Abstract
We summarize our current understanding of PD-1 and its ligands ranging from discovery to clinical significance....
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PMID: 21061197
PDF is available here.
Abstract
We combined these procedures and used it to equalize lower limb length....
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PMID: 21830168
PDF is available here.
Abstract
Comparison of surgical results on obese patients undergoing hysterectomy by robot-assisted laparoscopy or laparotomy.
University hospital.
All women (n=114) with a BMI ≥30 kg/m(2) who underwent a simple hysterectomy as the main surgical procedure bet...
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PMID: 21854364
PDF is available here.
Mohamed L Sorror,
Brenda M Sandmaier,
Barry E Storer,
Georg N Franke,
Ginna G Laport,
Thomas R Chauncey,
Edward Agura,
Richard T Maziarz,
Amelia Langston,
Parameswaran Hari,
Michael A Pulsipher,
Wolfgang Bethge,
Firoozeh Sahebi,
Benedetto Bruno,
Michael B Maris,
Andrew Yeager,
Finn Bo Petersen,
Lars Vindeløv,
Peter A McSweeney,
Kai Hübel,
Marco Mielcarek,
George E Georges,
Dietger Niederwieser,
Karl G Blume,
David G Maloney and
Rainer Storb
Abstract
A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematologic malignancies who are older or have comorbid conditions.
To describe outcomes of patients 60 years or older afte...
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PMID: 22045765
PDF is available here.
Abstract
We studied the impact of early pancreas graft failure on long-term kidney and patient survival. METHODS.: We included all primary SPK transplants performed in the United States between January 1, 2000, and December 31, 2007, who had maintained kidney graft function at 90 days posttransplantation. Ka...
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PMID: 21832957
PDF is available here.
Abstract
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
To determine if dietary su...
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PMID: 21976613
PDF is available here.
Abstract
Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results.
To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free...
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PMID: 21990299
PDF is available here.
Abstract
The deep brain stimulation (DBS) is an emerging treatment option in brain disorders in which randomized multicenter trials proved its efficacy leading to licensing different DBS methods in various brain diseases. More recently more and more brain structures have become candidates for...
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PMID: 22059367
PDF is available here.
Ryu R Kanzaki,
Masahiko M Higashiyama,
Kazuyuki K Oda,
Ayako A Fujiwara,
Toshiteru T Tokunaga,
Jun J Maeda,
Jiro J Okami,
Koji K Tanaka,
Tatsushi T Shingai,
Shingo S Noura,
Masayuki M Ohue and
Ken K Kodama
Abstract
The outcomes after repeat pulmonary resection for colorectal cancer (CRC) and the factors associated with the prognosis of these patients remain uncharacterized.
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PMID: 21824604
PDF is available here.
Abstract
To evaluate the effect of increasing female obesity on response to and outcome of assisted reproductive technology (ART) treatment.
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PMID: 21821244
PDF is available here.
Abstract
: To estimate the association of age, medical comorbidities, functional status, and unintentional weight loss (as a marker of frailty) with postoperative complications in women undergoing major gynecologic surgery.
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PMID: 21934441
PDF is available here.
Abstract
Postoperative radiotherapy remains controversial in non-small cell lung cancer. The conclusions of several meta-analysis are still questioned, partly because of flaws in the randomized trials taken into account. The technological improvements of modern radiotherapy and several clinical observations h...
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PMID: 21820931
PDF is available here.
Rodrigo R Bagur,
Juan Maria JM Manazzoni,
Éric É Dumont,
Daniel D Doyle,
Jean J Perron,
François F Dagenais,
Patrick P Mathieu,
Richard R Baillot,
Éric É Charbonneau,
Jacques J Metrás,
Siamak S Mohammadi,
Mélanie M Côté,
François F Philippon,
Pierre P Voisine and
Josep J Rodés-Cabau
Abstract
To assess the incidence of conduction disturbances leading to permanent pacemaker implantation (PPI) following isolated aortic valve replacement (AVR) in a large cohort of elderly patients with severe symptomatic aortic stenosis, and to determine the predictive factors and prognostic value of PPI fol...
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PMID: 21828221
PDF is available here.
Abstract
Hereditary hemorrhagic telangiectasia (HHT) is a rare systemic fibrovascular dysplasia also known as Rendu-Osler-Weber disease. Epistaxis is often the first and foremost symptom of the disease and recurrent epistaxis is the main complaint.
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PMID: 21816895
PDF is available here.
Abstract
Microvascular decompression is an etiological strategy for the therapy of trigeminal neuralgia (TN). Preoperative identification of neurovascular compression, therefore, could have an impact on the determination of appropriate treatment for TN.
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PMID: 21835888
PDF is available here.
Abstract
A 9-year-old bitch was presented because of lethargy and abdominal distension. Abdominal ultrasound revealed an enlarged, fluid-filled uterus and associated mass. Subsequent exploratory laparotomy revealed unilateral uterine torsion involving the mass. Recovery following ovariohysterectomy was uneven...
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PMID: 21933164
PDF is available here.
Abstract
Objective To identify the common serotypes and antimicrobial resistance patterns of Salmonella spp. associated with diarrhoea in Australian dairy calves under the age of 6 weeks. Design Cross-sectional study. Methods Faecal samples were collected from outbreaks of diarrhoea in dairy and dair...
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PMID: 21933168
PDF is available here.
Abstract
Bariatric surgery procedures, including laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy, and Roux-en-Y gastric bypass, result in an average weight loss of 50 percent of excess body weight. Remission of diabetes mellitus occurs in approximately 80 percent of p...
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PMID: 22010619
PDF is available here.
Abstract
To ascertain if breast cancer subtypes had prognostic effect on breast cancer specific survival, distant metastases and local relapse rates in women affected by early stage breast cancer.
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PMID: 21824742
PDF is available here.
Abstract
To evaluate the feasability of immediate breast reconstruction (IBR) following mastectomy after neoadjuvant chemotherapy (NACT) and radiation therapy (RT) for operable invasive breast cancer (OIBC), in terms of incidence of local complications, locoregional control and survival.
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PMID: 21843920
PDF is available here.
V V Semiglazov,
W W Eiermann,
M M Zambetti,
A A Manikhas,
A A Bozhok,
A A Lluch,
S S Tjulandin,
M D MD Sabadell,
A A Caballero,
P P Valagussa,
J J Baselga and
L L Gianni
Abstract
To describe surgical outcomes in patients with HER2-positive locally advanced (LABC) or inflammatory breast cancer (IBC) participating in the NeOAdjuvant Herceptin (NOAH) study (ISRCTN86043495).
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PMID: 21843921
PDF is available here.
Abstract
The most common complication after breast cancer surgery is seroma formation. It is a source of significant morbidity and discomfort. Many articles have been published describing risk factors and preventive measures. The aim of this paper is to provide a systematic review of studies and reports on ri...
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PMID: 21849243
PDF is available here.
Abstract
We present our early experience with an attempt to optimize extracorporeal membrane oxygenation, emphasizing reduced adjunctive mechanical ventilatory support and aggressive rehabilitation, with a goal of ambulation. This strategy has been enabled by the introduction of a dual-lumen draw and return...
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PMID: 21924145
PDF is available here.
Abstract
Patients undergoing elective percutaneous coronary intervention (PCI) are generally observed overnight in the hospital. The association between same-day discharge of older patients and death or readmission is unclear.
To evaluate the prevalence and outcomes of same-da...
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PMID: 21972308
PDF is available here.
Abstract
Injectable hydrogels are being developed as potential translatable materials to influence the cascade of events that occur after myocardial infarction. These hydrogels, consisting of both synthetic and natural materials, form through numerous chemical crosslinking and assembly mechan...
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PMID: 21710332
PDF is available here.
Abstract
To establish a tissue engineering therapy for the treatment of large tympanic membrane perforation (TMP) without the need for conventional surgical therapy.
Randomized control trial.
General hospital.
A total of 63 chronic TMPs were ran...
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PMID: 21897328
PDF is available here.
Abstract
We would like to report our experience of using rituximab in cyclophosphamide refractory, rapidly progressive interstitial lung disease (ILD) in a patient with limited scleroderma. A 40-year-old man presented with 10-week history of inflammatory polyarthritis, which responded to a short course of or...
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PMID: 21593063
PDF is available here.
Abstract
We provide an updated look at the clinical data on immunotherapeutic interventions, which potentiate the immune system's response to lung tumor cells.
We searched articles on PubMed and abstracts from recent oncology meetings for publications on immunotherapies with clinical applicab...
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PMID: 21876456
PDF is available here.
Abstract
We describe two patients treated with sodium thiosulfate with good results. Moreover, we also performed a PubMed literature search of sodium thiosulfate treatment for calciphylaxis. We found 41 cases of which most (90%) presented a rapid and sustained resolution, indicating this drug is a very good...
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PMID: 21834598
PDF is available here.
Abstract
Hypertension is an important cardiovascular risk factor for the development of atrial fibrillation (AF). Increased atrial electromechanical coupling time interval measured by tissue Doppler is accepted as an important factor for prediction of AF development in hypertensive patients....
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PMID: 21983766
PDF is available here.
Abstract
We conducted a single-center, randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to receive cytisine or matching placebo for 25 days; participants in both groups received a minimal amount of counseling during the study. The primary outcome measure was sustained,...
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PMID: 21991893
PDF is available here.
Abstract
Therapeutic methotrexate serum concentrations (30-100µmol/l) were achieved in 72.5% of the cases. Repeated treatments resulted similar serum levels. Hepatotoxicity and hypoproteinemia occurred in 17% and in 48.9% of the cases. There was significant correlation between serum 7-hydroxi-methotrexate a...
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PMID: 21945870
PDF is available here.
Abstract
Persistence of postintubation esophago-tracheal fistulas is a difficult therapeutic problem. Authors present and discuss two successfully operated cases. Surgical reconstruction was done via left lateral cervical approach, including dissection of the fistulous tract, closure of the d...
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PMID: 21945871
PDF is available here.
Abstract
We describe a modified form of WBT which has been applied for the first time to children suffering from emotional and behavioral disorders in order to test its feasibility and potential effects in reducing symptoms and in improving new skills. Four cases particularly interesting by a clinical point...
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PMID: 21938080
PDF is available here.
Abstract
Relief of post-operative pain has a bearing on the patient's well-being, mobilisation and time confined to bed. The article discusses indications, contraindications and the efficacy of the various treatment modalities.
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PMID: 21946595
PDF is available here.
Abstract
We describe a child with a grade III traumatic lesion of the pancreas, who was successfully treated conservatively. Furthermore, we discuss diagnostic and treatment strategies of paediatric pancreatic injuries....
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PMID: 21936978
PDF is available here.
Abstract
We report the case of a 17-year-old patient with HI who presented with bilateral juvenile idiopathic arthritis of the hips who underwent bilateral total hip replacements. Our standard operative and postoperative regime was followed and no complications occurred. One year after the second procedure o...
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PMID: 21936072
PDF is available here.
Abstract
Hepatic encephalopathy (HE) is a common and serious complication of liver disease. Minimal HE has major impact on all aspects of a patient's life. The aim of this study was to asses the efficacy of probiotics in minimal hepatic encephalopathy in patients with cirrhosis of the liver.
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PMID: 21922877
PDF is available here.
Abstract
Aprotinin was a commonly used pharmacological agent for homeostasis in cardiac surgery but was discontinued, resulting in the extensive use of lysine analogues. This study tested the hypothesis that early postoperative adverse events and blood product utilization would affected in this post-aprotinin...
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PMID: 21911820
PDF is available here.
Abstract
Evidence supporting the use of bioprostheses for heart valve replacement in young adults is accumulating. However, reoperation data, which may help guide clinical decision making in young patients, remains poorly defined in the literature.
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PMID: 21911822
PDF is available here.
Satoshi S Kainuma,
Kazuhiro K Taniguchi,
Takashi T Daimon,
Taichi T Sakaguchi,
Toshihiro T Funatsu,
Haruhiko H Kondoh,
Shigeru S Miyagawa,
Koji K Takeda,
Yasuhiro Y Shudo,
Takafumi T Masai,
Shinichi S Fujita,
Masami M Nishino,
Yoshiki Y Sawa and
Abstract
It remains controversial whether restrictive mitral annuloplasty (RMA) for functional mitral regurgitation (MR) can induce functional mitral stenosis (MS) that may cause postoperative residual pulmonary hypertension (PH).
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PMID: 21911824
PDF is available here.
Leslee J LJ Shaw,
Jennifer H JH Mieres,
Robert H RH Hendel,
William E WE Boden,
Martha M Gulati,
Emir E Veledar,
Rory R Hachamovitch,
James A JA Arrighi,
C Noel Bairey CN Merz,
Raymond J RJ Gibbons,
Nanette K NK Wenger,
Gary V GV Heller and
Abstract
There is a paucity of randomized trials regarding diagnostic testing in women with suspected coronary artery disease (CAD). It remains unclear whether the addition of myocardial perfusion imaging (MPI) to the standard ECG exercise treadmill test (ETT) provides incremental information to improve clini...
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PMID: 21844080
PDF is available here.
Abstract
Although localized delivery of biocomposite materials, such as calcium hydroxyapatite (CHAM), have been demonstrated to potentially attenuate adverse left ventricular (LV) remodeling after myocardial infarction (MI), the underlying biological mechanisms for this effect remain unclear. This study test...
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PMID: 21911817
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We previously showed that adenoviral-delivered overexpression of an endogenous inhibitor, the tissue inhibitor of metalloproteinases-3 (TIMP-3), significantly retarded intimal thickening in short-term autologous porcine arteriovenous interposition grafts (28 days). However, it is essential to determ...
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PMID: 21911803
PDF is available here.
Circulation (124)11 Suppl 2011
Mei Huang,
Patricia Nguyen,
Fangjun Jia,
Shijun Hu,
Yongquan Gong,
Patricia E de Almeida,
Li Wang,
Divya Nag,
Mark A Kay,
Amato J Giaccia,
Robert C Robbins and
Joseph C Wu
Abstract
We performed a cell trafficking experiment, which demonstrated significantly greater recruitment of bone marrow cells to the ischemic myocardium in the double-knockdown group. Fluorescence-activated cell sorting showed significantly higher activation of endogenous c-kit(+) cardiac progenitor cells....
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PMID: 21911818
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We used bioinformatics analysis and experimental validation assays to show that Bim, a critical apoptotic activator, is an important target gene of the microRNA cocktail, which collectively can bind to the 3'UTR region of Bim and suppress its expression.
We have demonstrated that a m...
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PMID: 21911815
PDF is available here.
Abstract
Surgical Obstructive Jaundice can be life-threatening. Management of these patients can be a major diagnostic and therapeutic challenge.
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PMID: 21913546
PDF is available here.
Abstract
Nearly 90% of the diabetic patients are suffering of type 2 diabetes while approximately 60-65% of patients with type 2 diabetes are treated with oral antidiabetic drugs. In the last couple of years a new treatment option, namely incretin-based therapy, became available. The dipeptid...
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PMID: 21893477
PDF is available here.