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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Autoimmune Diseases (21):
- Pemphigus
- Glomerulonephritis, Membranous
- Familial Mediterranean Fever
- Anti-Glomerular Basement Membrane Disease
- Lambert-Eaton Myasthenic Syndrome
- Thyroiditis, Autoimmune
- Hepatitis, Autoimmune
- Diabetes Mellitus, Type 1
- Ophthalmia, Sympathetic
- Glomerulonephritis, IGA
- Addison Disease
- Lupus Erythematosus, Systemic
- Autoimmune Diseases of the Nervous System
- Arthritis, Rheumatoid
- Purpura, Thrombocytopenic, Idiopathic
- Pemphigoid, Bullous
- Graves Disease
- Antiphospholipid Syndrome
- Polyendocrinopathies, Autoimmune
- Anemia, Hemolytic, Autoimmune
- Dermatitis Herpetiformis
Recent article
Autoimmune Diseases
Abstract
We studied Tregs in the pancreas and peripheral blood.
We recruited 44 patients with IgG4-related AIP. For comparison, we recruited 37 patients with other pancreatic diseases and 27 healthy subjects as controls. We studied infiltrating cells in the pancreas by immunohistochemistry an...
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PMID: 21926547
PDF is available here.
PDF is available here.
| < More recent | Older article > |
New England Journal of Medicine (365)13 2011
Abstract
Abstract
We have shown, both in vitro and in vivo, that NF-κB blockade on DCs by andrographolide or rosiglitazone can significantly enhance the tolerogenic capacity of DCs. Furthermore, we have observed that expression ratio of the activating FcγRIII or the inhibitory FcγRIIb is determinant for the tolero...
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PMID: 20941620
PDF is available here.
PDF is available here.
Abstract
We show that in vivo in mice, TIM-1 is predominantly expressed on B rather than T cells. Importantly, TIM-1 was expressed by a large majority of IL-10-expressing regulatory B cells in all major B cell subpopulations, including transitional, marginal zone, and follicular B cells, as well as the B cel...
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PMID: 21821911
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
We included all patients with systemic autoimmune diseases in whom the indication for treatment with TPE was a flare of the disease between 1999 and 2010. The indications for treatment, complications and outcomes were obtained from review of medical records.
A total of 31 patients (1...
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PMID: 21569864
PDF is available here.
PDF is available here.
Abstract
We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases....
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PMID: 21928689
PDF is available here.
PDF is available here.
Abstract
Abstract
Hematopoietic stem cells (HSCs) differentiate into mature lineage restricted blood cells under the influence of a complex network of hematopoietic cytokines, cytokine-mediated transcriptional regulators, and manifold intercellular signaling pathways. The classical model of hematopoie...
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PMID: 21426948
PDF is available here.
PDF is available here.
Abstract
Recent investigations of regulatory myeloid cell mobilization and amplification in response to cancer and chronic inflammation associated with infectious disease and autoimmunity have provided numerous insights into the suppressive mechanisms, pathobiology and potential pharmaceutica...
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PMID: 21315784
PDF is available here.
PDF is available here.
Abstract
We report a successful management of primary AIN patient by estimating the granulopoiesis according to CRP levels without administration of G-CSF or increase of prednisolone when peripheral neutrophil counts dropped down. Transient elevation of CRP associated with severe drop down in neutrophil coun...
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PMID: 21316504
PDF is available here.
PDF is available here.
Abstract
We analyzed the effects of systemic delivery of polyinosinic:polycytidylic acid (poly(I:C)), a mimic of viral dsRNA, in the induction of EAU. We found that TLR3 agonist poly(I:C) enhanced EAU scores, DTH responses and Ag-specific T cell proliferation. In addition, Ag-specific Interleukin 17 (IL-17)...
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PMID: 21296697
PDF is available here.
PDF is available here.
Abstract
Monoclonal antibodies have emerged as a new class of agents causing drug-related pulmonary involvement in patients with systemic rheumatologic autoimmune diseases. The most frequently associated noninfectious pulmonary diseases are interstitial pneumonia (118 cases reported by August 2010), sarcoid-l...
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PMID: 21531225
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)7 2011
Abstract
Autoimmune diseases are frequently associated with the production of autoantibodies by cells that escaped the protective mechanisms that control self-tolerance. Some of these cells develop into long-lived plasma cells which are predominantly located in the bone marrow. The generation...
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PMID: 21224017
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)7 2011
Abstract
Numerous autoimmune-inflammatory rheumatic diseases have been associated with accelerated atherosclerosis or other types of vasculopathy leading to increased cardio- and cerebrovascular disease risk. Traditional risk factors, as well as the role of systemic inflammation including cyt...
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PMID: 21281743
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)7 2011
Abstract
Autoimmune neutropenia, caused by neutrophil-specific autoantibodies is a common phenomenon in autoimmune disorders such as Felty's syndrome and systemic lupus erythematosus. Felty's syndrome is associated with neutropenia and splenomegaly in seropositive rheumatoid arthritis which c...
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PMID: 21255689
PDF is available here.
PDF is available here.
Revue medicale suisse (7)290 2011
Abstract
Autoimmune glomerulopathies are an important cause of chronic kidney disease. Conventional treatments based on steroids, antiproliferative and cytotoxic agents are efficacious, but highly toxic. Because of their central role in the pathogenesis of autoimmunity, B cells have become an...
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PMID: 21595313
PDF is available here.
PDF is available here.
Drugs of Today (47)4 2011
Abstract
We will briefly review the structure and biological effects of TNF-α, the old and recent indications of adalimumab, the pretreatment considerations, the reported adverse events and finally, the recommendations for its use in pregnancy.
2011 Prous Science, S.A.U. or its licensors. Al...
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PMID: 21573251
PDF is available here.
PDF is available here.
Abstract
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of th...
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PMID: 21035432
PDF is available here.
PDF is available here.
Abstract
The immune system is balanced with cells that respond to microbes by developing into effector cells and cells that regulate the activity of effector cells. In many immune responses a subset of effector T cells termed Th17 are necessary for complete immunity because the cytokine IL-17...
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PMID: 20708723
PDF is available here.
PDF is available here.
Abstract
Inflammation is a disease of vigorous uncontrolled activated immune responses. Overwhelming reports have suggested that the modulation of immune responses by curcumin plays a dominant role in the treatment of inflammation and metabolic diseases. Observations from both in-vitro and in...
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PMID: 20828642
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)5 2011
Abstract
We are currently reaching a period of rapid data production. Several themes are already rising from the first wave of results. First, some genetic variants clearly predispose to multiple autoimmune diseases, thus providing evidence for a shared autoimmune genetic background. Second, multiple genes a...
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PMID: 20863905
PDF is available here.
PDF is available here.
Abstract
We categorized LE into 5 groups. LE caused by virus infection, autoantibody-mediated LE, LE with autoimmune disease, LE associated with drugs and LE during pregnancy. LE having the antibodies against intracellular antigens frequently related to cancer and are resistant to treatment. While, LE with a...
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PMID: 21400836
PDF is available here.
PDF is available here.
Abstract
We proposed the classification of IAE with poor prognosis from the neuroradiological findings. Four types of encephalopathy seem to be differentiated from each other, acute necrotizing encephalopathy (ANE) type, hemorrhagic shock and encephalopathy syndrome (HSES) type, acute brain swelling (ABS) ty...
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PMID: 21400830
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (231)1-2 2011
Abstract
Although myasthenia gravis (MG) has long been considered a well-established autoimmune disease associated with autoantibodies, which are convincingly pathogenic, accumulating data indicate both clinical and biological heterogeneity similar to many other putative autoimmune disorders....
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PMID: 21093931
PDF is available here.
PDF is available here.
Abstract
We addressed four major autoimmune-rheumatological diseases investigated through proteomic techniques and provide evidence-based data on the highlights obtained in systemic sclerosis, primary and secondary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis.
Cop...
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PMID: 21246742
PDF is available here.
PDF is available here.
Immunotherapy (3)2 2011
Abstract
We are grateful for their participation. This meeting report describes key points and themes arising from this conference....
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PMID: 21322755
PDF is available here.
PDF is available here.
Toxicology (279)1-3 2011
Abstract
Abstract
We revisited the subclassification of AIP and examine whether this provides clinically and prognostically meaningful information. We evaluated 29 pancreatic resection specimens from patients with AIP. Demographic, clinical, and imaging data were recorded, as was evidence of extrapancreatic manifesta...
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PMID: 21164284
PDF is available here.
PDF is available here.
Abstract
Unbalanced Th1/Th2 T-cell responses in the liver are a characteristic of hepatic inflammation and subsequent liver fibrosis. The recently discovered Th17 cells, a subtype of CD4(+) T-helper cells mainly producing IL-17 and IL-22, have initially been linked to host defense against inf...
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PMID: 21197451
PDF is available here.
PDF is available here.
Abstract
We review the contribution of innate immune response to type 1 diabetes, with a particular emphasis to Toll-like receptors (TLR) and NK cells....
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PMID: 20383637
PDF is available here.
PDF is available here.
Abstract
We review the contribution of innate immune response to type 1 diabetes, with a particular emphasis to Toll-like receptors (TLR) and NK cells....
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PMID: 20383637
PDF is available here.
PDF is available here.
Abstract
We review the contribution of innate immune response to type 1 diabetes, with a particular emphasis to Toll-like receptors (TLR) and NK cells....
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PMID: 20383637
PDF is available here.
PDF is available here.
Abstract
Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases. Earlier studies showed that it ameliorated EAU; however, the mechanisms involved in this inhibition are still largel...
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PMID: 21573074
PDF is available here.
PDF is available here.
Abstract
Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's an...
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PMID: 20843756
PDF is available here.
PDF is available here.
Medicinski pregled (64)3-4 2011
Abstract
Screening for autoimmune thyroid diseases should be recommended in everyday clinical practice, in patients with primary organ-specific or organ non-specific autoimmune disease. Otherwise, in patients with primary thyroid autoimmune disease, there is no good reason of seeking for all other autoimmune...
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PMID: 21905597
PDF is available here.
PDF is available here.
Abstract
We have shown that CD26 interacts with structures with essential cellular functions in T cell responses. We will review emerging data that suggest CD26 may be an appropriate therapeutic target for the treatment of selected immune disorders....
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PMID: 21404914
PDF is available here.
PDF is available here.
Abstract
We carried out a cross-sectional study of 114 patients with IgG4-related disease. On the basis of the location of the lesions, the patients were classified into 5 groups: head and neck (n=23), thoracic (n=16), hepatic and pancreatobiliary (n=27), retroperitoneal (n=13), and systemic (n=35). All grou...
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PMID: 21107087
PDF is available here.
PDF is available here.
Neuroscience Bulletin (26)6 2010
Abstract
Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Besides its well-established functions on bone health, multiple lines of evidence have indicated...
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PMID: 21113195
PDF is available here.
PDF is available here.
Abstract
Nature Immunology (11)12 2010
Abstract
In autoimmune disease, multifaceted approaches are being explored to tailor a particular treatment that targets a specific cell at the appropriate disease stage. The key roles of B lymphocytes have enabled them to enter the clinical arena. In turn, clinical trials have suggested seve...
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PMID: 21079626
PDF is available here.
PDF is available here.
Abstract
There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells and are involved in the signaling of multiple cytokines importan...
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PMID: 21105711
PDF is available here.
PDF is available here.
Epidemiology (21)6 2010
Abstract
We explored associations between parental autoimmune disorders and children's diagnosis of autism by linking Swedish registries.
Data for each participant were linked across 3 Swedish registries. The study includes 1227 cases and 25 matched controls for each case (30,693 controls with parental linka...
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PMID: 20798635
PDF is available here.
PDF is available here.
Abstract
We provide a comprehensive review of the target diseases for which the use of BTK inhibitors may be helpful as well as the activity profiles of BTK inhibitors.
We review the currently available translational research, biomarker as well as patent literature regarding BTK molecular target and BTK inhi...
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PMID: 20831363
PDF is available here.
PDF is available here.
Abstract
Lck (p56(lck) or lymphocyte specific kinase) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence from knockout mice and human mutations demonstrates that Lck kinase activity is critical for T cell receptor (TCR)-mediated signaling,...
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PMID: 20831362
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (114)11 2010
Abstract
Nippon Ganka Gakkai zasshi (114)11 2010
Abstract
We investigated whether oral administration of STA-5326 is effective in influencing experimental autoimmune uveoretinitis (EAU). Clinical and histopathological analysis of our results show that oral administration of STA-5326 during the entire phase reduced the severity of EAU. Furthermore, oral adm...
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PMID: 21141074
PDF is available here.
PDF is available here.
Abstract
The rs5029939 G allele was found to be significantly associated with SSc susceptibility (pooled OR=2.08 (95% CI 1.59 to 2.72); p=1.16×10⁻⁷), whereas the rs10499194 and rs6920220 variants displayed no association. Only one of the predicted haplotypes investigated in the French sample was signifi...
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PMID: 20511617
PDF is available here.
PDF is available here.
Abstract
Significant advances have been made in the characterization of Vitamin D and the Vitamin D receptor (VDR) in immune function. The studies of signaling pathways involved in the response to infection and inflammation have led to a more detailed understanding of the cellular response to Vitamin D throu...
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PMID: 20639756
PDF is available here.
PDF is available here.
Abstract
We investigated the frequency of PGAs and other lesions in all nonconsultation gastric biopsies and resections (1988 to 2008) diagnosed as AMAG. We further selected cases confirmed as AMAG by immunohistochemical identification of the gastric body (negative gastrin) and linear and nodular enterochrom...
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PMID: 20975338
PDF is available here.
PDF is available here.
Abstract
We report the case of a 65-year-old man who had encephalitis with a high titer of voltage-gated potassium channel antibodies (VGKC-Abs). His initial symptoms included memory disturbance, confusion, and seizures. Laboratory tests revealed a low plasma sodium concentration and a strong positive result...
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PMID: 21068462
PDF is available here.
PDF is available here.
Autoimmunity (43)7 2010
Abstract
We describe the potential of SCNP to inform on the biological characterization of autoimmune disease, the application in clinical medicine, and the utility in drug development....
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PMID: 20482423
PDF is available here.
PDF is available here.
Autoimmunity (43)7 2010
Abstract
We herein describe the preclinical stages of typical small-molecule research programmes and outline hurdles that may have to be overcome. A few examples of small molecules that are currently under clinical evaluation and arose from diverse discovery pathways will be discussed....
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PMID: 20388059
PDF is available here.
PDF is available here.
Abstract
We show that T(H)17 differentiation can occur in the absence of TGF-β signalling. Neither IL-6 nor IL-23 alone efficiently generated T(H)17 cells; however, these cytokines in combination with IL-1β effectively induced IL-17 production in naive precursors, independently of TGF-β. Epigenetic modifi...
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PMID: 20962846
PDF is available here.
PDF is available here.
Abstract
We have generated a cell-permeable Foxp3 protein by fusion with the unique human HHph-1-PTD (protein transduction domain), examined its regulatory function in T cells, and characterized its therapeutic effect in autoimmune and allergic disease models. HHph-1-Foxp3 was rapidly and effectively transdu...
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PMID: 20937878
PDF is available here.
PDF is available here.
Nature Biotechnology (28)10 2010
Abstract
We are learning how aberrant placement of these epigenetic marks and mutations in the epigenetic machinery is involved in disease. Thus, a comprehensive understanding of epigenetic mechanisms, their interactions and alterations in health and disease, has become a priority in biomedical research....
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PMID: 20944598
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)39 2010
Abstract
Abstract
To test whether CD4+ T cells proliferate in mixed cell reactions with autologous lacrimal gland (LG) acinar cells and whether these cells can autoadoptively transfer disease.
Purified acinar cells were gamma irradiated and cocultured with peripheral blood lymphocytes. Activated CD4+ T cells were sor...
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PMID: 20577087
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)12 2010
Abstract
The number of 2009 publications in indexed journals dealing with 'autoimmunity' has maintained its increasing trend compared to the previous five years. Numerous developments have been proposed in our understanding of systemic and organ-specific autoimmune diseases (particularly mult...
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PMID: 20716447
PDF is available here.
PDF is available here.
Abstract
Annals of Medicine (42)7 2010
Abstract
We analyzed 3,511 subjects with matched samples from 1974 (CLUE I) and 1989 (CLUE II). To avoid a selection bias regarding survival, we also screened 840 CLUE I participants who deceased after the 1974 survey. Outcome measure. CD autoimmunity (positivity to auto-antibodies) over time.
CD autoimmunit...
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PMID: 20868314
PDF is available here.
PDF is available here.