Abstract
We present a revision of our previously published model of circadian effects in cancer (Sephton and Spiegel, 2003) based on evaluation of new data from divergent lines of investigation. Human clinical studies show circadian endocrine disruption may be accompanied by suppressed functional cellular im...
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PMID: 20097011
PDF is available here.
Abstract
The ultrastructure of the reproductive gland, dorsal body (DB), of Megalobulimus abbreviatus was analysed. Electron microscope immunohistochemistry was used to detect FMRFamide-like peptides in the nerve endings within this gland. Nerve backfilling was used in an attempt to identify the neurons invo...
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PMID: 20379650
PDF is available here.
Abstract
The survey response rate was 69% (46/67); 85% were practicing endocrine surgeons and 15% were fellows. In all, 72% of respondents completed an endocrine surgery fellowship, 17% completed surgical oncology, and the remaining individuals completed no fellowship. The mean age was 38 (32-49) years; 39%...
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PMID: 19939426
PDF is available here.
Abstract
Motherhood is a physiological status in which certain behavioural patterns are exhibited. Maintenance of the life of the species in mammals is dependent upon the presentation of motherhood services in a certain period that the child is dependent on the mother. Absence of the mother causes some defic...
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PMID: 20204906
PDF is available here.
Abstract
The role of hedgehog signaling is analyzed in relation to the developing endocrine glands: pituitary, ovary, testis, adrenal cortex, pancreas, prostate, and epiphyseal growth. Experimental and pathological correlates of these organs are also discussed. The second section addresses a number of topics...
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PMID: 20013843
PDF is available here.
Abstract
The objective of the present study was to analyse changes of morphological properties in the organs of immune and endocrine systems in subjects with opioid addiction and chronic alcoholic intoxication (CAI) based on the results of 322 autopsies. These included 190 cases of drug addiction from 0.5 to...
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PMID: 20394195
PDF is available here.
Abstract
The review summarizes information about the intraovarian modulators of folliculogenesis. Consistently described auto-and paracrine factors and mechanisms involved in the regulation of follicular development from the entry in the growth of primordial follicles before ovulation of the dominant follicl...
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PMID: 20209891
PDF is available here.
Abstract
We conclude that the major components of the sex pheromone of H. arenicola are Z7-14:OAc and Z5-14:OAc. Currently, a triangle trap baited with the synthetic compounds Z7-14:OAc, Z5-14:OAc, and Z7-14:OH in a 1:0.4:0.25 ratio at 825 microg/trap dosage can be effectively used to monitor the H. arenicol...
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PMID: 20653244
PDF is available here.
Abstract
The role of adipose tissue as an important endocrine organ is today beyond doubt. The adipose tissue is known to be a source of many biologically active substances, adipocitokines, one of them being the adiponectine possessing anti-inflammatory, antiatherogenic and cardioprotective properties; it is...
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PMID: 19957894
PDF is available here.
Abstract
The antiepileptic drugs (AED) have been widely used for a great deal of people--in the treatment of epilepsy and other diseases--throughout the world. Continuous and prolonged use of AED may be associated with adverse effects in different systems, including a variety of endocrine and metabolic abnor...
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PMID: 19942980
PDF is available here.
Abstract
Endocrine system can be affected by various organic compounds. The review describes the effects of major industrial solvents on adrenal, thyroid and parathyroid glands in man and experimental animals. Further, their toxicity in pancreas, pituitary, testis and ovary has also been discussed. An attemp...
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PMID: 19761037
PDF is available here.
Abstract
Limited data are available on the short- and long-term effects of smoking cessation on hypothalamic- and thyroid-pituitary-adrenal axes, sex hormones, energy homeostasis, and lipid and glucose metabolism. Initial data indicate that smoking cessation is associated with decreased cortisol levels and i...
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PMID: 19205076
PDF is available here.
Abstract
We have cloned cDNAs of two rat membrane melatonin receptor subtypes, melatonin receptor 1a (MT1) and melatonin receptor 1b (MT2), using a rapid amplification of cDNA end (RACE) method. The rat MT1 and MT2 cDNAs encode proteins of 353 and 364 amino acids, respectively, and show 78-93% identities wit...
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PMID: 19340560
PDF is available here.
Abstract
We describe the chronic health problems encountered by survivors and discuss the development of a long-term follow-up service for childhood cancer survivors.
Copyright (c) 2009 S. Karger AG, Basel....
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PMID: 19293608
PDF is available here.
Abstract
The hexadecapeptide cerebellin (CER) is derived from a larger protein, cerebellin 1 precursor protein (Cbln1). At present four precerebellins (Cbln1-4) are known. They are highly expressed in the brain, in particular in the cerebellum. Since CER is involved in regulating endocrine functions, present...
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PMID: 19082514
PDF is available here.
Abstract
Nitrite is an intrinsic signaling molecule. Its ability to form nitric oxide (NO) under hypoxic conditions as well as its ability to form S-nitrosothiols under normoxic conditions has transformed this once inert anion into a critical molecule in maintaining NO and nitroso homeostasis throughout the...
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PMID: 19273390
PDF is available here.
Abstract
We used high-resolution scanning and automated image processing to automatically analyze and quantify cell numbers in the range of 20,000. For optimisation of the approach, human gland stem cells (GSC) were differentiated to the adipogenic phenotype comprising inclusion of lipid vesicles. Oil red O...
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PMID: 19046627
PDF is available here.
Abstract
The overview presents an outline of the radiobiological mechanisms governing the origin of tissue reactions manifested by a number of systems influencing the course and the outcomes of chronic exposure of man. The issues under consideration include the key mechanisms of tissue reactions and adaptati...
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PMID: 19368316
PDF is available here.
Abstract
At the dawn of the 20th century in Lisbon, Augusto Celestino da Costa advocated a model of university practice based on research and defended the promotion of a scientific culture and the dissemination of Science in society. As a scientist, Celestino da Costa made numerous original descriptions of t...
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PMID: 19247951
PDF is available here.
Abstract
Endocrine glands communicate with remote target cells via a mixture of continuous and intermittent signal exchange. Continuous signaling allows slowly varying control, whereas intermittency permits large rapid adjustments. The control systems that mediate such homeostatic corrections operate in a sp...
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PMID: 18940916
PDF is available here.
Abstract
We describe a female patient of North African ancestry, homozygous for a frameshift mutation in the POMC gene (6922InsC) that impairs the production of all melanocortin peptides, and that is associated with novel clinical features. Repeated clinical investigations from birth to age 18 yr are present...
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PMID: 18765507
PDF is available here.
J J Grill,
S S Puget,
E E De Carli,
L L Amoroso,
M M Taylor,
R R Brauner,
P P Leblond,
V V Kieffer,
A A Laurent-Vannier,
C C Dufour,
M M Bourgeois,
P P Wicart,
F F Dhermain,
D D Oppenheim,
C C Sainte-Rose and
C C Kalifa
Abstract
This chapter presents guidelines for the follow-up of children with brain tumors, whether benign or malignant, in their transition to adulthood. The consequences of their disease and its treatment overlap greatly. The complications and long-term follow-up are detailed based on the specialists involv...
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PMID: 18799170
PDF is available here.
Abstract
Subcutaneous and visceral adipose compartments act, not only as fatty acid depots, but also as active endocrine organs that undergo hyperplastic changes and significantly enhance their function in obesity. Akipokines and other proteins secreted by both adipocytes and stromal cells play a central rol...
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PMID: 19062531
PDF is available here.
Abstract
We show AQP1 is in dense-core secretory granule (DCSG) membranes of endocrine tissue: pituitary and adrenal medulla. The need for AQP1 in endocrine cell function was examined by stable transfection of AQP1 antisense RNA into AtT20 cells, a pituitary cell line, to down-regulate AQP1 expression. These...
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PMID: 18511498
PDF is available here.
Foued S FS Espindola,
Silmara R SR Banzi,
Luciana K LK Calabria,
Rodrigo J RJ Custódio,
Ricardo A RA Oliveira,
Leandro D LD Procópio,
Andreia B P AB Lima,
Jair P JP Cunha-Junior,
Milton V MV Coelho,
Iêda M L IM Guedes,
Cláudia H CH Pellizzon,
Roy E RE Larson and
Enilza M EM Espreafico
Abstract
We provide an immunohistochemical view of the tissue distribution of myosin-Va in the major endocrine organs. Myosin-Va is highly expressed in the pineal and pituitary glands and in specific cell populations of other endocrine glands, especially the parafollicular cells of the thyroid, the principal...
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PMID: 18568366
PDF is available here.
Abstract
We disrupted Foxo1 expression in the liver of mice lacking hepatic Irs1 and Irs2 (DKO mice). DKO mice were small and developed diabetes; analysis of the DKO-liver transcriptome identified perturbed expression of growth and metabolic genes, including increased Ppargc1a and Igfbp1, and decreased gluco...
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PMID: 18590693
PDF is available here.
Abstract
The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. FGF23 is a bone-derived hormone that regulates phosphate and vitamin D met...
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PMID: 18660672
PDF is available here.
Abstract
We observe that the endocrine function of adipocytes receives much attention, while its paracrine and autocrine functions are underestimated. Also, we provide examples that species specificity should not be neglected. We conclude that adipose tissue primarily is an energy storage organ, well support...
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PMID: 18264975
PDF is available here.
Abstract
OBJECTIVE: To observe effects of acupuncture under guidance of qi street theory on endocrine function in the patient of epilepsy. METHODS: Sixty cases of epilepsy were randomly divided into an acupuncture-medicine group and a medication group, 30 cases in each group. The medication group were treate...
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PMID: 18678157
PDF is available here.
Abstract
Vasopressin, also called antidiuretic hormone, is a 9 amino-acid peptide, synthesized from a precursor containing neurophysin II, by neurones from the supra-optic and peri-ventricular nuclei, and then stored in the posterior hypophysis. Vasopressin regulates plasmatic osmolality and volaemia via V2...
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PMID: 18683473
PDF is available here.
Abstract
The prevalence of obesity is increasing rapidly in both industrialized and developing nations. Obesity causes complex metabolic, endocrine, and hemodynamic changes that may lead to adverse cardiovascular outcomes such as coronary heart disease and congestive heart failure. Adipose tissue is no longe...
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PMID: 18456027
PDF is available here.
Abstract
Postpartum endocrine syndromes occur in the year after delivery. They are due to immunologic and vascular modifications during pregnancy. The Sheehan syndrome is the first described postpartum endocrine syndrome and consists on a hypophyse necrosis in relation with a hypovolemic shock during deliver...
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PMID: 18314279
PDF is available here.
Abstract
We report on an inbred Emirati family of Baluchi origin with ocular colobomas, ichthyosis, and endocrine abnormalities associated with midline brain malformations and mental retardation. All affected children had ocular colobomas, developmental delay and midline brain malformations. Hypoplastic pitu...
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PMID: 18271001
PDF is available here.
Abstract
We have demonstrated that these compounds display very weak oestrogenic activity in vitro, although no obvious oestrogenic activity was found in young rats or zebrafish. We demonstrated, however, that the oestrogenic effect of these compounds is cell- and oestrogen receptor-type specific, raising th...
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PMID: 17971161
PDF is available here.
Margret Schlumpf,
Stefan Durrer,
Oliver Faass,
Colin Ehnes,
Michaela Fuetsch,
Catherine Gaille,
Manuel Henseler,
Luke Hofkamp,
Kirsten Maerkel,
Sasha Reolon,
Barry Timms,
Jesus A F Tresguerres and
Walter Lichtensteiger
Abstract
Our data indicate that the potential risk posed by endocrine active UV filters warrants further investigations....
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PMID: 18194281
PDF is available here.
Abstract
We review herein the physiological basis and initial, albeit so far scarce, experimental evidence supporting such possibility....
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PMID: 17971159
PDF is available here.
Abstract
Fully brominated diphenyl ether, decabromodiphenyl ether (DBDE), is one of the most widely used brominated flame retardants worldwide. Little data is available about the metabolic fate of DBDE in animal models and nothing at all about the extent of foetal exposure. In this work, pregnant Wistar rats...
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PMID: 17481732
PDF is available here.
Abstract
Despite aromatherapy's popularity, efficacy data are scant, and potential mechanisms are controversial. This randomized controlled trial examined the psychological, autonomic, endocrine, and immune consequences of one purported relaxant odor (lavender), one stimulant odor (lemon), and a no-odor cont...
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PMID: 18178322
PDF is available here.
Abstract
Several animal studies have shown that both the epilepsy itself and many antiepileptic drugs (AEDs) affect reproductive endocrine function in both males and females. Epileptic activity may lead to arrested ovarian cyclicity, anovulatory cycles, polycystic ovaries, and endocrine changes in female ani...
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PMID: 18155932
PDF is available here.
Masahiro Matsunaga,
Tokiko Isowa,
Kenta Kimura,
Makoto Miyakoshi,
Noriaki Kanayama,
Hiroki Murakami,
Sayaka Sato,
Toshihiro Konagaya,
Tsuyoshi Nogimori,
Seisuke Fukuyama,
Jun Shinoda,
Jitsuhiro Yamada and
Hideki Ohira
Abstract
We demonstrated associations among these systems by simultaneously recording brain, endocrine, and immune activities when positive emotions were evoked in participants as they watched films featuring their favorite persons. Interestingly, the activity of peripheral circulating natural killer cells a...
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PMID: 17977695
PDF is available here.
Abstract
Prohormones often undergo extensive cellular processing prior to secretion. These post-translational processing events occur in organelles of the constitutive or regulated secretory pathway. The aim of this study was to examine the relationship between post-translational modifications and the secret...
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PMID: 18057001
PDF is available here.
Abstract
We demonstrated that the four known sinus gland (SG) isoforms of Cancer productus crustacean hyperglycemic hormone precursor-related peptide (Capr-CPRP I-IV) are differentially distributed in conserved patterns among individual crabs. This finding strongly supported the presence of multiple prepro-c...
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PMID: 17961562
PDF is available here.
Abstract
We hypothesize that CsGC-YO1 is an MIH receptor. In studies reported here, antipeptide antibodies (anti-CsGC-YO1) were raised against a fragment of the extracellular domain of CsGC-YO1. Western blots showed affinity purified anti-CsGC-YO1 bound to the heterologously expressed extracellular domain, a...
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PMID: 18093588
PDF is available here.
Abstract
We investigated whether 9CRA and ATRA also plays a role in glucose homeostasis in freshwater crab, Oziotelphusa senex senex. Injection of 9CRA into intact crabs significantly increased the hemolymph glucose level in a dose-dependent manner. Such 9CRA-induced hyperglycemia was apparently mediated by...
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PMID: 17964575
PDF is available here.
Abstract
The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse...
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PMID: 18023280
PDF is available here.
Abstract
A number of observations support the concept of important physiological interactions between the endocrine and immune systems. It could be confirmed that hormones secreted by the neuroendocrine system play an important role in communication and regulation of the cells of the immune system. Among pro...
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PMID: 18817298
PDF is available here.
Abstract
We demonstrated the expression of hGHRH-R and its splice variants in various human cancers. Antiproliferative action of GHRH antagonists on these cancers indicates that the direct inhibitory effects of GHRH antagonists are mediated by tumoral GHRH receptors....
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PMID: 18288987
PDF is available here.
Abstract
We investigate the role of Nkx2.2 within the small intestine. We have determined that Nkx2.2 is expressed at the onset of intestinal epithelial cell differentiation in specific intestinal cell populations, including a subset of enteroendocrine cells. Similar to its role in the pancreatic islet, Nkx2...
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PMID: 18022152
PDF is available here.
Abstract
Diet is a significant source of exposure to endocrine disrupting chemicals (EDC); health risks cannot be excluded, in particular long-term effects in vulnerable Groups such as children. However, food safety assessment must also consider the effects of natural food components modulating the endocrine...
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PMID: 18469377
PDF is available here.
Abstract
Hormones have an influence on many tissues and organs, including the cardio-vascular system (CVS). Depending on their activity on CVS, they can be divided into 4 groups: having hypertensive or hypotensive influence and chronotropic positive or negative action. Endocrine regulation in CVS may occur i...
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PMID: 18979453
PDF is available here.
Abstract
The intracerebroventricular infusions of genistein (total 40 mug) were made in male sheep (November) to test its influence on melatonin, growth hormone (GH) and luteinizing hormone (LH) secretion. The analysis of the results encompassed 3 similar periods: before the infusion (afternoon hours) the fi...
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PMID: 18389014
PDF is available here.