Find your PDFs fast.
Recent article
Arsenicals
Abstract
Arsenic trioxide (ATO) treatment is a useful therapy against human acute promyelocytic leukemia (APL), however, it concomitantly brings potential adverse consequences including serious side effect, human carcinogenicity and possible development of resistance. This investigation revealed that those p...
|
PMID: 20950636
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We investigated the potential synergy between miR-15a/16-1 and ATO on Bcr-Abl positive leukemic K562 cells. In this study, we found that combination of miR-15a/16-1 and ATO synergistically induced growth inhibition and apoptosis in K562 cells. The apoptosis, at least in part, through regulating mito...
|
PMID: 21056550
PDF is available here.
PDF is available here.
Abstract
Inorganic arsenic is a ubiquitous environmental contaminant that has long been considered a human carcinogen. Recent studies raise further concern about the metalloid as a major, naturally occurring carcinogen in the environment. However, during this same period it has proven difficult to provide ex...
|
PMID: 20812815
PDF is available here.
PDF is available here.
Abstract
We identify phosphorylated proteins, which are related to post-translational modifications after phenylarsine oxide (PAO) inoculation to HeLa cells. PAO was chosen because of its high cytotoxicity, measured earlier in these labs. In this study, size exclusion chromatography coupled to inductively co...
|
PMID: 20803194
PDF is available here.
PDF is available here.
Environmental Pollution (158)11 2010
Abstract
Groundwater polluted with phenylarsenicals from former warfare agent deposits and their metabolites was investigated with respect to the behavior of relevant arsenic species. Depth profiles at the estimated source and at about 1km downgradient from the source zone were sampled. The source zone is ch...
|
PMID: 20667635
PDF is available here.
PDF is available here.
Optics Express (18)20 2010
Abstract
We propose and analyze three electrically-pumped nanowire single-photon source structures, which achieve output efficiencies of more than 80%. These structures are based on a quantum dot embedded in a photonic nanowire with carefully tailored ends and optimized contact electrodes. Contrary to conven...
|
PMID: 20941017
PDF is available here.
PDF is available here.
Abstract
To isolate and characterize an anaerobic bacterial strain from the deeper polluted lagoon sediment able to use as electron acceptors [As(V)] and sulfate (SO4(2-)), using lactate as an electron donor.
Methods for isolation from polluted lagoon sediments included anaerobic enrichment cultures in the p...
|
PMID: 20860773
PDF is available here.
PDF is available here.
Optics Express (18)18 2010
Abstract
We exploit a number of strategies for enhancing the tuning range of external cavity quantum-dot lasers. Different waveguide designs, laser configurations and operation conditions (pump current and temperature) are investigated for optimization of output power and tunability....
|
PMID: 20940839
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
We aimed at investigating its potential application to clinical therapeutics in oral cancer. In this preclinical animal test, primarily cultured cells from the tumor sites and normal sites of a two-drug (200 μg/ml 4-nitroquinoline 1-oxide (4NQO) plus 500 μg/ml arecoline)-induced oral cancer C57BL/...
|
PMID: 20944150
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We used bisulphate modification and nested-methylation specific PCR to determine the levels of methylated and unmethylated promoter sequences in untreated and As2O3-treated cells. We used semi-quantitative RT-PCR and immunoblotting to quantify CDKN2B and CDKN2A mRNA and protein levels, respectively....
|
PMID: 20596618
PDF is available here.
PDF is available here.
Environmental Research (110)6 2010
Abstract
Variation in individual susceptibility to arsenic-induced disease may be partially explained by genetic differences in arsenic metabolism. Mounting epidemiological evidence and in vitro studies suggest that methylated arsenic metabolites, particularly monomethylarsonic (MMA3), are more acutely toxic...
|
PMID: 20670920
PDF is available here.
PDF is available here.
Abstract
Down-regulation of HSP70 improves ATO and 17-DMAG effects on constitutive STAT3 activity. These results further provide a basis for studying the combined role of ATO with a HSP90 inhibitor such as 17-DMAG in AML with constitutive STAT3 activity....
|
PMID: 20035426
PDF is available here.
PDF is available here.
Abstract
We report on a detailed analysis of the effects of doping on the main device parameters of In(0.5)Ga(0.5)As/GaAs/Al(0.2)Ga(0.8)As quantum dots-in-a-well infrared photodetectors. Due to the relatively large conduction band offset of GaAs/Al(0.2)Ga(0.8)As (167 meV) transitions from wetting layer to qu...
|
PMID: 20648338
PDF is available here.
PDF is available here.
Abstract
Environmental Research (110)5 2010
Abstract
We report the results obtained with a mu-XANES experimental setup based on Kirkpatrick-Baez X-ray focusing optics that maintains high flux of incoming radiation (>10(11)ph/s) at micrometric spatial resolution (1.5 x 4.0 microm(2)). This original experimental setup enabled the direct speciation analy...
|
PMID: 19800058
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (178)1-3 2010
Abstract
The traditional techniques for removing low concentration arsenic are unsuitable. The biosorption characteristics of arsenite (iAs(III)) and monomethyl arsonate (MMA(V)) from aqueous solution by Acidithiobacillus ferrooxidans BY-3 (At. f BY-3) were investigated as a function of pH, contact time, ini...
|
PMID: 20122794
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (178)1-3 2010
Abstract
This paper reports arsenic methylation in betaine-nontronite clay-water suspensions under environmental conditions. Two nontronites (<0.05 mm), NAu-1 (green color, Al-enriched) and NAu-2 (brown color, Al-poor, contains tetrahedral Fe) from Uley Mine - South Australia were selected for this study. Be...
|
PMID: 20189716
PDF is available here.
PDF is available here.
Medical Oncology (27)2 2010
Abstract
We first applied transdermal drug delivery system to deliver realgar nanoparticles to investigate its anticancer effect and toxicity in vivo. In this study, MTT assay and flow cytometry analysis demonstrated that realgar significantly suppressed the proliferation and induced apoptosis of B16 melanom...
|
PMID: 19280372
PDF is available here.
PDF is available here.
Biodegradation (21)3 2010
Abstract
Microorganisms capable of degrading diphenylarsinic acid (DPAA) were enriched from contaminated soil using the soil-charcoal perfusion method. Two novel bacterial strains, L2406 and L2413, that can degrade DPAA in a mineral salt medium supplemented with DPAA as the sole carbon source were isolated....
|
PMID: 19949836
PDF is available here.
PDF is available here.
Nanotechnology (21)20 2010
Abstract
We determine that differences in crystal quality, here quantified as the stacking fault density, are not the primary cause for variations in resistivity of the material studied. The effects of some n-dopant precursors (S, Se, Si, Sn) on InAs nanowire morphology, crystal structure and resistivity wer...
|
PMID: 20413840
PDF is available here.
PDF is available here.
Optics Express (18)11 2010
Abstract
The authors report on the fabrication of hybrid planar micro-resonators based on InGaAs microdisks with an evaporated organic material. Samples of InGaAs grown on InP(100) substrates are obtained by Chemical Beam Epitaxy, and microdisks of InGaAs with different diameters are fabricated by focused io...
|
PMID: 20589023
PDF is available here.
PDF is available here.
Optics Express (18)11 2010
Abstract
We demonstrate a novel high yield fabrication process for single-mode ridge-waveguide GaAs/AlGaAs ring lasers with significantly lower threshold currents than previously reported for similar devices. In this fabrication process, the ridge waveguide structure is patterned using a metallic etch mask,...
|
PMID: 20588984
PDF is available here.
PDF is available here.
Optics Express (18)11 2010
Abstract
The modes in a circular metallic waveguide loaded with a high permittivity dielectric rod may possess similar dispersion relations to the modes in the left-handed metamaterial (LHM) waveguide. Therefore such dielectric-loaded metallic waveguide may also support slow light with parameters properly se...
|
PMID: 20588972
PDF is available here.
PDF is available here.
Optics Express (18)10 2010
Abstract
An electrically pumped InAs/GaAs quantum dot laser on a Si substrate has been demonstrated. The double-hetero laser structure was grown on a GaAs substrate by metal-organic chemical vapor deposition and layer-transferred onto a Si substrate by GaAs/Si wafer bonding mediated by a 380-nm-thick Au-Ge-N...
|
PMID: 20588912
PDF is available here.
PDF is available here.
Abstract
The synthetic potential of stereoselective, palladium-catalyzed hydro(het)arylation reactions of bi-, tri- and tetracyclic (hetero)alkenes in the presence of phospines and arsines as highly efficient ligands was studied. The mechanism of this reductive Heck reaction becomes more complex in the case...
|
PMID: 20657489
PDF is available here.
PDF is available here.
Abstract
We explored the effect of combining alkylating agents and arsenic trioxide (ATO) on the suppression of tumor cells with inherited or acquired resistance to therapeutic agents. Our results showed that combining ATO and a synthetic derivative of 3a-aza-cyclopenta[a]indenes (BO-1012), a bifunctional al...
|
PMID: 20454509
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)5 2010
Abstract
We conclude that low-level aluminum gallium arsenide laser therapy is not effective at the wavelength, dosage, and power studied for the treatment of hands among patients with rheumatoid arthritis....
|
PMID: 20082104
PDF is available here.
PDF is available here.
Chemosphere (79)8 2010
Abstract
Arsenic species in municipal landfill leachates (MLL) were investigated by HPLC-DRC-ICPMS and LC-ESI-MS/MS. Various arsenic species including arsenate (iAs(V)), arsenite (iAs(III)), monomethylarsonic acid (MMA(V)), dimethylarsinic acid (DMA(V)), as well as sulfur-containing organoarsenic species wer...
|
PMID: 20363013
PDF is available here.
PDF is available here.
Abstract
The present study was aimed to evaluate curcumin as a potential natural antioxidant to mitigate the genotoxic effects of arsenic (As) and fluoride (F) in human peripheral blood lymphocytes. The study was divided into nine groups consisting of negative control, positive control treated with ethyl met...
|
PMID: 20170701
PDF is available here.
PDF is available here.
Abstract
The speciation of arsenic(III) and arsenic(V) by using Streptococcus pyogenes immobilized on Sepabeads SP 70 resin has been investigated with solid-phase extraction method. The arsenic levels were determined hydride generation atomic absorption spectrometry (HGAAS) in sample solutions. The procedure...
|
PMID: 20226225
PDF is available here.
PDF is available here.
Abstract
We treated female F344 rats for 5 weeks with sodium arsenite at dietary doses of 0, 1, 10, 25, 50, and 100 ppm. Cytotoxicity, cell proliferation and hyperplasia of urothelial superficial cells were increased in a dose-responsive manner, with maximum effects found at 50 ppm As(III). There were no eff...
|
PMID: 20045014
PDF is available here.
PDF is available here.
Abstract
Our previous study found that arsenic trioxide (ATO)-induced activation of p21(WAF1/CIP1) (p21) led to A431 cell death through the antagonistic effects of the signaling of ERK1/2 and JNK1. In the current study, the inhibitory effects of JNK1 on ATO-induced p21 expression were explored. Over-expressi...
|
PMID: 20074581
PDF is available here.
PDF is available here.
Abstract
Arsenobetaine has always been referred to as a non-toxic but readily bioavailable compound and the available data would suggest that it is neither metabolised by nor accumulated in humans. Here this study investigates the urine of five volunteers on an arsenobetaine exclusive diet for twelve days an...
|
PMID: 20383363
PDF is available here.
PDF is available here.
Abstract
We show that arsenic binds directly to cysteine residues in zinc fingers located within the RBCC domain of PML-RARalpha and PML. Arsenic binding induces PML oligomerization, which increases its interaction with the small ubiquitin-like protein modifier (SUMO)-conjugating enzyme UBC9, resulting in en...
|
PMID: 20378816
PDF is available here.
PDF is available here.
Abstract
We describe a 9-year-old girl who had an isolated external auditory canal and middle ear relapse after treatment with all-trans retinoic acid and chemotherapy. A patient with cytogenetically and molecularly confirmed acute promyelocytic leukemia developed isolated extramedullary relapse in the audit...
|
PMID: 20186102
PDF is available here.
PDF is available here.
Abstract
The odds ratio for skin lesions was almost three times higher in the highest tertile of urinary %MA than in the lowest tertile. Men who smoked cigarettes and bidis (locally produced cigarettes; 33% of referents, 58% of cases) had a significantly higher risk for skin lesions than did nonsmoking men;...
|
PMID: 20064784
PDF is available here.
PDF is available here.
Abstract
I report on the first indication that the environmental concentration of total arsenic in topsoils - in the 7-18ppm range - is exponentially related to the prevalence and mortality of Alzheimer's disease and other dementias in European countries. This evidence defies the imputed absence of verified...
|
PMID: 20123147
PDF is available here.
PDF is available here.
Abstract
We report that application of modern technologies allowed identification of novel molecular targets modulating the anti-tumour activity of natural products derived from TCM. Moreover, we tried to cross the bridge between TCM and Western modern medicine to be able to implement them for the sake of ca...
|
PMID: 20156142
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Acute promyelocytic leukemia (APL) represents a paradigm of therapeutic success in clinical hematology. Since the introduction of all-trans-retinoic-acid in the early 1980s, complete remission rates exceed 90% and the cure rate is > 70%. Notwithstanding, various questions co...
|
PMID: 20163270
PDF is available here.
PDF is available here.
Abstract
Optics Express (18)5 2010
Abstract
The sensitivities of resonant wavelengths of photonic crystal (PhC) membrane nanocavities with embedded InAs quantum dots to the ambient refractive index are reported for use in (bio) chemical sensing. The resonances for the different modes of several point-defect type cavities are obtained by photo...
|
PMID: 20389419
PDF is available here.
PDF is available here.
Abstract
We observed that (i) bundles of flagella on swarmer cells remain cohesive during frequent collisions with neighboring cells, (ii) flagella on nonmotile swarmer cells at the leading edge of the colony protrude in the direction of the uncolonized agar surface and are actively rotated in a thin layer o...
|
PMID: 20023074
PDF is available here.
PDF is available here.
Optics Express (18)2 2010
Abstract
InGaAs PIN photodetectors heterogeneously integrated on silicon-on-insulator waveguides are fabricated and characterized. Efficient evanescent coupling between silicon-on-insulator waveguides and InGaAs photodetectors is achieved. The fabricated photodetectors can work well without external bias and...
|
PMID: 20174003
PDF is available here.
PDF is available here.
Acta Haematologica (123)3 2010
Abstract
Abstract
We applied a systems biology approach to identify gene biomarkers that underlie tumor cell responses to arsenic-induced cytotoxicity. The baseline gene expression levels of 14,500 well characterized human genes were associated with the GI50 data of the NCI-60 tumor cell line panel from the developme...
|
PMID: 20707922
PDF is available here.
PDF is available here.
Abstract
Arsenic trioxide inhibited the growth of human gastric cancer SGC7901 cells and induced apoptosis. There were two Bcl-2 phenotypes coexisting in SGC7901 cells and the Bcl-2 cytoprotective phenotype could change into a cytodestructive phenotype following conformational change of Bcl-2, triggered by a...
|
PMID: 20403207
PDF is available here.
PDF is available here.
Abstract
A 67-year-old Japanese woman who presented with erythema on the abdomen and pancytopenia was found to have acute promyelocytic leukemia (APL). A skin biopsy revealed invasion of APL cells. She was started on induction treatment with all-trans retinoic acid (ATRA) at 45 mg/m(2). On da...
|
PMID: 20035486
PDF is available here.
PDF is available here.
Abstract
Results show that all doses of arsenic trioxide used in this study induced apoptosis in NB4 cells. The frequency of induced apoptosis was dose dependent and significantly higher than the controls (P<0.05 - 0.01). In contrast, vitamin D3 at concentrations of 100 - 600 nM produced no significant effec...
|
PMID: 20039766
PDF is available here.
PDF is available here.
Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering (45)1 2010
Abstract
We proposed a methodology to evaluate and integrate risk from a single source affecting different biologic receptors. Here, we propose an alternative approach estimating arsenic exposure in children and kangaroo rats using probabilistic simulation with Monte Carlo modeling. The estimates are then as...
|
PMID: 20390846
PDF is available here.
PDF is available here.
Abstract
Biochemical Journal (427)3 2010
Abstract
We verified whether one or both VDAC1 cysteine residues are involved in VDAC1-mediated transport or apoptosis activities. To assess the function of VDAC1 cysteine residues in channel activity and to probe cysteine topology with respect to facing the pore or the bilayer, we used thiol-modifying agent...
|
PMID: 20192921
PDF is available here.
PDF is available here.
Abstract
In the present paper, a procedure for the determination of total arsenic and arsenic (III) in phosphate fertilizers and phosphate rocks by slurry sampling (SS) with hydride generation atomic absorption spectrometry (HG-AAS) is proposed. Arsenic (III) is determinated directly and total arsenic is det...
|
PMID: 19836581
PDF is available here.
PDF is available here.
Abstract
Abstract
We compared the initial analyses from 1989 with those performed 15 years later and found that the average differences for the proportion of urinary iAs, monomethylarsonic acid (MMA(V)), and dimethylarsinic acid (DMA(V)) were -4.90%, -6.80%, and 11.69%, respectively. The elderly and those residents w...
|
PMID: 20049204
PDF is available here.
PDF is available here.
Optics Express (17)24 2009
Abstract
We develop an interferometer which has high spectral sensitivity based on the dispersive property of the semiconductor GaAs in the near-infrared region. Our experiment demonstrates that the spectral sensitivity could be greatly enhanced by adding a slow light medium into the interferometer and is pr...
|
PMID: 19997473
PDF is available here.
PDF is available here.
Abstract
In this group of Bangladeshi adults, cobalamin appeared to facilitate the first As methylation step among folate-sufficient individuals. Given the toxicity of MMA(III), our findings suggest that in contrast to folate, cobalamin may not favorably influence As metabolism....
|
PMID: 20049124
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (331)1-2 2009
Abstract
We used the human leukemia (HL-60) cell line as a test model to study the cellular and molecular mechanisms of anti-cancer properties of As(2)O(3). We hypothesized that As(2)O(3)-induced expression of stress genes and related proteins may play a role in the cellular and molecular events leading to c...
|
PMID: 19444595
PDF is available here.
PDF is available here.
Optics Express (17)22 2009
Abstract
The authors report on the achievement of lasing in rolled-up semiconductor microtubes at room temperature, wherein self-organized InGaAs/GaAs quantum dots are incorporated as the gain medium. The free-standing quantum dot microtubes, with a diameter of approximately 5-6 microm and wall thickness of...
|
PMID: 19997217
PDF is available here.
PDF is available here.
Optics Express (17)22 2009
Abstract
By extending the net-gain modulation phasor approach to account for the discrete distribution of the gain and saturable absorber sections in the cavity, a convenient model is derived and experimentally verified for the cavity design of two-section passively mode-locked quantum dash (QDash) lasers. T...
|
PMID: 19997194
PDF is available here.
PDF is available here.