Abstract
Poly(lactide-co-glycolide) (PLGA) beads have been widely studied as a potential drug/protein carrier. The main shortcomings of PLGA beads are that they lack bioactivity and controllable drug-delivery ability, and their acidic degradation by-products can lead to pH decrease in the vic...
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PMID: 21210517
PDF is available here.
Abstract
We addressed four major autoimmune-rheumatological diseases investigated through proteomic techniques and provide evidence-based data on the highlights obtained in systemic sclerosis, primary and secondary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis.
Cop...
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PMID: 21246742
PDF is available here.
Abstract
We hypothesized that restriction of carbon sources--including glucose--in the ASL is required for sterility of the lungs. We found that airway epithelia deplete glucose from the ASL via a novel mechanism involving polarized expression of GLUT-1 and GLUT-10, intracellular glucose phosphorylation, and...
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PMID: 21311590
PDF is available here.
Abstract
This paper reports a microfluidic synthesis of biopolymer microparticles aiming at smart swelling. Monodisperse aqueous emulsion droplets comprising biopolymer and its cross-linking agent were formed in mineral oil and solidified in the winding microfluidic channels by in situ chaotic mixing, which...
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PMID: 20833004
PDF is available here.
Abstract
This study was intended to evaluate the incidence and the long-term outcome of fluid collecting between the hepatic resection surface and a collagen patch. To our knowledge, this is the first study to analyze these aspects.
All patients undergoing hepatic resection wi...
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PMID: 21830420
PDF is available here.
Abstract
Results from toxicological analyses in death investigations are used to determine whether foreign substances were a cause of death, whether they contributed to death, or whether they caused impairment. Drug concentrations are likely to change during pre-terminal stages due to altered pharmacokinetic...
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PMID: 20204545
PDF is available here.
Abstract
A systematic investigation of the human metabolism of hydroxycinnamic acid conjugates was carried out. A set of 24 potential human metabolites of coffee polyphenols has been chemically prepared, and used as analytical standards for unequivocal identifications. These included glucuronide conjugates a...
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PMID: 20842300
PDF is available here.
Leah Grossman,
Eli Utterback,
Adam Stewart,
Siddharth Gaikwad,
Kyung Min Chung,
Christopher Suciu,
Keith Wong,
Marco Elegante,
Salem Elkhayat,
Julia Tan,
Thomas Gilder,
Nadine Wu,
John Dileo,
Jonathan Cachat and
Allan V Kalueff
Abstract
Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug that strongly affects animal and human behavior. Although adult zebrafish (Danio rerio) are emerging as a promising neurobehavioral model, the effects of LSD on zebrafish have not been investigated previously. Several behavioral paradi...
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PMID: 20561961
PDF is available here.
Abstract
We focus on the presentation of main methodological approaches that have been developed for the study of secreted proteins and the results thereof from the analysis of secretome in different types of malignancies; special emphasis is given on correlation of findings with protein expression in body f...
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PMID: 20637910
PDF is available here.
Abstract
We constructed one standard, reference, RXc-score graph and RXc-tolerance ellipses (50, 75 and 95%) that can be used with any analyser. Mean PA was 3.14 (SD 0.43)° (3.12 (SD 0.39)° for males and 3.17 (SD 0.48)° for females). Considering the overlapping of ellipses of males and females with the ge...
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PMID: 20594393
PDF is available here.
Abstract
The interaction between photosensitizer anticancer drug hematoporphyrin monomethyl ether (HMME) and ctDNA has been studied based on the decreased resonance light scattering (RLS) phenomenon. The RLS, UV-vis and fluorescence spectra characteristics of the HMME-ctDNA system were investigated. Besides,...
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PMID: 20643575
PDF is available here.
Abstract
In this paper a simple, selective and inexpensive kinetic method was developed for the determination of morphine based on its inhibitory effect on the Janus green-bromate system in sulfuric acid media. The reaction was monitored spectrophotometrically at 618 nm by a fixed time method. The effect of...
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PMID: 20634129
PDF is available here.
Abstract
We have done a comparative evaluation of the structural features of the HAp coatings, prepared by using simulated body fluid (SBF) at 25 degrees C for various time periods, on a nonporous metal substrate titanium-aluminium-vanadium (Ti-6Al-4V) alloy and a bioinert ceramic substrate alpha-alumina (al...
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PMID: 20730928
PDF is available here.
Abstract
The trace element contents in the body fluid and hair are the important monitoring indicators for many diseases. The analysis of the trace element contents in the samples of lung cancer patients is helpful to the early diagnosis and treatment effectiveness evaluation to the patients. The aim of this...
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PMID: 20704825
PDF is available here.
Abstract
A rapid and sensitive voltammetric sensor based on reduction of betamethasone has been developed using single wall carbon nanotube modified edge plane pyrolytic graphite electrode (SWNT/EPPGE). The reduction of betamethasone occurred in a well-defined, pH dependent peak. Linear calibration curve was...
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PMID: 20426744
PDF is available here.
Abstract
We aimed to establish the endoscopic pancreatic function test (ePFT) as a method that can safely obtain pancreatic fluid for mass spectrometric analysis from patients during upper endoscopy and to reproducibly identify pancreas-specific proteins.
We performed a sodium dodecyl sulfate-polyacrylamide...
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PMID: 20182389
PDF is available here.
Abstract
Phosphate-based glasses (PGs) and their composites are of interest as bone repair and tissue engineering scaffolds due to the totally degradable nature of the materials. This study has investigated the effect of Si and Fe on the properties of PG particulate-filled polycaprolactone (P...
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PMID: 20206722
PDF is available here.
Abstract
Phosphate-based glasses (PGs) and their composites are of interest as bone repair and tissue engineering scaffolds due to the totally degradable nature of the materials. This study has investigated the effect of Si and Fe on the properties of PG particulate-filled polycaprolactone (P...
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PMID: 20206722
PDF is available here.
Abstract
These results suggest that surveillance with NQ-ETA is better than the Q-ETA in predicting the development and causative pathogen of VAP in patients who have already been receiving antibiotic therapy....
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PMID: 20661200
PDF is available here.
Abstract
Topical antimicrobials, or microbicides, are being developed to prevent HIV transmission through local, mucosal delivery of antiviral compounds. While hydrogel vehicles deliver the majority of current microbicide products, intravaginal rings (IVRs) are an alternative microbicide moda...
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PMID: 20222027
PDF is available here.
Abstract
The purpose of the present study was to study the impact of free fatty acid and monoglyceride level and ratio on the nanostructural composition and solubilizing capacity of media simulating fed state intestinal fluids (SIFs). SIFs, without or with oleic acid/monoolein (OA/MO) in rati...
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PMID: 20564382
PDF is available here.
Abstract
We also explore how relatively small increases in large pore numbers dramatically increase J(v) during acute inflammation....
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PMID: 20200043
PDF is available here.
Abstract
We will discuss the role of small GTPases for the maintenance of microvascular barrier functions under resting conditions as well as under conditions of increased permeability and their involvement in signalling pathways downstream of both barrier-stabilizing and inflammatory mediators. Rac1 and Cdc...
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PMID: 20299335
PDF is available here.
Abstract
Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown...
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PMID: 20400620
PDF is available here.
Abstract
We focus on current problems that limit the integration of our knowledge of mechanisms investigated in detail at the cellular level into a more complete understanding of modulation of blood-to-tissue exchange in whole organs when the endothelial barrier is exposed to acute and more long-term inflamm...
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PMID: 20418473
PDF is available here.
Abstract
We discuss the evidence demonstrating the role of eNOS in the elevation of microvascular permeability. We also examine the relative importance of eNOS phosphorylation and localization in its function to promote elevated microvascular permeability as well as emerging topics with regard to eNOS and mi...
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PMID: 20462865
PDF is available here.
Abstract
In response to infections or tissue injury, circulating leucocytes adhere to and migrate from the vessel lumen to interstitial inflammatory sites to combat invading pathogens. However, these defensive actions may also cause host tissue injury and microvascular dysfunction through oxi...
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PMID: 20472564
PDF is available here.
Abstract
This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P(if)) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regula...
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PMID: 20472565
PDF is available here.
Abstract
There was a strong correlation between ELM status and VA (r = -0.75, P < .001), and that was higher than that of the IS/OS (r = -0.69, P < .001). Multivariate analysis showed that ELM status is the most important factor for VA. Other parameters that correlated with VA included age, status of the int...
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PMID: 20609705
PDF is available here.
Abstract
Magnesium alloy stent has been employed in animal and clinical experiment in recent years. It has been verified to be biocompatible and degradable due to corrosion after being implanted into blood vessel. Mg-Y-Gd-Nd alloy is usually used to construct an absorbable magnesium alloy stent. However, the...
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PMID: 20352299
PDF is available here.
Abstract
Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this s...
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PMID: 20127996
PDF is available here.
Mingmin Chen,
Anurag Singh,
Fang Xiao,
Ulrike Dringenberg,
Jian Wang,
Regina Engelhardt,
Sunil Yeruva,
Isabel Rubio-Aliaga,
Anna-Maria Nässl,
Gabor Kottra,
Hannelore Daniel and
Ursula Seidler
Abstract
PEPT1 function in mouse intestine has not been assessed by means of electrophysiology and methods to assess its role in intracellular pH and fluid homeostasis. Therefore, the effects of the dipeptide glycilsarcosin (Gly-Sar) on jejunal fluid absorption and villous enterocyte intracel...
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PMID: 20430876
PDF is available here.
Abstract
We examined how well BIS estimates body fluid volume in mice. Using C57/Bl6 mice, the BIS system demonstrated <5% intermouse variation in total body water (TBW) and extracellular (ECFV) and intracellular fluid volume (ICFV) between animals of similar body weight. TBW, ECFV, and ICFV differed between...
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PMID: 20462974
PDF is available here.
Abstract
Although exposure of the rat alveolar epithelium to S-ketamine decreases amiloride-sensitive transalveolar Na+ transport and AFC, IV S-ketamine at clinically relevant bolus concentrations does not affect AFC, even in the presence of mild lung injury....
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PMID: 20519416
PDF is available here.
Abstract
The primary objective of this review is to discuss recent technological developments in the field of solid-phase microextraction that have enhanced the utility of this sample preparation technique in the field of bioanalysis. These developments include introduction of various new biocompatible coati...
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PMID: 20031143
PDF is available here.
Abstract
In vitro bioaccessibility (IVBA) studies were carried out on samples of mercury (Hg) mine-waste calcine (roasted Hg ore) by leaching with simulated human body fluids. The objective was to estimate potential human exposure to Hg due to inhalation of airborne calcine particulates and hand-to-mouth ing...
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PMID: 20491469
PDF is available here.
Abstract
Asthma, chronic obstructive pulmonary disease (COPD) and lung cancer cause extensive mortality and morbidity worldwide. However, the current state-of-the-art diagnosis and management schemes of these diseases are suboptimal as the incidence of asthma has risen by 250% over the last two decades and t...
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PMID: 20536308
PDF is available here.
Abstract
Neither metastasis nor recurrence has occurred in the 6-month period since resection. A review of the literature did not reveal any similar description of intramuscular GCT-ST. CONCLUSION: GCT-ST should be included in the differential diagnosis of soft tissue tumors with FFLs....
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PMID: 20432041
PDF is available here.
Abstract
Metabolomics is a new approach based on the systematic study of the full complement of metabolites in a biological sample. This technology consists of two sequential steps: (1) an experimental technique, based on mass spectrometry or nuclear magnetic resonance (NMR) spectroscopy, designed to profile...
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PMID: 21089734
PDF is available here.
Abstract
Our goal is to identify reliable markers for the detection of OS in physiology and pathology. These biomarkers can be useful for several clinical purpose such as to monitor the response to any antioxidant intervention and then develop preventive strategies. The standardization and a large clinical u...
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PMID: 21089735
PDF is available here.
Abstract
TBC is a major infectious emergency in the world. OMS suggest that there are 8 millions of affected every year and 2 millions of deaths. Italy is considered a country with low prevalence, but the increase of the immigration from Africa Asia and Est Europa (country with high risk) imposes attention t...
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PMID: 21090072
PDF is available here.
Abstract
These results suggested that MFCs located in large intestine could be a promising power source for IMDs.
2010 Elsevier B.V. All rights reserved....
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PMID: 20299200
PDF is available here.
Abstract
The BF mode on the Sysmex XE-5000 offers rapid and accurate RBC and WBC (differential) counts in clinically relevant concentration ranges in CSF and other fluids. In addition, the exclusion of high fluorescent cells, such as mesothelial cells and macrophages from WBC counting may reduce the number o...
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PMID: 20187854
PDF is available here.
Abstract
The corrosion behaviour of AZ31 magnesium alloy with different grain sizes immersed in simulated body fluids was compared in chloride solution (8 gl(-1)) and in phosphate-buffer solution (PBS). The influence of immersion time was also analyzed. Electrochemical techniques such as open circuit potenti...
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PMID: 19446048
PDF is available here.
Abstract
The aim of this work was to collect and compare data from different published reports which focused on the description of the influence of different electrochemical setups for the assessment of magnesium corrosion. Based on this, a comparison with our own results, obtained for LAE 442 and AZ 31, was...
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PMID: 20051271
PDF is available here.
Abstract
The mean concentrations of VEGF measured using Luminex were 97.7 +/- 6.2, 47.3 +/- 8.1, 24.9 +/- 2.2, and 14.2 +/- 1.8 pg/mL at 100, 50, 25, and 12.5 pg/mL dilutions, respectively. Similarly, the mean concentrations of VEGF measured using enzyme-linked immunosorbent assay for equivalent dilutions we...
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PMID: 20084052
PDF is available here.
Abstract
Of 8 patients with acute posterior multifocal placoid pigment epitheliopathy evaluated by the uveitis service at the Illinois Eye and Ear Infirmary between 2003 and 2008, 4 eyes of 3 patients presented with macular subretinal fluid. Confirmatory optical coherence tomography was performed in two pati...
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PMID: 19996817
PDF is available here.
Abstract
The formation of cell membranes through the physical-chemical interaction of two hydrophilic colloidal fluids is applied to the formation of the membranes of brain and neural cells. Also described is the membrane mechanism of transfer of ions and compounds necessary for brain and neural cell functio...
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PMID: 20094775
PDF is available here.