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Alkaloids (31):
- Arecoline
- Aconitine
- 1-Deoxynojirimycin
- Tropanes
- Swainsonine
- Ryanodine
- Ergot Alkaloids
- Veratrum Alkaloids
- Solanaceous Alkaloids
- Pilocarpine
- Muscarine
- Dihydro-beta-Erythroidine
- Camptothecin
- Benzylisoquinolines
- Sparteine
- Opiate Alkaloids
- Colchicine
- Benzophenanthridines
- Xanthines
- Indole Alkaloids
- Harringtonines
- Pyrrolizidine Alkaloids
- Emetine
- Cinchona Alkaloids
- Amaryllidaceae Alkaloids
- Salsoline Alkaloids
- Mescaline
- Anabasine
- Acridones
- Lobeline
- Betalains
Recent article
Alkaloids
Toxicology (289)1 2011
Abstract
We hypothesized that the effects of these compounds could be reflected by changes in biochemical substrates and cholinergic receptors and have examined the levels of four proteins involved in maturation of the brain, neuronal growth and synaptogenesis and the densities of both muscarinic and nicotin...
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PMID: 21820030
PDF is available here.
PDF is available here.
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Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti (60)2 2011
Abstract
The paper aims to specify all important active principles in the herb Genista tinctoria which exert different biological activities. It also mentions the methods of chemical evaluation of these substances.
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PMID: 21650007
PDF is available here.
PDF is available here.
Organic Letters (12)24 2010
Abstract
An enantioselective α-amination of aryl oxindoles catalyzed by a dimeric quinidine has been developed. The reaction is general, broad in substrate scope, and affords the desired products in good yields with good to excellent enantioselectivities. This study provides the first exampl...
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PMID: 21070065
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)12 2010
Abstract
Two new alkaloids, dysideanins A (1) and B (2), along with two known diketopiperazines, cyclo-(Pro-Leu) (3) and cyclo-(Pro-Ile) (4), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B (2) exhibited antibacterial activity. The thiom...
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PMID: 21063424
PDF is available here.
PDF is available here.
Abstract
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline as the key step. Although its structure was confirmed by X-ray analysis, the spectroscopic data d...
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PMID: 20848034
PDF is available here.
PDF is available here.
Abstract
A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkal...
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PMID: 21061224
PDF is available here.
PDF is available here.
Abstract
The conversional synthesis of taxoids by the BAC sequence from the C(19)-diterpenoid alkaloids, 14-acetyltalatisamine (1), yunaconitine (12), and 14-acetylchasmanine (19), was designed and explored. Two aconane-type diterpenes 17 and 28, the advanced intermediates for our conversional synthesis, wer...
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PMID: 21061219
PDF is available here.
PDF is available here.
Abstract
Sophoridine (SRI), one of the quinolizidine alkaloids, is a new anticancer drug with noticeable antitumor action and lower toxicity. To our knowledge, there is no report about its effect on colitis. Repeated colitis was induced by administration of four cycles of 4% DSS. The severity of colitis was...
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PMID: 21061213
PDF is available here.
PDF is available here.
Abstract
Condensation of an aldehyde with an α-amino-ester, followed by a tandem process involving cyclization to a seven-membered ring, deprotonation to an intermediate azomethine ylide and intramolecular dipolar cycloaddition gave tricyclic products related to stenine and neostenine.
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PMID: 20737084
PDF is available here.
PDF is available here.
Abstract
An efficient synthesis of the N-methylwelwistatin tetracyclic core in only two steps from Kornfeld's ketone is described, whose key transformation involves the generation of a fused bicyclo[4.3.1]decane ring system through a one-pot sequence comprising a Michael-intramolecular aldolization anionic d...
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PMID: 20717611
PDF is available here.
PDF is available here.
Abstract
Malaria has been, and remains, one of the biggest global health concerns as far as infectious diseases are concerned, with yearly incidence and mortality figures running into millions. One of the major drawbacks to the control of this disease has been the emergence of drug resistant...
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PMID: 20695842
PDF is available here.
PDF is available here.
Abstract
Malaria has been, and remains, one of the biggest global health concerns as far as infectious diseases are concerned, with yearly incidence and mortality figures running into millions. One of the major drawbacks to the control of this disease has been the emergence of drug resistant strains of the c...
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PMID: 20695842
PDF is available here.
PDF is available here.
Abstract
A new spirocyclic diketopiperazine alkaloid, namely, 7-O-methylvariecolortide A (1), together with recently reported known compounds variecolortides A-C (2-4), were isolated and identified from the liquid fermentation cultures of Eurotium rubrum, an endophytic fungus that was isolated from the inner...
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PMID: 21121253
PDF is available here.
PDF is available here.
Abstract
Alkaloids and lignans from the stems of Piper betle were studied. Compounds were isolated and purified by repeated silica gel, reverse phase silica gel, Sephadex LH-20 column chromatography and preparative thin layer chromatography. The structures were elucidated on the basis of spectral analysis. F...
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PMID: 21137339
PDF is available here.
PDF is available here.
Abstract
To investigate the representation methods of dissolubility property of total alkaloid extract from Peganum hamala in different solvents, and to investigate the evaluation method of the dissolubility property of extracts from traditional Chinese medicine.
The dissolubility property of the whole extra...
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PMID: 21137330
PDF is available here.
PDF is available here.
Abstract
To investigate the total alkaloid content and find out the variation of total alkaloids content in Dendrobium officinale with different germplasms and harvesting ages with the aim of providing scientific basis for the authenticity identification and the breeding of D. officinale.
Forty one samples w...
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PMID: 21141483
PDF is available here.
PDF is available here.
Abstract
To develop a HPLC method for determination of matrine, oxymatrine; ferulic acid, L-shikonin and beta, beta-dimethylacrylshikonin in compound preparatioti of Dangguishuan.
The chromatogtaphic separation was performed on a Kromasil ODS C18 column (4.6 mm x 250 mm, 5 microm) maintaining at 30 degrees C...
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PMID: 21141487
PDF is available here.
PDF is available here.
Abstract
A new alkaloid (1a), named pandamarilactonine-H, which possesses a methyl-2-(pyrrolidin-2-yl)acetate function, was isolated from the roots of Pandanus amaryllifolius. Eleven known alkaloids were also isolated. Unambiguous assignment of the structure of 1a, including the absolute configuration, was a...
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PMID: 20701299
PDF is available here.
PDF is available here.
Abstract
Eight novel tirucallane-type alkaloids (1-8) and 11 known compounds were isolated from a methanol extract of the bark of Dysoxylum laxiracemosum. The structures of 1-8 were elucidated using extensive NMR spectrometric and mass spectroscopic methods. Compounds 1 and 5, named laxiracemosins A and E, s...
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PMID: 20669932
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17),...
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PMID: 20079811
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
Callus and differentiated shoots initiated from Solanum tuberosum L. on MS media containing BA, IAA, and Kin. Glycoalkaloids are produced in callus and shoots in concentrations higher than original tubers using HPLC. Callus methanolic extract had promising anticancer activity with low IC(50) values...
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PMID: 20227470
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
Together with apigenine dimethylether and piperchabamide A, a new amide alkaloid, Kaousine and the Z form of antiepilepsirine were isolated from the aerial part of Piper capense L.f (Piperaceae). Their structures were elucidated by spectrometric methods and their in vitro antiparasitic activities we...
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PMID: 20227469
PDF is available here.
PDF is available here.
Abstract
To determine the pharmacokinetics, distribution and mutual transformation of the total alkaloids, jatrorrhizine, coptisine, berberine and palmatine from Coptis chinensis in rats.
After the total alkaloids and berberine were fed into rats, their contents in plasma, tissues and gastrointestinal tract...
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PMID: 20931859
PDF is available here.
PDF is available here.
Abstract
To study the hasubanan type alkaloids in Stephania hernandifolia.
The dried herbs of S. hernandifolia. were extracted with 95% ethanol. After removal of the solvent, the residue was first partitioned between acid water and petroleum ether, then the aqueous layer was basified and extracted with chlor...
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PMID: 20931849
PDF is available here.
PDF is available here.
Phytomedicine (17)10 2010
Abstract
The alkaloid fraction of Radix Linderae, the main active component of this herb drug, has been proven to exhibit anti-inflammatory, analgesic and antimicrobial activities. The present study was undertaken to investigate the therapeutic potential of norisoboldine, the major isoquinoline alkaloid pres...
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PMID: 20363113
PDF is available here.
PDF is available here.
Veterinary Parasitology (171)3-4 2010
Abstract
These results provided evidence that the studied plant extract, as well as the isolated compounds, especially sanguinarine, might be potential plant-based medicines for the treatment of D. intermedius infection.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20413222
PDF is available here.
PDF is available here.
Abstract
Six new bisbenzylisoquinoline alkaloids, racemosidines A-C (1-3) and racemosinines A-C (4-6), and four known compounds were isolated from the roots of Cyclea racemosa. Compound 1 is the first bisbenzylisoquinoline alkaloid reported that has diphenyl ether bridges at C-11/C-7' and C-8/C-12' and a ben...
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PMID: 20593839
PDF is available here.
PDF is available here.
Abstract
Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids (1-4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of these compounds were determined by spectroscopic methods, and the absolute configuration of the major compound (1) was determined by X-ray c...
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PMID: 20550123
PDF is available here.
PDF is available here.
Abstract
The first total synthesis of the Lycopodium alkaloid (+)-fastigiatine has been accomplished in 15 steps and 30% overall yield from known compounds. Noteworthy transformations include a convergent fragment coupling via a nucleophilic cyclopropane opening, a highly diastereoselective formal [3 + 3]-cy...
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PMID: 20568766
PDF is available here.
PDF is available here.
Abstract
Mitotic kinesin spindle protein (KSP) is involved in the assembly of the bipolar spindle during cell division. On the basis of a common 2,3-fused indole substructure within the complex frameworks of terpendole E and other KSP inhibitors, the carbazoles with a bulky alkyl group were identified as a n...
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PMID: 20521839
PDF is available here.
PDF is available here.
Abstract
A phytochemical study of the bark of Fissistigma latifolium (Annonaceae) yielded a new aporphine alkaloid, (-)-N-methylguattescidine (1), and eight known alkaloids: liriodenine (2), oxoxylopine (3), (-)-asimilobine (4), dimethyltryptamine (5), (-)-remerine (6), (-)-anonaine (7), columbamine (8) and...
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PMID: 20657378
PDF is available here.
PDF is available here.
Abstract
Fungi, in particular, are able in common with the higher plants and bacteria, to produce metabolites, including alkaloids. Alkaloids, along with other metabolites are the most important fungal metabolites from pharmaceutical and industrial point of view. Based on this observation, the authors of thi...
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PMID: 20566453
PDF is available here.
PDF is available here.
Abstract
We analyzed the effects of taspine on Hek293/FGFR1 cell and MCF-7 cell. In conclusion, Hek293/FGFR1 was successfully constructed. The results demonstrate that taspine can down-regulate phosphorylation of FGFR1 and ERK, and inhibit Hek293/FGFR1 and MCF-7 cell proliferation.
Copyright 2010 Elsevier In...
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PMID: 20434485
PDF is available here.
PDF is available here.
Abstract
Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-m...
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PMID: 20476748
PDF is available here.
PDF is available here.
Abstract
Three new pentacyclic alkaloids were isolated from different chromotypes of the western Mediterranean ascidian Cystodytes dellechiajei. The purple color morph collected in Catalonia contained the known compounds kuanoniamine D (1), shermilamine B (2), N-deacetylkuanoniamine D (3), and styelsamine C...
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PMID: 20491501
PDF is available here.
PDF is available here.
Abstract
We have established absolute configurations of brevisin and its related metabolite brevisamide using a modified Mosher's esterification method. For brevisin, analysis was carried out on both the 31-monokis- and the 10,31-bis-MTPA esters. The results suggest that both metabolites, like other polyethe...
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PMID: 20527743
PDF is available here.
PDF is available here.
Abstract
We examined whether matrine could inhibit the differentiation of 3T3-L1 preadipocytes and further explored the possible inhibitory mechanisms. Evidenced by Oil Red O staining and AdipoRed assay, matrine dose-dependently inhibited lipid accumulation at concentrations of 125, 250 and 500 microg/ml. At...
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PMID: 20451501
PDF is available here.
PDF is available here.
Abstract
Drug discovery from plants plays an important role in the pharmaceutical therapy field and the alkaloids lycorine and candimine are candidates for this purpose. Trichomonas vaginalis is a parasite that infects the human urogenital tract and causes trichomonosis, the most prevalent non-viral sexually...
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PMID: 20176129
PDF is available here.
PDF is available here.
Abstract
Three new C(19)-diterpenoid alkaloids, umbrosumines A-C (1-3), and 11 known compounds (4-14) were isolated from the roots of Delphinium umbrosum. Their structures were elucidated on the basis of the spectroscopic data interpretation.
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PMID: 20552490
PDF is available here.
PDF is available here.
Abstract
Our extensive investigation on this plant material afforded two new compounds, including a cadinane-type sesquiterpenoid and a pyrazine derivative, along with seven known compounds. The structures of the new compounds, tatarinowin B and tatarinine A, were elucidated as 2-oxocadinan-1(10),3-dien-5-ol...
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PMID: 20552480
PDF is available here.
PDF is available here.
Abstract
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G (1), along with the previously isolated compound, psammaplysin F (2). When tested aga...
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PMID: 20462236
PDF is available here.
PDF is available here.
Phytochemistry (71)8-9 2010
Abstract
Our studies further support the notion that 1-phenylpropane-1,2-dione and (S)-cathinone are biosynthetic precursors of the ephedrine alkaloids in E. sinica stems and that the activity of (S)-cathinone reductases directs and determines the stereochemical branching of the pathway. Further methylations...
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PMID: 20417943
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)6 2010
Abstract
Eighty percent (80%) aqueous acetone extract from fruit of Piper chaba (Piperaceae) was found to have a hepatoprotective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. Among the isolates, several amide constituents inhibited D-GalN/tumor necrosis factor-alp...
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PMID: 20519856
PDF is available here.
PDF is available here.
Abstract
Chemical investigation of the roots and fruits of Zanthoxylumleprieurii Guill. et Perr. led to the isolation of three new alkaloids including two acridone derivatives, 3-hydroxy-1,4-dimethoxy-10-methyl-9-acridone (2) and 3-hydroxy-1,2-dimethoxy-10-methyl-9-acridone (3) named helebelicine A and B, re...
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PMID: 20413315
PDF is available here.
PDF is available here.
Abstract
A new synthetic route to the key framework of aspidosperma alkaloid was devised from the cycloadduct of 3-(2-nitrophenyl)-5-bromo-2-pyrone via intramolecular imino Diels-Alder reaction.
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PMID: 20377274
PDF is available here.
PDF is available here.
Abstract
The phenanthroindolizidine alkaloid (S)-(+)-tylophorine was synthesized from L-proline in nine linear steps including a double bromination and a free-radical cyclization of an N-aziridinylimine as the key steps. The phenanthrene moiety was prepared from homoveratric acid and veratraldehyde and permi...
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PMID: 20377275
PDF is available here.
PDF is available here.
Abstract
Three hundred and sixty 14-day-old chickens were divided into seven groups. The chickens, except for blank control group, were vaccinated with Newcastle disease vaccine, repeated at 28 days old. At the same time of the first vaccination, the chickens in three astragalus polysaccharide-oxymatrine (AP...
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PMID: 20149818
PDF is available here.
PDF is available here.
Abstract
An efficient synthesis of a methyl derivative of the indoloquinoline alkaloid cryptosanguinolentine based on microwave-assisted reactions is described. The microwave-assisted synthesis of an intermediate 4-hydroxy-2-methylquinoline yielded 86% of the desired product and other intermediates prepared...
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PMID: 20657469
PDF is available here.
PDF is available here.
Abstract
Our results showed that introducing Hsc70 increased HBV replication in HBV(+) human hepatocytes (HepG2.2.15 cells). The coiled-coil region on Hsc70 (nucleotides 1533 to 1608; amino acids 511 to 536) was the key sequence for HBV replication. Knockdown of Hsc70 expression by RNA interference (RNAi) la...
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PMID: 20176893
PDF is available here.
PDF is available here.
Abstract
We investigated cyanobacterial toxins, specifically cylindrospermopsin (CYN), the microcystins (MCYST) and the "paralytic shellfish toxins" (PST), in Lago Catemaco (Veracruz, Mexico). Lago Catemaco is a tropical lake dominated by Cylindrospermopsis, specifically identified as Cylindrospermopsis cate...
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PMID: 19651152
PDF is available here.
PDF is available here.
Phytochemistry (71)7 2010
Abstract
Five dihydrobenzophenanthridine alkaloids, named as maclekarpine A-E, were isolated from the roots of Macleaya microcarpa, together with 10 known benzophenanthridine/dihydrobenzophenanthridine derivatives and a known amide. Their structures were determined on the basis of spectroscopic methods. The...
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PMID: 20226485
PDF is available here.
PDF is available here.
Phytochemistry (71)7 2010
Abstract
The absolute configuration (AC) of 6beta-hydroxy-3alpha-senecioyloxytropane (1), 3alpha-hydroxy-6beta-tigloyloxytropane (2), 3alpha-hydroxy-6beta-senecioyloxytropane (3), and 3alpha-hydroxy-6beta-angeloyloxytropane (4) was assigned as (1R,3R,5S,6R) using density functional theory (DFT) calculations...
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PMID: 20189614
PDF is available here.
PDF is available here.
Abstract
Acortatarins A (1) and B (2), two novel spiroalkaloids with a naturally unusual morpholine motif, were isolated from the rhizome of Acorus tatarinowii. Their structures with absolute configuration were determined by spectroscopic methods, X-ray diffraction analysis, and Mosher's method. Importantly,...
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PMID: 20329735
PDF is available here.
PDF is available here.
Abstract
A quantitative method for the determination of caffeine, formic acid, trigonelline and 5-(hydroxymethyl)furfural (5-HMF) in soluble coffees by applying the proton nuclear magnetic resonance technique ((1)H NMR) is proposed. Each of these compounds records a singlet signal at the 7.6-9.5 ppm interval...
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PMID: 20188932
PDF is available here.
PDF is available here.
Abstract
We found that N,N-disubstituted Betti base derivative has a typical Mannich structure of o-naphthol. When it carried out a base-catalyzed formation of o-quinone methide, an efficient non-hydrogenative N-debenzylation was achieved, and the alkene and alkyne groups survived. To demonstrate the efficie...
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PMID: 20449496
PDF is available here.
PDF is available here.
Chemical Communications (46)15 2010
Abstract
Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.
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PMID: 20461849
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
Among the different aerial parts, leaves, stems/large branches and stem bark of Banisteriopsis caapi, HPLC analysis revealed that most of the dominant chemical and bioactive markers (1, 2, 5, 7-9) were present in high concentrations in dried bark of large branch. A library of HPLC chromatograms has...
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PMID: 20219660
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
The four major Stemona alkaloids in Stemona tuberosa do not contribute equally to antitussive potency in guinea pigs. Neotuberostemonine, tuberostemonine and stemoninine target on peripheral cough reflex pathway. Croomine acts on central sites in the cough reflex pathway and demonstrates central res...
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PMID: 20219659
PDF is available here.
PDF is available here.
Abstract
Tall larkspur populations with a lower MDL-type-to-MSAL-type alkaloid concentration ratio required a greater amount of MSAL-type alkaloids to cause the expected clinical signs of toxicosis (including increased heart rate) in cattle. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that the typi...
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PMID: 20367059
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)4 2010
Abstract
We used an alkaloid test and a brine shrimp bioassay to assess the bioactivity of the medicinal plants used by eastern Nicaraguan healers in traditional medicine. Ethnomedicinal uses were obtained from interviews of traditional healers. Aqueous extracts derived from 30 species of angiosperms were as...
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PMID: 20645724
PDF is available here.
PDF is available here.