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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Immune System (10):
Recent article
Immune System
Abstract
We present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end librar...
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PMID: 21832995
PDF is available here.
PDF is available here.
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Immunology Letters (138)1 2011
Proceedings from the NVVI-Dutch society for Immunology Course, Lunteren, March 31st-April 1st, 2010.
Abstract
Abstract
We explored guinea pigs as a model system. On intranasal instillation of a fully virulent strain, Yersinia pestis CO92, guinea pigs developed lethal lung infections with hemorrhagic necrosis, massive bacterial replication in the respiratory system, and blood-borne dissemination to other organ system...
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PMID: 21406168
PDF is available here.
PDF is available here.
Abstract
We have addressed this issue by comparing the immune responses within the airway luminal and granuloma compartments. We found that despite having a similar immune cellular profile to that in the airway lumen, the granuloma displayed severely suppressed type 1 immune cytokine but enhanced chemokine r...
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PMID: 21406169
PDF is available here.
PDF is available here.
Integrative Biology (3)4 2011
Abstract
I conclude with wondering how much longer what I call the 'Hunter Paradigm' will dominate cancer research and immunology and how timely it is to acknowledge in the first decade of a new century, Mina Bissell as a pioneer in the change of that paradigm in Cancer Research. "Suppose he'd listened to th...
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PMID: 21180734
PDF is available here.
PDF is available here.
Abstract
We will try to bring brief and comprehensive description of the current understanding of this fascinating topic....
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PMID: 21460406
PDF is available here.
PDF is available here.
Abstract
We describe a 56-year-old woman who presented with fatigue and easy bruising, eventually became pancytopenic, and was diagnosed with MDS. After treatment with a clinical protocol using alemtuzumab, an anti-CD52 antibody, her blood cell counts returned to normal and she has remained in complete remis...
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PMID: 21343581
PDF is available here.
PDF is available here.
Abstract
The pathogenesis of inflammatory bowel disease (IBD) is complex and involves both innate and adaptive immune responses. This article addresses, in a selective and speculative fashion, the topic of how the various components of the intestinal innate immune system can be manipulated fo...
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PMID: 21309670
PDF is available here.
PDF is available here.
Abstract
We prospectively studied the intra-host evolution of the HCV heterogeneity in 8 coinfected subjects, selected from a cohort of 32 patients initiating HAART: 5 immunological responders (group A) and 3 immunological non-responders (group B), and in two HCV singly infected controls not assuming drugs (...
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PMID: 21304985
PDF is available here.
PDF is available here.
Abstract
Sex hormones play an important role as modulators of the immune system. A growing body of evidence shows reciprocal relationship between sex steroids and the immune system. Since the innate immune response determines the type of adaptive immune response, hormonal effects on the innat...
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PMID: 21463251
PDF is available here.
PDF is available here.
Abstract
New paradigms in translational research are focused on deep understanding of all aspects of the human immune system in response to diseases or perturbations such as vaccination or therapy. To obtain this knowledge, coordinated, comprehensive assessments by genomics, proteomics, and cytomics are nece...
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PMID: 20600079
PDF is available here.
PDF is available here.
Abstract
We review several moderators and mediators that may accompany MDD and that may give rise to these comorbid medical conditions. We first review the moderating effects of psychological styles of coping, genetic predisposition, and epigenetic modifications (eg, secondary to childhood adversity). We the...
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PMID: 21485744
PDF is available here.
PDF is available here.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer (186) 2011
Abstract
This chapter presents the epidemiologic evidence on the association between physical activity and hematologic cancers and related hypothesized biologic mechanisms. Some preliminary indications of a protective role for physical activity for non-Hodgkin's lymphoma, leukemia, multiple myeloma, and Hodg...
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PMID: 21113763
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)6 2011
Abstract
To assess the feasibility, safety, and toxicity of autologous tumor lysate-pulsed dendritic cell (DC) vaccination and toll-like receptor (TLR) agonists in patients with newly diagnosed and recurrent glioblastoma. Clinical and immune responses were monitored and correlated with tumor gene expression p...
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PMID: 21135147
PDF is available here.
PDF is available here.
Immunology (131 Suppl 1) 2010
Abstract
Abstract
OBJECTIVE: To investigate the alteration of immune function and possible immunopathogenesis in the children with 2009 influenza A (H1N1) infection. METHOD: Sixty patients with 2009 influenza A (H1N1) infection hospitalized in Shenzhen Children's Hospital between November 1, 2009 and...
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PMID: 21215192
PDF is available here.
PDF is available here.
Abstract
We highlight the biology of therapeutic fever-range hyperthermia, discuss how hyperthermia is administered and dosed, demonstrate how heat can be added to other treatment regimens, and summarize the data supporting the role of hyperthermia in the management of bladder cancer....
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PMID: 21141697
PDF is available here.
PDF is available here.
Abstract
We will be able to understand the heterogeneity observed in natural history, response to treatments, susceptibility to infections, genetic risk factors, and associations with other atopic disorders....
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PMID: 20944637
PDF is available here.
PDF is available here.
Abstract
High-fiber diets have been shown to reduce plasma concentrations of inflammation markers. Increased production of fermentation-derived short-chain fatty acids (SCFAs) is one of the factors that could exert these positive effects. This review examines the effects of SCFAs on immune cells and discusse...
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PMID: 20823773
PDF is available here.
PDF is available here.
Abstract
We identify the need for future studies that compare purified forms of β-glucans from different sources to further the understanding of the mechanisms of action and aid in the development of clinical studies.
β-Glucans appear to be effective at enhancing immune function and reducing susceptibility...
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PMID: 20842027
PDF is available here.
PDF is available here.
Abstract
In this issue of Immunity, a collection of detailed reviews summarizes needs, opportunities, and roadblocks to the development of new vaccines, all in the context of our current knowledge and understanding of key aspects of immune function and microbial interactions with the host. This Perspective i...
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PMID: 21029956
PDF is available here.
PDF is available here.
Abstract
The aim of our project was to test the hypothesis that patients with dry eye have a significant degree of inflammation and lymphocyte infiltration in conjunctival epithelium by using flow cytometry analysis of cells stored in cell culture medium. Impression cytology specimens were collected in 15 no...
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PMID: 20654615
PDF is available here.
PDF is available here.
Abstract
The recent application of concepts of evolution to human disease is proving useful to understand certain pathophysiological mechanisms of different entities that span genomic alterations of immunity, respiratory and hormone function, and the circulatory and neural systems. However, e...
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PMID: 20675202
PDF is available here.
PDF is available here.
Abstract
Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL-23 and inhibits their pharmacological activity. To evaluate potential effects of ustekinumab treatment during pregnancy, developmental studies were conducted in cynomolgus macaques....
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PMID: 20540088
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Two M5.1 and M15.2 B complex congenic lines of Fayoumi chickens were evaluated for body weight loss and faecal oocyst counts as parameters of avian coccidiosis. M5.1 chickens exhibited resistance to E. maxima compared with M15.2. To correlate the differential responses of the M5.1 and M15.2 lines to...
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PMID: 18817295
PDF is available here.
PDF is available here.
Abstract
To review the role of microorganisms in interstitial lung disease (ILD) and to emphasize their importance in initiation and course of ILD.
ILD can be idiopathic but often causality such as drugs or connective tissue disease can be found. Multiple microorganisms have been associated with ILD. On the...
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PMID: 20592601
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)11 2010
Abstract
There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases. An international expert panel formulated recommendations on vitamin D for clinical practice, taking into considera...
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PMID: 20601202
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)11 2010
Abstract
There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases. An international expert panel formulated recommendations on vitamin D for clinical practice, taking into considera...
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PMID: 20601202
PDF is available here.
PDF is available here.
Abstract
It is now well established that important regulatory interactions occur between the cells in the hematopoietic, immune and skeletal systems (osteoimmunology). B lymphocytes (B cells) are responsible for the generation and production of antibodies or immunoglobulins in the body. Toget...
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PMID: 20601290
PDF is available here.
PDF is available here.
Abstract
We show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells...
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PMID: 20633308
PDF is available here.
PDF is available here.
Abstract
The conceptual framework for reproductive immunology was put in place over 50 years ago when the survival of the fetal semi-allograft within an immunocompetent mother was first considered. During this time, a number of paradigms have emerged and the mechanisms receiving current attention are those r...
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PMID: 20576205
PDF is available here.
PDF is available here.
Abstract
There may be a causal relationship between n-6 PUFA intake and allergic disease and there are biologically plausible mechanisms, involving eicosanoid mediators of the n-6 PUFA arachidonic acid, that could explain this. There is some evidence that high linoleic acid intake is linked with increased ri...
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PMID: 20462467
PDF is available here.
PDF is available here.
Experimental Dermatology (19)8 2010
Abstract
We chose different skin diseases (cutaneous leishmaniasis, contact hypersensitivity, UV radiation-induced suppression, and graft-versus-host disease) to describe the biological interactions between different DC subtypes and T cells that lead to the development of efficient or unwanted immune respons...
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PMID: 20590820
PDF is available here.
PDF is available here.
Abstract
Epidermal keratinocytes are the main component cells of the epidermis and their function is regulated by various kinds of growth factors, cytokines, and chemokines. Of these, members of the epidermal growth factor and fibroblast growth factor families, as wells as hepatocyte growth factor and insuli...
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PMID: 20570492
PDF is available here.
PDF is available here.
Marine Biotechnology (12)4 2010
Abstract
All metazoans possess innate immune defence system whereas parameters of the adaptive immune system make their first appearance in the gnathostomata, the jawed vertebrates. Fish are therefore the first animal phyla to possess both an innate and adaptive immune system making them very interesting as...
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PMID: 20352271
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Toll-like receptors (TLRs) are innate immune receptors critical in the innate immune defense against invading pathogens. Recent advances also reveal a crucial role for TLRs in shaping adaptive immune responses, conferring a potential therapeutic value to their modulation in...
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PMID: 20560798
PDF is available here.
PDF is available here.
Abstract
Epidemiologic evidence remains limited, and to date data are insufficient to draw firm conclusions regarding the role of PFOA for any of the diseases of concern....
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PMID: 20423814
PDF is available here.
PDF is available here.
Abstract
We decided to evaluate the immunological effects of two different types of humic acids, differing in source and biochemical characteristics. Using both components either alone or in combination with the well-established yeast-derived immunomodulator glucan, we measured their effects on both the cell...
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PMID: 20553181
PDF is available here.
PDF is available here.
Abstract
We highlight the signaling cascades initiated by the major signaling motifs in CD28, focusing on PI-3 kinase-dependent and -independent pathways and how these are linked to specific cellular outcomes. Recent studies using gene targeted knockin mice have clarified the relative importance of these mot...
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PMID: 20534709
PDF is available here.
PDF is available here.
Abstract
Abstract
We hypothesised that the developmental absence of vitamin D3 may alter thymic development and thus produce associated functional changes in T cells. We have developed a model of developmental vitamin D3 (DVD) deficiency in Sprague-Dawley rats, in which the vitamin D3 deficiency is transient and rest...
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PMID: 20304054
PDF is available here.
PDF is available here.
Abstract
We now know that when cells of the immune system such a macrophages sense a bacterial infection they acquire the capacity to convert circulating 25D into 1,25D. Moreover, 1,25D thus produced is a direct inducer of expression of genes encoding antimicrobial peptides, in particular cathelicidin antimi...
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PMID: 20302931
PDF is available here.
PDF is available here.
Abstract
We investigated the expression and kinetics of vitamin D-related genes in human activated T lymphocytes. Different activation stimuli elicited increased VDR- and 1-alpha-hydroxylase expression, with a highly similar kinetic pattern. Addition of 1,25(OH)2D3 effectively triggered VDR signaling, as evi...
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PMID: 20302932
PDF is available here.
PDF is available here.
Abstract
We earlier reported a correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and regulatory T cell (Treg) function. In the present study, the correlation of serum levels of 1,25-dihydroxyvitamin D (1,25(OH)2D), intact parathyroid hormone (PTH), and total calcium with Treg number and function...
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PMID: 20211254
PDF is available here.
PDF is available here.
Abstract
Topical creams containing the active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH)2D3) or analogues of this compound are currently used with some success to treat skin conditions including psoriasis and vitiligo. As well as targeting inflammatory processes in the skin, topical application of...
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PMID: 20211255
PDF is available here.
PDF is available here.
Abstract
PURPOSE. Current studies suggest that the immune system plays a critical role in blinding eye disorders. The eye is an immune-privileged site, and FasL expression is a major part of that mechanism because Fas/FasL interactions regulate inflammation and neovascularization, preventing damage to delica...
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PMID: 20164456
PDF is available here.
PDF is available here.
Molecular Immunology (47)11-12 2010
Abstract
We discuss the function of human serine proteases in inflammation, apoptosis and tissue remodeling. Furthermore, we address their impact on development and progression of immune mediated-diseases. Understanding the mode of action of serine proteases will help to unravel molecular processes involved...
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PMID: 20537709
PDF is available here.
PDF is available here.
Biological Chemistry (391)7 2010
Abstract
Adaptive immunity in jawless vertebrates is mediated by antigen receptors that are fundamentally different from those of jawed vertebrates. Whereas antibodies and T cell receptors (TCRs) are composed of immunoglobulin (Ig) domains, the variable lymphocyte receptors (VLRs) of jawless fish consist of...
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PMID: 20482318
PDF is available here.
PDF is available here.
Nature Materials (9)7 2010
Abstract
We developed an intranasal vaccine-delivery system with a nanometre-sized hydrogel ('nanogel') consisting of a cationic type of cholesteryl-group-bearing pullulan (cCHP). A non-toxic subunit fragment of Clostridium botulinum type-A neurotoxin BoHc/A administered intranasally with cCHP nanogel (cCHP-...
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PMID: 20562880
PDF is available here.
PDF is available here.
Abstract
Circulation (121)24 2010
Abstract
Abstract
We use IL-4 and IL-13 reporter mice to track lineage-negative innate cells that arise during type 2 immunity or in response to IL-25 and IL-33 in vivo. Unexpectedly, lineage-negative IL-25 (and IL-33) responsive cells are widely distributed in tissues of the mouse and are particularly prevalent in m...
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PMID: 20534524
PDF is available here.
PDF is available here.
Abstract
We report the generation of a recombinant influenza virus carrying a GFP reporter gene in the NS segment (NS1-GFP virus). Although attenuated when compared with wild-type virus, the NS1-GFP virus replicates efficiently in murine lungs and shows pathogenicity in mice. Using whole-organ imaging and fl...
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PMID: 20534532
PDF is available here.
PDF is available here.
Clinical Infectious Diseases (50)12 2010
Abstract
Our study demonstrated that ASCT in HIV-infected persons with lymphoma does not worsen the initial immune impairment and does not enhance viral replication or the peripheral HIV reservoir in the long term....
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PMID: 20450419
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
We jointly model HIV viral dynamics and time to decrease in CD4/CD8 ratio in the presence of CD4 process with measurement errors, and estimate the model parameters simultaneously via a method based on a Laplace approximation and the commonly used Monte Carlo EM algorithm. The approaches and many of...
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PMID: 19673859
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)6 2010
Abstract
Signal-transducing adaptor protein-2 (STAP-2) was recently identified as a novel adaptor protein and is a family of STAP adaptor protein and has a variety of functions in cellular signal transductions. Especially STAP-2 has a crucial role in immune systems by controlling cytokine signal transduction...
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PMID: 20519854
PDF is available here.
PDF is available here.
Abstract
The susceptibility of elderly people to infectious diseases is usually associated to increasing risk factors found in young adults. However, the role of immune function ageing is associated with the decline of immune function but this decline is not homogenous. Some functions such as the cellular im...
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PMID: 20092974
PDF is available here.
PDF is available here.
Abstract
Surgical trauma causes stereotyped systemic proinflammatory and compensatory anti-inflammatory reactions. It is leukocyte reprogramming rather than general immune suppression. The list of recent findings is long. Preoperative infectious challenge was found to increase survival. Obesity is associated...
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PMID: 20375890
PDF is available here.
PDF is available here.
Abstract
Over the last 20 years, there has been increasing awareness of a subset of squamous cell carcinomas of the head and neck (HNSCC), i.e. HPV-positive HNSCC. These cancers seem to differ somewhat from HPV-negative HNSCC. Patients with HPV-positive HNSCC tend to be younger and have a lower intake of tob...
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PMID: 20553531
PDF is available here.
PDF is available here.
Journal of Asthma (47)5 2010
Abstract
Stress in childhood and adulthood resulted in different HPA axis responsiveness in the exacerbation of markers of asthma. These data provide the first evidence of the long-term normalizing effects of music on asthmatic rats....
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PMID: 20560827
PDF is available here.
PDF is available here.