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Nebulizers and Vaporizers (1):
Recent article
Nebulizers and Vaporizers
Abstract
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Abstract
Many factors in tracheal intubation lead to postoperative sore throat from mucosal injury. Mometasone furoate spray is a moderate potency corticosteroid that prevents influx of inflammatory cells into the mucosa. The present study assessed the efficacy of this drug for reducing posto...
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PMID: 21863678
PDF is available here.
PDF is available here.
Respiratory Care (56)7 2011
Posture perfect: the role of positioning during bronchodilator administration with oxygen or heliox.
Abstract
Medicina Intensiva (35)4 2011
Abstract
To analyze the efficacy of nebulized colistin in the microbiological eradication and clinical improvement of patients with pulmonary infection by multi-resistant Acinetobacter baumannii (MAB).
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PMID: 21396739
PDF is available here.
PDF is available here.
Abstract
Respiratory Care (56)7 2011
Abstract
Heliox and forward-leaning posture (torso inclined forward at 50-60° with the elbows resting on the thighs) are adjuncts in the administration of nebulized bronchodilator to patients with acute asthma.
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PMID: 21352660
PDF is available here.
PDF is available here.
Respiratory Care (56)7 2011
Abstract
We proposed a new chest physiotherapy (CPT) secretion clearance method to treat respiratory syncytial virus bronchiolitis in infants. Our new CPT method consists of 15 prolonged slow expirations, then 5 provoked cough maneuvers.
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PMID: 21352671
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (47 Suppl 2) 2011
Abstract
Bronchial asthma is a chronic inflammatory disease that affects both the large-caliber airways and the smaller-caliber bronchioles. In the last few years, a major therapeutic advance has been made with the development of new systems of inhalation solutions, which produce extra-fine p...
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PMID: 21640282
PDF is available here.
PDF is available here.
Arerugi = [Allergy] (60)1 2011
Abstract
Abstract
Abstract
Our aim was to investigate the potential of the DustGun aerosol technology integrated with the isolated, perfused, and ventilated lung of the rat (IPL) to study the pulmonary disposition of an inhaled model biopharmaceutical, the 40-kDa protein horseradish peroxidase (HRP).
The DustGun aerosol techn...
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PMID: 20455769
PDF is available here.
PDF is available here.
Abstract
Droplet evaporation has been known to bias cascade impactor measurement of aerosols generated by jet nebulizers. Previous work suggests that vibrating mesh nebulizers behave differently from jet nebulizers. Unlike jet nebulizers, vibrating mesh nebulizers do not rely on compressed air to generate dr...
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PMID: 20455771
PDF is available here.
PDF is available here.
Abstract
Our study suggests that the use of prefilled dry powder inhalers as well as inhalation instruction increases correct inhalation technique. Simultaneous use of different types of inhalation devices has to be discouraged....
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PMID: 20804428
PDF is available here.
PDF is available here.
Abstract
These results may have infection control implications for other airborne infections, such as severe acute respiratory syndrome and tuberculosis, as well as for pandemic influenza infection....
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PMID: 20923611
PDF is available here.
PDF is available here.
Anesthesiology (113)4 2010
Abstract
Southern Medical Journal (103)9 2010
Abstract
Abstract
In this study, the ability to control the shell thickness of hollow polymeric microspheres prepared using electrohydrodynamic processing at ambient temperature was investigated. Polymethylsilsesquioxane (PMSQ) was used as a model material for the microsphere shell encapsulating a core of liquid perf...
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PMID: 20519216
PDF is available here.
PDF is available here.
Abstract
The Staccato system employs a thermal vaporization technology to generate pure drug aerosols with a particle size optimized for alveolar deposition, leading to rapid absorption of the drug into the systemic circulation. Unlike most traditional aerosol-generation techniques, the particle size of the...
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PMID: 20528148
PDF is available here.
PDF is available here.
Abstract
Acquisition of Pseudomonas aeruginosa, the most prevalent organism isolated from cystic fibrosis (CF) airways, is associated with an accelerated clinical deterioration and reduced survival. Strategies to chronically suppress P. aeruginosa infections in individuals with CF have evolved over the last...
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PMID: 20658904
PDF is available here.
PDF is available here.
Anaesthesia (65)8 2010
Abstract
We have previously found that a display of predicted future values speeds step changes in end-tidal sevoflurane. In this study anaesthetists made step changes of 0.3% in effect site sevoflurane, with and without the display and as increases and decreases. We analysed 91 changes. When the predictive...
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PMID: 20569248
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)8 2010
Abstract
Our results suggest that nasal deposition of albuterol aerosol generated by a pneumatic nebulizer in 9-month-old infants may be significantly affected by changes in TV, ranging between 50 to 200 mL, whereas total lung deposition may not be affected. These results also predict that environmental loss...
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PMID: 20496045
PDF is available here.
PDF is available here.
Respiratory Care (55)7 2010
Abstract
Nebulizer placement prior to the humidifier increased drug delivery with both the jet nebulizer and the vibrating-mesh nebulizer, with a greater increase with the vibrating-mesh nebulizer. Higher bias flow reduced drug delivery. Drug delivery with the vibrating-mesh nebulizer was 2-4-fold greater th...
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PMID: 20587095
PDF is available here.
PDF is available here.
Respiratory Care (55)7 2010
Abstract
This paper reviews the history of aerosol therapy; discusses patient, drug, and device factors that can influence the success of aerosol therapy; and identifies trends that will drive the science of aerosol therapy in the future. Aerosol medication is generally less expensive, works more rapidly, an...
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PMID: 20587104
PDF is available here.
PDF is available here.
Respiratory Care (55)7 2010
Abstract
The vibrating-mesh nebulizer, ultrasonic nebulizer, and pMDI with spacer were most efficient in position 2 with both non-humidified (30.2 +/- 1.0%, 24.7 +/- 4.4%, and 27.8 +/- 3.3%, respectively) and heated/humidified circuits (16.8 +/- 2.6%, 16.5 +/- 4.3%, and 17 +/- 1.0%, respectively). In contras...
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PMID: 20587094
PDF is available here.
PDF is available here.
Respiratory Care (55)7 2010
Abstract
Respiratory Care (55)7 2010
Abstract
Abstract
BACKGROUND: Asthma affects minority citizens in Chicago disproportionately. Policy changes introducing hydrofluroalkane (HFA) inhalers may worsen already-existing health disparities related to asthma. AIMS: To teach internal medicine residents about the transition to HFAs so they can better counsel...
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PMID: 20690317
PDF is available here.
PDF is available here.
Abstract
The diagnosis, investigation and particularly management of bronchiectasis has been largely empirical and the subject of relatively few controlled clinical trials. There are no clear guidelines, although an Australian position statement has been published concerning bronchiectasis in children. The p...
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PMID: 20627931
PDF is available here.
PDF is available here.
Intensive Care Medicine (36)7 2010
Abstract
Emergence of multidrug-resistant strains in intensive care units has renewed interest in colistin, which often remains the only available antimicrobial agent active against resistant Pseudomonas aeruginosa. The aim of this study is to compare lung tissue deposition and antibacterial...
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PMID: 20397007
PDF is available here.
PDF is available here.
Abstract
No differences were detected regarding either the aerosol delivery system used or the need for hospitalization in relation to the plasma concentrations of salbutamol. However, higher plasma levels were found in patients >2 years vs patients < or =2 years [median (IQR): 9.40 (6.32-18.22) vs. 4.65 (2....
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PMID: 20195589
PDF is available here.
PDF is available here.
Abstract
We found that the absorption rates of the formulations were similar after aerosolization and deposition in a multistage liquid impinger, which simulates more realistically the detachment of the drug crystals from the carrier lactose and their aerodynamic particle size-dependent deposition in the res...
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PMID: 20073555
PDF is available here.
PDF is available here.
Hospital practice (1995) (38)3 2010
Abstract
Abstract
The droplet size affects the final product in fluid-bed granulation and coating. In the present study, spray characteristics of aqueous granulation liquid (purified water) were determined in situ in a fluid-bed granulator. Droplets were produced by a pneumatic nozzle. Diode laser stroboscopy (DLS) w...
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PMID: 20211713
PDF is available here.
PDF is available here.
Abstract
Given the important role of insulin in the treatment of diabetes mellitus and in light of common barriers to insulin use, new strategies for insulin delivery by routes other than intravenous and subcutaneous injection have been investigated since the discovery of insulin in the 1920s. Most companies...
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PMID: 20462282
PDF is available here.
PDF is available here.
Abstract
Abstract
Inhaled corticosteroids (ICS) are the most effective anti-inflammatory agents for the management of chronic persistent asthma and are therefore recommended as first-line antiasthmatic therapy in children and adults. In various settings, the administration of ICS via nebulizer rather than hand-held i...
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PMID: 19961948
PDF is available here.
PDF is available here.
Abstract
This article reviews current concepts regarding the clinical and scientific rationale for the combined use of glucocorticosteroids and beta-2-adrenoreceptor (beta2AR) agonists in the treatment of childhood asthma.
Several studies have demonstrated that inhaled corticosteroids (ICS) and beta2AR agoni...
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PMID: 20164771
PDF is available here.
PDF is available here.
Abstract
Successful management of pain reduces morbidity and improves patient satisfaction of patient after a chest trauma. The purpose of the study was to evaluate the efficacy of the respiratory administration of nebulized morphine in such patients.
Patients were included in this prospective and randomized...
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PMID: 20537851
PDF is available here.
PDF is available here.
Veterinary Record (166)19 2010
Abstract
Abstract
The main goals for developing effective treatments for pediatric asthma are to improve the quality of life of children with asthma by reducing symptoms and the frequency of exacerbations, to allow undisturbed sleep and performance of daily activities, and to ensure a more healthy adult future. Despi...
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PMID: 20419601
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)5 2010
Abstract
Aerosol ICS dissolution into the limited aqueous fluid volume differed kinetically due to ICS solubility and aerosol mass, size, formulation and/or generation....
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PMID: 20229134
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)5 2010
Abstract
Results indicate that dextran 10 has promise as a novel excipient for dry powder inhalation drug delivery, in a preclinical setting, over a wide range of drug loadings....
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PMID: 20232119
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
Conventional aerosol delivery systems and the availability of new technologies have led to the development of "intelligent" nebulizers such as the I-neb Adaptive Aerosol Delivery (AAD) System. Based on the AAD technology, the I-neb AAD System has been designed to continuously adapt to changes in the...
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PMID: 20373904
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The in vitro characterization of device-related parameters such as the rate of aerosol output, total aerosol output, particle size, and fine particle fraction, is essential when assessing the potential performance of a nebulizer or making comparisons with other nebulizers as they are indicative of p...
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PMID: 20373905
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The trial showed that it was possible to build telehealth technology into an advanced nebulizer system, and that patient acceptance of the technology was unlikely to be a barrier to the adoption of such a telehealth system....
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PMID: 20373906
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
This study provides preliminary evidence of the acceptability of the TIM breathing maneuver in patients with CF and their ability to perform repeated TIM breathing during simulated nebulizer therapy with the I-neb AAD System....
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PMID: 20373907
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The results of the present study showed that lung deposition with the slow and deep inhalation achieved through the I-neb AAD System in TIM was superior to the lung deposition achieved during tidal breathing in TBM. With the combination of high lung deposition, almost no loss of aerosol during exhal...
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PMID: 20373908
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The results demonstrated that by using the I-neb AAD System in TIM, a 40-50% reduction of nebulizer treatment times, and a high level of compliance could be achieved. The results also showed that the patients found the I-neb AAD System easy to use....
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PMID: 20373909
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The I-neb AAD System enhanced AAT delivery by inhalation-only aerosol generation and a low-residual dose. Predicted lung dose was high for both TBM and TIM, but longer inspiratory times with TIM reduced the administration time to one-third that of tidal breathing. We conclude that slow, deep, contro...
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PMID: 20373910
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Abstract
The results from this study demonstrated that patients were more satisfied with the I-neb AAD System and found it easier to use than their previous nebulizer systems. In addition, the I-neb AAD System significantly improved dyspnea and fatigue compared with the patients' previous nebulizer systems,...
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PMID: 20373911
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (23 Suppl 1) 2010
Intelligent nebulizers in the age of the Internet: The I-neb Adaptive Aerosol Delivery (AAD) system.
Abstract
Abstract
This study demonstrated that flexible dip tubes can improve the performance of many nasal sprays, and that shaking may have negative effects on spray weight uniformity....
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PMID: 19778208
PDF is available here.
PDF is available here.
Abstract
In the FTIR scan, all characteristic peaks of lactose and LMWH were observed, suggesting that there was no strong interaction between lactose and LMWH. Although the aerodynamic diameter of the formulation (DPI-2) that was sieved through 170- and 230-mesh screens was similar to that of the formulatio...
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PMID: 19778265
PDF is available here.
PDF is available here.
Abstract
The results of this study suggest that nanoemulsion-based vaccines do not require specially engineered delivery devices and support their potential use as nasopharyngeal vaccine adjuvants....
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PMID: 19778268
PDF is available here.
PDF is available here.
Abstract
In conclusion, local treatment with APC, AT, heparin, or danaparoid attenuate pulmonary coagulopathy, but not inflammation, in rats with endotoxemia-induced lung injury....
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PMID: 20073557
PDF is available here.
PDF is available here.
Abstract
Abstract
Respiratory Care (55)4 2010
Abstract
The total emitted mass of albuterol per actuation that exited the VHC was marginally greater during spontaneous breathing (12.1 +/- 1.8 microg) than during manual resuscitation (10.0 +/- 1.1 microg) (P = .046). Albuterol delivery via mechanical ventilation, though comparable with the premature-neona...
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PMID: 20406509
PDF is available here.
PDF is available here.