Abstract
We evaluated the stability of amoxicillin in those medical devices, with particular focus on both drug concentration and storage temperature. Stability of 20, 40, and 60g/L amoxicillin solutions in 300 mL portable pumps stored at 20 or 35 degrees C was studied by visual examination and drug concentr...
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PMID: 21901990
PDF is available here.
Abstract
We present a 17-month-old female patient, who had been diagnosed as WS by genetic analysis, admitted to our clinic for the investigation of severe hypercalcemia (4.02 mmol/L). Because the patient did not respond very well to fluid administration, furosemide infusion, and dietary calcium restriction,...
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PMID: 21528818
PDF is available here.
Abstract
We reviewed all critical incident reports at three tertiary care hospitals dated January 1, 2002, to February 28, 2009. In this longitudinal cohort study, critical incidents attributable to PCA errors were identified, and each incident was investigated. A safety intervention was implemented in Febru...
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PMID: 21068659
PDF is available here.
Abstract
We present our experience with ultrasound-guided TAP perineural catheter insertion and subsequent management of ambulatory TAP local anesthetic infusions after inguinal hernia repair.
Three patients scheduled for unilateral open inguinal hernia repair underwent preoperative posterior TAP catheter pl...
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PMID: 20975474
PDF is available here.
Abstract
There was a nonsignificant trend toward lower total propofol doses with PCS relative to EPCS (medians 1.36 versus 1.60 mg/kg, respectively; median difference -0.15 mg/kg; 95% confidence interval of the difference -0.33 to 0.05 mg/kg; P=.14). Adverse events, requirement for treatment of adverse event...
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PMID: 20538368
PDF is available here.
Tsukasa Kimata,
Eiji Sakamoto,
Aya Kawachi,
Yayoi Takahashi,
Asako Kuroki,
Masashi Nakamura,
Yoshihiro Kawade,
Kenji Tokui,
Tatsuya Suzuki,
Takashi Oyama,
Toshiki Uchida,
Tomonori Yamada,
Masahiro Kondoh and
Michinori Ogura
Abstract
We have experienced many cases of incomplete infusion and delays for the above reasons. We changed the specifications of the infusion pump to correspond to the kinematic viscosity of 5-FU and made all drug solution amounts uniform. We measured the time required to administer the drug solution from t...
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PMID: 20716877
PDF is available here.
Abstract
To evaluate the efficacy and safety of a 24-hour continuous infusion of paclitaxel in combination with oxaliplatin in the treatment of advanced esophageal cancer.
A total of 43 subjects with III-IV stage advanced esophageal cancer were enrolled from March 2008 to June 2009. There were squamous cell...
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PMID: 20979865
PDF is available here.
Abstract
We can, in this way, to supply with parenteral nutrition to all the requirements that these special patients have. In the first approach to the seriously ill newborn, the umbilical vessels, are the first choice to use,we have the way more fast, stable and easy, to guarantee: the emergency therapy, m...
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PMID: 21090088
PDF is available here.
Abstract
New ECG changes were noted in 20.2% of cases and consisted of 1.1% T-wave flattening, 1.1% T-wave inversion and 14.8% ST depression and 4.2% psuedonormalization. Abnormal ECG changes were noted after dipyridamole infusion in approximately 27.7% of patients with and 14.3% of patients without reversib...
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PMID: 20145578
PDF is available here.
Abstract
Objectively, all 12 patients experienced a significant reduction in fluctuations and dyskinesias while achieving a better gait function. Three patients received Duodopa as 24-hour treatment with good effect on severe nocturnal dystonic pain. One patient suffered a severe complication (peritonitis)....
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PMID: 20515603
PDF is available here.
Abstract
The design of a medical device should include active consideration of the way in which real users will actually use the device in the real environment of use. This consideration must include making the way in which the user interfaces with the device, for example, the buttons, the displays, the conn...
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PMID: 20541072
PDF is available here.
Abstract
There is no integrated pharmacokinetic/pharmacodynamic analysis that can supply parameter estimates to be programmed into pumps for either plasma or effect-site concentration determination over the broad paediatric age range. The six pharmacokinetic parameter sets available for children out of infan...
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PMID: 20386438
PDF is available here.
Abstract
Few studies address the dynamic effect of opioids on respiration. Models with intact feedback control of carbon dioxide on ventilation (non-steady-state models) that correctly incorporate the complex interaction among drug concentration, end-tidal partial pressure of carbon dioxide concentration, an...
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PMID: 20461001
PDF is available here.
Abstract
To assess the efficacy of continuous bupivacaine infusion at the iliac crest donor site in reducing postoperative pain and inpatient hospital stay.
Forty consecutive cleft lip/palate patients who underwent alveolar bone grafting at a single institution between 2003 and 2008 were identified, and thei...
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PMID: 20426678
PDF is available here.
Abstract
To assess a drug's toxic or carcinogenic effects on neonatal and adult mice and rats, researchers often carry out oral gavage studies. Whether dosed singly or in various combinations, provided as soluble solutions or as colloidal suspensions, the drug must be delivered in accurate and precise doses....
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PMID: 20410899
PDF is available here.
Abstract
We formerly reported the most suitable volumes of medicinal solution for continuous 5FU infusion over 46 hours in the FOLFOX6 and FOLFIRI regimens, respectively, by analyzing the relation of the total volume of the medicinal solution in a portable disposable infusion pump (SUREFUSER A) and the durat...
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PMID: 20372010
PDF is available here.
Abstract
It was investigated whether continuous rate infusion of the alpha(2)-adrenoceptor agonist dexmedetomidine can suppress memory formation by mechanisms other than reducing perception of sensory input in a fear-conditioning paradigm. Different groups of rats infused with either saline or dexmedetomidin...
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PMID: 19958768
PDF is available here.
Abstract
We interviewed patients and carers in their own homes and conducted two focus groups with community nurses who had an interest in palliative care but were not specialists. Despite the wide use of syringe drivers within palliative care, our study found their use among community nurses, particularly i...
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PMID: 20357705
PDF is available here.
Neurosurgery (66)3 Suppl Operative 2010
Abstract
Patients receiving continuous local anesthetic infusion used significantly less narcotics (P < .05) during the first 4 PODs: 24.4% on day 1, 34.1% on day 2, 53.5% on day 3, and 58.1% on day 4. A lower average pain score was observed among study patients on each POD (P < .05): 31.5% less on day 1, 13...
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PMID: 20173578
PDF is available here.
Abstract
Continuous pyridostigmine infusion improves muscle weakness after 7 days and 14 days of immobilization. The up-regulation of acetylcholine receptors and the concomitant resistance to atracurium is attenuated in animals treated with pyridostigmine after 7 days of immobilization....
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PMID: 20009758
PDF is available here.
Abstract
The authors' findings highlight the heterogeneous postoperative pain requirements among patients and the consequent complex process of efficiently managing postoperative pain....
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PMID: 20179507
PDF is available here.
Abstract
We investigated the possible role of tau phosphorylation in mediating this synergistic pathological cross talk between apoE4 and the amyloid cascade. This revealed that in both apoE4 and apoE3 mice, activating the amyloid cascade by inhibiting neprilysin triggers the accumulation of AT100 phosphoryl...
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PMID: 20160452
PDF is available here.
Abstract
A total of 190 abstracts were obtained from the above search, and a total of 12 RCTs met the above inclusion criteria. There was no difference in weighted visual analog scale pain scores between IVPCA tramadol versus IVPCA opioid at 48 hours postoperatively or risk of sedation or fatigue. IVPCA tram...
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PMID: 20481179
PDF is available here.
Abstract
The infusion test showed itself to be more useful as a way of revealing the compensatory parameters of the intracranial space than as a prognostic tool. The outcome of shunted patients with giant hydrocephalus was uncertain, owing to the relatively high rate of complications. We may therefore sugges...
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PMID: 20228469
PDF is available here.
Abstract
We have evaluated the GIT2 test to measure AR unaffected by cardio-pulmonary recirculation (CPR), based on a short glucose infusion in place of the bolus and on a two-operator sampling, differently from the classical glucose infusion test (GIT). The GIT2 test is based on four steps: 1) basal (B) glu...
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PMID: 20383860
PDF is available here.
Abstract
In mature murine adipocytes, rASP significantly stimulated fatty acid uptake (+243% vs PBS, P < 0.05) while Anti-ASP neutralized the rASP response. Mice treated with Anti-ASP showed elevated energy expenditure (P < 0.0001), increased skeletal muscle glucose oxidation (+141%, P < 0.001), reduced live...
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PMID: 20416070
PDF is available here.
Abstract
Errors in programming patient-controlled analgesia (PCA) pumps unfortunately occur in hospitals. At this hospital, quality improvement efforts were combined with staff development programming to decrease PCA pump errors. A significant decrease in PCA pump errors was found after 1:1 staff education....
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PMID: 20885136
PDF is available here.
Abstract
We hypothesized that systemic nicotine may not affect bone development, but may affect osseointegration in both the short and long term. Thirty rats were assigned to 4 groups. Group 1 (n = 10) was subdivided into 2 groups, which both received nicotine during the duration of the experiment. Half of t...
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PMID: 20553172
PDF is available here.
Abstract
Cortical and spinal spasticity appear to parallel each other with no significant differences in daily dosing, dosing changes, and mode of delivery of intrathecal baclofen. This did not hold true at all time points for the multiple sclerosis subgroup. The significant difference noted within groups fo...
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PMID: 20397440
PDF is available here.
Abstract
This paper demonstrates the benefits of adopting model-based design techniques for engineering medical device software. By using a patient-controlled analgesic (PCA) infusion pump as a candidate medical device, the authors show how using models to capture design information allows for i) fast and ef...
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PMID: 21142522
PDF is available here.
Abstract
Administration of the FOLFIRI or FOLFOX regimen in a traditional day hospital setting was less costly when considering the direct costs. However, a fully ambulatory pump permitted to better employ hospital resources and could permit cost-saving in those units in which more than five patients per day...
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PMID: 20845805
PDF is available here.
Abstract
Vessel dilator and ANP (each at 100 microM) (n=6 for each) resulted in a 33% (p<0.01) and 17% (p<0.05) elimination of human pancreatic adenocarcinomas, respectively, while the tumor volume increased 64-fold (p<0.001) in the placebo-treated mice (n=12). During the 4 weeks of treatment, the growth vel...
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PMID: 20363982
PDF is available here.
Abstract
The paper evaluates the efficiency and safety of the developed osmotherapy protocol using controlled continuous infusion of 15% mannitol solution. Two hundred and nine patients with intracranial hypertension (ICH) syndrome of various etiologies had 15% mannitol infusion, the rate of which was determ...
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PMID: 20919541
PDF is available here.
Abstract
Two types of new electrical infusion pumps (pump) scheduled to be introduced to the Japanese market in this autumn, were featured focusing on patient controlled analgesia (PCA). For the successful introduction of PCA pumps into clinical practice, initial investments including both finance and manpow...
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PMID: 19928504
PDF is available here.
Abstract
Implementing this technology can immediately and significantly reduce a facility's error rate.
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PMID: 20029289
PDF is available here.
Abstract
We did not observe fewer falls when the continuous infusion was stopped 12 hours after surgery....
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PMID: 19553071
PDF is available here.
Abstract
B-type natriuretic peptide (BNP) is an established first-line therapy for acute decompensated heart failure (HF), but its efficacy in preventing left ventricular (LV) remodeling after myocardial injury is unknown. The goal of this study was to evaluate the effects of BNP therapy on remodeling after...
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PMID: 19525373
PDF is available here.
Abstract
We compared sodium excretion before and after blockade of the 2 main distal nephron sodium transporters by IV amiloride (5 mg/kg of body weight) plus bendroflumethiazide (12 mg/kg of body weight) in male C57/BL6 anesthetized control mice (n=10) and in chronic Ang II-infused mice (n=8). Chronic Ang I...
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PMID: 19487583
PDF is available here.
Abstract
In the examined groups there were no statistically significant differences in the duration of anesthesia (68.29 +/- 6.47 vs 66.29 +/- 11.97 min, p = 0.327). The time to eye opening was significantly shorter in the group VIMA compared to the group TCI (4.49 +/- 1.20 vs 7.42 +/- 1.25 min, p = 0.000),...
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PMID: 19583138
PDF is available here.
Abstract
The reported pain scores and opioid consumption did not differ significantly between the groups. However, functional recovery up to the third postoperative day was significantly worse in the femoral catheter group. CONCLUSION: Using stimulating catheters for pain therapy the three methods are largel...
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PMID: 19308464
PDF is available here.
Lars Maegdefessel,
Torsten Linde,
Thomas Michel,
Kathrin Hamilton,
Ulrich Steinseifer,
Ivar Friedrich,
Sebastian Schubert,
Baerbel Hauroeder,
Uwe Raaz,
Michael Buerke,
Karl Werdan and
Axel Schlitt
Abstract
We hypothesise that continuous infusion of argatroban or bivalirudin are optimal treatment options for patients with HIT after mechanical heart valve replacement for adapting oral to parenteral anticoagulation or vice versa....
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PMID: 19492162
PDF is available here.
Abstract
These results suggest that intraportal insulin administration could augment liver graft regeneration during the first postoperative week....
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PMID: 19994469
PDF is available here.
Abstract
OBJECTIVE: To prepare effervescent osmotic pump tablet (EOPTs) according to the rhythm of coronary heart disease based on efficacy material and the mechanism of compound Danshen and to study the mechanism of drug released of that tablets. METHOD: Since compound Danshen consist of compounds with poly...
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PMID: 19623978
PDF is available here.