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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Notochord (0):
Recent article
Notochord
Abstract
We have characterized chick smoothened expression pattern and have found that the PSM expresses both patched1 and smoothened Shh signal transducers. Upon notochord ablation, patched1, gli1, and fgf8 are down-regulated, whereas gli2 and gli3 are overexpressed. Strikingly, notochord-deprived PSM segme...
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PMID: 20615943
PDF is available here.
PDF is available here.
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Developmental Biology (340)2 2010
Abstract
We showed that disruption of the notochord and floor plate by diphtheria toxin (DTA)-mediated cell ablation did not disrupt nephrogenesis, but resulted in kidney fusions, resembling horseshoe kidneys in humans. Axial disruptions led to more medially positioned metanephric mesenchyme (MM) in midgesta...
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PMID: 20152829
PDF is available here.
PDF is available here.
Journal of Experimental Biology (213)Pt 7 2010
Abstract
We measured the expression level of the gene in the tissue compartments of the vertebrae, the collagen turned out to be 150 and 25 times more highly expressed in the notochord and compact bone respectively, relative to the expression in the trabecular bone. Gene expression was induced in response to...
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PMID: 20228357
PDF is available here.
PDF is available here.
Acta Cytologica (54)5 Suppl 2010
Abstract
We report a case of primary cervical chordoma of extranotochordal origin clinically presenting as a thyroid neoplasm. The cytomorphologic features of chordoma and its cytologic differential diagnoses are discussed.
An 82-year-old man presented with hoarseness of voice and difficulty in swallowing. H...
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PMID: 21053549
PDF is available here.
PDF is available here.
Abstract
We pursue novel investigations and treatment strategies for degenerative disc disease, how do we isolate these unique cells and what is the role of the primordial notochordal cell that may well linger within the NP far longer and perhaps in a different phenotypic appearance than previously thought?...
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PMID: 20587085
PDF is available here.
PDF is available here.
Cells Tissues Organs (192)2 2010
Abstract
We could track Noto-GFP-expressing cells from the tail bud over the tail cord to the caudal notochord, and confirm a morphological continuum from the tail bud mesenchyme to the caudal notochord. Loss of Noto affected tail bud morphogenesis: Noto-GFP-expressing cells were scattered in the tail bud me...
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PMID: 20197654
PDF is available here.
PDF is available here.
Abstract
This editorial addresses the debate concerning the origin of adult nucleus pulposus cells in the light of profiling studies by Minogue and colleagues. In their report of several marker genes that distinguish nucleus pulposus cells from other related cell types, the authors provide novel insights int...
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PMID: 20497604
PDF is available here.
PDF is available here.
médecine/sciences (25)10 2009
Abstract
Turkish Neurosurgery (19)3 2009
Abstract
We present a case of 22-year-old man who presented with headache and confusion. MR imaging and CT revealed intracranial ecchordosis physaliphora associated with intratumoral hemorrhage and vasogenic edema. The neurological findings resolved completely after medical therapy....
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PMID: 19621298
PDF is available here.
PDF is available here.
Developmental Biology (331)1 2009
Abstract
We report a novel function of PEM independently of its function in cleavage regulation; it controls cell fate by excluding competence to respond to the FGF signal for notochord induction from posterior-vegetal cells. PEM was found to regulate the nuclear accumulation of beta-catenin, an upstream act...
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PMID: 19406117
PDF is available here.
PDF is available here.
Abstract
There is a single postnatal growth spurt in the mouse IVD, between birth and 9 weeks of age. Cell proliferation was found in the nucleus pulposus (NP) and anulus fibrosus (AF) only until 3 weeks of age. Most of the postnatal growth of the IVD is due to accumulating extracellular matrix. NP cell numb...
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PMID: 19247165
PDF is available here.
PDF is available here.
Abstract
On profile radiographs of adults, an association between fusions of cervical vertebrae, deviations in the cranial base and mandibular retrognathia has been documented radiographically. An elaboration of this association on a histological level is needed. In human triploid fetuses severe mandibular r...
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PMID: 19161148
PDF is available here.
PDF is available here.
Developmental Dynamics (237)12 2008
Abstract
We now report the cloning and further characterization of one such mutant, gulliver(m208) (gul(m208)). The notochord defect in gul(m208) mutants is exacerbated under conditions of copper depletion or lysyl oxidase cuproenzyme inhibition that are without a notochord effect on wild-type embryos. The g...
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PMID: 19035365
PDF is available here.
PDF is available here.
Developmental Dynamics (237)12 2008
Abstract
We provide the first direct evidence that all cell types in the adult mouse nucleus pulposus are derived from the embryonic notochord. Additionally, rare isolated embryonic notochord cells remained in the vertebral column and resembled "notochordal remnants," which in humans have been proposed to gi...
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PMID: 19035356
PDF is available here.
PDF is available here.
Toxicological Sciences (106)1 2008
Abstract
We hypothesized that NaM-induced transcriptional changes during somitogenesis would reveal the major molecular targets in the zebrafish embryo. Embryos were exposed to NaM beginning at 4 hpf (1000 cells) and total RNA was isolated from embryos at the 3 somite (11 hpf), 10 somite (14 hpf), 18 somite...
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PMID: 18648088
PDF is available here.
PDF is available here.
Human Molecular Genetics (17)19 2008
Abstract
We have investigated the embryological cause of Zic2-associated HPE and the relationship between Zic2 and the Shh pathway using mouse genetics. We show that Zic2 does not interact with Shh to produce HPE. Moreover, molecular defects that are able to account for the HPE phenotype are present in Zic2...
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PMID: 18617531
PDF is available here.
PDF is available here.
Abstract
We describe herein 3 cases of incidental notochordal remnants identified in surgically removed adult intervertebral disks. Their histologic features were reminiscent of notochordal vestiges in the fetus. However, they raised the differential diagnosis of benign notochordal cell tumor and chordoma. N...
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PMID: 18545146
PDF is available here.
PDF is available here.
Developmental Dynamics (237)8 2008
Abstract
We analyzed their expression patterns in avian embryos by in situ hybridization, from embryonic day 1 to 3. Btg1 was distinctively expressed in the Hensen's node, the notochord, the cardiogenic mesoderm, the lens vesicle, and in the apical ectodermal ridge and mesenchyme of the limb buds. On the oth...
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PMID: 18651656
PDF is available here.
PDF is available here.
Development (135)14 2008
Abstract
We use Xenopus laevis, a system in which the polarized cell motility that drives this active cell intercalation has been related to the development of forces that close the blastopore and elongate the body axis, to examine the role of myosin IIB in convergence and extension. We find that myosin IIB...
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PMID: 18550716
PDF is available here.
PDF is available here.
Developmental Biology (318)2 2008
Abstract
We functionally characterized five notochord enhancers, whose sequence is highly conserved, and systematically mutated two of them. Two subregions were identified to be essential for expression in the notochord of the zebrafish embryo. Synthetic enhancers containing the two essential regions in fron...
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PMID: 18455719
PDF is available here.
PDF is available here.
Abstract
We examined the role of Tead genes by generating mouse mutants for Tead1 and Tead2. Tead2(-/-) mice appeared normal, but Tead1(-/-); Tead2(-/-) embryos died at embryonic day 9.5 (E9.5) with severe growth defects and morphological abnormalities. At E8.5, Tead1(-/-); Tead2(-/-) embryos were already sm...
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PMID: 18332127
PDF is available here.
PDF is available here.
Abstract
We review the dynamic patterns of cell behaviours in the marginal zone of amphibians with a focus on how the progressive nature and the geometry of these behaviours drive blastopore closure. Mediolateral cell intercalation behaviour and epithelial-mesenchymal transition are used in different combina...
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PMID: 18192174
PDF is available here.
PDF is available here.
Abstract
Shh expression in PME cells is involved in the pathogenesis of ethanol-induced HPE. Ethanol may impair Shh expression indirectly by activating PKA. The inhibition of excessive apoptosis in PME cells by antioxidants implies that oxidative stress may underlie the teratogenic actions of ethanol. Thus,...
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PMID: 18338389
PDF is available here.
PDF is available here.
Abstract
We present a case of nontumoral notochordal inclusions in vertebral bone marrow, giving rise to an MRI detectable lesion without osteolysis. MRI detection of such lesions may cause concern or overtreatment. Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cel...
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PMID: 18072879
PDF is available here.
PDF is available here.
Cell and Tissue Research (332)1 2008
Abstract
We have analyzed the spatial relationships between capillary networks and the localization of these molecules during mouse and chick development. ChM-I and TeM proteins have been localized to the PECAM-1-negative avascular region: ChM-I is expressed in the avascular cartilage, whereas TeM is detecta...
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PMID: 18239943
PDF is available here.
PDF is available here.
Abstract
We have thus taken advantage of these unique features of femtosecond laser-based TPLSM for vital 3D imaging in conjunction with advanced spatial-volume rendering modalities to compare morphologies of NCs/clusters from pig caudal discs with chondrocyte-like IVD cells from bovine caudal discs, both in...
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PMID: 18189326
PDF is available here.
PDF is available here.
Skeletal Radiology (37)4 2008
Abstract
Benign notochordal cell tumors may be found during routine clinical examinations and do not require surgical management unless they show extraosseous disease. These tumors should be recognized by radiologists, pathologists, and orthopedic surgeons to prevent operations, which usually are extensive....
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PMID: 18188556
PDF is available here.
PDF is available here.
Developmental Biology (316)1 2008
Abstract
We have determined the complete zebrafish collagen XV primary sequence and analysed its expression and function in embryogenesis. During the segmentation period, expression of the Col15a1 gene is mainly found in the notochord and its protein product is deposited exclusively in the peri-notochordal b...
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PMID: 18281032
PDF is available here.
PDF is available here.
Abstract
We have documented independent association of Vangl1 and Vangl2 gene mutations with NTDs. In the Looptail mouse, homozygosity (but not heterozygosity) for loss-of-function alleles at Vangl2 causes the severe NTD craniorachischisis, whereas heterozygosity for mutant variants of VANGL1 is associated w...
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PMID: 18296642
PDF is available here.
PDF is available here.
Histopathology (52)4 2008
Abstract
Abstract
We examined several candidate posterior/mesodermal inducing molecules using permanent blastula-type embryos (PBEs) as an assay system. Candidate molecules were injected individually or in combination with the organizer factor chordin mRNA. Injection of chordin alone resulted in a white hemispherical...
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PMID: 18318733
PDF is available here.
PDF is available here.
EMBO Journal (27)4 2008
WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation.
Abstract
We report the identification of the weak-similarity GEF (WGEF) gene by a microarray-based screen for notochord enriched genes, and show that WGEF is involved in Wnt-regulated convergent extension. Overexpression of WGEF activated RhoA and rescued the suppression of convergent extension by dominant-n...
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PMID: 18256687
PDF is available here.
PDF is available here.
Biological Bulletin (214)1 2008
Abstract
We have used confocal microscopy and BrdU labeling to examine the development of the Oikopleura notochord from hatching through adult stages. We show that as the notochord undergoes the typical urochordate transition from a stacked row of cells to a tubular structure, cell number begins to increase....
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PMID: 18258772
PDF is available here.
PDF is available here.
Abstract
We developed a simple operation method to ablate the SC completely and minimize the damage to the tadpole using Xenopus laevis. The SC-ablated tadpole regenerated a twisted and smaller tail. These morphological abnormalities were attributed to defects in the notochord (NC), as the regenerated NC in...
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PMID: 18211586
PDF is available here.
PDF is available here.
Abstract
We used comparative proteomics to identify PTRF (also called Cav-p60, Cavin) as a putative caveolar coat protein. PTRF-Cavin selectively associates with mature caveolae at the plasma membrane but not Golgi-localized caveolin. In prostate cancer PC3 cells, and during development of zebrafish notochor...
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PMID: 18191225
PDF is available here.
PDF is available here.
Abstract
We conclude that intradural extramedullary bronchiogenic cysts may appear also at lumbar levels. Surgical resection can be achieved with good outcome.
(c) 2008 S. Karger AG, Basel....
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PMID: 17728545
PDF is available here.
PDF is available here.
Abstract
Here, we reveal a potential role for Mek1/2 during notochord development by using the small molecule Mek1/2 inhibitor U0126 which blocks phosphorylation of the Mek1/2 target gene Erk1/2 in vivo. Applying the inhibitor from early gastrulation until the 18-somite stage produces a specific and consiste...
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PMID: 18419805
PDF is available here.
PDF is available here.
Abstract
We developed a knowledge database called "CINOBI: CionaNotochord and Brachyury-downstream gene Index" to create comprehensive catalogues of Brachyury-downstream gene sets in Ciona intestinalis. Combining genome and large-scale cDNA data, we were able to characterize 450 non-redundant Brachyury-downs...
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PMID: 18184356
PDF is available here.
PDF is available here.
Pediatric Neurology (38)1 2008
Abstract
A 2-year-old boy exhibited congenital right Horner's sign and right finger, wrist, and elbow flexion arthrogryposis. He had dyspnea and feeding difficulty 12 hours after birth. Radiologic examination revealed a thoracoabdominal intestinal tube and mediastinal cystic lesion at the right side, with ve...
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PMID: 18054693
PDF is available here.
PDF is available here.
Abstract
Concentrations of TATA box-binding protein (TBP)-type genes affect chordamesodermal gene expression.
Abstract
We show that the alteration of concentration of each TBP-type gene affected mutually one another's expression, suggesting that an optimal ratio of concentrations of TBP-type genes induce expression of specific genes....
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PMID: 18415937
PDF is available here.
PDF is available here.
Toxicology Letters (175)1-3 2007
Abstract
Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent pheno...
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PMID: 17890024
PDF is available here.
PDF is available here.
Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord.
Abstract
We describe two new Cre transgenic mouse lines, Foxa2 NFP-Cre and Nodal PNC-Cre, with activity in two organizer domains, the posterior notochord (PNC) and notochord. These lines were made using defined regulatory elements from the Foxa2 and Nodal genes that direct Cre expression in overlapping domai...
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PMID: 18064671
PDF is available here.
PDF is available here.
Developmental Biology (311)2 2007
Abstract
We show that early notochord development in Xenopus embryos is regulated by apoptosis. We find apoptotic cells in the notochord beginning at the neural groove stage and increasing in number as the embryo develops. These dying cells are distributed in an anterior to posterior pattern that is correlat...
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PMID: 17920580
PDF is available here.
PDF is available here.
Developmental Dynamics (236)11 2007
Abstract
We examine how beta-catenin coordinately affects gastrulation movements and dorsal mesoderm differentiation. The reduction of beta-catenin protein levels by morpholino oligonucleotides complementary to beta-catenin mRNA causes a disruption in gastrulation movements. Time-lapse imaging of beta-cateni...
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PMID: 17907203
PDF is available here.
PDF is available here.
Abstract
Oxidative stress significantly increased apoptosis of rat notochordal cells (2.1% vs. 4.75%, P = 0.008) and led to activations of initiators of intrinsic (caspases-9) and extrinsic (caspase-8) pathways as well as their common executioner (caspase-3). It also caused cleavages of Bid and PARP. Flow cy...
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PMID: 18090083
PDF is available here.
PDF is available here.
Abstract
We report here its genetic mapping using a microsatellite scan together with outcrosses to Mus spretus and M. castaneous followed by a subsequent testcross to T, T1, and T2 mutants. Surprisingly, tint interacts with T2 but not with T1. The implications of our data suggest that T2 may be part of the...
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PMID: 17954925
PDF is available here.
PDF is available here.
Abstract
We show that Noto is also essential for node morphogenesis, controlling ciliogenesis in the posterior notochord, and the establishment of laterality, whereas organizer functions in anterior-posterior patterning are apparently not compromised. In mutant embryos, left-right asymmetry of internal organ...
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PMID: 17884984
PDF is available here.
PDF is available here.
Abstract
We describe the cloning and expression of one member from each family in the zebrafish. A novel gene, vgl-2b, with closest homology to mouse and human vgl-2, is expressed transiently in nascent notochord and in muscle fibres as they undergo terminal differentiation during somitogenesis. Muscle cells...
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PMID: 17916448
PDF is available here.
PDF is available here.
Abstract
BNCTs were identified in 7.3% of sacral/coccygeal resections performed for primary chordoma. We speculate that this finding provides further evidence that BNCT is the precursor lesion for chordoma. Additional investigations are needed to further understand this relationship....
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PMID: 17895760
PDF is available here.
PDF is available here.
Developmental Dynamics (236)10 2007
Abstract
We demonstrate essential roles of C&E in slow muscle morphogenesis. During segmentation, the adaxial cells change shapes and migrate laterally to form slow muscles at the myotome surface. Using confocal imaging techniques, we show that the adaxial cells undergo three-step shape changes, including do...
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PMID: 17849437
PDF is available here.
PDF is available here.
Developmental Biology (309)2 2007
Abstract
We characterize an earlier set of adaxial cell behaviors; the transition from a roughly 4x5 array of cuboidal cells to a 1x20 stack of elongated cells, prior to the migration event. We find that adaxial cells display a highly stereotypical series of behaviors as they undergo this rearrangement. Furt...
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PMID: 17689522
PDF is available here.
PDF is available here.
Development (134)17 2007
Abstract
We investigated the molecular signals that regulate the formation of dorsolateral hinge points (DLHPs). We show that Bmp2 expression correlates with upper spinal neurulation (in which DLHPs are absent); that Bmp2-null embryos exhibit premature, exaggerated DLHPs; and that the local release of Bmp2 i...
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PMID: 17693602
PDF is available here.
PDF is available here.
Abstract
Chordoma and notochordal cells both expressed NGF as well as TrkA and p75 receptors. While the mean percentage of p75 receptor expression was very similar between chordoma and notochordal cells (P = 0.394), the mean percentages of TrkA and NGF expressions were significantly higher in chordoma cells...
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PMID: 17700442
PDF is available here.
PDF is available here.
Developmental Biology (308)2 2007
Abstract
We made use of a large-scale oligo-DNA microarray to further investigate and identify genes with specific or correlated expression profiles, and we report global gene expression profiles for about 66% of all the C. intestinalis genes that are expressed during its life cycle. We succeeded in categori...
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PMID: 17572404
PDF is available here.
PDF is available here.
Developmental Dynamics (236)8 2007
Abstract
We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over-bifurcation of yolk sac blood vessels, and late...
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PMID: 17654721
PDF is available here.
PDF is available here.
Abstract
We produced an Ab against the homeodomain protein Lim1 from X. laevis as a tool for the comparative analysis of development. By the expression of Lim1, we were able to identify the dorsal side of the G. riobambae early gastrula, which otherwise was difficult to detect. Moreover, the Lim1 expression...
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PMID: 17606898
PDF is available here.
PDF is available here.
Developmental Biology (307)2 2007
Abstract
We identified approximately 20,000 each ESTs (i. e. 10,000 clones each were sequenced from both 5' and 3' ends) of adult gonads, cleaving-embryos, gastrulae/neurulae, embryos before hatching, and hatched larvae of the anural ascidian Molgula tectiformis, in order to comprehensively investigate the m...
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PMID: 17540363
PDF is available here.
PDF is available here.
Developmental Biology (307)2 2007
Abstract
We now demonstrate that beta-aminopropionitrile, a known inhibitor of the copper-dependent lysyl oxidases, causes notochord distortion in the zebrafish embryo identical to that seen in copper deficiency. Characterization of the zebrafish lysyl oxidase genes reveals eight unique sequences, several of...
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PMID: 17543297
PDF is available here.
PDF is available here.
Journal of Cell Science (120)Pt 13 2007
Abstract
We have used zebrafish to examine the role of caveolin-1 and caveolae during early embryonic development. During development, expression is apparent in a number of tissues including Kupffer's vesicle, tailbud, intersomite boundaries, heart, branchial arches, pronephric ducts and periderm. Particular...
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PMID: 17550965
PDF is available here.
PDF is available here.