Abstract
We aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused on the pathophysiological basis of the disease. Furthermore, we review stud...
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PMID: 21929511
PDF is available here.
Abstract
Prion replication in the periphery precedes neuroinvasion in many experimental rodent scrapie models, and in natural sheep scrapie and chronic wasting disease (CWD) in cervids. Prions propagate in the germinal centers of secondary lymphoid organs and are strongly associated with foll...
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PMID: 22043911
PDF is available here.
Abstract
We studied CD103 and CD123 expression by the malignant cells in 300 B-cell lymphoproliferative disorder (BC-LPD) cases, including 114 hairy cell leukemia (HCL), 20 HCL variant (HCLv), 9 splenic marginal zone lymphoma (SMZL; in 5, only CD103 was evaluated), 133 chronic lymphocytic leukemia (CLL), 3 f...
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PMID: 21917686
PDF is available here.
Abstract
We would like to report our experience of using rituximab in cyclophosphamide refractory, rapidly progressive interstitial lung disease (ILD) in a patient with limited scleroderma. A 40-year-old man presented with 10-week history of inflammatory polyarthritis, which responded to a short course of or...
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PMID: 21593063
PDF is available here.
Abstract
We identified 433 dippers and 230 subjects with a nocturnal non-dipping pattern. Nocturnal SBP dipping was independently of office SBP associated with decreased PWV (p = 0.008), lower ACR (p = 0.001) and NT-proBNP (p = 0.001) and increased GFR (p<0.001).
We conclude that diurnal BP v...
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PMID: 21546328
PDF is available here.
David J Thurman,
Ettore Beghi,
Charles E Begley,
Anne T Berg,
Jeffrey R Buchhalter,
Ding Ding,
Dale C Hesdorffer,
W Allen Hauser,
Lewis Kazis,
Rosemarie Kobau,
Barbara Kroner,
David Labiner,
Kore Liow,
Giancarlo Logroscino,
Marco T Medina,
Charles R Newton,
Karen Parko,
Angelia Paschal,
Pierre-Marie Preux,
Josemir W Sander,
Anbesaw Selassie,
William Theodore,
Torbjörn Tomson and
Samuel Wiebe
Abstract
We discuss: (1) conceptual and operational definitions of epilepsy, (2) data resources and recommended data elements, and (3) methods and analyses appropriate for epidemiologic studies or the surveillance of epilepsy. Variations in these are considered, taking into account differing resource availab...
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PMID: 21899536
PDF is available here.
Abstract
Experimental evidences have shown that tumor necrosis factor (TNF)-α may play a role in the pathogenesis of nonsegmental vitiligo, and successful cases of vitiligo treated with TNF-α inhibitors have been recently reported.
Two cases of refractory generalized vitilig...
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PMID: 21388239
PDF is available here.
Abstract
Refractory vasculitis occurs in 4-5% of patients with anti-neutrophil cytoplasmic antibody associated vasculitis (AAV). Differences between therapies used for refractory disease are mostly reflected in the percentages of complete and partial remissions, but also in the number of seri...
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PMID: 21600312
PDF is available here.
Abstract
To determine prevalence and risk factors for hypertension and isolated office hypertension diagnosed by ambulatory blood pressure monitoring in HIV-infected patients.
Cross-sectional study of 310 patients. A 24-hour ambulatory blood pressure monitoring procedure was p...
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PMID: 21654497
PDF is available here.
Abstract
We have experience exciting developments regarding the approval of new treatment options but few patients are reaching sustained remission and refractory patients continue to be a problem. Thus, it is critical to understand how clinicians can decrease the risk of refractoriness by close monitoring d...
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PMID: 21570496
PDF is available here.
Abstract
Primary hyperparathyroidism is systemic, polymorphic disease. Authors present a case of woman suffered from primary hyperparathyroidism misdiagnosed as disseminated neoplastic disease. There was shown a clinical picture complex, difficulties in diagnostic process, treatment and facto...
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PMID: 21991847
PDF is available here.
Abstract
The use of the latest classification of a PPA seems to be an interesting proposition to improve methods for identifying, testing and treatment of this complex clinical syndrome. On each stage of the diagnostic and therapeutic process, patient required individually adjusted neuropsychological cogniti...
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PMID: 21991849
PDF is available here.
Abstract
Our experience includes 12 such cases. The aim of the study was to analyze patients after suicidal calcium channel blockers overdose.
In all cases medical interview, physical examination, neurological consultation, ecg, echocardiography, laboratory tests and in most cases--gasometry...
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PMID: 21991842
PDF is available here.
Abstract
Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology, which is characterized by a variable clinical presentation and course. The diagnosis of this disease is usually supported by the three elements: compatible clinical and radiologic findings, tissue biopsy speci...
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PMID: 21991850
PDF is available here.
Abstract
Sexual dysfunction in patients diagnosed with depressive disorders affect all phases of sexual response: a decline in libido, erectile dysfunction, ejaculation disorders in men and orgasm and menstruation in women. It is estimated that are present in approximately 70% of patients, af...
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PMID: 21991854
PDF is available here.
Abstract
We identified studies examining the burdens associated with HAE. Conducting larger studies using claims analyses for HAE is particularly challenging, owing to the rarity of the disease in health plans and to diagnostic/coding challenges. Because the data have been limited, larger surveys of patients...
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PMID: 21991862
PDF is available here.
Abstract
We conducted an analysis from our prospective database of 466 adults' ReLT between February 1984 and September 2010. Mean follow-up was 3 years. Each independent predictor for allograft failure was assigned risk score (RS) points of 1 or 2, proportional to the corresponding parameter estimate under...
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PMID: 21817890
PDF is available here.
Abstract
DISEASE OVERVIEW: Follicular lymphoma (FL) is generally an indolent B-cell lymphoproliferative disorder of transformed follicular center B cells. FL is characterized by diffuse lymphoadenopathy, bone marrow involvement, splenomegaly, and less commonly other extranodal sites of involv...
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PMID: 21850659
PDF is available here.
Abstract
We reviewed 861 episodes of FN in outpatients with solid tumours, including 692 (80%) episodes with apparent clinical stability. We aimed to investigate the prognosis of this latter group and explore the possibility of stratifying it according to the presenting features. A case-control study was per...
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PMID: 21811253
PDF is available here.
Abstract
We focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes....
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PMID: 21817166
PDF is available here.
Abstract
dal-PLAQUE is a placebo-controlled multicenter study designed to assess the effect of dalcetrapib on imaging measures of plaque inflammation and plaque burden. dal-PLAQUE is a multimodality imaging study in the context of the large dal-HEART Program. Decreased high-density lipoprotei...
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PMID: 21835280
PDF is available here.
Abstract
Cutaneous lupus erythematosus (CLE) is an autoimmune inflammatory skin disease seen in patients with or without systemic lupus erythematosus. The management of CLE includes treatment and prevention of lesions as well as routine assessment for systemic disease. Treatment options inclu...
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PMID: 21503694
PDF is available here.
Abstract
Anemia, leukopenia, and/or thrombocytopenia can occur as a result of non-immune- and immune-mediated mechanisms in patients with systemic lupus erythematosus. Although the differential diagnosis of these cytopenias is broad and warrants a thorough evaluation, lupus disease activity a...
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PMID: 21503695
PDF is available here.
Abstract
We investigated the subpopulation distribution, response to stimulation, and levels of the nuclear transcription factor NF-κB/p65 in peripheral blood B cells from patients with severe chronic sarcoidosis. Patients with severe chronic sarcoidosis had absolute B-cell lymphopenia and exhibited signifi...
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PMID: 21653741
PDF is available here.
Abstract
We obtained and analysed samples of blood serum from 23 patients with MF, and 29 psoriasis patients and 22 healthy donors as controls. Protein profiling was carried out using SELDI TOF MS SELDI-TOF and also profiling of 27 cytokines with multiplex immunoassay technology was implemented....
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PMID: 21751413
PDF is available here.
Elizabeth R Remily-Wood,
Richard Z Liu,
Yun Xiang,
Yi Chen,
C Eric Thomas,
Neal Rajyaguru,
Laura M Kaufman,
Joana E Ochoa,
Lori Hazlehurst,
Javier Pinilla-Ibarz,
Jeffrey Lancet,
Guolin Zhang,
Eric Haura,
David Shibata,
Timothy Yeatman,
Keiran S M Smalley,
William S Dalton,
Emina Huang,
Ed Scott,
Gregory C Bloom,
Steven A Eschrich and
John M Koomen
Abstract
The Quantitative Assay Database (QuAD), http://proteome.moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression and modification....
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PMID: 21656910
PDF is available here.
Abstract
We present here two siblings with a history of recurrent oral and genital ulcers, neurological and gastrointestinal manifestations. The diagnosis of Behçet's disease in a context of familial aggregation was assumed. Facing repeated steroid-dependent flares and failure of maintenance therapies with...
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PMID: 21683309
PDF is available here.
Abstract
To determine the aqueous humour levels of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in eyes with diabetic macular oedema before and after intravitreal EPO injection.
Prospective interventional case series.
Eleven eyes of 11 pat...
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PMID: 21819507
PDF is available here.