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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neural Plate (0):
Recent article
Neural Plate
Abstract
We report the dynamic, autonomous formation of the optic cup (retinal primordium) structure from a three-dimensional culture of mouse embryonic stem cell aggregates. Embryonic-stem-cell-derived retinal epithelium spontaneously formed hemispherical epithelial vesicles that became patterned along thei...
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PMID: 21475194
PDF is available here.
PDF is available here.
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Abstract
We demonstrate that Tbx6-dependent regulation of Sox2 determines the fate of axial stem cells. In wild-type embryos, enhancer N1 of the neural primordial gene Sox2 is activated in the caudal lateral epiblast, and the cells staying in the superficial layer sustain N1 activity and activate Sox2 expres...
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PMID: 21331042
PDF is available here.
PDF is available here.
Abstract
I focus on the culture of the human hair follicle mini-organ, discussing both the practical issues involved and some possible research applications of this assay....
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PMID: 21042975
PDF is available here.
PDF is available here.
Developmental Cell (19)4 2010
Abstract
We report a cell-intrinsic mode of BMP response control executed by the membrane protein Jiraiya. In the Xenopus embryo, zygotic Jiraiya, expressed exclusively in the neuroectoderm, is essential and sufficient for limiting dorsal neural development, which is dependent on BMP signals. In animal cap a...
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PMID: 20951346
PDF is available here.
PDF is available here.
Experimental Cell Research (316)14 2010
Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages.
Abstract
We demonstrate that murine Klf7 gene expression is required for in vitro differentiation of neuroectodermal and mesodermal cells. Specifically, we show a correlation of Klf7 silencing with down-regulation of the neuronal marker microtubule-associated protein 2 (Map2) and the nerve growth factor (NGF...
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PMID: 20580711
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We show that neural tube closure in Xenopus depends on orthologs of two proteins: MID1, which is responsible for Opitz G/BBB syndrome in humans, and its paralog MID2. Depletion of the Xenopus MIDs (xMIDs) by morpholino-mediated knockdown disrupted epithelial morphology in the neural plate, leading t...
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PMID: 20534674
PDF is available here.
PDF is available here.
Abstract
We show that the retinoid receptor antagonist AGN193109 causes a posterior hindbrain defect in Xenopus, comparable to that seen in other vertebrates. We show that this defect arises during gastrulation. Blocking endogenous retinoid activity during gastrulation causes downregulation of the most 3' Ho...
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PMID: 20209433
PDF is available here.
PDF is available here.
Development (136)14 2009
Abstract
We effectively abolish FGF signaling in the anterior neural plate via deletion of three FGF receptor (FGFR) genes. Triple FGFR mutant mice exhibit a complete loss of the telencephalon, except the dorsal midline. Disruption of FGF signaling prior to and coincident with telencephalic induction reveals...
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PMID: 19542358
PDF is available here.
PDF is available here.
Abstract
We treated embryoblast-derived human embryonic stem cells (hESCs) with ICI 174,864, a delta-opioid receptor antagonist, and RU-486 (mifepristone), a P(4) receptor competitive antagonist. Both antagonists potently inhibited the differentiation of hESC into embryoid bodies, an in vitro structure akin...
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PMID: 18803462
PDF is available here.
PDF is available here.
Developmental Dynamics (238)4 2009
Abstract
We show that prior to RB differentiation, prdm1a overlaps extensively with the epidermal marker dlx3b but shows little overlap with the neuroectodermal markers sox3 and sox19a. Birthdating analysis reveals that the majority of RBs are born during gastrulation in zebrafish, suggesting that it is duri...
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PMID: 19301392
PDF is available here.
PDF is available here.
Prenatal Diagnosis (29)4 2009
Abstract
We describe the process of neural tube formation, discuss the cellular mechanisms involved and highlight recent findings that provide links between molecular signaling pathways and morphogenetic tissue movements....
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PMID: 19206138
PDF is available here.
PDF is available here.
Cytotherapy (11)7 2009
Abstract
Multipotent human neural stem cells (hNSC) have traditionally been isolated directly from the central nervous system (CNS). To date, as a therapeutic tool in the treatment of neurologic disorders, the most promising results have been obtained using hNSC isolated directly from the human fetal neuroec...
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PMID: 19903095
PDF is available here.
PDF is available here.
Abstract
We show that Cripto(-/-) embryos can still form functional neural stem cells that are able to differentiate and maintain a neural phenotype both in vivo and in vitro. These data suggest that signals emanating from the mesoderm and endoderm might not be essential for the formation and differentiation...
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PMID: 19247965
PDF is available here.
PDF is available here.
Abstract
A total of 42 preterm infants were divided into two groups: preterm infants with ROP and preterm infants without ROP. Preterm infants with ROP who had myopia showed increased lens thickness with similar anterior segment lengths compared to preterm infants without ROP and preterm infants with ROP who...
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PMID: 19496495
PDF is available here.
PDF is available here.
Abstract
We interrogate the NC-GRN in the lamprey, taking advantage of its slow development and basal phylogenetic position to resolve early inductive events, 1 regulatory step at the time. To establish regulatory relationships at the neural plate border, we assess relative expression of 6 neural crest netwo...
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PMID: 19104059
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)6 2008
Abstract
We investigated the function of Cdc42 in maintaining adherens junctions (AJs) and apical polarity in the Drosophila melanogaster neuroectodermal epithelium. About one third of cells exit the epithelium through ingression and become neuroblasts. Cdc42-compromised embryos lost AJs in the neuroectoderm...
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PMID: 19064670
PDF is available here.
PDF is available here.
Developmental Biology (324)1 2008
Abstract
We report the first attempt to define the specific contribution of the neuroectoderm to this inductive process in Xenopus. To this end we tested the ability of segments of the neural plate (NP), isolated from different axial levels, to induce the otic marker Pax8 when recombined with blastula stage...
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PMID: 18831968
PDF is available here.
PDF is available here.
Abstract
We report here the establishment of anteroposterior polarity and the formation of a primitive streak-like region in the embryoid body, dependent on local activation of the Wnt pathway. In this region, cells undergo an epithelial-to-mesenchymal transition and differentiate into mesendodermal progenit...
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PMID: 18983966
PDF is available here.
PDF is available here.
Human Reproduction (23)10 2008
Abstract
Our results show that CTAs, in addition to their role in germ cells, may be involved in early development of various types of somatic cells, and suggest that they are implicated in specific differentiation processes....
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PMID: 18611917
PDF is available here.
PDF is available here.
Developmental Dynamics (237)8 2008
Abstract
We analyzed their expression patterns in avian embryos by in situ hybridization, from embryonic day 1 to 3. Btg1 was distinctively expressed in the Hensen's node, the notochord, the cardiogenic mesoderm, the lens vesicle, and in the apical ectodermal ridge and mesenchyme of the limb buds. On the oth...
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PMID: 18651656
PDF is available here.
PDF is available here.
Abstract
We found marked apical accumulation of Rho in developing chick embryos undergoing folding of the neural plate during neural tube formation, with similar accumulation of activated myosin II. The timing of accumulation and biochemical activation of both Rho and myosin II was coincident with the dynami...
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PMID: 18337466
PDF is available here.
PDF is available here.
Brain Research Bulletin (75)2-4 2008
Abstract
We quantitatively analyzed the developing prospective neural and non-neural ectoderm during chicken gastrulation on semithin transverse sections. At stage PS8 (primitive streak stage 8 of Lopez-Sanchez et al. [C. Lopez-Sanchez, L. Puelles, V. Garcia-Martinez, L. Rodriguez-Gallardo, Morphological and...
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PMID: 18331890
PDF is available here.
PDF is available here.
Abstract
We show that midline exit also requires the stimulation of axon outgrowth by Stem Cell Factor (SCF, also known as Steel Factor). SCF is expressed by midline floor plate cells, and its receptor Kit, a receptor tyrosine kinase, is expressed by commissural axons. In Steel and Kit mutant mice, the major...
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PMID: 18304480
PDF is available here.
PDF is available here.
Developmental Biology (315)1 2008
Abstract
We show that expression of FoxI1e, a gene essential for normal ectoderm formation, is expressed regionally within the animal hemisphere, in a highly dynamic fashion. In situ hybridization shows that FoxI1e is expressed in a wave-like fashion that is initiated on the dorsal side of the animal hemisph...
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PMID: 18234171
PDF is available here.
PDF is available here.
Developmental Dynamics (237)3 2008
Abstract
We demonstrate that a key regulator of anterior neural plate patterning, the homeodomain transcriptional repressor Xanf1/Hesx1, can bind to the LIM-domain protein Zyxin, which is known to regulate cell morphogenetic movements via influence on actin cytoskeleton dynamics. Using a set of deletion muta...
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PMID: 18297730
PDF is available here.
PDF is available here.
Stem Cells (26)3 2008
Abstract
We have reported previously that hESC differentiate into cardiomyocytes when cocultured with a visceral endoderm-like cell line (END-2). Insulin/insulin-like growth factors and their intracellular downstream target protein kinase Akt are known to protect many cell types from apoptosis and to promote...
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PMID: 18096723
PDF is available here.
PDF is available here.
Developmental Biology (314)2 2008
Abstract
We directly tested BMP4's ability to induce RBs; beads soaked in either 1 or 10 ng/ml were able to induce RBs in cultured neural plate tissue. Conversely, RBs fail to form when neural plate tissue from embryos with decreased BMP activity, either from injection of noggin or a dominant negative BMP re...
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PMID: 18191829
PDF is available here.
PDF is available here.
Developmental Biology (314)2 2008
Abstract
We show that Xenopus Ena (Xena) is localized to apical adhesive junctions of neuroepithelial cells during neurulation and that Xena knockdown disrupts cell behaviors integral to neural tube closure. Changes in the shape of the neural plate as well as apical constriction within the neural plate are p...
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PMID: 18201691
PDF is available here.
PDF is available here.
Differentiation (76)2 2008
Abstract
We report the characterization of a stem-cell population isolated from tissue explants of rat amniotic membrane. Similar to mesenchymal stem cells, these amnion-derived stem cells (ADSCs) express the surface markers CD29 and CD90, but were negative for the lymphohematopoietic markers CD45 and CD11b....
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PMID: 17608732
PDF is available here.
PDF is available here.
Genes & Development (22)2 2008
Abstract
We demonstrate prospective and clonal isolation of neural rosette cells (termed R-NSCs), a novel NSC type with broad differentiation potential toward CNS and PNS fates and capable of in vivo engraftment. R-NSCs can be derived from human and mouse ESCs or from neural plate stage embryos. While R-NSCs...
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PMID: 18198334
PDF is available here.
PDF is available here.
Abstract
We will describe in vitro electroporation techniques that are useful to study the development of somites (and any other derivative of the primitive streak and epiblast), and discuss potential applications of these methods....
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PMID: 18485301
PDF is available here.
PDF is available here.
Abstract
We identified cold-inducible RNA binding protein (CIRP) as novel XTcf-3 specific target gene. Furthermore, we show that knockdown of XTcf-3 by injection of an antisense morpholino oligonucleotide results in a general broadening of the anterior neural tissue. Depletion of XCIRP by antisense morpholin...
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PMID: 18687117
PDF is available here.
PDF is available here.
Developmental Biology (313)1 2008
Abstract
We performed a detailed analysis of the regulation of the soxB1 gene, sox3, one of the earliest genes expressed in the neuroectoderm. Using ectodermal explant assays, we analyzed the role of BMP, Wnt and FGF signaling in the regulation of sox3 and the closely related soxB1 gene, sox2. Our results de...
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PMID: 18031719
PDF is available here.
PDF is available here.
Abstract
We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. SIGNIFICANCE:...
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PMID: 18446220
PDF is available here.
PDF is available here.
Abstract
We know very little about the mechanisms controlling Sox2 expression and thus neural plate identity. Here, we use electroporation for gain- and loss-of-function in the chick embryo, in combination with bimolecular fluorescence complementation, two-hybrid screens, chromatin immunoprecipitation, and r...
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PMID: 18184035
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
We performed microarray analysis to isolate genes regulated by canonical Wnt signaling and abundantly expressed in the anterior neuroectoderm at the early neurula stage. We identified xCyp26c, a Cyp26 (RA-metabolizing protein)-family gene. In situ hybridization showed xCyp26c expression restricted t...
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PMID: 18956319
PDF is available here.
PDF is available here.
Transplantation (84)11 2007
Abstract
Our findings suggest that intrinsic characteristics of mesenchymal cells may stimulate host inflammation, and thus may not represent an ideal donor source for transplantation to the adult brain....
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PMID: 18091528
PDF is available here.
PDF is available here.
Development (134)19 2007
Abstract
We have defined unique molecular signatures for each of the eight cells in the posterior-most two rows of the neural plate - rows I and II. Using a combination of morpholino gene knockdown, dominant-negative forms and pharmacological inhibitors, we tested the role of three signalling pathways in def...
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PMID: 17728350
PDF is available here.
PDF is available here.
Abstract
Our results indicate that BYHWD could exert a promotion effect on neurite outgrowth and differentiation of NEPs....
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PMID: 17982912
PDF is available here.
PDF is available here.
Development (134)11 2007
Abstract
We describe an ENU-induced mutation, limulus (lulu), which disrupts gastrulation and the organization of all three embryonic germ layers. Positional cloning and analysis of additional alleles show that lulu is a null allele of the FERM-domain gene erythrocyte protein band 4.1-like 5 (Epb4.1l5). Duri...
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PMID: 17507402
PDF is available here.
PDF is available here.
Abstract
We have subcutaneously injected mouse pluripotent ES cells containing a single freely segregating supernumerary human chromosome 21 (HSA21) into syngeneic mice, to generate transchromosomic teratomas. Transchromosomic cells and parental control cells were injected into opposite flanks of thirty mice...
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PMID: 18047653
PDF is available here.
PDF is available here.
Abstract
We performed real-time analysis by utilizing glutamate decarboxylase (GAD)67/green fluorescence protein (GFP) knock-in mice and an electroporation-based gene transfer of DsRed into the ganglionic eminence (GE) of a mouse embryo. Cortical interneurons show a diverse mode of migration. In coronal slic...
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PMID: 18494255
PDF is available here.
PDF is available here.
Abstract
We will focus on describing our recent studies on the laminar and area patterning of the mammalian neocortex. We describe a novel IgCAM, MDGA1, that is a unique laminar and area specific marker, and functional studies showing its influence on radial migration. We also describe time-lapse imaging stu...
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PMID: 18494257
PDF is available here.
PDF is available here.