the protein, tumour beta-mRNA levels remained either unchanged (breast and lung adenocarcinomas) or significantl...
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PMID: 20028336
PDF is available here.
PDF is available here.
Abstract
The hemagglutination activities of midgut (MG) fractions of red palm weevil, Rhynchophorus ferrugineus against mammalian erythrocytes (RBC) from man (ABO), rabbit, horse and sheep were studied. The highest titers were seen with rabbit RBC (p < 0.05) followed by human group B, human group O, horse, h...
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PMID: 20464944
PDF is available here.
PDF is available here.
Xenobiotica (40)3 2010
Abstract
These results demonstrated that CS-8958 administered intratracheally to rats was converted/hydrolysed to R-125489 in the target tissues, and that the R-125489 was slowly excreted into the urine via an absorption rate-limiting process. Such distinctive pharmacokinetics attributed to the slow release...
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PMID: 20146556
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
In vitro, high-resolution (1)H and (31)P NMR based qualitative and quantitative analyses of the lipid components of the tissue, serum, and CSF of patients with primary brain tumors were performed. Proton NMR spectra of the lipid extract of serum (blood specimen collected before the s...
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PMID: 19774696
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
The aim of this work was to investigate the effect of experimental conditions on the visibility of polyamines. In solution the chemical shift of the three groups of peaks (at approximately 1.8, 2.1 and 3.1 ppm) were found to be pH dependent. Relaxation times in aqueous solution at pH...
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PMID: 19757478
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
In vitro, high-resolution (1)H and (31)P NMR based qualitative and quantitative analyses of the lipid components of the tissue, serum, and CSF of patients with primary brain tumors were performed. Proton NMR spectra of the lipid extract of serum (blood specimen collected before the s...
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PMID: 19774696
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
The aim of this work was to investigate the effect of experimental conditions on the visibility of polyamines. In solution the chemical shift of the three groups of peaks (at approximately 1.8, 2.1 and 3.1 ppm) were found to be pH dependent. Relaxation times in aqueous solution at pH...
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PMID: 19757478
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
In vitro, high-resolution (1)H and (31)P NMR based qualitative and quantitative analyses of the lipid components of the tissue, serum, and CSF of patients with primary brain tumors were performed. Proton NMR spectra of the lipid extract of serum (blood specimen collected before the s...
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PMID: 19774696
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
In vitro, high-resolution (1)H and (31)P NMR based qualitative and quantitative analyses of the lipid components of the tissue, serum, and CSF of patients with primary brain tumors were performed. Proton NMR spectra of the lipid extract of serum (blood specimen collected before the s...
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PMID: 19774696
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
The aim of this work was to investigate the effect of experimental conditions on the visibility of polyamines. In solution the chemical shift of the three groups of peaks (at approximately 1.8, 2.1 and 3.1 ppm) were found to be pH dependent. Relaxation times in aqueous solution at pH...
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PMID: 19757478
PDF is available here.
PDF is available here.
NMR in Biomedicine (23)2 2010
Abstract
The aim of this work was to investigate the effect of experimental conditions on the visibility of polyamines. In solution the chemical shift of the three groups of peaks (at approximately 1.8, 2.1 and 3.1 ppm) were found to be pH dependent. Relaxation times in aqueous solution at pH...
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PMID: 19757478
PDF is available here.
PDF is available here.
médecine/sciences (26)2 2010
Abstract
BMC Genomics (11) 2010
Abstract
Several Echinacea species have been used as nutraceuticals or botanical drugs for "immunostimulation", but scientific evidence supporting their therapeutic use is still controversial. In this study, a phytocompound mixture extracted from the butanol fraction (BF) of a stem and leaf (S+L) extract of...
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PMID: 21040561
PDF is available here.
PDF is available here.
Abstract
This work provides, for the first time, evidences about miRNAs misexpression in DM1 muscle tissues, adding a new element in the pathogenesis of this complex genetic disease....
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PMID: 20487562
PDF is available here.
PDF is available here.
Abstract
We investigated whether mosquito saliva alters APC signaling during arbovirus infection, and if alterations in cell recruitment occur when WNV infection is initiated with mosquito saliva. Accordingly, experiments were performed with cultured dendritic cells and macrophages, flow cytometry was used t...
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PMID: 20661470
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
The complementary gel-based and gel-free proteomic strategies have been compared and evaluated for the study of crystallin phosphorylation from whole tissue extracts of porcine eye lenses. Technically, the IMAC method facilitates direct site-specific identification of phosphorylation residues in len...
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PMID: 20182557
PDF is available here.
PDF is available here.
Abstract
We introduce several methods to examine the interaction of transcriptional factors with and their sequestration by expanded polyglutamine proteins in vitro and in vivo....
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PMID: 20700715
PDF is available here.
PDF is available here.
Abstract
We found the earthworm (EW) water extracts caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as the expressions of growth associated protein 43 and synapsin I. In the in vivo study, silicone rubber chambers filled with EW extracts were used to...
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PMID: 20503471
PDF is available here.
PDF is available here.
Abstract
Members of the family of carcinoembryonic antigen (CEA)-related cell adhesion molecules (CEACAMs) belonging to the immunoglobulin (Ig) superfamily are expressed in a variety of normal and malignant human tissues. As components of the cell membrane, these glycoproteins can make contact with adjacent...
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PMID: 20034698
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We present protocols that we have used for the analysis of tubulin isotypes and PTMs present in tubulin isolated from cells in culture or tissues and for the identification of tubulin regions altered by microtubule-stabilizing agents. Tubulin proteomics complements structural and computer modeling i...
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PMID: 20466132
PDF is available here.
PDF is available here.
Abstract
We used Timp3(-/-) mice to assess the role of this inhibitor in acute lung injury. After bleomycin-induced injury, inflammation, as indicated by the influx of neutrophils in bronchoalveolar lavage (BAL), peaked at 7 days post-injury in the wild-type mice and began to wane thereafter; however, in Tim...
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PMID: 20008147
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Northwest Therapeutics' DCvax-prostate consists of autologous dendritic cells (DCs) loaded with prostate-specific membrane antigen (PSMA) peptides, administered intravenously. Phase I-II testing, a decade ago, showed clinical benefit and immunological response in some patients. More rece...
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PMID: 19916735
PDF is available here.
PDF is available here.
Mayo Clinic Health Letter (27)12 2009
Abstract
Parasitology (85 (Pt 3))03 2009
Abstract
Activation of prophenol oxidase of Fasciola gigantica has been demonstrated using biochemical and electrophoretic techniques. Based on the difference in the electrophoretic pattern of the proenzyme and activated enzyme, a probable mechanism of activation of the prophenol oxidase is suggested. A role...
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PMID: 6817288
PDF is available here.
PDF is available here.
Abstract
Interactions with the extracellular matrix (ECM) play an important role in regulating cell function. Cells cultured in, or on, three-dimensional ECM recapitulate similar features to those found in vivo that are not present in traditional two-dimensional culture. In addition, both nat...
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PMID: 19115821
PDF is available here.
PDF is available here.
Abstract
These results indicate that Solcoseryl has a mucosal protective effect which may contribute to the mechanism of its anti-ulcer effect....
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PMID: 2595292
PDF is available here.
PDF is available here.
Abstract
The proximate and fatty acid composition of two locally important freshwater fish, Schizothorax zarudnyi and Schizocypris altidorsalis, from Sistan Province in Iran were investigated for their nutritional value. The protein and lipid content in the S. zarudnyi were 14.67 and 6.36%, respectively. In...
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PMID: 19943467
PDF is available here.
PDF is available here.
Abstract
Environmental pollutants are suspected to be a cause of global declines in amphibian populations, but few data are available on the bioaccumulation of polybrominated diphenyl ethers (PBDEs) in amphibians. To examine the tissue distribution, biomagnification potential, and maternal transfer of PBDEs...
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PMID: 19708343
PDF is available here.
PDF is available here.
Abstract
Administration of the DN (up to 75 g/d) to horses for 84 days did not induce any adverse effects. In the other experiment, synovial fluid PGE(2), GAG, and protein concentrations and leukocyte count increased after intra-articular injections of IL-1beta (compared with effects of saline solution injec...
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PMID: 19566470
PDF is available here.
PDF is available here.
Abstract
We found that even in the presence of the proinflammatory cytokines interleukin (IL)-1alpha, IL-beta, and a mixture of tumor necrosis factor (TNF)alpha + IL-17, scabies extract still downregulated the levels of IL-8 secretion from keratinocytes and fibroblasts and of granulocyte/macrophage-colony st...
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PMID: 19645287
PDF is available here.
PDF is available here.
Parasitology (90 ( Pt 3))03 2009
Abstract
We examined tissues of the small intestine infected with other species of Eimeria for a similar lethal activity. Extracts were prepared from intestinal tissues of chickens infected with either E. acervulina, E. brunetti, E. maxima, E. mitis or E. necatrix. Appropriate control extracts from tissues o...
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PMID: 4011320
PDF is available here.
PDF is available here.
Abstract
I mRNA expression, the secretion of procollagen I carboxyterminal propeptide (PICP) and osteocalcin in MG63 osteoblasts. Protein synthesis was increased and procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. Synovial fluid stimulated the total PICP...
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PMID: 18350290
PDF is available here.
PDF is available here.
Abstract
We applied activity-based protein profiling using fluorophosphonate-based probes to display the activities of Ser hydrolases in the model plant Arabidopsis thaliana. Multidimensional protein identification technology and in-gel analysis of fluorophosphonate-labeled leaf extracts revealed over 50 Ser...
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PMID: 19136719
PDF is available here.
PDF is available here.
Abstract
We developed a quantifiable luciferase reporter assay that measures the degradation of a long-lived polyglutamine protein aggregate, polyQ80-luciferase. Using this reporter, the induction of autophagy via starvation or rapamycin in cells preferentially decreases polyQ80-luciferase when compared with...
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PMID: 19305149
PDF is available here.
PDF is available here.
Cell and Tissue Research (336)2 2009
Abstract
We examined whether systemic depletion of monocytes/macrophages had a beneficial or adverse effect on the development of lesions in hyperlipemic hamsters injected twice weekly (for 2 months) with clodronate-encapsulated liposomes (H+Lclod), a treatment that selectively induces significant monocyte a...
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PMID: 19301037
PDF is available here.
PDF is available here.