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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Hormone Antagonists (7):
Recent article
Hormone Antagonists
Deutsche Medizinische Wochenschrift (136)1-2 2011
Abstract
Hyponatremia is an electrolyte disorder that is defined by a serum sodium concentration of less than 135 mmol/L. Hyponatremia occurs at a high incidence. It is commonly associated with mild to moderate mental impairment. Hypoosmolar hyponatremia occurs in the setting of plasma volume deficiency ("hy...
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PMID: 21181613
PDF is available here.
PDF is available here.
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Oral Diseases (16)7 2010
Abstract
To define the influence of cholecystokinin and melatonin on the inflammatory response of the lipopolysaccharide-exposed rat parotid gland.
Bacterial lipopolysaccharide was infused retrogradely into the parotid duct. The degree of inflammation three hours postadministration was estimated from the act...
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PMID: 20846152
PDF is available here.
PDF is available here.
Abstract
A kinetic study of atosiban was conducted following repeated intravenous administration in Wistar rats. Sample analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) following full validation of an in-house method. Eptifibatide, a cyclic peptide, was used as an intern...
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PMID: 20356809
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We found that cortisol induced the expression of PGRA, which was attenuated by inhibiting PG synthesis with indomethacin. Knockdown of PGRA expression or inhibition of endogenous progesterone production with trilostane significantly enhanced the induction of PLA2G4A by cortisol, whereas overexpressi...
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PMID: 20156884
PDF is available here.
PDF is available here.
Abstract
We examined whether Gonadotrophin-releasing hormone (GnRH) analogues [leuprolide acetate (LA) and ganirelix acetate (GA)] modulate gene expression in Ishikawa cells used as surrogate for human endometrial epithelial cells in vitro. The specific aims were: (i) to study the modulatory effect of GnRH a...
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PMID: 20203127
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)6 2010
Abstract
We determined whether the ability of the CRF(1)R antagonist, CP-154,526 (CP; 0, 10, 15 mg/kg, i.p.), to blunt binge-like drinking required normal HPA axis signaling by comparing the effectiveness of CP in adrenalectomized (ADX) and normal mice. Results showed that i.c.v. infusion of a 1 microg dose...
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PMID: 20130533
PDF is available here.
PDF is available here.
Gastroenterology (138)5 2010
Abstract
Glucocorticosteroides specifically increase HCV entry by up-regulating the cell entry factors occludin and scavenger receptor class B type I. Our data suggest that the potential effects of high-dose glucocorticosteroids on HCV infection in vivo may be due to increased HCV dissemination.
Copyright 20...
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PMID: 20152835
PDF is available here.
PDF is available here.
Abstract
Improvements in HRQOL after treatment with mifepristone are partly explained by improvements in pain and bleeding, but not uterine size. However, most of the improvement in HRQOL is not explained by improvements in these clinical parameters.
Copyright International Federation of Gynecology and Obste...
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PMID: 20132932
PDF is available here.
PDF is available here.
Biology of Reproduction (82)4 2010
Abstract
We compared the effect of both GnRH antagonist and agonist long protocols on the endometrial receptivity by analyzing, to our knowledge for the first time, the global gene expression profile shift during the prereceptive and receptive stages of stimulated cycles under the two GnRH analogue protocols...
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PMID: 20042535
PDF is available here.
PDF is available here.
Abstract
Analogues of the gonadotropin releasing hormone (GnRH) inhibit the hypothalamic-pituitary-gonadal axis. This has provided treatment modalities for advanced and metastatic prostate cancer. The latest group of analogues, the GnRH antagonists, make promising treatments available that avoid the transien...
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PMID: 20398443
PDF is available here.
PDF is available here.
Abstract
Reproduction (139)4 2010
Abstract
The objective of this study was to investigate the effects of abnormal cannabidiol (abn-cbd) on oxytocin-induced myometrial contractility occurring during pregnancy. Isometric tension recordings were performed in isolated myometrial strips from biopsies obtained at elective cesarean section. The eff...
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PMID: 20068032
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
We tested the effect of the GC dexamethasone (Dex) on TIMP-1 production in murine osteoblastic MC3T3-E1 cells and further determined whether this action is associated with Dex-induced osteoblast apoptosis. Dex decreased TIMP-1 production in MC3T3-E1 cells, and this effect was blocked by the glucocor...
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PMID: 19629637
PDF is available here.
PDF is available here.
Fertility and Sterility (93)6 2010
Abstract
OBJECTIVE: To test potential contraceptive mechanisms of the selective P receptor modulator CDB-2914 in the early luteal phase. DESIGN: Prospective randomized clinical trial. SETTING: Clinical research center. PATIENT(S): Fifty-six women with regular cycles. INTERVENTION(S): Women received a single...
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PMID: 19200989
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (315)1-2 2010
Abstract
We sought to identify progesterone-mediated transcriptional changes involved in apoptosis regulation. Granulosa cells from immature, gonadotropin-primed female rats were treated in vitro with 100 nM of the PGR antagonist Org 31710. Transcriptional effects were analyzed after 5 and 22 h of incubation...
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PMID: 19818377
PDF is available here.
PDF is available here.
Abstract
The objective of the present study was to assess the efficacy and safety of bromocriptine treatment for patients with antipsychotic-drug-induced hyperprolactinemia in clinical practice.
This was an 8-week randomized, single-blind, placebo-controlled, multicenter study...
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PMID: 19968833
PDF is available here.
PDF is available here.
Abstract
The aim of study was to investigate a contribution of hypothalamic-pituitary-adrenocortical (HPA) axis and opioid system in corticotrophin-releasing factor (CRF)-induced analgesic effect in conscious rats during thermal stimulus. The contribution of HPA axis in CRF-induced analgesia was studied with...
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PMID: 20432720
PDF is available here.
PDF is available here.
Abstract
We are reviewing two patients with pancreatic islet cell carcinomas and with both Zollinger-Ellison and Cushing's syndromes, one followed up for more than 5 years, and the other still receiving therapy, 5 years since diagnosis. A literature review showed that surgery has limited utility as the major...
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PMID: 19770666
PDF is available here.
PDF is available here.
Abstract
I (IGF-I) levels (938 ng/ml, nv 40-190), prolactin (PRL) (98.0 ng/ml, nv 1.7-24.0) and mean growth hormone (GH) nocturnal concentration (147 ng/ml). Basal adrenal, gonadal and thyroid functions were normal. Hand-wrist bone age was 3.6 years. Magnetic resonance imaging revealed a macroadenoma with mo...
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PMID: 20190543
PDF is available here.
PDF is available here.
Abstract
Our study evaluated whether a greater PBM could be achieved either in the progesterone nuclear receptor knockout mice (PRKO) or by using a nuclear progesterone receptor (nPR) antagonist, RU486 in mice. Compared to their wild type (WT) littermates the female PRKO mice developed significantly higher c...
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PMID: 20625385
PDF is available here.
PDF is available here.
Abstract
This review begins by discussing the importance of clinical congestion as the dominant presenting manifestation of acute heart failure syndromes (AHFS). The pathophysiology of the cardiorenal syndrome is reviewed, including its relationship to the use of current therapy, that is, loo...
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PMID: 20226956
PDF is available here.
PDF is available here.
Abstract
I (bromocriptine @ 50 microg/kg body weight), nine (90%) in Group II (cabergoline @ 5 microg/kg body weight), eight (80%) in Group III (thyroxine @10 microg/kg body weight) and seven (70%) in Group IV (thyroxine @ 5 microg/kg body weight) responded by evincing proestrual bleeding. The mean (+/-SEM)...
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PMID: 20012189
PDF is available here.
PDF is available here.
Abstract
100 of 233 cycles (42.9%) showed a subtle Prog rise in this study. The mean serum Prog levels and area under curve (AUC) in the group with Prog > or =1.2 ng/ml was significantly higher than that in the Prog <1.2 ng/ml group on cycle day 8 (1.17 +/- 0.4 and 0.80 +/- 0.3 ng/ml, respectively, for Prog...
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PMID: 20203521
PDF is available here.
PDF is available here.
The Nurse Practitioner (35)1 2010
Abstract
Abstract
The effects of administration of cortisol or glucocorticoid receptor antagonist RU 38486 to male rats from days 1 to 5 of postnatal life on the stress reactivity of the pituitary-adrenocortical axis, open field behavior, and anxiety in an elevated-plus maze were studied. Neonatal cortisol administra...
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PMID: 20297693
PDF is available here.
PDF is available here.
La Tunisie medicale (87)12 2009
Abstract
There was no significant difference in term of cancellation rate (2.8% vs 1.8%; NS). Duration of gonadotrophin stimulation (9.7 +/- 0.7 vs. 11.2 +/- 1.9 days; p < 0.001) and gonadotrophin consumption (2209.0 +/- 548.3 vs. 1411.1 +/- 217.9 UI: p < 0.001) were significantly decreased with GnRH antagon...
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PMID: 20209851
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Pegvisomant is a genetically engineered molecule, which exhibits specific growth hormone (GH) antagonism by directly interacting with the GH receptor. It is currently licensed for the treatment of acromegaly where surgery and medical therapy with somatostatin analogues have failed. OBJEC...
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PMID: 19916734
PDF is available here.
PDF is available here.
Oncology (Williston Park, N.Y.) (23)14 Suppl 5 2009
Abstract
Osteoporosis is a skeletal disorder characterized by low bone mass that is associated with increased risk of fracture. Nearly 40% of the 12 million cancer survivors in the United States were diagnosed with breast and prostate cancer. Therapy for these two diseases is not uncommonly associated with b...
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PMID: 20128324
PDF is available here.
PDF is available here.
Oncology (Williston Park, N.Y.) (23)14 Suppl 5 2009
Abstract
Metastasis to the bone represents a frequent complication of visceral cancers, most commonly in patients with advanced breast, prostate, and lung cancer. More than 50% of patients with advanced breast or prostate cancer have identifiable bone metastasis, and 30% to 40% of patients with non-small-cel...
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PMID: 20128325
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (60 Suppl 7) 2009
Abstract
We investigated whether glucocorticoid hormones participate in a realization of gastroprotective effect of ischemic preconditioning. Rats were exposed to prolonged gastric ischemia-reperfusion (30 min occlusion of celiac artery followed by 3 h of reperfusion) alone or with brief preliminary ischemic...
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PMID: 20388959
PDF is available here.
PDF is available here.
Behavioral Neuroscience (123)6 2009
Abstract
We hypothesized that the anxiolytic effect of MS15 is partly due to increased intestinal release of cholecystokinin (CCK) in rat pups as a result of increased maternal contact. We predicted that rats with a history of MS15 would display less anxiety in the elevated plus maze (EPMZ) and novelty-suppr...
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PMID: 20001102
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (34 Suppl 1) 2009
Abstract
We present a brief overview of the relationship between HPA axis dysfunction and neuropsychological impairment in mood disorders and the specific links between glucocorticoids and cognition in health and illness states. Finally we examine the neuropsychological effects of drugs that specifically tar...
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PMID: 19541428
PDF is available here.
PDF is available here.
Therapeutische Umschau (66)11 2009
Abstract
Vasopressin plays a physiological role in regulation of blood pressure, fluid volume, and serum osmolality. In heart failure inadequate release of vasopressin may result in excess fluid retention and hyponatremia. Vasopressin receptor antagonists are a new class of orally active drugs targeted to in...
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PMID: 19885790
PDF is available here.
PDF is available here.
Oncology Reports (22)5 2009
Abstract
We investigated the ability of mifepristone, an anti-progestin drug, to modulate the cytotoxic effect of cisplatin in two cervical cancer cell lines and in human xenograft cervical tumors. The effect of cisplatin alone or combined with mifepristone on cellular proliferation was studied with the XTT...
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PMID: 19787245
PDF is available here.
PDF is available here.
Future Oncology (5)9 2009
Abstract
Endocrine therapy is a major treatment modality for hormone-dependent breast cancer. It has a relatively low morbidity, and there is evidence that antihormonal treatments have had a significant effect in reducing mortality for breast cancer. Despite this, resistance to endocrine therapy, either prim...
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PMID: 19903069
PDF is available here.
PDF is available here.
Abstract
We used in vitro and in vivo models of TNBC to investigate if these receptors are suitable targets for the treatment with the LHRH antagonist cetrorelix. Receptors for LHRH were expressed in all tumor samples and in the TNBC cell lines HCC1806 and HCC1937. The proliferation of both TNBC cell lines w...
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PMID: 19724914
PDF is available here.
PDF is available here.
Journal of Neurotrauma (26)10 2009
Abstract
We report here (1) a downregulation of phosphorylated extracellular signal-regulated kinases 1 and 2 (pERK 1/2) after the combined treatment of RS and acoustic trauma; (2) activation of phospho-p38 in the auditory nerve after RS; (3) the abolition of these two effects by pretreatment with metyrapone...
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PMID: 19413500
PDF is available here.
PDF is available here.
Abstract
Atosiban was comparable in clinical effectiveness and was associated with fewer maternal and fetal adverse effects, so that fenoterol cannot be recommended. Completion of tocolytic therapy 12 hours after arrest of preterm labour is effective and associated with a short mean duration.
Georg Thieme Ve...
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PMID: 19856243
PDF is available here.
PDF is available here.
Abstract
We found the localization of progesterone (P4) receptors (PR) in prostate and prostatic tumors. These findings suggest the involvement of P4 in the mechanism of hormone-dependent growth of prostate and tumors. To study the influence of P4 on the growth of ventral (VP) and dorsolateral prostate (DLP)...
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PMID: 19827300
PDF is available here.
PDF is available here.
Abstract
ACE inhibitor/ARB combinations showed equivocal effects on clinical outcomes. DRI/ACE inhibitor and DRI/ARB combinations reduced markers of organ damage, but longer-term trials are required to establish whether more complete renin--angiotensin--aldosterone system control with aliskiren-based therapy...
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PMID: 19635044
PDF is available here.
PDF is available here.
La Tunisie medicale (87)8 2009
Abstract
Abstract
Randomized double-blind placebo-controlled trials have been conducted with mifepristone, CDB-4124 (Proellex), CDB-2914 (VA 2914, Ulipristal) and asoprisnil (J867). All these PRMs are effective in the treatment of uterine fibroids where they are associated with a reduction in pain, bleeding and impro...
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PMID: 19602929
PDF is available here.
PDF is available here.
Endocrinology (150)8 2009
Abstract
We expressed a form of hCG that lacks three of its four N-linked glycosylation sites and tested its efficacy as an antagonist. The hCG-Ant binds the LH receptor with an affinity similar to native hCG and inhibits cAMP response in vitro. In a rat model for ovarian stimulation, hCG-Ant dramatically re...
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PMID: 19443574
PDF is available here.
PDF is available here.
Endocrinology (150)8 2009
Abstract
We investigated the regulatory mechanisms controlling expression of Timp1 and Timp3 mRNA in periovulatory granulosa cells. Granulosa cells were isolated from immature pregnant mare serum gonadotropin-primed (10 IU) rat ovaries and treated with human chorionic gonadotropin (hCG; 1 IU/ml). At 4 h afte...
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PMID: 19389837
PDF is available here.
PDF is available here.
Abstract
According to the corticoid receptor hypothesis of depression, hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system is one of the major pathophysiological factors for the development of depression and opens a broad range of new antidepressant treatment options that are related to d...
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PMID: 19589050
PDF is available here.
PDF is available here.
Abstract
We studied whether follicle-stimulating hormone (FSH) regulates cholangiocyte proliferation. FSH receptor (FSHR) and FSH expression was evaluated in liver sections, purified cholangiocytes, and cholangiocyte cultures (NRICC). In vivo, normal female and male rats were treated with FSH or immediately...
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PMID: 19389804
PDF is available here.
PDF is available here.
Abstract
We conducted a prospective observational study in 17 HD patients with SHPT. Cinacalcet was started at 25 mg/day, and the dose was increased step by step based on serum calcium level. A significant decrease in serum Ca and intact PTH concentration was found within 2 weeks. Tartrate-resistant acid pho...
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PMID: 19548062
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: The World Health Organization (WHO) report has predicted that major depression will become a key cause of illness-induced disability by the year 2020, second only to ischemic heart diseases. OBJECTIVES/METHODS: Although a large number of antidepressant drugs (from monoamine oxidase inhib...
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PMID: 19426122
PDF is available here.
PDF is available here.
Aktuelle Urologie (40)3 2009
Abstract
At present medical castration employing luteinising hormone releasing hormone (LHRH) agonists is the standard of care for patients with advanced prostate cancer. LHRH agonists suppress the synthesis of testosterone to a castration level. In contrast to surgical castration, medical castration is reve...
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PMID: 19399720
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To evaluate the application of gonadotrophin-releasing hormone antagonist (GnRH-ant) in patients with risk of poor response to controlled ovarian stimulation in IVF-ET. METHODS: Clinical data of 48 patients undergoing IVF with or without ICSI were retrospectively analyzed. Among them 24 p...
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PMID: 19504641
PDF is available here.
PDF is available here.
Abstract
Our data suggest that modifications of glucose homeostasis induced by SSA may have an overall minor clinical impact in acromegaly....
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PMID: 19208728
PDF is available here.
PDF is available here.
Abstract
Polycystic ovary syndrome is a condition present in approximately 5 to 10 percent of women of childbearing age. Diagnosis can be difficult because the signs and symptoms can be subtle and varied. These may include hirsutism, infertility, menstrual irregularities, and biochemical abnormalities, most...
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PMID: 19405411
PDF is available here.
PDF is available here.
Abstract
Our results suggest that cessation of the GnRH antagonist on the day of hCG administration during a flexible multiple-dose protocol could reduce the total dose of GnRH antagonist without compromising IVF results....
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PMID: 19399268
PDF is available here.
PDF is available here.
Abstract
These results suggest that the OTR is expressed on the smooth muscle of the stomach and mediates excitatory effect of OT on gastric motility....
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PMID: 19309416
PDF is available here.
PDF is available here.
Fertility and Sterility (91)4 Suppl 2009
Abstract
We studied 152 IVF cycles. The PCOS patients undergoing COH using the GnRH agonist protocol (n = 50) showed a significantly higher pregnancy rate (36% vs. 19.6%, respectively), compared with the GnRH antagonist protocol (n = 102)....
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PMID: 18774558
PDF is available here.
PDF is available here.
Fertility and Sterility (91)4 Suppl 2009
Abstract
We compared the stimulation characteristics of ten cycles which included ultrashort flare GnRH agonist combined with flexible multidose GnRH antagonist with the patients' earlier failed IVF attempts. The use of ultrashort GnRH agonist/GnRH antagonist COH protocol resulted in a significantly higher n...
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PMID: 18675974
PDF is available here.
PDF is available here.
Clinical Science (116)6 2009
Abstract
Left ventricular diastolic dysfunction represents a frequent clinical condition and is associated with increased cardiovascular morbidity and mortality. Diastolic dysfunction is the most common cause of HF-PSF (heart failure with preserved ejection fraction). Therefore it becomes important to unders...
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PMID: 19200056
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (113)3 2009
Abstract
Abstract
More precise cut thresholds for both LH and progesterone are necessary for accurate prediction of the cycle outcomes....
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PMID: 19224360
PDF is available here.
PDF is available here.