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Pancreas (3):
Recent article
Pancreas
Abstract
We studied the effect of exercise training on islet and β-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted...
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PMID: 21810930
PDF is available here.
PDF is available here.
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Abstract
Abstract
Our simple culture system might offer the potential of a source of mature β cells....
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PMID: 21926540
PDF is available here.
PDF is available here.
Abstract
We studied Tregs in the pancreas and peripheral blood.
We recruited 44 patients with IgG4-related AIP. For comparison, we recruited 37 patients with other pancreatic diseases and 27 healthy subjects as controls. We studied infiltrating cells in the pancreas by immunohistochemistry an...
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PMID: 21926547
PDF is available here.
PDF is available here.
Abstract
We investigated whether interaction of ECs with mouse embryoid bodies (EBs) in culture promotes differentiation of pancreatic progenitors and insulin-producing cells and the mechanisms involved. We developed a co-culture system of mouse EBs and human microvascular ECs (HMECs). An increase in the exp...
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PMID: 21298405
PDF is available here.
PDF is available here.
Abstract
We cross-mated Akita mice with leptin-expressing transgenic (LepTg) mice to produce Akita mice with physiological hyperleptinemia (LepTg:Akita). Metabolic parameters were monitored for 10 months. Pair-fed studies and glucose and insulin tolerance tests were performed. The pancreata and kidneys were...
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PMID: 21810600
PDF is available here.
PDF is available here.
Abstract
Alcohol abuse is the leading etiologic factor of pancreatitis, although many heavy drinkers do not develop pancreatic damage. Alcohol promotes pancreatitis through a combination of remote (e.g., increased gut permeability to bacterial products such as lipopolysaccharide) and more pro...
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PMID: 21460613
PDF is available here.
PDF is available here.
Abstract
We report a miniseries of five cases treated surgically in our centre over a period of four years. A review of the literature is also discussed.
Patients undergoing pancreaticoduodenectomy over a four-year period were retrospectively reviewed. Patients with a confirmed histological d...
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PMID: 21546697
PDF is available here.
PDF is available here.
Abstract
We have developed a directed differentiation protocol to obtain insulin-producing cells from ESCs. The ESCs are first induced towards a homogeneous monolayer of definitive endoderm-like cells by co-culture with primary hepatocytes. Pancreatic commitment is induced by plating the ESC-derived endoderm...
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PMID: 20717889
PDF is available here.
PDF is available here.
Abstract
Abstract
We report several proteins and peptides that exhibit heightened degradation sensitivity, for instance superoxide dismutase in liver, and peptidyl-prolyl cis-trans isomerase and insulin C-peptides in pancreas. Tissue sampling based on snap freezing produces a greater amount of degradation products an...
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PMID: 20110281
PDF is available here.
PDF is available here.
Acta Physiologica (201)3 2011
Abstract
We specifically focus in this review on the impact of those adipocytokines on the modulation of insulin action in skeletal muscle.
© 2011 The Author. Acta Physiologica © 2011 Scandinavian Physiological Society....
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PMID: 21040498
PDF is available here.
PDF is available here.
Abstract
Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell so...
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PMID: 20589399
PDF is available here.
PDF is available here.
Abstract
We assessed the changes in the expression of selected genes essential for the function of these cells during Tregs generation.
The examined group consisted of 20 children with type 1 diabetes mellitus, the control group consisted of 20 non -diabetic children. From the peripheral bloo...
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PMID: 21722510
PDF is available here.
PDF is available here.
Abstract
We revisited the subclassification of AIP and examine whether this provides clinically and prognostically meaningful information. We evaluated 29 pancreatic resection specimens from patients with AIP. Demographic, clinical, and imaging data were recorded, as was evidence of extrapancreatic manifesta...
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PMID: 21164284
PDF is available here.
PDF is available here.
Ugeskrift for laeger (173)1 2011
Abstract
The course of acute pancreatitis is in the initial phase dominated by a systemic inflammatory response, later by local complications. A new classification defines three specific types of pancreatitis: 1) interstitial oedematous pancreatitis and 2) necrotizing pancreatitis with pancreatic parenchymal...
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PMID: 21199621
PDF is available here.
PDF is available here.
Abstract
Primary pancreatic leiomyosarcomas are rare lesions and not well described, yet they are the most common primary pancreatic sarcoma. English-language medical literature reports 29 cases as single cases or small series. A systematized nomenclature of medicine (SNOMED) search of Mayo Clinic surgical p...
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PMID: 21107091
PDF is available here.
PDF is available here.
Abstract
We evaluated the therapeutic potential of a novel small molecule GPR119 agonist, AS1535907, which was modified from the previously identified 2,4,6-tri-substituted pyrimidine core agonist AS1269574. AS1535907 displayed an EC50 value of 4.8 μM in HEK293 cells stably expressing human GPR119 and stimu...
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PMID: 20937249
PDF is available here.
PDF is available here.
Abstract
Insulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes. This article presents pilot study results of the dynamic insulin sensitivity and secretion test (DISST), a high-resolution, low-intensity test to diagnose insulin sensitivity (IS) and characterize...
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PMID: 21129337
PDF is available here.
PDF is available here.
Abstract
We rely on data generated by sequencing the genomes of seven pancreatic cancer metastases to evaluate the clonal relationships among primary and metastatic cancers. We find that clonal populations that give rise to distant metastases are represented within the primary carcinoma, but these clones are...
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PMID: 20981102
PDF is available here.
PDF is available here.
Journal of Trauma (69)5 2010
Abstract
Abstract
Endoscopic ultrasound (EUS) is often used to detect the cause of acute pancreatitis (AP) after the acute attack has subsided. The limited data on its role during hospitalization for AP are reviewed here. The ability of EUS to visualize the pancreas and bile duct, the sonographic appearance of the pa...
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PMID: 20954274
PDF is available here.
PDF is available here.
Abstract
To evaluate long-term endocrine and exocrine pancreatic function, quality of life and health care costs after mild acute pancreatitis and severe acute pancreatitis (SAP).
Patients prospectively included in 2001-2005 were followed-up after 42 (36-53) mo. Pancreatic function was evaluated with laborat...
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PMID: 20954281
PDF is available here.
PDF is available here.
Abstract
We will therefore present new insights into beta-cell development with focus on beta-cell regeneration.
Copyright © 2010 Elsevier Ltd. All rights reserved....
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PMID: 20688184
PDF is available here.
PDF is available here.
Abstract
Medical Journal of Australia (193)7 2010
Abstract
We describe a patient who developed inflammation and fibrosis in multiple organs over 20 years, sequentially involving his pancreas, bile ducts, gallbladder, submandibular and lacrimal glands, and kidneys. He had an elevated serum IgG4 level. Retrospective analysis of biopsies showed strongly positi...
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PMID: 20919976
PDF is available here.
PDF is available here.
Abstract
We report the case of a 67-year-old asymptomatic man who had a 1.3-cm, incidentally detected, pancreatic tail mass. The mass was round, well-circumscribed, and hypervascular with uniform enhancement. The image findings were highly suggestive of a pancreatic endocrine neoplasm. An endoscopic ultrasou...
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PMID: 20923303
PDF is available here.
PDF is available here.
European Journal of Pharmacology (643)2-3 2010
Abstract
Acute pancreatitis is a sudden inflammation of the pancreas that may be life threatening disease with high mortality rates; particularly in presence of systemic inflammatory response and multiple organ failure despite of the conventional antibiotic and symptomatic treatment. Oxidative stress has bee...
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PMID: 20599924
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Abstract
We have scrutinized available data with regard to the effect of every drug of the class on glycemic outcomes. Experimental data describing mechanisms through which these drugs potentially modify the metabolism of carbohydrates have been described. In order to identify statins which may be preferenti...
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PMID: 20507274
PDF is available here.
PDF is available here.
Abstract
We present a system that combines image segmentation and information visualization principles for an integrated analysis of fluorescence micrographs of tissue samples. The analysis aims at the detection and annotation of cells of the Islets of Langerhans and the whole pancreas, which is of great imp...
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PMID: 19969439
PDF is available here.
PDF is available here.
Abstract
Southern Medical Journal (103)9 2010
Abstract
Among exocrine pancreatic tumors, adenosquamous carcinoma (ASC) is a rare, aggressive subtype with a worse prognosis and a higher potential for metastases compared to its more conventional glandular counterpart, adenocarcinoma. The disease distribution shows an approximately 1:1 male/female ratio an...
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PMID: 20697320
PDF is available here.
PDF is available here.
Abstract
Birth under water has become a widely disseminated technique that is promoted to improve the quality of labor. The case of a 42-week gestation male infant is reported who died of respiratory and multiorgan failure secondary to florid pneumonia and sepsis due Pseudomonas aeruginosa following a water...
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PMID: 20436337
PDF is available here.
PDF is available here.
Abstract
Abstract
To explore the significance of the expression of carcinoembryonic antigen receptors (CEAR) in digestive organs.
Specimens were procured from 20 male BALB/c mice including esophagus, small intestine, stomach, colon, pancreas, and liver. Kupffer cells were obtained by d...
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PMID: 20737316
PDF is available here.
PDF is available here.
Abstract
The beneficial role of dietary restriction (DR) was studied in streptozotocin (STZ)-induced diabetes in mice. The DR mice exhibited the lower blood glucose (mg/dl) level as compared to ad libitum (AL) fed ones. After 3 months' DR, STZ treatment to both AL and DR mice showed significant (p < 0.001) e...
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PMID: 21174954
PDF is available here.
PDF is available here.
Cancer Letters (295)1 2010
Abstract
The present study was undertaken to estimate the therapeutic benefit to down-regulate the MUC4 mucin for reversing chemoresistance of pancreatic cancer (PC) stem/progenitor cells and their progenies. The results have revealed that MUC4 mucin is overexpressed in CD133(+) and CD133(-) pancreatic cells...
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PMID: 20303649
PDF is available here.
PDF is available here.
Abstract
Abstract
We tested the effects of the irreversible arginase inhibitor (+)-S-2-amino-6-iodoacetamidohexanoic acid (AIHA) on L-arginine-induced acute pancreatitis.
The inhibitory effect of AIHA on arginase activity was tested on rat liver homogenate and purified bovine arginase. Male Wistar rats were administe...
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PMID: 20697209
PDF is available here.
PDF is available here.
Abstract
We aimed to establish the endoscopic pancreatic function test (ePFT) as a method that can safely obtain pancreatic fluid for mass spectrometric analysis from patients during upper endoscopy and to reproducibly identify pancreas-specific proteins.
We performed a sodium dodecyl sulfate-polyacrylamide...
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PMID: 20182389
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the relationship between IAPP expression and glucose homeostasis in pancreatectomized patients. Human pancreatic head tissues were collected from 46 pancreatic tumor patients. We divided the diabetic cases into two groups, patients with higher IAPP-expressing islets (DM-H) and patien...
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PMID: 20421596
PDF is available here.
PDF is available here.
Abstract
No patient with benign IPMN died within 5 years. Recurrences in the remnant pancreas were observed in 9 cases: 4 (4.9%) among the 81 cases of benign IPMNs and 5 (22.7%) among the 22 cases of CIS. All recurrences were considered as multicentric because none recurred at the true resection margin of th...
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PMID: 20434746
PDF is available here.
PDF is available here.
Abstract
We have generated and validated a mathematical model of type 1 diabetes pathophysiology in a well-characterized animal model of spontaneous type 1 diabetes, the non-obese diabetic (NOD) mouse. The model is based on an extensive survey of the public literature and input from an independent scientific...
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PMID: 20491795
PDF is available here.
PDF is available here.
Abstract
Laser ablation with a neodymium:yttrium aluminum garnet (Nd:YAG) laser can achieve a high rate of complete tissue necrosis and has been applied as a minimally invasive, palliative option in hepatocellular carcinoma, liver metastasis in colorectal cancer, and malignant thyroid nodules.
To assess the...
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PMID: 20541187
PDF is available here.
PDF is available here.
Abstract
We have previously generated a transgenic mouse strain (LSL-TβRI(CA)) containing a Cre-inducible constitutively active TGFβ type I receptor (Bartholin et al., 2008, Genesis 46: 724-731). Transgene expression depends on the excision of a floxed-transcriptional STOP (LSL, Lox-STOP-Lox) located upstr...
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PMID: 20645310
PDF is available here.
PDF is available here.
Abstract
These data suggest that CD133+ cells exhibit more aggressive behavior, such as increased cell proliferation, migration, and invasion, especially in the presence of pancreatic stromal cells. The targeting therapy for the interaction between CD133+ cancer cells and stromal cells may be a new approach...
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PMID: 20564084
PDF is available here.
PDF is available here.
Abstract
We have generated a conditional null allele. Homozygous germline deletion of Wls confirmed prenatal lethality and failure of embryonic axis formation. Deletion of Wls using Wnt1-cre phenocopied Wnt1 null abnormalities in the midbrain and hindbrain. In addition, conditional deletion of Wls in pancrea...
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PMID: 20614471
PDF is available here.
PDF is available here.
Abstract
We describe one of the underlying molecular mechanisms behind this observation. Incubation of these cells with IL-1beta at doses from 0.5 to 3.0 ng/ml caused significant cell death at 36 h. This was accompanied with marked increases in JNK and p38 phosphorylation together with increased levels of th...
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PMID: 20411335
PDF is available here.
PDF is available here.
Abstract
We report a 55-year-old woman with an asymptomatic pancreatic mass incidentally discovered on abdominal ultrasonography. Contrast-enhanced computed tomography (CT) showed a well-demarcated exophytic mass in the pancreatic head with prolonged and delayed enhancement. The mass showed hypointensity on...
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PMID: 20661701
PDF is available here.
PDF is available here.
Abstract
We have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral ad...
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PMID: 19851307
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We have found that insulin(+) cells are continuous with duct cells in the epithelium that makes up the hyperplastic ducts of both chronic pancreatitis and pancreatic cancer in humans. Therefore, we tested the hypothesis that both hyperplastic ductal cells and their associated insulin(+) cells arise...
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PMID: 20534672
PDF is available here.
PDF is available here.
Pediatric Research (68)1 2010
Abstract
Our objective was to determine whether protein restriction has a similar effect on the offspring in mice, and if this alters the capacity for beta cell regeneration after STZ. Pregnant Balb/c mice were fed a control (C) (20% protein) or an isocaloric LP (8% protein) diet during gestation. Pups were...
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PMID: 20386490
PDF is available here.
PDF is available here.
Abstract
Ventromedial hypothalamic lesions may change the expression of cell proliferation-related genes and neuron-related genes in a rat pancreas....
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PMID: 20118822
PDF is available here.
PDF is available here.
Abstract
The number of reports of laparoscopic hepato-biliary-pancreatic (HBP) surgery has gradually been increasing, however, because of the high degree of proficiency required, these operations have not been widespread. Laparoscopic HBP surgery results in reduced operative blood loss and early recovery com...
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PMID: 20662217
PDF is available here.
PDF is available here.
Abstract
Most pancreatic masses in VHL do not require annual surveillance. Arterial-phase CT improves mass detection, but many masses remain prospectively missed....
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PMID: 20657218
PDF is available here.
PDF is available here.
Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia.
Abstract
We have generated a rabbit polyclonal antibody (pAb849) against aa 424-443 of mCLCA1/2. In HEK293 cells transfected with mCLCA1; pAb849 detected two specific protein bands at approximately 125 kDa and 90 kDa, representing full-length precursor and N-terminal cleavage product, respectively. pAb849 al...
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PMID: 20385786
PDF is available here.
PDF is available here.
Abstract
We have previously shown that RYR inhibition reduces pathological intra-acinar protease activation, an early marker of pancreatitis. In this study, we examined whether pretreatment with the RYR inhibitor dantrolene attenuates the severity of caerulein-induced pancreatitis in mice. Immunofluorescent...
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PMID: 20448143
PDF is available here.
PDF is available here.
Abstract
We examined the influence of GDNF on the expression of neurogenin3 (Ngn3) and other transcription factors implicated in early beta-cell development, as well as on beta-cell proliferation during embryonic and early postnatal mouse pancreas development. Embryonic day 15.5 (E15.5) mouse pancreatic tiss...
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PMID: 20448145
PDF is available here.
PDF is available here.