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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Immune System Diseases (9):
Recent article
Immune System Diseases
Abstract
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Abstract
Abstract
Immunoglobulin (Ig) therapy is an important method of treatment for a number of immunological, hematological, neurological and dermatological disorders. Over the years, the range of indications in which Ig therapy, either replacement or immunomodulatory, is effective has substantiall...
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PMID: 21595597
PDF is available here.
PDF is available here.
Drugs of Today (47)4 2011
Abstract
We will briefly review the structure and biological effects of TNF-α, the old and recent indications of adalimumab, the pretreatment considerations, the reported adverse events and finally, the recommendations for its use in pregnancy.
2011 Prous Science, S.A.U. or its licensors. Al...
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PMID: 21573251
PDF is available here.
PDF is available here.
Abstract
Sex hormones play an important role as modulators of the immune system. A growing body of evidence shows reciprocal relationship between sex steroids and the immune system. Since the innate immune response determines the type of adaptive immune response, hormonal effects on the innat...
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PMID: 21463251
PDF is available here.
PDF is available here.
Abstract
We have recently found that such activities can be scrutinized by using mixed lymphocyte reaction, cAMP, and differential expression of Notch ligand isoforms. Application of these methods for the analyses of atopic dermatitis and experimental autoimmune encephalomyelitis will be discussed....
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PMID: 21646788
PDF is available here.
PDF is available here.
Abstract
We will first review the physiological role of HO-1 as determined by the analysis of HO-1-deficient individuals. This will be followed by an examination of the effect of HO-1 within immunopathological contexts such as immune disorders (autoimmunity and allergy) or infections. A section will be devot...
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PMID: 20941616
PDF is available here.
PDF is available here.
BMC Medicine (9) 2011
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
PDF is available here.
BMC Medicine (9)1 2011
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
PDF is available here.
Abstract
IL-17 is a multifunctional cytokine produced by activated CD4+ and CD8+ lymphocytes as well as stimulated unconventional Tγδ and natural killer T cells. IL-17 induces expression of chemokines, proinflammatory cytokines and metalloproteinases, thereby stimulating the inflammation an...
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PMID: 21441609
PDF is available here.
PDF is available here.
Immunology (131 Suppl 1) 2010
Abstract
Abstract
We report 4 cases to support this postulation. The patients were male adults aged 42 to 89 years, who presented with an infiltrative, firm cervical mass. Two patients also had IgG4-related chronic sclerosing sialadenitis of submandibular gland and lymphadenopathy. Histologically, the cervical soft t...
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PMID: 20871392
PDF is available here.
PDF is available here.
Autism Research (3)5 2010
Abstract
We recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis ("exploratory phase"), followed by intra- and inter-component cross-correlati...
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PMID: 20878720
PDF is available here.
PDF is available here.
Abstract
There may be a causal relationship between n-6 PUFA intake and allergic disease and there are biologically plausible mechanisms, involving eicosanoid mediators of the n-6 PUFA arachidonic acid, that could explain this. There is some evidence that high linoleic acid intake is linked with increased ri...
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PMID: 20462467
PDF is available here.
PDF is available here.
Abstract
Abstract
We have described how an understanding of patterns of disease may be used to develop new strategies for reducing the prevalence and risk of major immune-based illnesses and diseases influenced by environmental stimuli.
Examples of recently defined patterns of diseases that begin in childhood include...
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PMID: 20483701
PDF is available here.
PDF is available here.
Abstract
Abstract
Interest in sphingosine-1-phosphate (S1P)(1) receptor agonists has increased steadily since the discovery that the mechanism of action of fingolimod (FTY-720)-induced lymphopenia is linked to the S1P GPCR family. Fingolimod is an agonist at four out of the five S1P family receptors. Adoptive cell tr...
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PMID: 20597031
PDF is available here.
PDF is available here.
Abstract
A cardinal feature of inflammation is the tissue recruitment of leukocytes, a process that is mediated predominantly by chemokines via their receptors on migrating cells. CCR2 and CCR5, two CC chemokine receptors, are important players in the trafficking of monocytes/macrophages and in the functions...
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PMID: 20360402
PDF is available here.
PDF is available here.
Clinical Infectious Diseases (50)12 2010
Abstract
This study demonstrated that long-term (18-month) zinc supplementation at nutritional levels delayed immunological failure and decreased diarrhea over time. This evidence supports the use of zinc supplementation as an adjunct therapy for HIV-infected adult cohorts with poor viral control. Trial regi...
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PMID: 20455705
PDF is available here.
PDF is available here.
Deutsche Medizinische Wochenschrift (135)25-26 2010
Abstract
Abstract
Mean postoperative follow-up was similar for both cases (18.6 +/- 6.6 months) and controls (18.4 +/- 8.7 months). Preoperative CT and endoscopy scores (i.e., disease severity) were similar in both cases and controls. Postoperative endoscopy scores were significantly improved for both cases (p < 0.00...
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PMID: 20537292
PDF is available here.
PDF is available here.
Cell Research (20)5 2010
Abstract
We showed that there is a species variation in the mechanisms of MSC-mediated immunosuppression: immunosuppression by cytokine-primed mouse MSCs is mediated by nitric oxide (NO), whereas immunosuppression by cytokine-primed human MSCs is executed through indoleamine 2, 3-dioxygenase (IDO). Additiona...
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PMID: 20368733
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1802)5 2010
Abstract
We describe the recent progress made in exploring the biological function of ISG15 and its reversible modification of target proteins and thus in their implication in immune diseases.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20153823
PDF is available here.
PDF is available here.
Abstract
The 2010 American Academy of Allergy, Asthma and Immunology (AAAAI) meeting, held in New Orleans, included topics covering new therapeutic developments in the fields of allergy, asthma and immunological diseases. This conference report highlights selected presentations on potential treatments for fo...
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PMID: 20432184
PDF is available here.
PDF is available here.
Abstract
The median follow-up of the patients was 6.2 years, and median overall survival was 5.3 years. Twenty-four patients (5.3%) developed MDS with median time of onset of 4.2 years (range, 8 months to 7.5 years). An additional 5 patients developed clonal karyotypic abnormalities in the bone marrow withou...
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PMID: 20371446
PDF is available here.
PDF is available here.
Abstract
Abstract
The precise mechanisms whereby gastro-oesophageal reflux disease causes reflux oesophagitis and Barrett's oesophagus are not clear, even though these diseases have been known to be linked for many years. Recent studies indicate a role for the reflux-induced inflammatory response of oesophageal squam...
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PMID: 20298181
PDF is available here.
PDF is available here.
Abstract
We have already shown that Thymosin alpha1 (Talpha1), a naturally occurring thymic peptide first described and characterized by Allan Goldstein in 1972, by modulating signals delivered through innate immune receptors on dendritic cells, affects adaptive immune responses via modulation of Th cell eff...
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PMID: 20536444
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for the efficient capture of infectious virus and for preventing viral replication. The latter process invol...
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PMID: 20578253
PDF is available here.
PDF is available here.
Current Drug Targets (11)3 2010
Abstract
We present an overview of Z-DNA and known ZBPs as drug targets, and summarize recent progress in the structure-based identification of ZBP inhibitors....
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PMID: 20210758
PDF is available here.
PDF is available here.
Abstract
We identified a mixture of probiotics that up-regulates CD4(+)Foxp3(+) regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced gener...
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PMID: 20080669
PDF is available here.
PDF is available here.
Biochemical Society transactions (38)Pt 1 2010
Abstract
We will discuss current platforms that report on E3 ligase activity and can detect E3 inhibitors, and underline the advantages and disadvantages of each approach....
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PMID: 20074047
PDF is available here.
PDF is available here.
Inhalation Toxicology (22)2 2010
Abstract
The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carr...
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PMID: 20044880
PDF is available here.
PDF is available here.
Drugs of Today (46)2 2010
Abstract
We critically analyze recent literature on the efficacy and safety of biologics in the management of rheumatoid arthritis, psoriasis, psoriatic arthritis and immune thrombocytopenia. Our analysis of benefits, resistance to the therapy, risk of infections, tumors and other serious complications relat...
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PMID: 20393640
PDF is available here.
PDF is available here.
Klinicheskaia meditsina (88)6 2010
Abstract
Modem immunopathogenetic concepts of tuberculosis infection are summarized. Th1-mediated immune response is shown to play a leading role in the formation of antituberculosis immunity. Cytokine balance (especially that of interferon-y) has marked influence on the outcome of infection....
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PMID: 21395021
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We have proposed several models to study this fact. The established models of premature aging have been mice and humans with poor response to stress and anxiety versus subjects of the same chronological age without that characteristic, isolation, males versus females, menopausal models (in rodents a...
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PMID: 20134206
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We will discuss the use of noninvasive methods to evaluate the immune system, ANS and HPA axis. Collection of sweat and saliva, and measurement of heart rate variability are noninvasive methods that can be applied to evaluate neuroimmune interactions. Recently, we validated a new methodology to simu...
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PMID: 20134204
PDF is available here.
PDF is available here.
Abstract
DPV576-C-treated aged mice showed an: (1) increase in the percentages of CD4(+) and CD8(+) T-cells and their activation markers, CD25 and CD69, over untreated aged mice; (2) enhancement of NK activity; and (3) absence of adverse side effects as determined histopathologically. CONCLUSION: The enhance...
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PMID: 20363985
PDF is available here.
PDF is available here.
Journal of Translational Medicine (8 Suppl 1) 2010
Abstract
Abstract
We summarize antiallergic/anti-inflammatory effects of helminths together along with our own study of the effects of Schistosoma mansoni on Th17-dependent experimental arthritis. We also discuss possible mechanisms of helminth-induced suppression according to the recent advances of immunology....
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PMID: 20169100
PDF is available here.
PDF is available here.
Abstract
Infusion reactions and cytokine release syndrome (CRS) are an emerging issue in drug development and are of particular importance with the development of new therapeutic proteins. Increasing concerns regarding patient safety require a better understanding of the mechanism involved and the developmen...
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PMID: 20047153
PDF is available here.
PDF is available here.
Abstract
Cutaneous involvement in extramedullary plasmacytoma represents a clinically aggressive variant of plasma cell tumor, which runs a rapid course and has associated devastating effects on the patient's innate immune system.
Copyright 2010 S. Karger AG, Basel....
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PMID: 20215803
PDF is available here.
PDF is available here.
Abstract
The present study was designed for immunological examination of 46 patients presenting with various forms of chronic suppurative otitis media. All the patients underwent surgical intervention on mastoid process (processus mastoideus). It was shown that exacerbation of catarrhal inflammation provoked...
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PMID: 21191352
PDF is available here.
PDF is available here.
Minerva Pediatrica (61)6 2009
Abstract
Minerva Pediatrica (61)6 2009
Abstract
Abstract
We review the current patents on leptin in different clinic applications....
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PMID: 19594439
PDF is available here.
PDF is available here.
Abstract
The identification of histamine H3 (H3R) and H4 (H4R) receptors some years ago revived interest in histamine research and exposed attractive perspectives for the potential therapeutic exploitation of these new drug targets. While the H3R is mainly localised in the CNS, the H4R is primarily expressed...
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PMID: 19758107
PDF is available here.
PDF is available here.
Clinical Immunology (133)1 2009
Abstract
We found that besides thymic output, naive (CD27(+)CD45RO(-)) T-cell proliferation contributed significantly to the establishment of the naive T-cell compartment. At birth, regulatory (CD25(+)CD127(-)CD4(+)) T cells (Tregs) mainly had a naive (CD27(+)CD45RO(-)) phenotype whereas 'memory or effector-...
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PMID: 19586803
PDF is available here.
PDF is available here.
Abstract
We focus on data supporting the pathogenic role of IL-21 in human inflammatory diseases and discuss pre-clinical studies that suggest that neutralization of IL-21 in vivo could be a new biological therapy to combat immune-mediated pathologies, such as inflammatory bowel diseases, diabetes, rheumatoi...
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PMID: 19616319
PDF is available here.
PDF is available here.
Abstract
Alloimmunization is the formation of antibodies when there is an exposition of the individual to non-self antigens, as it occurs, for example, in the transfusion of incompatible blood and pregnancies, in whom the fetus express in its sanguineous cells antigens exclusively of paternal origin. This ar...
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PMID: 19684967
PDF is available here.
PDF is available here.
Abstract
The formal sub-health survey questionnaire would include five domains and 25 questions in total. The whole questionnaire's Chronbach's alpha coefficient was 0.92. Cronbach's alpha of the four domains, including cardiovascular, digestive tract, immunity and mental health were no less than 0.7 while I...
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PMID: 19957623
PDF is available here.
PDF is available here.
Anaesthesist (58)6 2009
Abstract
Acute lymphoblastic leukaemia is the most common malignancy in childhood. This disease and its associated therapy may lead to specific life-threatening complications if general anaesthesia has to be carried out. The case of a 14-year-old boy suffering from aspergillosis because of immunosuppression...
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PMID: 19562397
PDF is available here.
PDF is available here.
Amino Acids (37)1 2009
Abstract
Gases, such as nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H(2)S), and sulfur dioxide (SO(2)) are known toxic pollutants in the air. However, they are now recognized as important signaling molecules synthesized in animals and humans from arginine, glycine (heme), and cysteine, respect...
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PMID: 19266154
PDF is available here.
PDF is available here.
Military Medicine (174)5 2009
Abstract
The goals of this study were to estimate blood group alloimmunization arising from combat-related transfusion and the prevalence of delayed serologic transfusion reactions (DSTRs) in military veteran patients. Blood group alloantibodies documented in the transfusion records at a Veterans Affairs (VA...
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PMID: 20731281
PDF is available here.
PDF is available here.
Abstract
Our study revealed a high rate of immune defects in patients with dysmorphic disorders, both during the initial study and 2 to 3 years later, which may contribute to their increased susceptibility to infections. This association was most obvious in patients with Down syndrome and Turner syndrome. Th...
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PMID: 19492666
PDF is available here.
PDF is available here.
Abstract
Since its discovery at the beginning of the 20th century, histamine has been established to play a pathophysiological regulatory role in cellular events through binding to four types of G-protein-coupled histamine receptors that are differentially expressed in various cell types. The discovery, at t...
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PMID: 19309354
PDF is available here.
PDF is available here.
Abstract
The most recent reports of clinical trials with Talpha(1) are pointing to important, hitherto unrecognized, applications in a number of diseases and disorders, including septic shock, acute respiratory distress syndrome, peritonitis, acute cytomegalovirus infection, TB, severe acute respiratory synd...
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PMID: 19392576
PDF is available here.
PDF is available here.
Abstract
We critically evaluated over 100 published articles on experimental research, focusing on their value for predicting the risk of non-cancer health effects in humans exposed to DE. Human controlled-exposure studies provide new evidence of lung inflammatory effects and thrombogenic and ischemic effect...
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PMID: 19280432
PDF is available here.
PDF is available here.