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Gonadal Disorders (7):
Recent article
Gonadal Disorders
Abstract
The most significant corporal change observed in adolescent girls is the onset of menstruation, which occurs between 12 and 13 years of age. In several cases, described with the term 'precocious puberty', pubertal development can begin at a significantly younger age. The term 'delayed puberty' refer...
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PMID: 20034856
PDF is available here.
PDF is available here.
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Abstract
The paper reviewed the clinical manifestation and potential mechanism of gonadal injury of Tripterygium wilfordii and the progression of its relative Chinese medicine therapy. The therapeutic effect of T. wilfordii is certain, but its adverse effect is obvious. Therefore, it is very important to inv...
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PMID: 19685735
PDF is available here.
PDF is available here.
Endokrynologia Polska (60)6 2009
Abstract
We review the ethiopathogenesis, clinical picture, diagnosis and treatment of various disorders causing peripheral precocious puberty and provide the reader with current recommendations concerning approach to the patient with this health problem....
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PMID: 20041371
PDF is available here.
PDF is available here.
Abstract
The onset of puberty marks a time of rapid linear growth, sexual development, and transition from childhood to maturity. The diagnosis and treatment of a childhood malignancy prior to the onset of puberty has the potential to profoundly affect the timing and the tempo of puberty. CNS tumors located...
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PMID: 19293602
PDF is available here.
PDF is available here.
Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych (15)2 2009
Abstract
Anticancer treatment for HL, independently of the age at diagnosis and clinical stage, leads to serious and persistent gonadal dysfunction. The patients should be informed about the problem of gonadal toxicity and possibility of fertility preservation at the moment of diagnosis....
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PMID: 19772815
PDF is available here.
PDF is available here.
Vnitrni lekarstvi (54)11 2008
Abstract
Inhibin B is a gonadal dimeric peptide, produced in men in testicular Sertolli cells. Inhibin B blood level knowledge can be a useful tool in the management of difficult diagnostic problems, such as ambiguous genitalia, the distinction between cryptorchidism and anorchidism and the hypogonadotrophic...
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PMID: 19069679
PDF is available here.
PDF is available here.
Therapeutische Umschau (65)8 2008
Abstract
Frailty is a geriatric syndrome that has been characterized by an increased vulnerability against external stressors. The aim of laboratory investigations in the context of frailty is to screen for conditions that are pathophysiologically related to the development of this syndrome. Successful thera...
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PMID: 18677692
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)8 2008
Abstract
Smallie (slie), a spontaneous, autosomal-recessive mutation causes dwarfing and infertility in mice. The purpose of this study was to determine and characterize the underlying molecular genetic basis for its phenotype. The slie locus was mapped to chromosome 1, and fine-structure mapping narrowed th...
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PMID: 18483174
PDF is available here.
PDF is available here.
Rinsho Ketsueki (49)3 2008
Abstract
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (14)6 2008
Abstract
To establish the optimal age of sexual maturation in Egyptian children, Tanner's maturity stages were determined for a sample of children and adolescents (1550 girls, 1563 boys) ranging from 6.5 to 18.5 years. The mean age for attainment of pubic hair (stage PH2) was 10.46 (SD 1.36) years for girls...
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PMID: 19161115
PDF is available here.
PDF is available here.
Annals of Saudi Medicine (28)5 2008
Abstract
The mean and standard deviation for age in the 56 patients (36 males and 20 females) was 15.62+/-4.44 years. Diabetes mellitus was present in 5 patients (8.9%), impaired fasting glucose was found in 16 patients (28.6%) and an impaired glucose tolerance test was found in 4 patients (7.1%). Short stat...
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PMID: 18779644
PDF is available here.
PDF is available here.
Abstract
Chronic stress represents a prolonged state of dyshomeostasis caused by intense and frequently imposed stressors. Obesity constitutes a chronic dysmetabolic state, leading progressively to a spectrum of metabolic complications, such as diabetes, dyslipidemia, hypertension and cardiovascular disease....
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PMID: 19121989
PDF is available here.
PDF is available here.
Medycyna wieku rozwojowego (12)4 Pt 2 2008
Abstract
In group I no alteration in hormonal status was observed, whereas in group II lower inhibin B was found (68.09 ng/l+/-54.87 vs 152.66 ng/l+/-72.09, p=0.0002). The levels of FSH, LH, testosterone and testicular volume did not differ from healthy adolescents. We did not observe a correlation between i...
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PMID: 19531817
PDF is available here.
PDF is available here.
Medycyna wieku rozwojowego (12)4 Pt 2 2008
Abstract
Cytotoxic chemotherapy and radiotherapy have improved the survival rates in many malignant conditions, particularly in paediatric patients with haematologic malignancies. Treatment is associated with significant morbidity in many patients, and alterations in gonadal function are among the most commo...
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PMID: 19531820
PDF is available here.
PDF is available here.
Medycyna wieku rozwojowego (12)4 Pt 2 2008
Abstract
Our observations show the possibility of different endocrine disturbances after combined treatment for HL, especially gonadal function disturbances. Considering these long-term complications, further follow-up is needed, even in the absence of clinical symptoms....
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PMID: 19531819
PDF is available here.
PDF is available here.
Fertility and Sterility (88)5 2007
Abstract
Fertility and Sterility (88)5 2007
Abstract
Abstract
Puberty is a complex, coordinated biological process with multiple levels of regulation. Epidemiological observations suggest that the timing of pubertal events is a heritable trait, although environmental factors can modulate such genetic influence. The study of pathological states of early and lat...
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PMID: 17927661
PDF is available here.
PDF is available here.
Abstract
We compared late side effects and quality of life (QoL) in 430 survivors of childhood acute leukaemia based on whether they had undergone haematopoietic cell transplantation (n=142) or not (n=288). Mean age was 18.2 years and mean follow-up duration was 11.9 years. Multivariate logistic regression a...
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PMID: 17704791
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)42 2007
Abstract
We first found that H12 could be directly reached from the ligand-binding pocket (LBP) by a chain positioned on the C18 atom of an androgen steroid nucleus. A set of 5alpha-dihydrotestosterone-derived molecules bearing various C18 chains were thus synthesized and tested for their capacity to bind hA...
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PMID: 17711855
PDF is available here.
PDF is available here.
Abstract
Early Human Development (83)9 2007
Abstract
Neonatal emergencies are uncommon, but may lead to significant morbidity and mortality if not recognised and managed promptly. Disorders of sex development, hypoglycaemia, thyrotoxicosis and calcium balance are discussed, with emphasis on the clinical assessment, investigations and management of the...
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PMID: 17703902
PDF is available here.
PDF is available here.
Abstract
We report the cases of 3 patients with brucellar gonadal abscess who were examined with gray-scale and color Doppler sonography. In these 3 cases, sonography revealed a thick-walled avarian (n = 2) or testicular (n = 1) abscess. Duplex Doppler sonography indicated a low-resistance type of flow in al...
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PMID: 17427212
PDF is available here.
PDF is available here.
Fertility and Sterility (88)2 2007
Abstract
This study investigates circulating concentrations of AMH and inhibin B in men with azoospermia. Serum AMH and inhibin B are significantly lower in the men with nonobstructive azoospermia compared to the controls and the men with obstructive azoospermia, suggesting that these hormones could be marke...
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PMID: 17462637
PDF is available here.
PDF is available here.
Abstract
The elevated TSH in these patients and prior demonstration of the in vitro ability of TSH to bind to the FSH receptor lead us to hypothesize that the gonadal stimulation in these patients is TSH-mediated. The fact that gonadal stimulation is not seen in all patients with severe hypothyroidism raises...
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PMID: 17937064
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1771)7 2007
Abstract
The synthesis of phosphatidylcholine (PtdCho), the major phospholipid in mammalian cells, is regulated by the CTP:phosphocholine cytidylyltransferase (CCT). Loss of the CCTbeta2 isoform expression in mice results in gonadal dysfunction. CCTbeta2(-/-) females exhibit ovarian tissue disorganization wi...
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PMID: 17560827
PDF is available here.
PDF is available here.
Abstract
In humans, circulating leptin levels are low in early childhood and rise until puberty, whereas the reverse occurs for the soluble leptin receptor (sOB-R). In women, leptin remains high and sOB-R remains low, but in men leptin declines after adolescence and sOB-R increases. These observations sugges...
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PMID: 17873322
PDF is available here.
PDF is available here.
Abstract
Prokineticins are multifunctional secreted proteins that were originally identified as regulators of intestinal contraction but subsequently shown to affect vascular function, hyperalgesia, spermatogenesis, neuronal survival, circadian rhythm, nociception, feeding behaviour, immune responses, haemat...
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PMID: 17208447
PDF is available here.
PDF is available here.
Drug Safety (30)3 2007
Abstract
Complex interactions exist amongst the various components of the neuroendocrine system in order to maintain homeostasis, energy balance and reproductive function. These components include the hypothalamus-pituitary- adrenal and -gonadal axes, the renin-angiotensin-aldosterone system, the sympathetic...
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PMID: 17343430
PDF is available here.
PDF is available here.
Abstract
We show that Pitx2's expression is markedly reduced in hypothyroid ovary as well as in ovarian granulosa cells, which is recovered with T(3)-supplementation both in vitro and in vivo conditions. Reduced Pitx2 expression could decrease Plod2 expression and hence facilitate ovarian ECM degradation. We...
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PMID: 17982271
PDF is available here.
PDF is available here.
Acta Oncologica (46)4 2007
Abstract
Gonadal dysfunction and fertility problems are adverse effects of cancer treatment or may be associated with specific malignancies. This review focuses on these problems in the young cancer survivors, where methods of protecting or restoring endocrine function and fertility need to be considered. In...
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PMID: 17497315
PDF is available here.
PDF is available here.
Vojnosanitetski pregled (63)12 2006
Abstract
Abstract
FD patients had higher baseline TSH levels than controls (P < 0.01). Three subjects were diagnosed with an early stage of subclinical primary hypothyroidism associated with negative antithyroid antibodies. A history of menses abnormalities, miscarriage, or assisted delivery was found in 89% of FD wo...
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PMID: 16926253
PDF is available here.
PDF is available here.
Clinical Oncology (18)9 2006
Abstract
Radiation therapy of benign diseases always resulted in gonadal doses below 1 Gy and therefore there was no risk for permanent gonadal failure. The excess risk of radiation-induced hereditary disorders in offspring was low in comparison with the natural frequency of these effects. However, there was...
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PMID: 17100150
PDF is available here.
PDF is available here.
European Journal of Cancer (42)12 2006
Abstract
The aim of this study was assess the activity of thalidomide in patients with progressive relapsed or platinum-refractory germ-cell tumours (GCT). Between April 2002 and January 2003, 15 patients with inoperable progressive GCT were treated with escalated daily doses of 200-600 mg thalidomide. All p...
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PMID: 16765039
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (254-255) 2006
Abstract
We review here briefly the effects of gonadotrophin subunit and receptor mutations on puberty in humans and contrast the information with findings on genetically modified mice with similar mutations....
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PMID: 16730882
PDF is available here.
PDF is available here.
Abstract
Abstract
Nippon rinsho. Japanese journal of clinical medicine (64 Suppl 4) 2006
Abstract
Abstract
Our best estimate is that perhaps one of every three women with epilepsy may be affected compared with one of seven in the general population. Menstrual disorders are significant because they are associated with anovulatory cycles that may increase the risks for infertility, migraine, emotional diso...
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PMID: 16567738
PDF is available here.
PDF is available here.
Revista Clínica Española (206)7 2006
Abstract
Most of the patients will develop almost all the complications. Juvenile DM in association with AO is its best diagnostic criteria. Early therapy should delay progression and control mortality causes....
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PMID: 16831380
PDF is available here.
PDF is available here.
Abstract
During puberty, girls may present with psychiatric illness necessitating treatment with psychotropic medications. Pubertal girls are especially vulnerable to medication-associated adverse events. Atypical antipsychotics and antidepressants have the potential to elevate prolactin levels, altering pub...
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PMID: 16321731
PDF is available here.
PDF is available here.
Prague medical report (107)1 2006
The existence of a male equivalent of the polycystic ovary syndrome--the present state of the issue.
Abstract
The polycystic ovary syndrome (PCOS) in women belongs to the most frequent endocrinopathies. This syndrome is characteristic by a hormonal and metabolic imbalance. It seems to be a kind of an oligogenic disease resulting from the interaction among several key genes and environmental effects. Conside...
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PMID: 16752800
PDF is available here.
PDF is available here.
Abstract
We recommend initial management as for bacterial urinary tract infection, until urine cultures results are obtained. This paper provides a comprehensive review with the related medical literature....
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PMID: 16951901
PDF is available here.
PDF is available here.
Abstract
We present a male patient with photosensitivity since the earliest months of his life, and pigmented macules in exposed areas, some showing clinical atypia, which increased in number over time. Molecular biology studies detected an alteration in DNA repair ability, so xeroderma pigmentosum was diagn...
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PMID: 16476302
PDF is available here.
PDF is available here.
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Pediatric Research (58)1 2005
Abstract
We hypothesized that an impaired signal-transduction pathway shared by several organs may provide a unifying explanation for both endocrinopathies. We assessed two possible transduction-pathway components associated with CH in DS: the G-protein adenylate-cyclase (AC) system and beta-adrenergic respo...
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PMID: 15774852
PDF is available here.
PDF is available here.
Abstract
Our results indicate a high incidence of gonadal dysfunction due to target organ failure in HSCT recipients not treated by TBI....
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PMID: 16048797
PDF is available here.
PDF is available here.
Abstract
We have briefly discussed the embryology and attempted to classify abnormal gonadal disorders. The aims of evaluating such a child are to: (1) establish genetic sex; (2) determine the hormonal milieu; (3) evaluate the anatomy of internal and external genitalia and gonads; and (4) in older children,...
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PMID: 15846569
PDF is available here.
PDF is available here.
Human Reproduction (20)1 2005
Abstract
We report on two siblings, a brother and a sister, both with de novo chromosomal rearrangements and gonadal deficiency including premature ovarian failure. They had normal phenotypes without additional manifestations of known chromosomal breakage syndromes (except for the gonadal dysfunction) and no...
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PMID: 15576395
PDF is available here.
PDF is available here.
Abstract
Anti-Mullerian hormone (AMH) is a gonadal hormone synthesized by granulose cells of the ovary and Sertoli cells of the testis. Anti-Mullerian hormone is used to facilitate the evaluation of intersex disorders and as a marker in some ovarian tumors or ovarian reserve assessment in the infertility cas...
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PMID: 16544718
PDF is available here.
PDF is available here.
Osteoporosis International (15)11 2004
Abstract
We observed a reduction of DHEA-S levels, expressed as standard score ( Z-score) values referred to a group of 180 healthy subjects stratified by sex and different age groups (<40 years, between 40 and 60 years, >60 years) to circumvent the pronounced effect of gender and age on such hormone (ACS DH...
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PMID: 15034643
PDF is available here.
PDF is available here.
Pediatric endocrinology reviews : PER (2 Suppl 1) 2004
Abstract
We review the most commonly used pharmacological therapies for these disorders and discuss treatment controversies and toxicities....
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PMID: 16456488
PDF is available here.
PDF is available here.