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Placenta (3):
Recent article
Placenta
Clinical Science (122)2 2012
Abstract
We aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused on the pathophysiological basis of the disease. Furthermore, we review stud...
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PMID: 21929511
PDF is available here.
PDF is available here.
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Abstract
Abstract
3 sets of monozygotic twins resulting from transfers of single embryos to recipient mares were examined.
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PMID: 21492048
PDF is available here.
PDF is available here.
Abstract
We therefore investigated expression of cell surface antigens on human term placenta-derived MSC (pMSC) in more detail and correlated expression pattern to the osteogenic differentiation capacity of the MSC. We report that pMSC expressed the typical cell surface antigens at levels comparable to bone...
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PMID: 21047215
PDF is available here.
PDF is available here.
Abstract
Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG 2011;118:624-628. Currently, there is no effective therapy for severe early-onset intrauterine growth restriction (IUGR). Sildenafil citrate vasodilates the myometrial arteries isolated from women...
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PMID: 21392225
PDF is available here.
PDF is available here.
Abstract
We analyzed gene expression in embryos of wild type mice and the Down Syndrome model Ts1Cje. Since current Down Syndrome screening markers are derived from placenta and fetal liver, these tissues were chosen as target.
Placenta and fetal liver at 15.5 days gestation were analyzed by...
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PMID: 21533146
PDF is available here.
PDF is available here.
Abstract
Presence of foreign tissue in a host's body would immediately lead to a strong immune response directed to destroy the alloantigens present in fetus and placenta. However, during pregnancy, the semiallogeneic fetus is allowed to grow within the maternal uterus due to multiple mechanisms of immune to...
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PMID: 20941623
PDF is available here.
PDF is available here.
Abstract
We report an H1N1 pandemic influenza 2009-positive female premature infant born at 32 weeks of gestation whose mother had a confirmed H1N1 2009 infection by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). This case suggests that H1N1 2009 virus might be transmitted across the pl...
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PMID: 21980848
PDF is available here.
PDF is available here.
Prenatal Diagnosis (31)1 2011
Abstract
To develop a model for prediction of spontaneous delivery before 34 weeks based on maternal factors, placental perfusion and function at 11-13 weeks' gestation.
Two groups of studies: first, screening study of maternal characteristics, serum pregnancy-associated plasm...
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PMID: 21210482
PDF is available here.
PDF is available here.
Abstract
We characterized by quantitative PCR, in situ hybridization and immunohistochemistry, the expression of four GPX (GPX1 to 4) in the placenta of normotensive (NP; n = 23) and PE pregnancies (n = 25) according to mode of delivery: vaginal delivery (with labor) or cesarean (without labor); the tissue l...
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PMID: 21145108
PDF is available here.
PDF is available here.
Abstract
We aim to provide an overview of the current knowledge on the ABCB1 and ABCG2 transporter expression profiles in the placenta and fetal tissues in humans relative to other species.
The available information on ABCB1 and ABCG2 temporal expression profiles in placenta and fetus indicates rather good c...
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PMID: 20738225
PDF is available here.
PDF is available here.
Clinical Chemistry (56)11 2010
Abstract
Abstract
Aromatase is the key enzyme for estrogen biosynthesis and is encoded by Cyp19 gene. Placental cotyledons are the main site of Cyp19 gene expression during pregnancy. The present study was aimed to investigate if DNA methylation and thus epigenetic mechanisms play a potential role in stage-specific r...
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PMID: 20691690
PDF is available here.
PDF is available here.
Abstract
Our data indicate that the terminal maturation and enucleation of human primitive RBCs occurs in first trimester placental villi. Extravascular ζ-globin(+) primitive erythroid cells were found in placental villi between 5-7 weeks of development, at which time the frequency of enucleated RBCs was hi...
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PMID: 20628147
PDF is available here.
PDF is available here.
Abstract
We investigate preventive and therapeutic effects of placental extract in contact hypersensitivity (CHS), a mouse model of allergic contact dermatitis. Administration of placental extract prior to the sensitization of allergic antigen (Ag) significantly inhibited the severity of CHS induced by Ag ch...
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PMID: 20619383
PDF is available here.
PDF is available here.
Abstract
We have previously found a significant elevation of adipsin, an activating factor of the alternative complement pathway, in mouse placentas from spontaneous abortions. The present study was aimed to evaluate regulation of the alternative complement pathway in placentas of mouse spontaneous abortions...
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PMID: 20484840
PDF is available here.
PDF is available here.
Abstract
In the pregnant bitch, the placenta is a major source of circulating relaxin, but its local expression in the reproductive organs is not clear. This study demonstrated expression of relaxin mRNA in the corpus luteum, uterus, uterine cervix as well as placenta in the pregnant and nonpregnant bitch by...
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PMID: 20495299
PDF is available here.
PDF is available here.
Revue medicale suisse (6)261 2010
Abstract
Abstract
Evaluation for etiology is vital in cases of stillbirth to facilitate emotional closure and for counseling regarding subsequent pregnancies. Patients should be treated in a sensitive manner and encouraged to allow an evaluation within the boundaries of their cultural and individual values. The most...
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PMID: 20661052
PDF is available here.
PDF is available here.
Abstract
Approximately 25% of stillbirths have been attributed to genetic etiologies. The most common cytogenetic abnormalities are similar to those seen in liveborns and include 45X, trisomy 21, trisomy 18, and trisomy 13. Cytogenetic abnormalities are more common when fetal structural anomalies are identif...
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PMID: 20661047
PDF is available here.
PDF is available here.
Abstract
Stillbirth affects approximately 1 in 200 pregnancies and is one of the most common serious complications of pregnancy. Stillbirth can occur as a consequence of diverse processes, including fetal abnormality, isoimmunization, infection, maternal preeclampsia, placental abruption, maternal medical co...
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PMID: 20661044
PDF is available here.
PDF is available here.
Abstract
We describe the placental characteristics that are most frequently listed in stillbirth case series, including entities associated with maternal diseases. First, we describe how macroscopic placental, cord, and membrane findings can provide answers to midwives and physicians at the time of delivery...
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PMID: 20661050
PDF is available here.
PDF is available here.
Early Human Development (86)9 2010
Abstract
We examined the differential associations of each parent's height and BMI with fetal growth, and examined the pattern of the associations through gestation. Data are from 557 term pregnancies in the Pune Maternal Nutrition Study. Size and conditional growth outcomes from 17 to 29 weeks to birth were...
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PMID: 20675085
PDF is available here.
PDF is available here.
Abstract
We assessed quantitative (number of syncytial knots and number of syncytial nuclei per syncytial knot) and qualitative (density and surface area) characteristics of syncytial knots in each placental sample. Statistical significance was tested using chi(2)-test, Student's t-test and Mann-Whitney U-te...
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PMID: 20627398
PDF is available here.
PDF is available here.
Abstract
We have previously shown that maternal diabetes profoundly affects gene expression in the developing embryo, in particular a suite of known NTD genes. In rodent experimental systems, NTDs present as phenotypes of incomplete penetrance in diabetic pregnancies. This property is difficult to reconcile...
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PMID: 20564432
PDF is available here.
PDF is available here.
Abstract
We describe recent data showing the intrinsic hematopoietic potential and appearance of hematopoietic cells in the mouse and human placenta and probe the biological rationale behind its hematopoietic function. As a rest tissue that contains potent hematopoietic stem cells (HSCs), the human placenta...
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PMID: 20580607
PDF is available here.
PDF is available here.
Abstract
Hypericum perforatum L., known as St. John's wort (SJW), is widely used in human therapeutics for wound healing and to treat depression; however, its recommendation during pregnancy is controversial. Hypericin, a polycyclic quinone isolated from this plant, has been studied and used to standardize t...
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PMID: 20553141
PDF is available here.
PDF is available here.
Abstract
PBDE body burdens of women from the e-waste site (milk 117 +/- 191, 8.89-457 ng/g fat, placenta 19.5 +/- 29.9, 1.28-72.1 ng/g fat, hair 110 +/- 210, 8.47-486 ng/g dry wt.) showed significantly higher levels than those from the reference site (milk 2.06 +/- 0.94, 1.0-3.56 ng/g fat, placenta 1.02 +/-...
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PMID: 20300869
PDF is available here.
PDF is available here.
Abstract
This unit describes a protocol to isolate hematopoietic progenitors and stem cells from human placentae isolated at different time points in development and at the full-term gestational stage. The placenta is extensively washed to eliminate blood contamination on its surface and inside the villi (th...
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PMID: 20814938
PDF is available here.
PDF is available here.
Abstract
Indoleamine 2,3-dioxygenase (IDO), an enzyme that plays a critical role in fetomaternal tolerance, exerts immunoregulatory functions suppressing T-cell responses. The aims of this study were to promote IDO expression in rat islets using a nonviral gene transfer approach, and to analyze the effect of...
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PMID: 20636452
PDF is available here.
PDF is available here.
Abstract
We localized BCS1L in inner mitochondrial membranes. In patient liver, kidney, and heart BCS1L and Rieske protein levels, as well as the amount and activity of complex III, were decreased. Major histopathology was found in kidney and liver with cirrhosis and iron deposition, but of iron-related prot...
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PMID: 20580947
PDF is available here.
PDF is available here.
Abstract
In order to gain deeper insights into the functional sites of human placental alkaline phosphatase, the structures of the enzyme with the putative regulators L-Phe, pNPP and 5'-AMP [Llinas et al. (2005), J. Mol. Biol. 350, 441-451] were re-refined. Significant variations in ligand positioning and id...
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PMID: 20693656
PDF is available here.
PDF is available here.
Abstract
We examined AhR protein expression in human placentas from normal (N) and severe preeclamptic (sPE) pregnancies, as well as human fetal tissues from the second trimester of pregnancy, using immunohistochemistry and/or Western blot analysis. In the placentas, the AhR immunoreactivity was present prim...
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PMID: 20354149
PDF is available here.
PDF is available here.
Abstract
We demonstrate here that inhibin betaC is expressed in human placenta. Expression of the inhibin betaC subunit was demonstrated at the protein level by means of immunohistochemical evaluation and at the transcriptional level by an inhibin betaC-specific RT-PCR analysis. Expression of inhibin betaC w...
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PMID: 20458061
PDF is available here.
PDF is available here.
Human Reproduction (25)8 2010
Abstract
Abnormal placentation is a potential mechanism to explain the increased incidence of low birthweight observed after IVF. This study evaluates, in a mouse model, whether the method of conception and embryo transfer affect placentation and fetal development.
IVF blastocysts (CF1 x B6D2F1/J) were cultu...
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PMID: 20576634
PDF is available here.
PDF is available here.
PLoS Genetics (6)7 2010
Abstract
We examined intra- and inter-individual variation in DNA methylation at the differentially methylated regions (DMRs) of the IGF2/H19 and IGF2R loci in a population of children conceived in vitro or in vivo. We found substantial variation in allele-specific methylation at both loci in both groups. Ab...
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PMID: 20661447
PDF is available here.
PDF is available here.
Abstract
The mouse placenta has been shown to have the potential to generate multipotential myelo-lymphoid hematopoietic stem/progenitor cells de novo. The cellular origin of HSCs generated in the placenta and other sites has been tracked to the hemogenic endothelium by using novel genetic and imaging-based...
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PMID: 20571394
PDF is available here.
PDF is available here.
Abstract
We propose a classification system for antenatal and postnatal TAPS.
Copyright 2010 S. Karger AG, Basel....
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PMID: 20339296
PDF is available here.
PDF is available here.
Abstract
To investigate the prognostic value of cardiac function assessment by the previously reported CHOP (Children's Hospital of Philadelphia) cardiovascular score in twin-twin transfusion syndrome (TTTS).
All consecutive monochorionic pregnancies presenting with TTTS over a 24-month period were evaluated...
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PMID: 20582931
PDF is available here.
PDF is available here.
Abstract
Pregnancy is associated with increased maternal calcitriol levels and placenta is an extrarenal source of this hormone. Calbindin-D9k and calbindin-D28k are vitamin D-dependent. Since calbindin-D28k has been considered as an antioxidant factor, the aim of the present work was to investigate the effe...
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PMID: 20214988
PDF is available here.
PDF is available here.
Abstract
Twelve hours after oral application of (13)C-labeled FAs, relatively stable tracer enrichment was achieved. We found a significantly higher ratio of (13)C-DHA concentrations in cord plasma than in maternal plasma, which was higher than that for the other studied FAs. (13)C-DHA is predominantly ester...
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PMID: 20444955
PDF is available here.
PDF is available here.
Prenatal Diagnosis (30)7 2010
Abstract
Hypertension (56)1 2010
Abstract
We investigated the ligand urotensin II (U-II), a potent endogenous vasoconstrictor and proangiogenic agent, for which levels have been reported to increase in patients with preeclampsia. We hypothesized that an increased sensitivity to U-II in preeclampsia might be achieved by upregulation of place...
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PMID: 20479331
PDF is available here.
PDF is available here.
Abstract
We reported that fetal weights of obese (OB) ewes [fed a diet of 150% of National Research Council (NRC) recommendations] were approximately 30% greater than those of control (C) ewes (fed a diet 100% of NRC recommendations) at midgestation (MG), but fetal weights were similar in late gestation (LG)...
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PMID: 20427725
PDF is available here.
PDF is available here.
Endocrinology (151)7 2010
Abstract
Vascular endothelial growth factor (VEGF) stimulated fetoplacental artery endothelial (oFPAE) cell migration and activated multiple signaling pathways including ERK2/1, p38MAPK, Jun N-terminal kinase (JNK1/2), v-Akt murine thymoma viral oncogene homolog 1 (Akt1), and c-Src in oFPAE cells. VEGF-induc...
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PMID: 20463056
PDF is available here.
PDF is available here.
Abstract
Acute hypoxia significantly increases the proportion of the placental blood passing through the DV and reduces the placental fraction of CO and the R/L heart ratio. These findings could be used as early signs of acute fetal hypoxia....
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PMID: 20236035
PDF is available here.
PDF is available here.
Abstract
Ang-1, Ang-2, and sTie2 are physiological constituents of AF that are GA and IAI regulated. Ang-2/Ang-1 ratio may play a role in modulating the fetal inflammatory response to IAI. Placental sTie2 shedding likely involves a Golgi-mediated mechanism....
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PMID: 20410222
PDF is available here.
PDF is available here.
Abstract
Recognizing placental membrane hypoxic lesions increases the sensitivity of placental examination in diagnosing placental hypoxia by at least 15%. The risk of in utero hypoxia is increased when microscopic chorionic pseudocysts and laminar necrosis occur in conjunction with villous hypoxic lesions....
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PMID: 20586626
PDF is available here.
PDF is available here.
Biology of Reproduction (83)1 2010
Abstract
We have found a stimulatory effect of 17beta-estradiol (E(2)) on endogenous leptin expression, as analyzed by Western blot, in both the BeWo choriocarcinoma cell line and normal placental explants. This effect was time and dose dependent. Maximal effect was achieved at 10 nM in BeWo cells and 1 nM i...
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PMID: 20237333
PDF is available here.
PDF is available here.
Abstract
NF is probably a specific substrate of BCRP, and BCRP has a major active role in NF transport in JAr cells. For the first time, we showed, that P-gp, MRPs, and the OATP2B1, probably have a negligible contribution to NF transport in JAr cells....
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PMID: 19924425
PDF is available here.
PDF is available here.
Abstract
Polyphenols are a group of widely distributed phytochemicals present in most foods of vegetable origin. A growing number of biological effects have been attributed to these molecules in the past few years and only recently has their interference with the transport capacity of epithelial barriers rec...
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PMID: 20392307
PDF is available here.
PDF is available here.
Abstract
Abstract
Using delivery within 36 hours of trauma as the clinical marker for the occurrence of placental abruption, positive radiologic readings showed 86% sensitivity and 98% specificity. The overall accuracy was 96%. CONCLUSION: Given that defined patterns on CT can be identified and those can be correlate...
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PMID: 20223441
PDF is available here.
PDF is available here.
Abstract
Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004...
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PMID: 20223448
PDF is available here.
PDF is available here.
Minerva Pediatrica (62)3 Suppl 1 2010
Abstract
TBC is a major infectious emergency in the world. OMS suggest that there are 8 millions of affected every year and 2 millions of deaths. Italy is considered a country with low prevalence, but the increase of the immigration from Africa Asia and Est Europa (country with high risk) imposes attention t...
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PMID: 21090072
PDF is available here.
PDF is available here.
Abstract
We found significantly higher expression of TLR2 in the amniotic cells and decidua cells in infected placentas as compared to non-inflamed placentas among the preterm placenta. A higher number of cases have TLR4 expression in the amnion of preterm infected placenta than in term placenta. This, howev...
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PMID: 20614721
PDF is available here.
PDF is available here.
Epigenetics (5)4 2010
Abstract
We explored the epigenetic modulation of IGF2/H19 during human development in 60 normal and 66 idiopathic IUGR (Intrauterine Growth Restriction) pregnancies, studying embryonic (cord blood) and extraembryonic (placenta and umbilical cord) tissues. We found ICR1 normal methylation levels ( approximat...
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PMID: 20418667
PDF is available here.
PDF is available here.
Abstract
From the cohort of tested microRNAs we excluded those ones, which were not detectable in maternal circulation during pregnancy (miR-136 and miR-519a) and/or were demonstrated in peripheral blood of healthy non-pregnant women (miR-34c, miR-224, miR-512-5p, miR-515-5p, miR-516-5p, miR-518f*, miR-519d,...
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PMID: 20731307
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Genomic imprinting imposes an obligate mode of biparental reproduction in mammals. This phenomenon results from the monoparental expression of a subset of genes. This specific gene regulation mechanism affects viviparous mammals, especially eutherians, but also marsupials to a lesser extent. Oviparo...
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PMID: 20510148
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)9 2010
Abstract
The objective of the present study is to assess the association between vitamin A deficiency (VAD) evaluated by serum retinol concentration from the mother and umbilical cord and placental concentration of retinol and carotenoids to propose placental values representative of deficiency. Two hundred...
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PMID: 20003626
PDF is available here.
PDF is available here.