Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
Abstract
This study investigates the features of neutropenic enterocolitis (NE) in adults.
Chart and radiology report reviews were used to identify neutropenic patients with hematological diseases undergoing chemotherapy, who had CT scans for the clarification of abdominal symptoms between October 2003 and O...
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PMID: 21077023
PDF is available here.
Abstract
We screened the IDH1 and IDH2 mutations in a cohort of 456 Chinese patients with various hematological malignancies and disorders. We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two m...
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PMID: 20946881
PDF is available here.
Abstract
The adverse effects of combination chemotherapy of ifosfamide, cisplatin, and etoposide (ICE) were evaluated in the treatment of various intracranial brain tumors.
108 cases were retrospectively reviewed. The histological diagnosis was newly diagnosed or recurrent germ cell tumor in 45 cases, medull...
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PMID: 21081811
PDF is available here.
Abstract
Systemic diseases may affect the oral tissues, i.e. oral mucosa, salivary glands, teeth or bone, and oral manifestations will frequently present early, i.e. in association with (non-fulminant) systemic disease. Thus, recognition and proper diagnosis is essential to initiate appropriate treatment sch...
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PMID: 21044560
PDF is available here.
Abstract
We were stratified patients into three groups according to TI that was calculated for each patient. The group with high value was found to include patients with grade 3 to 4 hematological toxicity with a significantly higher frequency than the group with low value (4.2% vs 57.1%, p=0.004). This risk...
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PMID: 21084813
PDF is available here.
Abstract
We have overcome these obstacles and describe a method whereby whole-mounts of bone marrow tissue were immunostained and imaged in 3 dimensions by confocal fluorescence and reflection microscopy. We have successfully mapped by multicolor immunofluorescence the localization pattern of as many as 4 ce...
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PMID: 20647571
PDF is available here.
Abstract
We examined the developmental trajectory of neuropsychological skills in a child with KS (seen at ages 4, 6, 7, 9, and 11). Examination of raw and age-corrected standard scores suggests that language-based skills developed appropriately, but visually based skills slowed and reached a plateau. Execut...
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PMID: 20812142
PDF is available here.
Abstract
Familial hypocalciuric hypercalcemia (FHH) results from a mutation of the calcium sensing receptor (CASR) gene and typically presents as asymptomatic hypercalcemia with inappropriately low urinary calcium excretion and normal or mildly elevated levels of parathyroid hormone.
To describe a case of FH...
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PMID: 21175100
PDF is available here.
Abstract
Patients with rheumatoid arthritis (RA) often have comorbidities that require multiple medications. Several of these medications may alter the efficacy or increase the toxicity of methotrexate (MTX). The purpose of our study was to determine which drugs used in combination with MTX (...
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PMID: 20436072
PDF is available here.
Wanruchada Katchamart,
Josiane Bourré-Tessier,
Timea Donka,
Julie Drouin,
Gina Rohekar,
Vivian P Bykerk,
Boulos Haraoui,
Sharon Leclerq,
Dianne P Mosher,
Janet E Pope,
Kam Shojania,
John Thomson,
J Carter Thorne,
Claire Bombardier and
Canadian 3e Initiative Consensus Group
Abstract
To develop recommendations for the use of methotrexate (MTX) in patients with rheumatoid arthritis.
Canadian rheumatologists who participated in the international 3e Initiative in Rheumatology (evidence, expertise, exchange) in 2007-2008 formulated 5 unique Canadian q...
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PMID: 20516029
PDF is available here.
Abstract
MicroRNAs are a recently discovered class of small (c. 22 nt) naturally occurring non-coding RNA molecules that regulate gene expression through binding to the un-translated region of target mRNA. MicroRNAs play key roles in many cellular pathways including haematopoiesis and aberran...
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PMID: 19912217
PDF is available here.
Abstract
To explore the role of bone marrow (BM) imprint in the diagnosis of hematological diseases.
Between January 2002 and June 2008, a total of 3024 cases with BM smears, imprints and sections conducted simultaneously were recruited. There were 1667 males and 1357 females with a median age of 55 years ol...
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PMID: 20973233
PDF is available here.
Abstract
Patients with LCPD had a hazard ratio (HR) of 1.70 (95% confidence interval [CI]: 1.39-2.09) for cardiovascular diseases, compared with individuals without LCPD. The point estimate was slightly higher among subjects >30 years of age at the follow-up (HR: 2.10 [95% CI: 1.52-2.91]). There were statist...
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PMID: 20439602
PDF is available here.
Chun-yan CY Liu,
Rong R Fu,
Yu-hong YH Wu,
Er-bao EB Ruan,
Wen W Qu,
Guo-jin GJ Wang,
Yong Y Liang,
Xiao-ming XM Wang,
Hong H Liu,
Jia J Song,
Jing J Guan,
Hua-quan HQ Wang,
Li-min LM Xing,
Li-juan LJ Li,
Jun J Wang and
Zong-hong ZH Shao
Abstract
To investigate the effects and related factors of itraconazole in the treatment of invasive fungal infection (IFI) in the patients with blood diseases (BD).
A total of 156 BD patients with IFI treated with itraconazole in General Hospital, Tianjin Medical University from 2005 to 2008, were retrospec...
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PMID: 20979739
PDF is available here.
Abstract
The inherited hemoglobin disorders sickle cell disease and thalassemia are the most common monogenetic disorders worldwide. Pulmonary hypertension is one of the leading causes of morbidity and mortality in adult patients with sickle cell disease and thalassemia, and hemolytic disorders are potential...
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PMID: 20522578
PDF is available here.
Abstract
Paraneoplastic syndrome is defined as tumor-associated symptoms and signs not related to the physical effects of primary or metastatic tumors. The mechanisms of this syndrome include the production of bioactive soluble factors by tumor cells and autoimmune diseases elicited by the immune responses a...
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PMID: 20567097
PDF is available here.
Abstract
Invasive aspergillosis (IA) remains one of the most significant causes of morbidity and mortality in patients with hematological malignancies undergoing chemotherapy and hematopoietic stem cell transplantation (HSCT), mainly due to the difficulty in its early diagnosis. Monitoring of galactomannan (...
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PMID: 20513124
PDF is available here.
Abstract
We evaluate the incidence of treatment-related adverse events associated with each of these compounds. We further review the management of these adverse events with a view to delivering optimal therapeutic outcomes in patients with newly diagnosed and relapsed and/or refractory multiple myeloma.
Cop...
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PMID: 20472185
PDF is available here.
Abstract
There has been no human epidemiological data regarding potential hematological effects of hexachloroethane-zinc oxide (HC/ZnO) inhalation. This is the first epidemiological study to investigate whether HC/ZnO inhalation exposure can induce hematological abnormalities in exposed soldiers. Twenty sold...
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PMID: 20384461
PDF is available here.
Abstract
The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix protein that belongs to the superfamily of environment-sensing PAS (Per-ARNT-Sim) proteins. A large number of ligands have been described to bind AhR and promote its nuclear translocation. In the nucleus, the AhR and its dimerization pa...
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PMID: 20171126
PDF is available here.
Abstract
Rituximab, a chimeric monoclonal antibody that depletes B cells by binding to the CD20 cell-surface antigen, has been investigated extensively in autoimmune disorders. Following the encouraging results in immune thrombocytopenia (ITP), the use of this agent was explored in other autoimmune hematolog...
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PMID: 20350664
PDF is available here.
Abstract
We evaluated whether early elevations of CRP were associated with various complications and nonrelapse mortality following HSCT in pediatric patients. Seventy pediatric patients had CRP levels drawn at regular time points during the first week following their transplants. Patients were followed for...
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PMID: 20005964
PDF is available here.
Abstract
Serious hematologic toxicity (or complications) developed in these 4 patients after 4-8.5 months of treatment. Two patients developed leukemias (AML, CML) and two, myelodysplastic syndrome. CONCLUSION: Whether or not these hematologic complications were related to erlotinib treatment is comprehensiv...
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PMID: 20393022
PDF is available here.
Abstract
HLA-haploidentical PBSCT conditioning including antithymocyte globulin without in vitro T cell depletion is feasible and safe. The immunological reconstitution, incidence of severe infection, incidence of relapse and treatment-related mortality are not significantly different between HLA-matched and...
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PMID: 20450650
PDF is available here.
Abstract
Twenty nine patients (3.2%) of the 901 malignant hematologic patients were diagnosed with urolithiasis, compared to 575 patients (1.4%) of 40,543 emergency room patients. There was a significant increase of the incidence of urolithiasis in the malignant hematologic group. Compared to the general pat...
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PMID: 20191017
PDF is available here.
Abstract
We have demonstrated that PBPC grafts are capable of long term engraftment regardless of the graft storage time or percentage of viable cells post-thaw, which confirms the robustness of CD34+ cells during the freeze/thaw procedures carried out in daily clinical practice. Granulocyte concentration in...
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PMID: 20432746
PDF is available here.
Abstract
We compared the incidence and risk factors for post-transplant cytomegalovirus (CMV) infections between these two biologically diverse subgroups of haematological conditions. Out of 105 allogeneic transplants, 64 and 41 were for underlying non-malignant and malignant indications respectively. CMV in...
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PMID: 20132656
PDF is available here.
Abstract
The greatest diagnostic hurdle in PGD is the paucity of molecular material in the single embryonic cell. WGA allows amplification of the entire genome, which greatly simplifies mutation analysis and increases the possibilities of multiple simultaneous genetic diagnoses. PGH can be applied to the amp...
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PMID: 19949337
PDF is available here.
Abstract
The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carr...
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PMID: 20044880
PDF is available here.
Abstract
The typical pattern of the patients admitted to our department for epistaxis is a middle-aged or elderly male with underlying co-morbidity and posterior epistaxis.
2009 Elsevier España, S.L. All rights reserved....
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PMID: 20004879
PDF is available here.
Abstract
The study was aimed at the experimental assessment of the efficacy of recombinant interleukin-1beta in the early therapy of haemopoiesis disorders caused by X-ray irradiation. The efficacy of the product was based on the 30-day survival rate and average life expectancy of dead animal...
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PMID: 21400980
PDF is available here.
Abstract
We review other factors that have a documented impact on haematological toxicity, including pemetrexed schedule, and pharmacokinetic parameters that are indicative of the extent of drug exposure. Further potential factors are explored in this review, such as the genotype of the pemetrexed metabolisi...
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PMID: 19839928
PDF is available here.
Abstract
The article deals with clinical results of medical examination and treatment of children residents of industrial districts in Sverdlovsk area, with various methods of analysis determining relationships between heavy metals, metalloids and marker anamnestic data and hematologic abnormalities (changes...
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PMID: 20402221
PDF is available here.
Abstract
Patients in the PIU tended to be complicated by insomnia or depression more than those in the SW, but the stay in the PIU was not significantly related to the incidence of insomnia or depression. Our findings indicated that use of CS was a risk factor for insomnia. The prevalence of depression was h...
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PMID: 20045996
PDF is available here.
Gianluca G Tomasello,
Matteo Dalla MD Chiesa,
Sebastiano S Buti,
Matteo M Brighenti,
Federica F Negri,
Rodrigo Kraft RK Rovere,
Mario M Martinotti,
Massimo M Buononato,
Antonio A Brunelli,
Silvia S Lazzarelli,
Gianvito G Donati and
Rodolfo R Passalacqua
Abstract
A dose-dense TCF regimen in metastatic gastric cancer is feasible, with activity comparable to previous results achieved with epirubicin-based chemotherapy and TCF q3wk in terms of overall survival and time to progression, and deserves to be further tested in randomized phase III studies....
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PMID: 20437857
PDF is available here.
Abstract
These data indicate increasing use of HCT for persons with blood and bone marrow disorders. Recent trends include increasing use of alternative donors including HLA-matched unrelated persons and of HLA-matched umbilical cord blood cells, increasing use of blood cell rather than bone...
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PMID: 21696033
PDF is available here.
Abstract
Basic hematological features of CEA/ABVD medication for Hodgkin's disease were studied. An effective model was worked out on the principle of data discrimination for predicting different leukocytic toxicities induced by cytostatics-1 administration, once in two weeks. It might predict individual lim...
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PMID: 21137237
PDF is available here.
Abstract
Our findings were used to make a case for clinical studies of dicarbamin for its potential of lowering hematological toxicity of antitumor therapy....
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PMID: 21137241
PDF is available here.
Abstract
Ninety-six patients with unresectable or metastatic colorectal cancer received first-line chemotherapy plus bevacizumab. The purpose of our study was to evaluate the safety and efficacy of the therapy. Median relapse-free survival lasted 10.4 months. Addition of bevacizumab was well tolerated and ma...
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PMID: 21137245
PDF is available here.
Abstract
The plasma hypertonicity is a severe and quite frequent disorder in children. The most frequent causes are hypernatremia related conditions, even though other causes of hyperosmolarity, such as hyperglycaemia and exogenous solutes accumulation also occur. The management and treatment of this conditi...
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PMID: 20654264
PDF is available here.
Abstract
Nonregenerative cytopenias such as nonregenerative anemia, neutropenia, and thrombocytopenia in cats with feline leukemia virus (FeLV) antigen are assumed to be caused by the underlying FeLV infection. In addition, cats with negative FeLV antigen-test results that have cytopenias of...
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PMID: 19925574
PDF is available here.
Abstract
Thalidomide is a drug with bad reputation from the 1960's as it appeared to be teratogenic by causing foetal anomalies. However, in the beginning of 1990s it was shown very antiangiogenic. Its immunological effects were known already from earlier studies. Nowadays its use is accepted in myeloma ther...
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PMID: 20617746
PDF is available here.
Abstract
We investigated 312 cases of blood dyscrasia which 296 cases had oral manifestations (86.2%). They had a mean age of 40,6 years (range from 7 to 86 years). The male to female ratio was 1.0:0.75 (178/134). Data were statistically analyzed by t test, chi-square, Wilcoxon, Kruskal-Wallis and two-tailed...
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PMID: 20701003
PDF is available here.
Abstract
Acute graft vs. host disease (aGVHD) is a major limitation of hematopoietic stem cell transplantation (HSCT), and it causes significant morbidity and mortality for this patient population. This immune-mediated injury occurs unpredictably and is caused by donor-derived T cells reacting to recipient a...
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PMID: 20563712
PDF is available here.
Abstract
Pharmacological manipulation of CXCR4 has proven clinically useful for mobilization of stem and progenitor cells and in several preclinical models of disease. It is a key component in the localization of leukocytes and stem cells. For patients with multiple myeloma and non-Hodgkin's Lymphoma, treatm...
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PMID: 20397073
PDF is available here.
Abstract
Allogeneic hematopoetic stem cell transplantation often presents the only chance for cure in a number of malignant and nonmalignant hematologic diseases. However, its beneficial effects are counterweighed by the development of potentially lethal complications, most importantly the development of acu...
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PMID: 20379809
PDF is available here.
Author(s) unavailable
Abstract
To study the impact of modified nutritional support (NS) versus standard NS on therapy tolerability and posttransplantation in patients with oncohematological diseases.
Fifty-three patients, who had been diagnosed as acute myeloblastic (n = 19) or acute lymphoblastic...
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PMID: 21516738
PDF is available here.