Abstract
The congress of Asco made the object of numerous summaries of congress made in the heat of the moment and the Bulletin du Cancer decided to ask to his editorial board, a digested summary, at distance of the congress, to try to sum up the data of the congress which are going to change practice. Of th...
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PMID: 21220230
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Abstract
Carcinoid tumors (CTs) represent the most common type of neuroendocrine tumors (NETs). Digestive CTs in the gastroduodenal and colorectal tracts may be assessed using endoscopy and echoendoscopy or endoscopic ultrasonography (EUS) with the goal of attempting local resection with curative intent with...
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PMID: 21039065
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Abstract
We therefore evaluated the diagnostic usefulness of forceps with a larger-sized cup and compared this with standard forceps for biliary biopsy.
This prospective study included consecutive patients with extrahepatic biliary strictures who underwent retrograde biliary biopsy between March 2005 and Mar...
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PMID: 20886402
PDF is available here.
Abstract
The image registrations were technically successful in all but one patient, who had severe scoliosis. The remaining 13 biopsy procedures yielded diagnostic results, which were positive for malignancy in 10 cases and negative in three cases. CONCLUSION: PET/CT-guided abdominal biopsy with use of prio...
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PMID: 20574103
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Abstract
PJS patients are markedly at risk for several malignancies, in particular gastrointestinal cancers and breast cancer. On the basis of these elevated risks, a surveillance recommendation is developed to detect malignancies in an early phase and to remove polyps that may be premalignant and may cause...
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PMID: 20051941
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Abstract
Survival following cancers of the colon and rectum has increased continuously over the observed period, yet Danish patients fall behind those in the other Nordic countries. The largest inter-country variation is seen for the rare cancers in the small intestine. There has been little increase in prog...
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PMID: 20491524
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Abstract
Alcohol consumption increases mortality from esophageal cancer and colon cancer in men....
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PMID: 20234107
PDF is available here.
Abstract
Somatostatin receptor imaging (SRI) with [(111)In-DTPA(0)]octreotide has proven its role in the diagnosis and staging of gastroenteropancreatic neuroendocrine tumors (GEPNETs). Newer radiolabeled somatostatin analogs which can be used in positron emission tomography (PET) imaging, and which have a h...
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PMID: 19995807
PDF is available here.
Abstract
Systemic therapy is one of a number of treatment options routinely used in the management of advanced, unresectable neuroendocrine tumours (NETs). In contrast to many of the other NET treatment modalities, there is at least some evidence base to justify its use. Even so, well-designed clinical trial...
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PMID: 20008097
PDF is available here.
Abstract
CTAP was performed by bolus tracking without failure in any of the patients. The mean scan start times in the normal liver group and liver cirrhosis group were 14.3 +/- 1.34 s and 18.5 +/- 2.46 s, respectively, which were significantly different from each other. The detection rates of HCC nodules fo...
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PMID: 20182850
PDF is available here.
Abstract
We also briefly describe the genetic basis of three other inherited states predisposing individuals to endocrine tumors, namely Carney's syndrome, hyperparathyroidism type 2 (HRPT2) and familial isolated pituitary adenoma (FIPA), which are related to inactivating mutations in the PRKAR1-alpha, HRPT2...
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PMID: 20669561
PDF is available here.
Abstract
Multiple endocrine neoplasia type 1 (MEN1) and type 2 (MEN2) are autosomal dominant inherited multiglandular diseases with familial and individual age-related penetrance and variable expression. The most frequent endocrine features of MEN1 are parathyroid involvement (> 95%), duodeno-pancreatic endo...
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PMID: 20669560
PDF is available here.
Abstract
Vacuolar H+-ATPases function in bone resorption, pH homeostasis and tumor metastasis, play an important role in regulating the extra- and intracellular pH (pHe and pHi) in various eukaryotic cells. Acidity is one of the main features of the tumors. The Vacuolar H+-ATPases are the primary responsible...
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PMID: 20385078
PDF is available here.
Abstract
We examined the expression of EBV latent membrane protein-1 (LMP-1) and EBV EBNA-2 as well as the immunohistochemical profile of AE-1/AE-3, vimentin, desmin, CK 5-6, smooth muscle actin (SMA), p63, S-100, p53 and CD-117 with the clinicopathological correlation of eight patients of sarcomatoid carcin...
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PMID: 21045407
PDF is available here.
Abstract
Neuroendocrine tumors of the digestive tract are relatively rare and comprise benign and malignant tumors. WHO classification system is based on recognized differences in morphology, function and clinical behavior. European Neuroendocrine Tumor Society(ENETS)proposed grading system and TNM classific...
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PMID: 19838017
PDF is available here.
Abstract
The results of the test on catalase in patients suffering from colorectal and gastric carcinoma indicate that the addition to the blood of the complex compound of Cu(II) significantly influences the activity of the enzyme in comparison with the control group in which the substance tested was not use...
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PMID: 19856872
PDF is available here.
Abstract
Histological classification of the neuroendocrine tumours ("carcinoids") of the alimentary tract, as well as the opinion on biological behaviour of these tumours, changed rapidly within the last decade. Advances in knowledge of cellular biology of the diffuse endocrine system and in clinical diagnos...
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PMID: 19764158
PDF is available here.
Abstract
Real time intraoperative confocal microscopy has significant potential application in detecting disease, and influencing decision-making at the time of surgery....
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PMID: 19387332
PDF is available here.
Abstract
Prior studies have suggested that the incidence of some neoplastic disorders, particularly malignant lymphoma and small intestinal adenocarcinoma, are increased in celiac disease. Earlier studies from the United Kingdom have also suggested a link between celiac disease and esophageal carcinoma, alth...
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PMID: 19340898
PDF is available here.
Abstract
In comparison with the CT scan, there was trend in favor of EUS/EUS-FNA for the superior diagnostic accuracy. EUS was distinctly superior to the CT scan in detecting the number of metastatic lesions. EUS-FNA was also useful to identify the nature of lesions that were too small to be characterized on...
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PMID: 18981929
PDF is available here.
Abstract
Contrast-enhanced CT defines the extent of thrombotic lesions, while the functional information from PET/CT characterizes the lesions. It appears that PET/CT may be helpful in the diagnosis of occult tumor thrombosis and its differentiation from VTE....
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PMID: 19432032
PDF is available here.
Abstract
I and phase II drug-metabolizing enzymes can be crucial factors in defining cancer of digestive system susceptibility. In this review our current knowledge about polymorphism in several of these genes is summarized....
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PMID: 19388522
PDF is available here.
Abstract
We did a retrospective review of 20 patients who underwent a palliative gastrojejunostomy as their primary surgical procedure. There were 10 patients in the laparoscopic group and 10 patients in the open one. We identified no significant difference between groups in mean surgery time (116 vs 116 min...
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PMID: 19280805
PDF is available here.
Abstract
This article reviews the use of minimally invasive surgical and endoscopic techniques in the field of surgical oncology. It reviews the indications and techniques of the use of minimally invasive surgery for several oncologic indications in general surgery. In particular, it reviews the currently pu...
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PMID: 19186231
PDF is available here.
Abstract
We found out that 25% of the anticancer prescriptions for digestive tumours in Tenon hospital are not known by the law of "Good Use". Half of these percentages were clearly recommended via the TNCD. The other half of these non-conform prescriptions were realized in an advanced disease in which there...
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PMID: 19258221
PDF is available here.
Abstract
A total of 6 of 60 patients (10%) who had cytoreductive surgery and hyperthermic intraperitoneal chemotherapy experienced VTE. All patients with VTE had extensive peritoneal disease and long durations of surgery: the median duration was 431 (range 330-683) minutes. Tachycardia (mean 104 beats/min) w...
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PMID: 19234647
PDF is available here.
Abstract
There is significant heterogeneity of MDR-related factors expression in LNMs of gastrointestinal carcinomas. Effective adjuvant chemotherapy after operation should target on the metastatic loci of the disease....
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PMID: 19563003
PDF is available here.
I I Borbath,
F F Jamar,
T T Delaunoit,
P P Demetter,
G G Demolin,
A A Hendlisz,
P P Pattyn,
M M Peeters,
G G Roeyen,
E E Van Cutsem,
Ph P Van Hootegem,
J L JL Van Laethem,
C C Verslype and
S S Pauwels
Abstract
We will review some of the most regularly observed false positive and false negative cases and provide clues to recognize and manage them properly. Particularly, the value of chromogranin-A as a serum tumour marker and Somatostatin receptor scintigraphy as an imaging test, are reviewed. Indeed, chro...
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PMID: 19402368
PDF is available here.
Abstract
The subperitoneal space is a large, unifying, anatomically continuous potential space that connects the peritoneal cavity with the retroperitoneum. This space is formed by the subserosal areolar tissue that lines the inner surfaces of the peritoneum and the musculature of the abdomen and pelvis. It...
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PMID: 20080454
PDF is available here.
Abstract
We begin with lessons learned from thalidomide as an effective single drug with multiple mechanisms of action to treat multiple myeloma. Examples of "supplements" or integrative therapy will be drawn from arsenic trioxide, medicinal mushrooms including Coriolus vesicular and Ganoderma lucidum, follo...
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PMID: 20008216
PDF is available here.
Abstract
The maximum tolerated dose (MTD) for untreated patients was irinotecan 65 mg/m(2) while the MTD for previously treated patients was irinotecan 40 mg/m(2). Neutropenia and diarrhea were the major dose-limiting toxicities. Antitumor activity was noted in gastric, esophageal and pancreatic cancers. CON...
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PMID: 19219674
PDF is available here.
Abstract
We conclude that the routine use of positive oral contrast material is unnecessary for follow-up multidetector CT for general oncology indications.
(c) RSNA, 2009....
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PMID: 19092097
PDF is available here.
Abstract
We present here clinical, immunological, and molecular findings of four patients with CD40 ligand deficiency associated with neuroendocrine carcinoma (NEC). NEC developed as a rapidly disseminated solid cancer leading to death in three patients. Data presented here and published previously suggest t...
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PMID: 18805740
PDF is available here.
Abstract
Seventy-seven patients were treated; 18 received chemoinfusion only. The treatment-related mortality rate was 7%. The overall response rate was 80% for patients with carcinoid or islet cell neoplasms. Median progression-free survival was 19 months. Median disease-specific survival was 39 months from...
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PMID: 19040993
PDF is available here.
Abstract
High-intensity contact ultrasound (HICU) under MRI guidance may provide minimally invasive treatment of endocavitary digestive tumors in the esophagus, colon or rectum. In this study, a miniature receive-only coil was integrated into an endoscopic ultrasound applicator to offer high-resolution MRI g...
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PMID: 19205075
PDF is available here.
Abstract
Loss of p27 and overexpression of cyclin E play a critical role in the aggressiveness of gastroenteropancreatic neuroendocrine tumors. This coincides with increased cell cycle progression. We propose a discussion whether to incorporate the immunohistochemical expression of p27 into a revised classif...
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PMID: 19010853
PDF is available here.
Abstract
Direct-PEG may be superior to the Pull-PEG method for a high-volume cancer center because of reduced risks of infection....
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PMID: 18954787
PDF is available here.
Abstract
The diffuse endocrine system (DES) includes a wide range of secretory cells that may be the source of tumours. Gastroenteropancreatic endocrine (GEP) tumours arising within the DES secrete a variety of peptides and amines that are found in the circulation and are responsible for the syndromes associ...
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PMID: 18941127
PDF is available here.
Abstract
The most common etiologies of obstructive jaundices were neoplasia and then common bile duct stone in the two genders. The results of ultrasonography were positive in less than half of the patients. However, the most positive results were related to endoscopic retrograde cholangiopancreatography (ER...
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PMID: 18842499
PDF is available here.
Yong Jiang,
Zi-Lin Huang,
Pei-Hong Wu,
Fu-Jun Zhang,
Ming Zhao,
Jin-Hua Huang,
Wei-Jun Fan,
Chuan-Xing Li,
Yang-Kui Gu,
Liang Zhang,
Fei Gao and
Wang Li
Abstract
Seventeen patients had pain caused by metastatic lymph nodes and 13 of them had the pain relieved at 5-14 days after 125I implantation, with a response rate of 76.5%. Of the 47 patients, 38 (80.9%) achieved complete remission (CR), 4 (6.4%) achieved partial remission (PR), 3 (4.3%) had no change (NC...
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PMID: 18851789
PDF is available here.
Abstract
The MSI was higher in TNM stage I + II than in stage III + IV of gastric, colonic and gallbladder carcinomas. The LOH was higher in TNM stage III + IV than in stage I + II of gastric, colonic and hepatocellular carcinomas. Lymphatic metastasis was also observed. The expression of nm23H1 protein was...
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PMID: 18810774
PDF is available here.
Abstract
Gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms, although their prevalence has increased substantially over the past three decades. Moreover, there has been an increased clinical recognition and characterization of these neoplasms. They show extremely variable biologic...
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PMID: 18803349
PDF is available here.
Abstract
Interest in confocal laser endomicroscopy and in-vivo diagnosis of gastrointestinal disorders has increased in the last few years. Confocal laser endomicroscopy can localize intraepithelial neoplasia in chronic ulcerative colitis and enable 'smarter' mucosal biopsy when combined with chromoendoscopy...
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PMID: 19122507
PDF is available here.
Abstract
Heavy alcohol consumption is associated with increased risk of cancers including digestive tract, liver, pancreas, colorectum and breast. Direct correlations between alcohol consumption and development of cancer are still unknown. The differences in activities of ADH and ALDH between cancer tissues...
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PMID: 18942344
PDF is available here.
Abstract
We found that haplamine showed significant antiproliferative efficacy on resistant SW620 colorectal cells, whereas the reference drug 5-FU was ineffective (32 vs. 73 microM, p < 0.01 t- test), thus suggesting that haplamine could be of interest for treating digestive cancers resistant to standard fl...
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PMID: 18666046
PDF is available here.
Abstract
We examined the association of intake of total flavonoids and 7 flavonoid subclasses with risk of lung, colorectal, breast, pancreatic and upper aerodigestive cancer among women in a large prospective cohort study. Study participants were 34,708 postmenopausal women in the Iowa Women's Health Study...
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PMID: 18491403
PDF is available here.
L M Smith,
A Nesterova,
M C Ryan,
S Duniho,
M Jonas,
M Anderson,
R F Zabinski,
M K Sutherland,
H-P Gerber,
K L Van Orden,
P A Moore,
S M Ruben and
P J Carter
Abstract
CD133/prominin-1 is a pentaspan transmembrane glycoprotein overexpressed in various solid tumours including colorectal and glioblastomas. CD133 was found here to be highly expressed in >or=50% of pancreatic, gastric and intrahepatic cholangiocarcinomas. Quantitative flow cytometric analysis showed t...
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PMID: 18542072
PDF is available here.
Abstract
Surgery was performed on 24 patients with responsive disease (RD) after imatinib, on 3 with focal progressive disease (FP), and on 7 with generalized progressive disease (GP). All gross tumors were completely resected in 19/24 (79%), 1/3 (33%), and 1/7 (14%) patients, respectively. Disease status at...
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PMID: 18452195
PDF is available here.
Abstract
Two thirds of all neuroendocrine tumors (NET) are located in the gastroentero-pancreatic system. Depending on its localisation, each tumor presents a different histological pattern as well as different clinical symptoms and prognosis. Symptoms are usually due to the mass effects of the local tumor o...
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PMID: 18597210
PDF is available here.