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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neurosecretory Systems (2):
Recent article
Neurosecretory Systems
Abstract
The role of neurohormones and neuropeptides in human hair follicle (HF) pigmentation extends far beyond the control of melanin synthesis by α-MSH and ACTH and includes melanoblast differentiation, reactive oxygen species scavenging, maintenance of HF immune privilege, and remodeling...
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PMID: 21108769
PDF is available here.
PDF is available here.
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Abstract
Inflammation is a major component in keeping the body in homeostasis. However, an overwhelmed inflammatory response may be associated to a loss of this homeostatic status, which may lead to tissue injury or organ dysfunction. A huge number of drugs interacts with the inflammatory response in a positi...
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PMID: 21612145
PDF is available here.
PDF is available here.
Abstract
Although energy balance is tightly regulated in order to maintain a specific level of adiposity, the incidence of obesity continues to increase. Consequently, it is essential that effective therapeutics for the treatment and prevention of obesity be developed. This review provides a...
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PMID: 20585249
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
Huntington's disease (HD) is neither a fatal hereditary neurodegenerative disorder without satisfactory treatments nor a cure. It is caused by a CAG repeat expansion in the huntingtin gene. The clinical symptoms involve motor-, cognitive- and psychiatric disturbances. Recent studies have shown that...
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PMID: 20594177
PDF is available here.
PDF is available here.
Abstract
Aging in women is a complex process that begins with the transition into reproductive senescence and evolves to impact not just women's procreative potential but also multiple health-related parameters including longevity. Although somatic aging is an equal opportunity nemesis, certain disease state...
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PMID: 20845237
PDF is available here.
PDF is available here.
Abstract
Evidence suggests that cytokines (IL-6) and alteration of the hypothalamic-pituitary-adrenal (HPA) axis play a crucial role in the etiology of depression. Patients with cancer show elevated prevalence rates for depression. The objective of this cross-sectional study was to investigat...
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PMID: 20702499
PDF is available here.
PDF is available here.
Aquatic Toxicology (99)3 2010
Abstract
We hypothesized that PPMEs are affecting the brain resulting in decreased reproductive performance. Our goal was to use gene expression profiling to test the hypothesis that PPMEs are having an effect on neural systems in the fathead minnow (FHM; Pimephales promelas) in vivo. Sexually mature male an...
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PMID: 20561691
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)8 2010
Abstract
Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private fu...
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PMID: 20504161
PDF is available here.
PDF is available here.
Hypertension Research (33)8 2010
Abstract
We compared high-intensity interval (aerobic interval training, AIT) and moderate-intensity continuous exercise training (CMT) with regard to hemodynamic, metabolic and hormonal variables in FH+ subjects. Forty-four healthy FH+ women (25.0+/-4.4 years) randomized to control (ConFH+) or to a three ti...
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PMID: 20448634
PDF is available here.
PDF is available here.
Behavioural Brain Research (211)2 2010
Abstract
We investigated the effects of repeated stress on behavioral, endocrine, and neural parameters relating to emotional and stress responses in young (3 months old) and aged (24 months old) F344/N male rats. Young and aged rats were either subjected to 1-h restraint stress for 14 consecutive days or le...
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PMID: 20307586
PDF is available here.
PDF is available here.
Abstract
Small cell neuroendocrine carcinoma (SCNEC) of the urinary bladder is a rare but aggressive neoplasm that usually exhibits neuroendocrine differentiation. Here, the authors report a case of SCNEC in an 80-year-old man. The patient had gross hematuria and nodular mass involving the wall of the urinar...
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PMID: 20594044
PDF is available here.
PDF is available here.
Abstract
Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-...
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PMID: 20609350
PDF is available here.
PDF is available here.
Nature Neuroscience (13)7 2010
Abstract
We found that the CNS is also an important regulator of cholesterol in rodents. Inhibiting the brain's melanocortin system by pharmacological, genetic or endocrine mechanisms increased circulating HDL cholesterol by reducing its uptake by the liver independent of food intake or body weight. Our data...
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PMID: 20526334
PDF is available here.
PDF is available here.
Abstract
Abstract
We also discovered that blockade of N-methyl-d-aspartate (NMDA) receptors reduces the fetal ACTH response to cerebral hypoperfusion. The present study was designed to test the hypothesis that PGHS-2 action and the downstream effect of HPA axis stimulation are stimulated by NMDA-mediated glutamatergi...
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PMID: 20445154
PDF is available here.
PDF is available here.
Hormones and Behavior (58)4 2010
Abstract
I introduce a novel perspective that incorporates the three main processes the nervous system uses to integrate and process information: electrophysiological, genomic, and neuroendocrine action potentials. After discussing several examples of neuroendocrine action potentials, I lay out the commonali...
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PMID: 20600047
PDF is available here.
PDF is available here.
Brain research (1336) 2010
Abstract
These results indicate that selective activation of GR within the CeA is anxiogenic, and peripheral administration of an ERbeta agonist can overcome this effect. These data suggest that estradiol signaling via ERbeta prevents glucocorticoid-dependent effects of the CeA on behavior and neuroendocrine...
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PMID: 20381466
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the combination of delay with feed-forward and feedback loops in the pituitary-adrenal system is sufficient to give rise to ultradian pulsatility in the absence of an ultradian source from a supra-pituitary site. Moreover, our model enables us to predict the different patterns of...
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PMID: 20129987
PDF is available here.
PDF is available here.
Abstract
This study was conducted to determine the clinical significance of neuroendocrine differentiation in cases of T3-T4 node-negative colorectal cancer. Eighty-nine patients diagnosed with T3-T4 node-negative colorectal cancer who underwent curative resection were enrolled. Tumors expressing neuroendocr...
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PMID: 19372085
PDF is available here.
PDF is available here.
Neurochemical Research (35)6 2010
Abstract
We hypothesized that it operates as the multipotent endocrine gland secreting SM to the general circulation and thereby providing the endocrine regulation of peripheral organs and the brain. The term "multipotent" means that the spectrum of the brain-derived circulating SM and their occupancy at the...
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PMID: 20135220
PDF is available here.
PDF is available here.
Abstract
We review the relevant literature and present some original data indicating that, compared to handling, which imposes an external manipulation on the mother-infant relationship, social enrichment, in the form of communal rearing, in mice has very profound effects on animal's emotionality and the res...
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PMID: 20171244
PDF is available here.
PDF is available here.
Abstract
In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pituitary somatotropes when differentiating and integrating the signals from these regu...
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PMID: 20596912
PDF is available here.
PDF is available here.
Abstract
There is only limited community-based practice safety information available regarding antidepressant use in pediatric patients. This study identifies the factors associated with incident neuroendocrine-related metabolic, digestive, and sexual/reproductive adverse events in children a...
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PMID: 19769598
PDF is available here.
PDF is available here.
Abstract
These results suggest that 5-HT neuronal functioning was generally responsive to aggressive events, irrespective of social rank, whereas NE neuronal activity within the PFC and hippocampus was more sensitive to the submissive/dominance attributes of the social situation. It is possible that NE and 5...
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PMID: 19545478
PDF is available here.
PDF is available here.
Abstract
The secretion of growth hormone (GH) is regulated through a complex neuroendocrine control system that includes two major hypothalamic regulators, namely GH-releasing hormone (GHRH) and somatostatin (SST) that stimulate and inhibit, respectively, GH release. Classical experiments inv...
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PMID: 19769635
PDF is available here.
PDF is available here.
Abstract
The current selective review emphasizes the heterogeneity of antisocial behaviour in children and adolescents. It focuses on the development of children of the early-starter subtype of conduct disorder who are at high risk for the development of an antisocial personality disorder. Especially the aut...
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PMID: 20112176
PDF is available here.
PDF is available here.
Abstract
We found, using a murine model, that restraint causing psychological stress exacerbates allergen-induced airway inflammation and Th2 cytokine expression via MOR in the central nervous system. A novel strategy for the management and prevention of stress-induced asthma should be developed, focusing on...
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PMID: 20408448
PDF is available here.
PDF is available here.
Cell and Tissue Research (339)2 2010
Abstract
We provide a more accurate morphological description by employing a novel LK-specific GAL4 line that recapitulates LK expression. In order to analyse the possible afferent and efferent neural candidates of LK neurons, we used this lk-GAL4 line together with other CNS-Gal4 lines, combined with antise...
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PMID: 19941006
PDF is available here.
PDF is available here.
Rivista di psichiatria (45)1 2010
Abstract
Laughter is a very common behaviour in everyday life, nevertheless scientific literature is lacking in studies which examine closely its nature. The study aims are: to summarise the present knowledge about laughter and its relation with depression and to make hypotheses on its possible therapeutic f...
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PMID: 20380236
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (82)9 2010
Abstract
The review summarizes data on the interference of the neuroendocrine and immune mechanisms of myocardial remodeling. It shows a role of the effectors of the renin-angiotensin-aldosterone (aldosterone and angiotensin II) and sympathoadrenal (noradrenaline) systems in the activation of macrophages, th...
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PMID: 21086627
PDF is available here.
PDF is available here.
Abstract
Effects of in utero and early life conditions on adult health and disease such as cardiovascular disease and type 2 diabetes are well documented by epidemiological and clinical observations. Animal models including intrauterine artery ligation, maternal restriction of iron, protein o...
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PMID: 20139673
PDF is available here.
PDF is available here.
Abstract
A large body of epidemiological data suggests that adverse early environments, including obesity during pregnancy or early postnatal life, are linked to an elevated prevalence of metabolic disease in adult offspring. The mechanisms underlying these effects are still poorly understood...
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PMID: 20139672
PDF is available here.
PDF is available here.
Abstract
Abstract
The central neuroendocrine systems are responsible for the control of homeostatic processes in the body, including reproduction, growth, metabolism and energy balance, as well as stress responsiveness. These processes are initiated by signals in the central nervous system, specifically the hypothala...
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PMID: 20363718
PDF is available here.
PDF is available here.
Abstract
There are more and more data supporting the importance of nervous regulation of both white and brown adipose tissue mass. This short paper will review the different physiological parameters which are regulated such as metabolism (lipolysis and thermogeneis), secretory activity (leptin and other adip...
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PMID: 20551671
PDF is available here.
PDF is available here.
Abstract
Rheumatology patients frequently note the occurrence of stressful or traumatic life events prior to the onset of their illness and/or a relationship between stress and disease flares. For our patients, identifying causal events could represent an effort to give meaning to a chronic and often disabli...
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PMID: 20587002
PDF is available here.
PDF is available here.
Abstract
Stressful events are thought to contribute to the aetiology, maintenance and exacerbation of rheumatic diseases. Given the growing interest in acute stress responses and disease, this review investigates the impact of real-life experimental psychosocial, cognitive, exercise and sensory stressors on...
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PMID: 20478029
PDF is available here.
PDF is available here.
Abstract
We also review the implications of early or late menarcheal age on a young woman's life....
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PMID: 20920296
PDF is available here.
PDF is available here.
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia (115)1-2 2010
Abstract
We summarise some of the main results that open new scenarios in the comprehension of the biologic activities of these peptides and allow to postulate a role for them as diagnostic tools....
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PMID: 21073007
PDF is available here.
PDF is available here.
Abstract
This review contains the data on the representation of dopaminergic system in the amygdala and its functional importance in the realization of neuroendocrine functions of the amygdala as a reproductive center. The evidence presented indicate the combined participation of dopamine and sex steroids in...
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PMID: 21513109
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We use a 3-day paradigm of chronic varied stress in Wistar rats infected with C. albicans. We find that stress mediators contribute to the spread of the fungus and downregulate critical functions of phagocytic cells at the infection site. Phenotypic and functional alterations of effector cells accou...
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PMID: 20134199
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We postulated that intrathymic T cell migration is a multivectorial process; each individual vector being represented by a given molecular interaction. In vivo and in vitro experiments revealed that migration of developing thymocytes, including the export of mature T cells, is upregulated by hormone...
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PMID: 20134187
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We focused on NO and endocannabinoid system participation on OXT and VP production and secretion during basal and stress conditions and found that eCB affect basal OXT and VP secretion by acting differently at each level of the hypothalamo-neurohypophyseal system. After LPS, there is an increase in...
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PMID: 20134190
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We review the complex interplay between most important cognitive, neuroendocrine and immunological changes reported in PTSD, focusing on long-term implications of childhood maltreatment. PTSD has been associated with significant biological changes related to impaired cognitive functions, attenuated...
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PMID: 20134200
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We have determined leptin, IL-18, and adrenal steroid plasma levels and body mass index (BMI) in newly diagnosed patients with mild, moderate and severe pulmonary TB, household contacts (HHC), and healthy controls (HCO). HHC displayed higher levels of leptin than HCO and TB patients. TB patients sho...
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PMID: 20134198
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We studied whether, in parallel to the activity of the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system, hypothalamic cytokine expression and monoaminergic neurotransmitter concentrations are affected during the development and chronification of arthritis induced by immunizatio...
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PMID: 20134193
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)2 2010
Abstract
Intrinsic expression of NF-kappaB was confirmed by RT-PCR. An active component of NF-kappaB (p65) was upregulated in the nuclear fraction by both TNF-alpha and IL-1beta treatment in a dose- and time-related manner. These cytokines potently stimulated the promoter activity of NF-kappaB and Nurr-1. We...
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PMID: 19923853
PDF is available here.
PDF is available here.
Abstract
We report how to use this model system to assess, for the first time, the performance of the MALDI LTQ Orbitrap XL mass spectrometer to perform MSI of secretory neuropeptides. The method involves the following steps: (1) rapid dissecting of neurosecretory tissue (i.e., insect neurohemal organ) in is...
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PMID: 20680606
PDF is available here.
PDF is available here.
Abstract
The aim of the study is to examine the tissue expression and localization of the somatostatin receptors (SSTRs) in prostate cancer (PCa) with neuroendocrine (NE) differentiation. The five SSTR subtypes (SSTR1 to 5) were evaluated immunohistochemically in the secretory cells of normal-looking epithel...
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PMID: 20646346
PDF is available here.
PDF is available here.
Abstract
Chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) belong to a family of uniquely acidic secretory proteins in elements of the diffuse neuroendocrine system. These "granins" are characterized by numerous pairs of basic amino acids as potential sites for intra- and extragranular...
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PMID: 20217490
PDF is available here.
PDF is available here.
Folia Biologica (Krakow) (58)1-2 2010
Abstract
Changes in fitness components including larval stage duration, relative growth rate (RGR), and mass of the gypsy moth, Lymantria dispar L. (Lepidoptera: Lymantriidae), were investigated in caterpillars fed a synthetic diet with or without a cadmium supplement (10, 30, 100, 250 microg Cd/g dry food w...
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PMID: 20420202
PDF is available here.
PDF is available here.
Abstract
Despite its high prevalence and significant rates of associated morbidity and mortality, the syndrome of decompensated heart failure (HF) remains poorly defined and vastly understudied. HF is due to several mechanisms including pump dysfunction disorder, neurohormonal activation disorder, and salt-w...
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PMID: 20427988
PDF is available here.
PDF is available here.
Abstract
Further investigation into the neurohumoral mechanisms activated in the heart failure patient is a promising avenue for advances in diagnosis, prognosis, and treatment of this prevalent and devastating disease.
Copyright (c) 64\C S. Karger AG, Basel....
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PMID: 20427993
PDF is available here.
PDF is available here.
Abstract
Immunity is regulated by its signal molecules, interleukins, as well as by cellular contacts; however, in addition to these 'local' mechanisms there is also neuroendocrine regulation of the immune system, at the level of the organism as a whole that attunes the immunoreaction up or down. The systemi...
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PMID: 19999543
PDF is available here.
PDF is available here.
Abstract
Actions of 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), in the midbrain ventral tegmental area (VTA) modulate sexual receptivity of female rats. Actions of 3alpha,5alpha-THP at GABAergic substrates in the VTA are known to modulate consummatory aspects of sexual behavior among rodents, such a...
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PMID: 19576238
PDF is available here.
PDF is available here.
Abstract
Abstract
We report a boy with anhidrotic/hypohidrotic ectodermal dysplasia and growth hormone neurosecretory dysfunction, an association not previously reported, and we discuss the possible causes as well as the patient's response to growth hormone treatment until he reached final height....
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PMID: 19960895
PDF is available here.
PDF is available here.
Bioscience Reports (29)4 2009
Abstract
We provide an overview of the synaptotagmin family, and review the recent mouse genetic studies aimed at understanding the functions of synaptotagmins in neurotransmission and endocrine-hormone secretion. Also, we discuss potential roles of synaptotagmins in non-traditional endocrine systems....
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PMID: 19500075
PDF is available here.
PDF is available here.
Abstract
Changes regarding the immune system and specifically the cytokine system, of which tumor necrosis factor-alpha (TNF-alpha) is a part, have been shown to be involved in the development of neurological and psychiatric disorders such as multiple sclerosis, Parkinson's and Alzheimer's disease, depressio...
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PMID: 19415585
PDF is available here.
PDF is available here.
Abstract
Until recently, the popular notion that psychoemotional stress can have an impact on hair growth has been treated with skepticism and assigned to the realm of folklore by many authorities. Yet it has long been appreciated that episodes of alopecia areata (AA) have occurred after severely stressful l...
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PMID: 19434088
PDF is available here.
PDF is available here.