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Corneal Diseases (7):
Recent article
Corneal Diseases
Abstract
To evaluate the therapeutic efficiency of tissue-engineered human corneal endothelia (TE-HCEs) on rabbit primary corneal endotheliopathy (PCEP), TE-HCEs reconstructed with monoclonal human corneal endothelial cells (mcHCECs) and modified denuded amniotic membranes (mdAMs) were transp...
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PMID: 21634043
PDF is available here.
PDF is available here.
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Ugeskrift for laeger (173)1 2011
Abstract
A 79-year-old female had vision loss due to wet age-related macular degeneration, corneal endothelial dystrophy with corneal oedema and cataract. She subsequently began hallucinating and saw imaginary vehicles, bridges, trees and houses on the road while driving (Charles Bonnet syndrome (CBS)). The...
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PMID: 21199624
PDF is available here.
PDF is available here.
Abstract
We performed DALK on her left eye for visual rehabilitation. Big-bubble technique was used to perform lamellar separation.
Corneal graft was clear 24 months after surgery. Best spectacle-corrected visual acuity of left eye was 20/25 with the correction of +0.75/-0.50 diopters × 170. At the last fol...
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PMID: 20856106
PDF is available here.
PDF is available here.
Abstract
We have described a method to improve the centration of donor trephination and reduce the incidence of eccentric donor punching....
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PMID: 20847687
PDF is available here.
PDF is available here.
Abstract
To describe the use of the Boston ocular surface prosthesis (BOSP) to successfully treat a persistent corneal epithelial defect (PCED) after herpes zoster ophthalmicus that was minimally responsive to conventional therapies.
A case report.
A 44-year-old man who developed a PCED in the right eye afte...
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PMID: 20847682
PDF is available here.
PDF is available here.
Abstract
I keratoprostheses implantation for unilateral visual impairment.
Seventeen patients who underwent implantation of a Boston type I keratoprosthesis and had a best-corrected visual acuity better than 20/50 in the contralateral eye before surgery were evaluated. All subjects prospectively underwent se...
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PMID: 20847681
PDF is available here.
PDF is available here.
Abstract
To report a patient with a tumor-like corneal keloid.
Retrospective review of clinical features and histopathologic findings.
A 68-year-old woman with a remote history of an orbital tumor treated with radiation developed a corneal tumor. A biopsy of the tumor showed fibrocellular tissue, and her bli...
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PMID: 20856108
PDF is available here.
PDF is available here.
Abstract
Obvious corneal calcification of the wound area along with a complete epithelial healing covering the calcified area was observed following exposure to phosphate hyaluronate eye-drops. Epithelial healing without calcification was achieved using citrate hyaluronate eye-drops. CONCLUSION: Clinical obs...
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PMID: 20650912
PDF is available here.
PDF is available here.
Abstract
The success rate in measuring IOP with DCT and GAT did not show any statistically significant difference. Both methods were less effective measuring the IOP after recent PKPs and regrafts. However, DCT seemed to be superior to GAT in corneas with more than 4 remaining sutures and in PKPs performed m...
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PMID: 20847755
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
To analyze morphometry of corneal epithelial cells in normal eyes and after anterior lamellar keratoplasty (ALK) using confocal microscopy.
This retrospective comparative case series included 29 eyes of patients who had undergone ALK (ALK group) and 29 subjects before refractive surgery with normal...
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PMID: 20639742
PDF is available here.
PDF is available here.
Abstract
The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made.
A thorough search for the total number of patients with...
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PMID: 20567200
PDF is available here.
PDF is available here.
Abstract
To report a case of Descemet stripping endothelial keratoplasty (DSEK) with a large posterior lamellar graft for the treatment of bullous keratopathy secondary to congenital glaucoma.
Bullous keratopathy secondary to unilateral congenital glaucoma with buphthalmos in a 36-year-old man was treated wi...
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PMID: 20595891
PDF is available here.
PDF is available here.
Abstract
Abstract
To study the outcome of phototherapeutic keratectomy (PTK) in children younger than 16 years, with corneal scars, dystrophies, and band-shaped keratopathy.
Records of 18 eyes of 14 patients younger than 16 years who had undergone PTK were retrospectively reviewed. Pre- and post-PTK visual acuity, co...
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PMID: 20622671
PDF is available here.
PDF is available here.
Abstract
We detected a subtle lagophthalmos, which was complicated by upper eyelid retraction in the right eye. A bilateral upper blepharotomy improved the keratopathy.
Patients with AIDS with severe weight loss can present with lagophthalmos because of adipose and muscular atrophy in the so-called wasting s...
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PMID: 20628297
PDF is available here.
PDF is available here.
Abstract
To report an unusual presentation of posterior polymorphous corneal dystrophy (PPCD) associated with band keratopathy, iridocorneal adhesions, heterochromia, keratoconus, and confocal microscopic findings suggestive of iridocorneal endothelial syndrome.
Confocal microscopy, corneal topography, elect...
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PMID: 20567203
PDF is available here.
PDF is available here.
Abstract
An 84-year-old white female with nonprogressive conjunctival scarring developed infectious crystalline keratopathy (ICK) recalcitrant to topical therapy. After determination of the causative organism's antibiotic sensitivities, superficial keratectomy was performed with intrastromal corneal infiltra...
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PMID: 20595892
PDF is available here.
PDF is available here.
Abstract
To evaluate the irregularity of the anterior and posterior cornea after Descemet stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK).
This clinical study comprised 39 eyes: 13 consecutive eyes after DSAEK, 13 consecutive eyes after PK, and 13 age-matched normal eye...
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PMID: 20567202
PDF is available here.
PDF is available here.
Abstract
We analyzed CCT and IOP in eyes before and after DSAEK to determine whether changes in corneal biomechanics because of edema, grafted tissue, and subsequent stromal deturgescence affect IOP measurement.
A retrospective chart review was performed on 32 eyes from 31 patients with corneal edema seconda...
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PMID: 20548237
PDF is available here.
PDF is available here.
Abstract
We report a case of corneal epithelial changes that occurred as ocular side effects of treatment with exemestane, a selective steroidal aromatase inhibitor. A 55-year-old woman presented to our outpatient department for routine eye examination. Clinical examination revealed bilateral corneal gray-wh...
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PMID: 20470238
PDF is available here.
PDF is available here.
Abstract
Abstract
At 6-month follow-up, a significant decrease was seen in the symptom scores from the baseline level in both the PTK and AMT groups (P = 0.011 and 0.017, respectively) with no difference between the groups (P = 0.593). Complete epithelialization was noted 2 weeks postoperatively in 13 of 13 eyes in t...
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PMID: 20517149
PDF is available here.
PDF is available here.
Abstract
The implanted KPro-donor cornea interface seems to be stable dynamically using AS-OCT. A gap that has been documented with this imaging tool showed neither gaping nor escape of anterior chamber fluid during dynamic cross-sectional imaging. Further studies will be needed to assess the cause of these...
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PMID: 20517152
PDF is available here.
PDF is available here.
Abstract
Eighty eyes met the inclusion criteria. Escalation of glaucoma therapy occurred in 13 eyes (16.3%) during a mean follow-up period of 27.1 months. Ten eyes required additional topical medical therapy, and 3 eyes required surgical intervention. Glaucoma therapy escalation was significantly associated...
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PMID: 20520533
PDF is available here.
PDF is available here.
Abstract
In normal corneas, there were small (clinically insignificant) differences among methods for ECD (P < 0.001) (mean +/- SD: flex center, 2846 +/- 248 cells/mm; center, 2870 +/- 253 cells/mm; and corner, 2892 +/- 254 cells/mm), CV (P < 0.001) (flex center, 33% +/- 3%; center, 30% +/- 3%; and corner, 3...
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PMID: 20520534
PDF is available here.
PDF is available here.
Abstract
Abstract
All patients had clinical resolution of the tumor. The mean time to resolution was 47 days. During the follow-up time after resolution of the lesion (mean 41 months), one patient had disease recurrence 7 months after clinical resolution. This was successfully treated with one further injection. CONC...
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PMID: 20662655
PDF is available here.
PDF is available here.
Abstract
Patients with corneal blindness secondary to autoimmune disease often fare poorly with available surgical treatments. Study of existing literature on prosthetic device complications in autoimmune diseases may help uncover common mechanisms of tissue destruction to establish perioperative immunomodul...
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PMID: 20662659
PDF is available here.
PDF is available here.
The ocular surface (8)3 2010
Abstract
Abstract
The primary objective of this trial was to explore the extent to which common contact lens-related symptoms may be improved among symptomatic daily wear contact lens wearers who habitually replaced their lenses at intervals of 1 to 4 weeks when fitted with DAILIES AquaComfort Plus fo...
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PMID: 20543705
PDF is available here.
PDF is available here.
Abstract
The NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire) was extended by several questions taking account of aesthetic and cosmetic aspects in addition to the mere visual function aspects. This amended questionnaire, named NEI-VQF +, was used to evaluate the perceived overall success of...
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PMID: 20645231
PDF is available here.
PDF is available here.
Abstract
Management options for postoperative ectasia include conservative management with various types of contact lenses such as rigid gas permeable lenses, custom wave front-guided soft contact lenses, hybrid lenses and tandem soft contact lens-rigid gas permeable lenses. Minimally invasive surgical optio...
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PMID: 20489623
PDF is available here.
PDF is available here.
Abstract
Abstract
Elevated and anterior stromal lesions respond best to PTK. PTK can also be used to effectively treat recurrent erosions. Smoothing agents and intraoperative mitomycin C can be helpful for certain disorders. SUMMARY: The preoperative evaluation is very important in order to establish whether the eye...
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PMID: 20467315
PDF is available here.
PDF is available here.
Abstract
Autologous cultures of limbal stem cells can regenerate a functional corneal epithelium in patients affected by unilateral LSCD. We showed a correlation between the clinical outcome and the molecular marker expression....
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PMID: 20489583
PDF is available here.
PDF is available here.
Abstract
Direct neurotization of the cornea using the contralateral, supraorbital, and supratrochlear branches of the ophthalmic division of the trigeminal nerve seems to be an effective method for restoration of corneal sensibility in patients with unilateral facial palsy and anesthetic cornea. This procedu...
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PMID: 20489582
PDF is available here.
PDF is available here.
Abstract
MOOKP is the keratoprosthesis of choice in bilateral end-stage ocular surface disorders in the Indian subcontinent. Complications do occur and have to be recognized and treated early....
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PMID: 20489578
PDF is available here.
PDF is available here.
Abstract
Topical nonpreserved 0.01% dexamethasone could be an effective therapy for recalcitrant chronic ocular surface disease....
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PMID: 20489601
PDF is available here.
PDF is available here.
Abstract
Abstract
The findings of abnormal intercellular collections at the basal epithelial layer of the cornea correlate with the previously reported histological findings. They are consistent with the abnormal keratocyte-to-keratocyte adhesions that are described both in the skin and cornea of Darier disease. The...
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PMID: 20489591
PDF is available here.
PDF is available here.
Abstract
In addition to being a protective shield, the cornea represents two thirds of the eye's refractive power. Corneal pathology can affect one or all of the corneal layers, producing corneal opacity. Although full corneal thickness keratoplasty has been the standard procedure, the ideal...
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PMID: 19941445
PDF is available here.
PDF is available here.
Abstract
Epithelial squamous metaplasia was found in 72 (100%) eyes, along with conjunctival goblet cells in 25 (34.72%) eyes. Squamous metaplasia was grade 1 in group GC and more advanced grades in group NGC. Corneal neovascularisation was present in 62 (82.11%) eyes. Vessel measure was more than 4 mm in 11...
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PMID: 19965819
PDF is available here.
PDF is available here.
Abstract
This is only the second published case of corneal deposits in conjunction with rifabutin therapy for Crohn's disease. This case uniquely confirms the persistence of the corneal deposits longer than previously documented....
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PMID: 20458240
PDF is available here.
PDF is available here.
Abstract
Formation of flap buttonhole is significantly more common in the second eye and with the usage of Moria M2 microkeratome and 90-microm blade. In thin-flap LASIK, the practice of using the same microkeratome blade for the fellow eye, as is commonly followed at many refractive surgery centres, should...
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PMID: 20458216
PDF is available here.
PDF is available here.
Abstract
Morphologic features of KPs in various types of uveitis are diverse. Stippled and globular KPs may be observed in almost all types of uveitis. Certain types of KPs are more frequently associated with specific forms of uveitis, that is, smooth-rounded KPs may be an indicative of a granulomatous uveit...
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PMID: 20458232
PDF is available here.
PDF is available here.
Abstract
Treatment with intravitreous bevacizumab may precipitate an immune response leading to the appearance of corneal subepithelial infiltrates....
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PMID: 20458242
PDF is available here.
PDF is available here.
Abstract
JXG is a benign histiocytic disorder that usually appears early in childhood but is also encountered in 13%-18% of cases in the second decade. The histiocytes usually stain positively for CD68 and negatively for S-100 and CD1a. Correctly distinguishing JXG from the more aggressive spectrum of Langer...
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PMID: 20458239
PDF is available here.
PDF is available here.
Abstract
Corneal larvae can be safely and successfully destroyed by Nd:YAG photodestruction. T. canis may be one of several nematodes responsible for DUSN. A careful examination of the anterior segment is essential in the management of patients with DUSN....
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PMID: 20458229
PDF is available here.
PDF is available here.
Abstract
We started administration of ganciclovir. There was resolution of the inflammation; however, bullous keratopathy was subsequently noted in the cornea. Additional PKP was performed with perioperative intravenous administration of ganciclovir. The failed graft obtained during the additional PKP was su...
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PMID: 20458221
PDF is available here.
PDF is available here.
Abstract
OSD is prevalent among medically treated patients with glaucoma. The severity of OSD symptoms is positively correlated to the number of IOP-lowering medications used....
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PMID: 20386433
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The aim of this study was to compare the presence and activity of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9 and 13 in human melted and cadaverous corneas. Twelve melted corneal specimens from three patients with rheumatoid arthritis, one patient with ocular cicatricial pemphigoid and one pat...
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PMID: 20153319
PDF is available here.
PDF is available here.
Effect of estrogen on electroretinographic responses in streptozotocin-induced diabetic female rats.
Abstract
The aim of this study is to investigate the effects of estrogen on functional changes in the retinas of streptozotocin (STZ)-induced diabetic rats by using an electroretinography. Female rats were randomly divided into four treatment groups: (1) Control (sham operation and vehicle administration); (...
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PMID: 20153747
PDF is available here.
PDF is available here.
Abstract
AIM To report the outcome of treatment of non-invasive ocular surface squamous neoplasia (or conjunctival-corneal intra-epithelial neoplasia (CCIN)) where topical mitomycin C (MMC) has been used in the treatment regimen. DESIGN Prospective, non-comparative interventional case series. PARTICIPANTS 91...
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PMID: 20447963
PDF is available here.
PDF is available here.
Abstract
AIMS To evaluate the effect of topical autologous plasma on nerve morphology in patients with neurotrophic keratopathy (NK) using the confocal microscope. METHODS Eleven eyes of six patients with neurotrophic keratopathy were evaluated for this study. Corneal fluorescein staining was done, and corne...
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PMID: 19965821
PDF is available here.
PDF is available here.
Abstract
Abstract
Transplantation of autologous stem cells cultivated on AM with or without subsequent PKP seems to be an effective way for visual rehabilitation in total LSCD. More work with more cases and longer follow-up are needed to optimize this procedure to provide and maintain an adequate supply of limbal ste...
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PMID: 20299977
PDF is available here.
PDF is available here.