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Microbubbles (0):
Recent article
Microbubbles
Abstract
Angiogenesis represents the formation of new capillaries from existing vasculature, and as such plays a critical role in the response to ischemia in the setting of chronic coronary artery and peripheral vascular disease. Recent technological advances in non-invasive imaging modalitie...
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PMID: 21538181
PDF is available here.
PDF is available here.
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Abstract
The evaluation of inflammatory activity in Crohn's disease (CD), a crucial aspect of treatment planning and monitoring, is currently based on a sum of clinical data and imaging findings. Among the contrast enhanced cross-sectional imaging techniques (CE-US, CE-CT, CE-MR), CE-US is less invasive, more...
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PMID: 20464392
PDF is available here.
PDF is available here.
Abstract
The present study demonstrates the targeting of ultrasound contrast agents to human xenograft tumors by exploiting the overexpression of the glycolipid Gb3 in neovasculature. To this end, microbubbles were functionalized with a natural Gb3 ligand, the B subunit of the Shiga toxin (ST...
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PMID: 21439258
PDF is available here.
PDF is available here.
Abstract
The activation of natural gas nuclei to induce larger bubbles is possible using short ultrasonic excitations of high amplitude, and is required for ultrasound cavitation therapies. However, little is known about the distribution of nuclei in tissues. Therefore, the acoustic pressure...
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PMID: 21429844
PDF is available here.
PDF is available here.
Abstract
We propose a method of dual-frequency excitation to further enhance the CTR of subharmonic imaging. A dual-frequency excitation pulse is an amplitude-modulated waveform which consists of two sinusoids with frequencies of f₁ (e.g., 9 MHz) and f₂ (e.g., 6 MHz) and the resulting envelope component...
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PMID: 21342823
PDF is available here.
PDF is available here.
Abstract
Golay-encoded excitation in combination with the third harmonic (3f₀) transmit phasing is examined for both signal-to-noise ratio (SNR) and contrast-to-tissue ratio (CTR) improvements in harmonic imaging of contrast microbubbles. To produce the cancellation pair of tissue harmonic...
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PMID: 21342820
PDF is available here.
PDF is available here.
Abstract
SURF contrast imaging, as described previously in the literature, is a contrast agent detection technique achieved by processing of the received signals from transmitted dual frequency band pulse complexes with overlapping high-frequency (HF) and low-frequency (LF) pulses. The transm...
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PMID: 21342814
PDF is available here.
PDF is available here.
Abstract
In this paper, a new Doppler technique based on pulse subtraction imaging (PSD) is described and compared with pulse inversion Doppler (PID). Combining a nonlinear contrast agent imaging technique with a Doppler process provides a tool for detecting motion of both contrast agents and...
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PMID: 21244976
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We have shown previously that perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles bind to injured vascular tissue and can be detected with ultrasound imaging techniques. Prior studies have shown that scavenger receptors (SRs) are regulators of innate and adaptive immune responses...
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PMID: 20966069
PDF is available here.
PDF is available here.
Abstract
Molecular imaging using GPIbα as a targeting moiety can detect the presence of activated vWF on the vascular endothelium. This strategy may provide a means to noninvasively detect an advanced prothrombotic and inflammatory phenotype in atherosclerotic disease.
Copyright © 2010 Amer...
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PMID: 20846630
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (37 Suppl 1) 2010
Abstract
Ultrasound can be used to image perfusion in two ways: the traditional one using Doppler and the more recent using microbubble contrast agents. Doppler is simple to use and inexpensive but is limited to larger vessels with faster flow rates. It cannot interrogate the microvasculature...
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PMID: 20640418
PDF is available here.
PDF is available here.
Abstract
Thoracic aortic aneurysms (TAAs) develop as a result of dysregulated extracellular matrix remodeling mediated by several matrix metalloproteinases (MMPs). Membrane type-1 MMP (MT1-MMP) is the prototypical member of a unique family of membrane-bound MMPs, possessing multiple substrates and functions....
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PMID: 20418476
PDF is available here.
PDF is available here.
British Journal of Radiology (83)991 2010
Abstract
Ultrasound examination of the gallbladder is accepted as the primary imaging modality in the assessment of gallbladder disease, with inherent superiority in comparison to other imaging modalities. Contrast-enhanced ultrasound is established as a reliable tool in the detection and characterisation of...
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PMID: 20603412
PDF is available here.
PDF is available here.
Biomaterials (31)19 2010
Abstract
We develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound applic...
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PMID: 20347484
PDF is available here.
PDF is available here.
Abstract
We have made direct measurements of the force between two bubbles in water under controlled collision conditions that are similar to Brownian particles in solution. The experimental results together with detailed modeling reveal the nature of hydrodynamic boundary conditions at the air/water interfa...
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PMID: 20534552
PDF is available here.
PDF is available here.
Nanotechnology (21)24 2010
Abstract
A modified optical tweezers set-up has been used to generate microbubbles in flowing, biologically relevant fluids and human whole blood that contains carbon nanotubes (CNTs) using low power (< or =5 mW), infrared (1064 nm wavelength), continuous wave laser light. Temperature driven effects at the t...
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PMID: 20484785
PDF is available here.
PDF is available here.
Nanotechnology (21)22 2010
Abstract
We demonstrated an in vivo model for rapid and precise testing of plasmonic nanotechnologies....
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PMID: 20453288
PDF is available here.
PDF is available here.
Abstract
The cavitation field generated by an ultrasonic horn at low frequency and high power is known to self-organize into a conical bubble structure. The physical mechanism at the origin of this bubble structure is investigated using numerical simulations and acoustic pressure measurements. The thin bubbl...
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PMID: 20371200
PDF is available here.
PDF is available here.
Investigative Radiology (45)5 2010
Abstract
For both groups of animals, after an initial increase, a transient decay of the longitudinal relaxation rate was observed, followed by a constant plateau after 20 minutes. The analysis of the mean relaxation rates in the liver showed significant (P < 0.01) higher values for the group with destructio...
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PMID: 20375844
PDF is available here.
PDF is available here.
Abstract
Abstract
Delivery of survivin siRNA using a microbubble contrast agent combined with ultrasound exposure can effectively inhibit survivin expression and induce apoptosis, providing a new promising approach for siRNA delivery in vivo....
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PMID: 20442583
PDF is available here.
PDF is available here.
Abstract
Focused ultrasound (FUS) in combination with microbubbles has been shown capable of delivering large molecules to the brain parenchyma through opening of the blood-brain barrier (BBB). However, the mechanism behind the opening remains unknown. To investigate the pressure threshold for inertial cavit...
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PMID: 20420973
PDF is available here.
PDF is available here.
Abstract
We demonstrate the immobilization of fluorescent IgG antibodies on stationary PDMS-lipid microbubbles through biotin-avidin interactions and on-chip trapping for immunoassays. A PDMS-lipid composition offers several advantages such as biocompatibility and biodegradability for future in vivo use as p...
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PMID: 20163798
PDF is available here.
PDF is available here.
Ultrasonic Imaging (32)2 2010
Abstract
We examined the effects of combining ultrasound, microbubbles and thrombolytic enzymes on thrombolysis. First, we evaluated the relations between inertial cavitation and the reduction in the weight of a blood clot. Inertial cavitation was varied by changing the amplitude and duration of the transmit...
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PMID: 20687276
PDF is available here.
PDF is available here.
Abstract
The Oak Ridge National Laboratory Spallation Neutron Source employs a high-energy pulsed proton beam incident on a mercury target to generate short bursts of neutrons. Absorption of the proton beam produces rapid heating of the mercury, resulting in the formation of acoustic shock waves and the nucl...
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PMID: 20370004
PDF is available here.
PDF is available here.
Abstract
We report a case of giant blood cyst originating from the anterior mitral valve leaflet in an 18-year-old white girl. Contrast real-time transthoracic echocardiogram showed the presence of microbubbles inside the cystic cavity during diastole, confirming the presence of blood passage between the ven...
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PMID: 19696684
PDF is available here.
PDF is available here.
Abstract
Exposure to pulsed ultrasound resulted in enhanced green fluorescent protein (EGFP) gene transfection efficiencies ranging from 0.2% to 2%. The transfection efficiency of HUVECs was approximately 3-fold higher in the presence of SonoVue than in its absence at the effective exposure time of 6 s. For...
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PMID: 20348943
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)4 2010
Abstract
TK gene could be injected precisely into hepatocellular carcinoma with ultrasound monitor, and the expression of TK protein was found in all 4 groups. Expression in group D was higher than others (P < 0.05). The rate of tumor growth inhibition were 0 in group A, 3.90%+/-1.80% in group B, 22.70%+/-2....
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PMID: 20460047
PDF is available here.
PDF is available here.
Abstract
Folate-targeted microbubbles showed high affinity to SKOV3 cells with FR overexpression. They are potentially useful for ultrasonic molecular imaging and treatment of FR-positive tumors and warrant further investigation....
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PMID: 20375379
PDF is available here.
PDF is available here.
Investigative Radiology (45)2 2010
Abstract
VEGFR2-targeted ultrasound contrast agents such as BR55 will likely prove useful in human for the early detection of tumors as well as for the assessment of response to specific treatments....
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PMID: 20027118
PDF is available here.
PDF is available here.
Abstract
Polymeric tissue engineering scaffolds prepared by conventional techniques like salt leaching and phase separation are greatly limited by their poor biomolecule-delivery abilities. Conventional methods of incorporation of various growth factors, proteins, and/or peptides on or in scaffold materials...
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PMID: 19327002
PDF is available here.
PDF is available here.
Abstract
Non-viral vectors are less efficient than the use of viral vectors for delivery of genetic material to cells in vitro and especially in vivo. However, viral vectors involve the use of foreign proteins that can stimulate both the innate and acquired immune response. In contrast, plasmid DNA can be de...
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PMID: 19949971
PDF is available here.
PDF is available here.
Abstract
Echogenic bubble formulations have wide applications in both disease diagnosis and therapy. In the current study, nanobubbles were prepared and the contrast agent function was evaluated in order to study the nanosized bubble's property for ultrasonic imaging. Coumarin-6 as a model drug was loaded in...
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PMID: 19781609
PDF is available here.
PDF is available here.
Abstract
Brain treatment through the skull with high-intensity focused ultrasound can be achieved with multichannel arrays and adaptive focusing techniques such as time reversal. This method requires a reference signal to be either emitted by a real source embedded in brain tissues or computed from a virtual...
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PMID: 19770084
PDF is available here.
PDF is available here.
Abstract
A novel method for mapping inertial cavitation activity during high-intensity focused ultrasound (HIFU) exposure is presented. Inertial cavitation has been previously shown to result in increased heat deposition and to be associated with broadband noise emissions that can be readily monitored using...
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PMID: 19628450
PDF is available here.
PDF is available here.
Abstract
The therapeutic efficacy of neurological agents is severely limited, because large compounds do not cross the blood-brain barrier (BBB). Focused ultrasound (FUS) sonication in the presence of microbubbles has been shown to temporarily open the BBB, allowing systemically administered agents into the...
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PMID: 19846365
PDF is available here.
PDF is available here.
Abstract
We have developed polymer ultrasound contrast agents (1.2-1.8 mum in diameter) containing doxorubicin (Dox) within the shell (100-150 nm). In vivo this platform is expected to circulate through the vasculature until activated at the tumor site with external focused ultrasound (US). In vitro, the age...
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PMID: 19709952
PDF is available here.
PDF is available here.
Abstract
Glomerular capillary hemorrhage (GCH) in rat kidney provided a model for assessing in vivo gas body efficacy in diagnostic or therapeutic applications of ultrasound. Two diagnostic ultrasound machines were utilized: one monitored the harmonic B-mode contrast enhancement of the left kidney and the ot...
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PMID: 19709948
PDF is available here.
PDF is available here.
Abstract
It has been established that while the inherent presence of bubbles increases heat generation due to scattering and absorption, inertial cavitation is responsible for elevated heating during high-intensity focused ultrasound (HIFU) application. The contribution of bubble-induced heating can be an im...
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PMID: 19651548
PDF is available here.
PDF is available here.
Abstract
We treated monolayers of human umbilical vein endothelial cells with ultrasound and the contrast agent BR14. Barrier function was assessed by measuring transendothelial electrical resistance (TEER). Ultrasound-activated BR14 significantly decreased TEER by 40.3% +/- 3.7% ( p < 0.01). After treatment...
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PMID: 19709954
PDF is available here.
PDF is available here.
Abstract
Multiple in vitro and animal models have demonstrated the efficacy of ultrasound to enhance fibrinolysis. Mechanical pressure waves produced by ultrasound energy improve the delivery and penetration of alteplase (recombinant tissue plasminogen activator [tPA]) inside the clot. In human stroke, the C...
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PMID: 20104930
PDF is available here.
PDF is available here.
Clinical Imaging (34)3 2010
Abstract
Correct characterization of FLLs in fatty liver by CEUS is possible based on their typical enhancement patterns....
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PMID: 20416486
PDF is available here.
PDF is available here.
Abstract
Gas-filled microbubbles are used as contrast agents in diagnostic ultrasound imaging. A preclinical, acute toxicity study of 2 surfactant-stabilized ultrasound contrast agents (ST68 and ST44) was conducted. Subjects were 104 Sprague-Dawley rats (experimental doses, 0.1, 0.2, 0.8, and 1.0 mL/kg; cont...
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PMID: 20008819
PDF is available here.
PDF is available here.
Abstract
We developed novel liposomal bubbles (Bubble liposomes (BLs)) containing the lipid nanobubbles of perfluoropropane which were utilized for contrast enhancement in ultrasonography. BLs were smaller in diameter than conventional microbubbles and induced cavitation upon exposure ultrasound. In addition...
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PMID: 20072902
PDF is available here.
PDF is available here.
Abstract
We are developing minimally-invasive contrast agent microbubble based therapeutic approaches in which the permeabilization and/or ablation of the microvasculature are controlled by varying ultrasound pulsing parameters. Specifically, we are testing whether such approaches may be used to treat malign...
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PMID: 21206463
PDF is available here.
PDF is available here.
Abstract
We have combined acoustic and optical methods to investigate the response of isolated lipid-shelled microbubbles to low-pressure (49 and 62 kPa peak negative pressure) ultrasound tone bursts. These bursts induced slow deflation of the microbubbles. The experimental setup included a microscope connec...
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PMID: 20040446
PDF is available here.
PDF is available here.
Abstract
We refer to this technique as transmission at a low frequency and reception at a high frequency (TLRH). Using this wideband, transient echo, we have developed and implemented a targeted imaging technique incorporating a multifrequency colinear array and the Siemens Antares imaging system. The multif...
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PMID: 20178897
PDF is available here.
PDF is available here.
Abstract
We explore the use of empirical mode decomposition (EMD) and ensemble empirical mode decomposition (EEMD) in the Hilbert-Huang transform (HHT) for possible contrast improvement. The HHT is designed for analyzing nonlinear and nonstationary data, whereas EMD is a method associated with the HHT that a...
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PMID: 20178898
PDF is available here.
PDF is available here.
Abstract
Docetaxel-loaded lipid microbubbles combined with UTMA could inhibit the growth of VX2 rabbit liver tumors by deferring proliferation and promoting apoptosis, which may provide a novel targeted strategy for chemotherapy of liver carcinoma....
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PMID: 20040776
PDF is available here.
PDF is available here.
Abstract
This work was to compare the encapsulation efficiency and ultrasound-triggered release for protein between microbubbles and liposomes. Bovine serum albumin (BSA) was used as a model. Final ratios between BSA and HPC in microbubbles and liposomes were 1:5, 1:7 and 1:10, respectively. Morphologic char...
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PMID: 19538032
PDF is available here.
PDF is available here.
Abstract
We study the dynamics of a single paramagnetic colloidal particle dispersed in water and circulating around a cylindrical magnetic domain ("magnetic bubble") when driven by an external rotating magnetic field. We record the particle trajectories and measure its angular displacement by changing the s...
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PMID: 20365025
PDF is available here.
PDF is available here.
Abstract
We recorded the vibrations of 78 single microbubbles in a dual-frequency ultrasound field. The results showed that the LF pulse induced significant compression-only behavior, which for microbubble sizes below and at HF resonance resulted in high radial amplitude modulation. It, however, also appeare...
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PMID: 19942524
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)39 2009
Abstract
UMMD may facilitate entrance of those SPIO particles with a bigger diameter and microbubbles into the aortal wall. This discovery may provide a new solution for penetration of complex macromolecule probes and gene-carried drug through the tunica intima of the aorta....
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PMID: 20137608
PDF is available here.
PDF is available here.
Ultrasonic Imaging (31)4 2009
Abstract
We used 76 canine thrombi for investigation. The targeting ability to thrombi was confirmed by microphotography and high-frequency ultrasound (40 MHz) imaging. The effect of the targeted microbubbles on thrombolysis enhancement was investigated using an in vitro flow system: targeted and nontargeted...
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PMID: 20458876
PDF is available here.
PDF is available here.
Optics Express (17)20 2009
Abstract
Marine micro-bubbles are one of those important constituents that influence scattering characteristics of water column. Monte Carlo Based simulations show that a water entrained bubble cloud generate a characteristic backscatter of incident laser light [M. Xia, J. Opt. A: Pure Appl. Opt. 8, 350 (200...
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PMID: 19907564
PDF is available here.
PDF is available here.
Abstract
We aimed to assess the efficiency of targeting MBs to circulating cells using antibodies. Our experiments showed that MBs efficiently bind to erythrocytes and B-lymphoma cells in blood. The maximum binding was reached at a cell/MB ratio of 1:1. Following binding, the cells acquired buoyancy that all...
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PMID: 19505207
PDF is available here.
PDF is available here.
Medical Physics (36)8 2009
Abstract
A fluorophore-quencher (F-Q) labeled microbubble system is proposed as a sensor for measuring externally applied static pressure distribution in a tumor. To quantify the sensitivity of such an F-Q bubble system to the externally applied pressure, a model describing bubble response to the static pres...
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PMID: 19746779
PDF is available here.
PDF is available here.
Abstract
Gas diffusion from an encapsulated microbubble is modeled using an explicit linear relation for gas permeation through the encapsulation. Both the cases of single gas (air) and multiple gases (perfluorocarbon inside the bubble and air dissolved in surrounding liquid) are considered. An analytical ex...
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PMID: 19616160
PDF is available here.
PDF is available here.
Abstract
Conventional methods used for measuring regional renal blood flow, such as laser-Doppler flowmetry, are highly invasive, and each measurement is restricted to a discrete location. The aim of this study was to determine whether ultrasound imaging in conjunction with enhanced contrast agent (microbubb...
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PMID: 19420115
PDF is available here.
PDF is available here.