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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Primitive Streak (0):
Recent article
Primitive Streak
Abstract
We have placed six copies of a TCF/Lef responsive element and an hsp68 minimal promoter in front of a fluorescent protein fusion comprising human histone H2B to GFP and used it to generate a strain of mice that would report Wnt/β-catenin signaling activity. Characterization of developmental and adu...
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PMID: 21176145
PDF is available here.
PDF is available here.
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Abstract
We report a detailed study of the precardiac cells located at the level of the primitive streak, employing different experiments with a variety of techniques combining double transplantations, microinjections and immunocytochemistry. Most cells of the more rostral segments of the primitive streak we...
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PMID: 19247942
PDF is available here.
PDF is available here.
FASEB Journal (23)1 2008
Abstract
We developed chemically defined serum-free culture conditions for the differentiation of embryonic stem (ES) cells into the PS-like cells. Cultures supplemented with Wnt showed induction of expression of a PS marker, the brachyury gene, followed by induction of the anterior PS markers goosecoid and...
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PMID: 18809738
PDF is available here.
PDF is available here.
Abstract
We report here the establishment of anteroposterior polarity and the formation of a primitive streak-like region in the embryoid body, dependent on local activation of the Wnt pathway. In this region, cells undergo an epithelial-to-mesenchymal transition and differentiate into mesendodermal progenit...
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PMID: 18983966
PDF is available here.
PDF is available here.
Development (135)17 2008
Abstract
We show that stabilized expression of beta-catenin perturbed human embryonic stem (hES)-cell self-renewal, such that up to 80% of the hES cells developed into the primitive streak (PS)/mesoderm progenitors, reminiscent of early mammalian embryogenesis. The formation of the PS/mesoderm progenitors es...
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PMID: 18667462
PDF is available here.
PDF is available here.
Current Biology (18)3 2008
Abstract
Formation of the primitive streak, the equivalent of the blastopore, is a critical step during the early development of amniote embryos. Medio-lateral cell intercalation and the planar cell polarity pathway play a role during this earliest step of gastrulation in the chick embryo.
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PMID: 18269906
PDF is available here.
PDF is available here.
Stem Cells (26)2 2008
Abstract
We describe an experimental system consisting of two types of embryonic stem cell lines capable of distinguishing between organizer and the middle section of the primitive streak region. Using this system, we were able to establish a defined culture condition that can separately induce distinct type...
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PMID: 17991917
PDF is available here.
PDF is available here.
Cell Stem Cell (2)1 2008
Abstract
The embryonic stem cell differentiation system was used to define the roles of the Activin/Nodal, BMP, and canonical Wnt signaling pathways at three distinct developmental stages during hematopoietic ontogeny: induction of a primitive streak-like population, formation of Flk1(+) meso...
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PMID: 18371422
PDF is available here.
PDF is available here.
Abstract
We observed distinct cell movement behaviours along the length of the streak and determined that this is position dependent with cells responding to environmental cues. The behaviour of cells was altered by exposing embryos or primitive streak explants to cell pellets expressing Wnt3a and Wnt5a, wit...
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PMID: 18541012
PDF is available here.
PDF is available here.
Developmental Dynamics (237)1 2008
Abstract
We investigated the cytoskeletal architecture during these morphogenetic processes and characterized microtubule organisation in whole chick embryos. This revealed the distribution of cells with polarized and radial microtubule (MT) arrays across different regions of the embryo. Cells in the epiblas...
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PMID: 18069691
PDF is available here.
PDF is available here.
Abstract
We discuss possible cellular mechanisms underlying this process, such as oriented cell division, cell-cell intercalation, chemotactic cell movement in response to attractive and repulsive signals and a combination of chemotaxis and contact following. We review current experimental evidence in favor...
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PMID: 18023726
PDF is available here.
PDF is available here.
Abstract
We provide a brief overview of grid-free methods for modeling multicellular systems. We focus on an approach based on Langevin equations, in which inertia is ignored, and stochastic effects on cell motion are included. The discussion starts with simpler models, in which cells are modeled as adhesive...
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PMID: 18023727
PDF is available here.
PDF is available here.
Abstract
Abstract
I summarize the last 10 years of research in this field.
2007 Wiley-Liss, Inc....
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PMID: 17893928
PDF is available here.
PDF is available here.
Development (134)24 2007
Abstract
In the gastrula stage embryo, the epiblast migrates toward the primitive streak and ingresses through the primitive groove. Subsequently, the ingressing epiblast cells undergo epithelial-mesenchymal transition (EMT) and differentiate into the definitive endoderm and mesoderm during gastrulation. How...
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PMID: 18003744
PDF is available here.
PDF is available here.
Abstract
We reveal a medio-lateral cell intercalation confined to the ectodermal subdomain where the streak will later form. This intercalation event differs from the convergent extension movements of the mesoderm described in fish and amphibians (anamniotes): it occurs before gastrulation and within a tight...
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PMID: 17928866
PDF is available here.
PDF is available here.
Stem Cells (25)9 2007
Abstract
We have utilized a serum- and stromal cell-free "spin embryoid body (EB)" differentiation system to investigate the roles of four growth factors, bone morphogenetic protein 4 (BMP4), vascular endothelial growth factor (VEGF), stem cell factor (SCF), and basic fibroblast growth factor (FGF2), singly...
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PMID: 17556598
PDF is available here.
PDF is available here.
Development (134)11 2007
Abstract
We describe an ENU-induced mutation, limulus (lulu), which disrupts gastrulation and the organization of all three embryonic germ layers. Positional cloning and analysis of additional alleles show that lulu is a null allele of the FERM-domain gene erythrocyte protein band 4.1-like 5 (Epb4.1l5). Duri...
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PMID: 17507402
PDF is available here.
PDF is available here.