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DNA Damage (2):
Recent article
DNA Damage
Journal of Biological Chemistry (286)44 2011
Abstract
We report here that testicular nuclear receptor 4 (TR4), a member of the nuclear receptor family, modulates DNA repair specifically through the transcription-coupled (TC) NER pathway but not the global genomic NER pathway. The level of Cockayne syndrome B protein (CSB), a member of the TC-NER pathwa...
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PMID: 21918225
PDF is available here.
PDF is available here.
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Abstract
We demonstrate that a single, site-specific, cyclobutane pyrimidine dimer leading-strand template lesion provides only a transient block to fork progression in vitro. The replisome remains stably associated with the fork after collision with the lesion. Leading-strand synthesis is then reinitiated d...
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PMID: 21998391
PDF is available here.
PDF is available here.
Abstract
A key to understanding the biological function(s) of the aryl hydrocarbon receptor (AHR) - a xenobiotic-activated receptor - is to identify its endogenous ligand(s). The discovery of a tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) as an endogenous, high affinity agonist of AHR filled...
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PMID: 21883026
PDF is available here.
PDF is available here.
Abstract
We show that ITC-induced apoptosis of oncogene-transformed cells involves thiol modification of DNA topoisomerase II (Top2) based on the following observations. 1) siRNA-mediated knockdown of Top2α in both SV40-transformed MEFs and Ras-transformed human mammary epithelial MCF-10A cells resulted in...
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PMID: 21828038
PDF is available here.
PDF is available here.
Abstract
Our aim was to construct and characterize (111)In-nuclear translocation sequence (NLS)-7G3, an Auger electron-emitting radioimmunotherapeutic agent that preferentially recognizes the expression of CD123 (interleukin-3 receptor [IL-3R] α-subchain) in the absence of CD131 (IL-3R β-subchain) displayed...
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PMID: 21816968
PDF is available here.
PDF is available here.
Molecular BioSystems (7)9 2011
Abstract
PELDOR (pulsed electron-electron double resonance) spectroscopy was applied to determine spin-spin distances in spin-labeled DNA duplexes (13-mer and 17-mer) containing the damaged sites 8-oxoguanine or uncleavable abasic site analogue tetrahydrofuran. The lesions were located in one...
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PMID: 21731955
PDF is available here.
PDF is available here.
Abstract
We examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombi...
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PMID: 21852501
PDF is available here.
PDF is available here.
Abstract
The paper deals with the samples of microorganisms isolated from biofilms of encrustation of 11 stationary points of monitoring on the vertical rock of biogeographical testing ground (island Galindez, Antarctic Region). They are presented by morphologically various forms of bacteria (n x 10(7) cells...
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PMID: 21809681
PDF is available here.
PDF is available here.
Abstract
The plasma proteome was analysed as a potential source of markers of radiosensitivity in patients treated with definitive radiotherapy for head and neck cancer.
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PMID: 21351848
PDF is available here.
PDF is available here.
Mutation Research (714)1-2 2011
Abstract
To investigate the mechanisms of the therapeutic action and drug resistance to the nitrogen mustard melphalan, melphalan-induced DNA damage repair and chromatin structure were examined along the p53, N-ras and d-globin gene loci in cells carrying different repair activities. In nucle...
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PMID: 21762707
PDF is available here.
PDF is available here.
Mutation Research (714)1-2 2011
Abstract
We have studied the ability of specialized DNA polymerases to substitute Pol I in DNA replication in Pseudomonas putida. Our results revealed that P. putida Pol I-deficient cells have severe growth defects in LB medium, which is accompanied by filamentous cell morphology. However, growth of Pol I-de...
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PMID: 21763330
PDF is available here.
PDF is available here.
Mutation Research (714)1-2 2011
Abstract
Much early work on environmental stress, including ionizing radiation and environmental toxins, emphasised their action on DNA and subsequent mutagenesis in long term effects including germ cell mutagenesis, carcinogenesis and trans-generational effect. However, recent studies are in...
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PMID: 21784086
PDF is available here.
PDF is available here.
Abstract
We recently identified that MSH2, a key DNA mismatch repair (MMR) protein integral to the suppression of tumorigenesis, is an NPM-ALK-interacting protein. In this study, we found in vitro evidence that enforced expression of NPM-ALK in HEK293 cells suppressed MMR function. Correlating with these fin...
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PMID: 21703420
PDF is available here.
PDF is available here.
Abstract
Cancer arises as a consequence of mutations in genomes of cancer cells, which over time allow them to proliferate and spread to distant sites. Large-scale sequencing of cancer genomes is revealing an increasing number of potential driver mutations that may allow specific targeting of cancer genes, pr...
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PMID: 21643984
PDF is available here.
PDF is available here.
Translational Research (157)6 2011
Abstract
Sirtuin 1 (SIRT1) is a longevity gene that protects cells against oxidative and genotoxic stress. This study aimed to investigate the associations of SIRT1 gene single nucleotide polymorphisms (SNPs), rs7895833, rs7069102, and rs2273773, with various laboratory data in 1279 Japanese...
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PMID: 21575918
PDF is available here.
PDF is available here.
Mutation Research (713)1-2 2011
Abstract
We show that hESC demonstrate high levels of endogenous reactive oxygen species (ROS) which can contribute to DNA damage and may arise from high levels of metabolic activity. To potentially counter genomic instability caused by DNA damage, we find that hESC employ two strategies: First, these cells...
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PMID: 21718709
PDF is available here.
PDF is available here.
Mutation Research (714)1-2 2011
Abstract
We carried out a systematic epistasis analysis between the RAD52-epistasis group genes and SGS1, MUS81, and RNH202, which encodes a subunit of RNase H2. Based on synthetic-fitness interactions and DNA damage sensitivities, we find that RAD52 is epistatic to MUS81 but not SGS1. In contrast, RAD54, RA...
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PMID: 21741981
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We investigate the mechanisms by which ETS fusions mediate their effects, and find that the product of the predominant ETS gene fusion, TMPRSS2:ERG, interacts in a DNA-independent manner with the enzyme poly (ADP-ribose) polymerase 1 (PARP1) and the catalytic subunit of DNA protein kinase (DNA-PKcs)...
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PMID: 21575865
PDF is available here.
PDF is available here.
Abstract
We performed comparative proteome analysis of lung tissue from patients with sporadic IPF (n = 14) and human donor lungs (controls, n = 10) using two-dimensional gel electrophoresis and MALDI-TOF-MS. Eighty-nine differentially expressed proteins were identified, from which 51 were up-regulated and 3...
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PMID: 21319792
PDF is available here.
PDF is available here.
DNA Repair (10)5 2011
Abstract
We show that FANCD2 deficient cells have a defective S-phase checkpoint after Hydrogen Peroxide (H(2)O(2)) induced oxidative damage. ATM dependent phosphorylation of FANCD2 at the S222 residue is necessary for normal S-phase checkpoint activation after oxidative stress, while FANCD2 monoubiquitinati...
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PMID: 21466974
PDF is available here.
PDF is available here.
médecine/sciences (27)5 2011
Abstract
Abstract
To investigate DNA methylation variation in human cells induces by B(a)P, and to explore the role of PARP1 during this process.
The changes of DNA methylation of 16HBE and its PARP1-deficient cells exposed to B(a)P (1.0, 2.0, 5.0, 10.0, 15.0, 30.0 µmol/L) were invest...
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PMID: 21756783
PDF is available here.
PDF is available here.
Mutation Research (713)1-2 2011
Abstract
We have investigated if the SNPs APE1 Asn148Glu, OGG1 Ser326Cys, and PARP-1 Val762Ala are associated to meningitis. The patient genotypes were investigated by PIRA-PCR or PCR-RFLP. DNA damages were detected in genomic DNA by Fpg treatment. IgG and IgA were measured from plasma and the cytokines and...
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PMID: 21651918
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to regulate the stability and DNA damage-independent act...
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PMID: 21415597
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We demonstrate that the absence of E2F1 leads to spontaneous DNA breaks and impaired recovery following exposure to ionizing radiation. E2F1 deficiency results in defective NBS1 phosphorylation and foci formation in response to DSBs but does not affect NBS1 expression levels. Moreover, an increased...
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PMID: 21512314
PDF is available here.
PDF is available here.
Abstract
We report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pathway in cells treated with DNA-damaging agents and est...
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PMID: 21490603
PDF is available here.
PDF is available here.
Mutation Research (722)1 2011
Abstract
We analysed the effect of ELF-MF on chromatin conformation in E. coli GE499 cells by the anomalous viscosity time-dependence (AVTD) technique. Possible genotoxic effects of the specific combination of static and ELF-MF, which has been proven to affect chromatin conformation, were investigated by a c...
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PMID: 21497670
PDF is available here.
PDF is available here.
Abstract
We investigated cytotoxic effect of solubilized single-walled CNTs (SWCNTs), which were dispersed in water by sodium dodesyl sulfate (SDS), in normal rat kidney epithelial cells (NRK-52E). SDS-SWCNT (0.125-10 μg/mL)-treated NRK-52E cells showed decreased cell viability and enhanced cytotoxicity mar...
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PMID: 21544732
PDF is available here.
PDF is available here.
Abstract
The intermolecular interactions of the photodamaged cyclobutane pyrimidine dimer (CPD) lesion with adjacent nucleobases in the native intrahelical DNA double strand are investigated at the level of density functional theory symmetry-adapted perturbation theory (DFT-SAPT) and compared to the original...
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PMID: 21452189
PDF is available here.
PDF is available here.
Mutation Research (722)1 2011
Abstract
We analyzed the effect of ELF on chromatin conformation in E. coli GE499 cells by the anomalous viscosity time dependence (AVTD) technique. Possible genotoxic ELF effects at the specific combination of static and ELF magnetic fields, that has been proven to have effects on chromatin conformation, we...
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PMID: 21453783
PDF is available here.
PDF is available here.
Abstract
Mutation Research (722)1 2011
Abstract
We used double mutant approach in D. melanogaster. We observed DNA damage as evident by changes in Comet assay DNA migration in cells of larvae of Oregon R(+) and single mutants of pre- (mei-9, mus201 and mus210) and post- (mei-41, mus209 and mus309) replication repair pathways and also in double mu...
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PMID: 21382505
PDF is available here.
PDF is available here.
Mutation Research (722)1 2011
Abstract
We have investigated the cyto- and genotoxic effects of single and multi-walled CNTs (SWCNTs, MWCNTs) and carbon black (CB) on the mouse macrophage cell line RAW 264.7. Specifically we have investigated inflammatory response, release of tumor necrosis factor-α (TNF-α), intracellular reactive oxyge...
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PMID: 21382506
PDF is available here.
PDF is available here.
Abstract
Mutation Research (722)1 2011
Abstract
N-Acyloxy-N-alkoxyamides (see structure 1, below) are direct-acting mutagens for which a QSAR has been established that predicts with accuracy their activity in the bacterial reverse-mutation assay (Ames test) in Salmonella typhimurium TA100. Steric bulk next to oxygen on the alkoxyl side-chain in st...
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PMID: 21356327
PDF is available here.
PDF is available here.
Mutation Research (711)1-2 2011
Abstract
Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons...
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PMID: 21376738
PDF is available here.
PDF is available here.
Mutation Research (711)1-2 2011
Abstract
We review the current state of knowledge on the role of ROS-induced oxidative stress in altering the genetic and epigenetic involvement during human carcinogenesis....
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PMID: 21419141
PDF is available here.
PDF is available here.
Abstract
We reported that RAGE is an important regulator of oxidative stress in pancreatic cancer cells. Upregulation of RAGE expression by the nuclear factor (NF)-κB pathway decreases reactive oxygen species (ROS)-induced oxidative injury. In contrast, suppression of RAGE expression increases pancreatic tu...
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PMID: 21317562
PDF is available here.
PDF is available here.
Cell Cycle (10)4 2011
Abstract
We report, that Chk1 co-localized with the nucleolar marker, fibrillarin in response to radiation-induced DNA damage in human cells. Interestingly, in vitro studies using GST pull down assays identified the dual-specificity serine/threonine nucleolar phosphatase Cdc14B as a Chk1 substrate. Furthermo...
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PMID: 21301228
PDF is available here.
PDF is available here.
Abstract
Our results suggested that apart from traditional end-points viz. growth parameters like root length, shoot length and dry weight, comet assay could also be included in a battery of tests for initial, rapid and effective selection of plants for restoration and phytoremediation of polluted sites....
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PMID: 21598787
PDF is available here.
PDF is available here.
Abstract
We have conducted an in vitro cell-based small interfering RNA (siRNA) screen of 500 genes aimed at identifying genes whose loss of expression alters tumor cell response to oxaliplatin. The siRNA screen identified twenty-seven genes, which when silenced, significantly altered colon tumor cell line s...
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PMID: 21169384
PDF is available here.
PDF is available here.
Abstract
High-fidelity replication of DNA, and its accurate segregation to daughter cells, is critical for maintaining genome stability and suppressing cancer. DNA replication forks are stalled by many DNA lesions, activating checkpoint proteins that stabilize stalled forks. Stalled forks may...
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PMID: 21278446
PDF is available here.
PDF is available here.
Abstract
(1) immediate decondensation if chromatin fibers concomitantly are induced to repel (e.g., through phosphorylation in the ooplasm) and (2) thiols freed from Zn(2+) are available to form disulfide bridges creating a superstabilized chromatin. Spermatozoa in the zinc rich prostatic fluid (in first eja...
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PMID: 21204594
PDF is available here.
PDF is available here.
Cell Cycle (10)3 2011
Abstract
We found that CK1ε has unique enzymatic activity on the serine residue in the DSG motif using a β-catenin N-terminal region as a substrate. We then examined whether CK1ε has activity on the DSG motif of Cdc25A. We found CK1ε directly phosphorylated Ser82 without any prior phosphorylation of Cdc2...
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PMID: 21252624
PDF is available here.
PDF is available here.
Abstract
These results suggest that oxidative stress caused by acute exercise induces an adaptive response responsible for the radioprotective effects of exercise training....
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PMID: 21326381
PDF is available here.
PDF is available here.
Abstract
We used fluorescence microscopy and 3-dimensional image analysis to compare mESC and differentiated cells, with regard to HR-mediated repair of spontaneous and X-ray-induced double-strand breaks (DSBs). Microscopic analysis of repair foci, flow cytometry, and functional assays of the major DSB repai...
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PMID: 20491544
PDF is available here.
PDF is available here.
Mutation Research (721)2 2011
Abstract
Genotoxicity of glue sniffing/huffing and tobacco use has been examined in 302 street boys (median age 13 years) and 50 age-matched control school boys who were neither tobacco nor glue users. All the street boys were tobacco users. In addition, 155 were addicted to gasp an industrial adhesive popula...
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PMID: 21281739
PDF is available here.
PDF is available here.
Mutation Research (711)1-2 2011
Abstract
This review describes the PARTRAC suite of comprehensive Monte Carlo simulation tools for calculations of track structures of a variety of ionizing radiation qualities and their biological effects. A multi-scale target model characterizes essential structures of the whole genomic DNA within human fib...
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PMID: 21281649
PDF is available here.
PDF is available here.
Abstract
We explored the cytogenetic potential of AZ, BZ, and LZ in human lymphocyte cultures, using an expanded sample set, administering the under-investigation medications at final concentrations equivalent to oral dosage. As a biomarker of genotoxicity we used sister chromatid exchanges, one of the most...
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PMID: 21265625
PDF is available here.
PDF is available here.
Mutation Research (721)2 2011
Abstract
We developed a modified protocol for the basic comet assay that increased efficiency without sacrificing assay reliability. A spreader was used to spread agarose-embedded cells on a slide, making the manipulation and processing of multiple samples easier. Using this technique, we are able to rapidly...
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PMID: 21262384
PDF is available here.
PDF is available here.
Mutation Research (727)1-2 2011
Abstract
The occurrence of cyanobacterial blooms has increased significantly in many regions of the world in the last century due to water eutrophication. These blooms are hazardous to humans, animals, and plants due to the production of cyanotoxins, which can be classified in five different groups: hepatotox...
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PMID: 21277993
PDF is available here.
PDF is available here.
Abstract
Novel discoveries in the DNA repair field have lead to continuous and rapid advancement of our understanding of not only DNA repair but also DNA replication and recombination. Research in the field transcends numerous areas of biology, biochemistry, physiology and medicine, making si...
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PMID: 21235357
PDF is available here.
PDF is available here.
Abstract
We identify a mechanism in which EZH2 expression-mediated downregulation of DNA damage repair leads to accumulation of recurrent RAF1 gene amplification in BTICs, which activates p-ERK-β-catenin signaling to promote BTIC expansion. We further reveal that AZD6244, a clinical trial drug that inhibits...
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PMID: 21215703
PDF is available here.
PDF is available here.
Abstract
We treated male CD-1 mice, New Zealand white rabbits and cynomolgus monkeys with MeOH (2.0 g/kg ip) and 6h later assessed oxidative damage to DNA, measured as 8-oxo-2'-deoxyguanosine (8-oxodG) by HPLC with electrochemical detection. We found no MeOH-dependent increases in 8-oxodG in lung, liver or k...
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PMID: 20950637
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)2 2011
Abstract
Pancreatic cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less than 5%. Current standard of care therapies offer little selectivity and high toxicity. Novel, tumor-selective approaches are desperately needed. Although prior work suggested that β-lap...
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PMID: 21224367
PDF is available here.
PDF is available here.
Abstract
We show that CAG/CTG tracts are stabilized in Saccharomyces cerevisiae by the alternative clamp loader/unloader Ctf18-Dcc1-Ctf8-RFC complex (Ctf18-RFC). Mutants in Ctf18-RFC increased all three forms of triplet repeat instability--expansions, contractions, and fragility--with effect over a wide rang...
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PMID: 21347277
PDF is available here.
PDF is available here.
Abstract
We here generated a mouse model with a conditional deletable Rad1(K185R) allele. The Rad1(K185) residue was found to be dispensable for Chk1 activation, DNA damage survival, and class switch recombination of immunoglobulin genes as well as recruitment of TLS polymerases during somatic hypermutation...
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PMID: 21304913
PDF is available here.
PDF is available here.
Abstract
We report that viral protein R (Vpr), which interacts with a uracil glycosylase, also counteracted A3G by diminishing the incorporation of uridine. However, this process resulted in activation of the DNA-damage-response pathway and the expression of natural killer (NK) cell-activating ligands. Our r...
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PMID: 21874023
PDF is available here.
PDF is available here.
Abstract
Abstract
We provide a description of the actual stage of knowledge of the nuclear structure of Trypanosoma cruzi. As an early divergent eukaryote, it presents unique and/or reduced events of DNA replication, transcription and repair as well as RNA processing and transport to the cytosol. Nevertheless, it sho...
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PMID: 21820560
PDF is available here.
PDF is available here.