Abstract
We compiled a data set of larval host use and adult nectar sources for 995 butterfly and moth species (Lepidoptera) in central Europe. Using a phylogenetic generalized least squares approach, we found that those Lepidoptera that fed on a wide range of plant species as larvae were also nectar feeding...
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PMID: 21828993
PDF is available here.
Abstract
This study evaluated telavancin activity against 3868 Staphylococcus aureus and 1003 coagulase-negative staphylococci (CoNS) collected from 33 European hospitals (2009-2010). Studies of telavancin potency included analysis of strains with decreased susceptibility to glycopeptides. Telavancin (MIC(50/...
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PMID: 21851873
PDF is available here.
Abstract
We summarize the design, efficacy, and safety of previous randomized controlled trials and propose adapted algorithms for US settings. We performed a systematic search and included all 14 randomized controlled trials (N = 4467 patients) that investigated procalcitonin algorithms for antibiotic treat...
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PMID: 21824946
PDF is available here.
Abstract
One of the most critical functions of the various Proteomics organizations is the training of young scientists and the dissemination of information to the general scientific community. The education committees of the Human Proteome Organisation (HUPO) and the European Proteomics Asso...
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PMID: 21815689
PDF is available here.
Abstract
Major depressive disorder, the most common psychiatric illness, is often chronic and a major cause of disability. Many patients with major depressive episodes who have an underlying but unrecognized bipolar disorder receive pharmacologic treatment with ineffective regimens that do no...
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PMID: 21810644
PDF is available here.
Abstract
Compared to other chronic inflammatory diseases, gout appears to based on a rather "simple" pathophysiology and therefore the amount of teaching time in medical school and during internship is rather limited. On the other hand, several problems in short- and long-term management stil...
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PMID: 21833886
PDF is available here.
Abstract
Both G-CSFs are recommended for clinical use according to instructions in the respective SPCs; there is no reason to prefer lenograstim over filgrastim in any of the approved indications for both. Costs calculations need to consider the advent of biosimilar filgrastim in Europe....
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PMID: 21781651
PDF is available here.
Laura L Calabresi,
Damiano D Baldassarre,
Sara S Simonelli,
Monica M Gomaraschi,
Mauro M Amato,
Samuela S Castelnuovo,
Beatrice B Frigerio,
Alessio A Ravani,
Daniela D Sansaro,
Jussi J Kauhanen,
Rainer R Rauramaa,
Ulf U de Faire,
Anders A Hamsten,
Andries J AJ Smit,
Elmo E Mannarino,
Steve E SE Humphries,
Philippe P Giral,
Fabrizio F Veglia,
Cesare R CR Sirtori,
Guido G Franceschini and
Elena E Tremoli
Abstract
Lecithin:cholesterol acyltransferase (LCAT) is the enzyme responsible for cholesterol esterification in plasma. LCAT is a major factor in HDL remodeling and metabolism, and it has long been believed to play a critical role in macrophage reverse cholesterol transport (RCT). The effect of LCAT on human...
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PMID: 21596929
PDF is available here.
Abstract
Study publication bias is the decision to publish or not publish a study based on its results. Compared to unpublished work, published studies are more likely to have positive or statistically significant findings. Outcome reporting bias is opting to publish of only a subset of the o...
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PMID: 21766733
PDF is available here.
Abstract
SummaryBackground and objectives Demand for hemodialysis among elderly patients is increasing worldwide. Although clinical care of this high-risk group is complex and challenging, no guidelines exist to inform hemodialysis practices. The Dialysis Outcomes and Practice Patterns Study...
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PMID: 21734085
PDF is available here.
Dorit D Knappe,
Anne-Catherine AC Pouleur,
Amil M AM Shah,
Susan S Cheng,
Hajime H Uno,
W Jackson WJ Hall,
Mikhail M Bourgoun,
Elyse E Foster,
Wojciech W Zareba,
Ilan I Goldenberg,
Scott S McNitt,
Marc A MA Pfeffer,
Arthur J AJ Moss,
Scott D SD Solomon and
Abstract
-Both mechanical dyssynchrony and contractile function are important independent correlates of benefit from CRT. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00180271....
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PMID: 21602574
PDF is available here.
Abstract
In the western industrialized world tuberculosis has receded from its peak with an annual mortality of 1 % some 150 to 250 years ago to currently 10 to 20 new cases annually per 100,000 population. The introduction of chemotherapy in the 1950s reduced case fatality from some 70 % to a small fraction....
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PMID: 21728152
PDF is available here.
Abstract
We screened free-living European tortoises (spur-thighed tortoises Testudo graeca, Hermann's tortoises Testudo hermanni, marginated tortoises Testudo marginata) temporarily housed in a wildlife center in Italy. We molecularly characterized 13 Mycoplasma isolates detected in all Testudo spp. studied,...
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PMID: 21719840
PDF is available here.
Abstract
Every few years, the European Committee for Hyperbaric Medicine (ECHM) publishes its recommendations concerning the clinical indications for hyperbaric oxygen therapy (HBOT). The last recommendations were issued during the 7th European Consensus Conference on Hyperbaric Medicine in 2004. Since then,...
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PMID: 21848114
PDF is available here.
Abstract
In recent years, acupuncture has rapidly become part of mainstream medicine in the West, where new developments in acupuncture clinical research show extensive progress in evaluating the efficacy and safety of the modality in many categories of disease, especially in pain conditions....
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PMID: 21695617
PDF is available here.
Abstract
We will present an overview of the process and the up to now scientific advice working party (SAWP) experience.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim....
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PMID: 21538915
PDF is available here.
Abstract
The transmission of bovine spongiform encephalopathy (BSE) to human beings and the spread of chronic wasting disease (CWD) among cervids have prompted concerns about zoonotic transmission of prion diseases. Travel to the United Kingdom and other European countries, hunting for deer or elk, and veniso...
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PMID: 21616198
PDF is available here.
Abstract
Chronic pulmonary infection with P. aeruginosa develops in most patients with cystic fibrosis (CF); by adulthood 80% of patients are infected and chronic P. aeruginosa infection is the primary cause of increased morbidity and mortality in CF. Chronic infection is preceded by an inter...
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PMID: 21658646
PDF is available here.
Abstract
Pulmonary exacerbations represent a key outcome variable in clinical trials of cystic fibrosis (CF). As there is variation in the trigger for use of intravenous antibiotics compared to the use of oral antibiotics or new nebulised therapy for treatment of exacerbations, the consensus...
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PMID: 21658647
PDF is available here.
Abstract
Small and middle-sized enterprises (SMEs) can make important contributions to medical progress through the development of new safe and effective drugs that address the greatest unmet needs of patients. Regulatory inconsistencies across agencies in various countries, however, remain m...
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PMID: 21658629
PDF is available here.
K K De Boeck,
V V Bulteel,
H H Tiddens,
T T Wagner,
I I Fajac,
S S Conway,
F F Dufour,
A R AR Smyth,
T T Lee,
I I Sermet,
B B Kassai,
S S Elborn and
Abstract
We describe the rationale for disease specific research networks in general as well as the aims and function of the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN) specifically. The ECFS-CTN was founded in 2009 with the aim of improving the quality and quantity of clinical resear...
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PMID: 21658644
PDF is available here.
C C Bombieri,
M M Claustres,
K K De Boeck,
N N Derichs,
J J Dodge,
E E Girodon,
I I Sermet,
M M Schwarz,
M M Tzetis,
M M Wilschanski,
C C Bareil,
D D Bilton,
C C Castellani,
H H Cuppens,
G R GR Cutting,
P P Drevínek,
P P Farrell,
J S JS Elborn,
K K Jarvi,
B B Kerem,
E E Kerem,
M M Knowles,
M M Macek,
A A Munck,
D D Radojkovic,
M M Seia,
D N DN Sheppard,
K W KW Southern,
M M Stuhrmann,
E E Tullis,
J J Zielenski,
P F PF Pignatti and
C C Ferec
Abstract
We present a proposal for consensus guidelines on cystic fibrosis transmembrane conductance regulator (CFTR)-related disorders (CFTR-RDs), reached after expert discussion and two dedicated workshops. A CFTR-RD may be defined as "a clinical entity associated with CFTR dysfunction that does not fulfil...
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PMID: 21658649
PDF is available here.
Abstract
A cloud of ash drifting from the erupting Eyjafjallajökull volcano in Iceland in April and May 2010 covered Europe and created an unprecedented situation. It resulted in an almost complete lockdown of European airspace in the period from 15th to 21st April, 2010: more than 100,000 f...
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PMID: 21835749
PDF is available here.
Abstract
At present, in four European countries euthanasia and/ or physician assisted suicide (PAS) are tolerated under strict legal conditions. However, in practice these patient groups are often deprived of the possibility to undergo such decisions. Particularly Catholic health care institutions have develo...
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PMID: 21877472
PDF is available here.
Abstract
Mitochondrial DNA (mtDNA) and Y-DNA analysis have been widely used to predict ancestral origin. Genetic anthropologists predict that human civilizations may have originated in central Africa one to two million years previously. Primary iron overload is not a common diagnosis among indigenous people o...
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PMID: 21766093
PDF is available here.
Abstract
In organic farming animal welfare is one important aspect included in the internationally agreed organic principles of health, ecology, fairness and care (IFOAM 2006), reflecting expectation of consumers and farmers. The definition of organic animal welfare includes-besides traditional terms of anima...
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PMID: 21559784
PDF is available here.
Abstract
The scope of implementation mostly depends on political factors, whereas economic and health-related variables scarcely account for cross-country variance. Only the scope and importance of the domestic information and communication technology market have a significant effect on the scope of implemen...
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PMID: 21476924
PDF is available here.
Abstract
We discussed below the diagnostic criteria of RCDI and RCDII, and the possible factors underlying the more severe expression of celiac disease in Europe....
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PMID: 21540899
PDF is available here.
Author(s) unavailable
Abstract
Genetic differentiation and gene geographic variation of house mouse from the territory of Russia and neighboring countries was examined based on the allozyme analysis of samples from natural, semisynanthropic, and obligate synanthropic populations. The results of analysis of genetic differentiation,...
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PMID: 21786673
PDF is available here.
Wolfgang W Janni,
Florian D FD Vogl,
Gro G Wiedswang,
Marit M Synnestvedt,
Tanja T Fehm,
Julia J Jückstock,
Elin E Borgen,
Brigitte B Rack,
Stephan S Braun,
Harald H Sommer,
Erich E Solomayer,
Klaus K Pantel,
Jahn J Nesland,
Klaus K Friese and
Bjørn B Naume
Abstract
Among breast cancer patients, persistent DTC during follow up significantly predicted increased risk for subsequent relapse and death. Analysis of DTC might serve as a clinically useful monitoring tool, and should be tested as an indicator for secondary adjuvant treatment intervention within clinica...
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PMID: 21415211
PDF is available here.
Abstract
In times of globalisation, the future of bio-medicolegal sciences in Europe depends on the scientific community's ability to develop new strategies for research, to introduce new and generally accepted standards, to develop new analytical methods, all in order to draw up inter-site, multidisciplinary...
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PMID: 21191611
PDF is available here.
Abstract
By exploring the central legal principles and issues regarding usage of the dead body in healthcare and especially in medical training, this article aims at drawing some general conclusions on the legal status of the dead body and the protection of the deceased's integrity, dignity and autonomy. The...
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PMID: 21870590
PDF is available here.
Abstract
Within the context of health and insurance law, an important question that arises is "to what extent is an applicant for private insurance truly capable of giving his/her 'free' and informed consent for a medical examination?". It should be borne in mind that it is the private insurer who requires a...
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PMID: 21870593
PDF is available here.
L L Morell,
J M JM Carrascosa,
C C Ferrándiz,
M M García-Bustinduy,
E E Fonseca,
G G Carretero,
E E Daudén,
S E SE Marrón,
J L JL López-Estebaranz,
M M Ferrán,
M M Sánchez-Regaña,
C C Muñoz-Santos,
I I Belinchón,
Luis L Puig and
Abstract
We sought to assess the relationships between clinical characteristics, treatment response, and disease course during efalizumab treatment and 12 and 24 weeks after suspension....
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PMID: 21530928
PDF is available here.
Pablo P Perez-Martinez,
Javier J Delgado-Lista,
Antonio A Garcia-Rios,
Jane F JF Ferguson,
Hanne L HL Gulseth,
Christine M CM Williams,
Brita B Karlström,
Beata B Kiec-Wilk,
Ellen E EE Blaak,
Olfa O Helal,
Malgorzata M Malczewska-Malec,
Catherine C Defoort,
Ulf U Risérus,
Wim H WH Saris,
Julie A JA Lovegrove,
Christian A CA Drevon,
Helen M HM Roche and
Jose J Lopez-Miranda
Abstract
The rs2953171 SNP interacted with plasma total saturated fatty acid (SFA) concentrations, which were significantly associated with insulin sensitivity (P < 0.031 for fasting insulin, P < 0.028 for HOMA-IR, and P < 0.012 for glucose effectiveness). G/G genotype was associated with lower fasting insul...
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PMID: 21389182
PDF is available here.
Abstract
Dietary NOC (NDMA) was associated with a higher gastrointestinal cancer incidence, specifically of rectal cancer. Plasma vitamin C may modify the relation between NDMA exposure and cancer risk....
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PMID: 21430112
PDF is available here.
Abstract
Serum thyroglobulin is an essential marker during the follow-up of patients with differentiated thyroid carcinoma. Demonstration of the total absence of thyroglobulin is not possible by immunoanalytic methods if thyroglobulin antibody is present in serum samples that occur in almost 20% of patients w...
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PMID: 21498164
PDF is available here.
Abstract
We present a method that has been used in the review process according to evidence-based medicine, which can be considered a role model for both individual and collective use in clinical practice, not only in the field of resuscitation but also in other areas of medicine....
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PMID: 21496962
PDF is available here.
Abstract
The technical success rate was 95% (97% in acute, 95% in chronic, and 93% in type B dissections). The type I endoleak rate was 7% (7% in acute and 8% in chronic dissections); all occurred in patients with type B dissections. Paraplegia, paraparesis, and stroke occurred in 4, 1, and 2 patients, respe...
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PMID: 21521051
PDF is available here.