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Isotopes (23):
- Sodium Isotopes
- Cerium Isotopes
- Phosphorus Isotopes
- Nitrogen Isotopes
- Zinc Isotopes
- Mercury Isotopes
- Yttrium Isotopes
- Strontium Isotopes
- Cobalt Isotopes
- Iron Isotopes
- Gold Isotopes
- Radioisotopes
- Oxygen Isotopes
- Cesium Isotopes
- Carbon Isotopes
- Deuterium
- Xenon Isotopes
- Iodine Isotopes
- Gallium Isotopes
- Calcium Isotopes
- Sulfur Isotopes
- Potassium Isotopes
- Chromium Isotopes
Recent article
Isotopes
Abstract
We quantitatively monitored the fibrogenesis process in CHB patients. We discovered many new valuable candidate biomarkers for the diagnosis of liver fibrosis and also partly identified the mechanism involved in liver fibrosis disease. These results provide a clearer understanding of liver fibrosis...
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PMID: 21574042
PDF is available here.
PDF is available here.
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Abstract
Two stable isotope dilution assays were developed for the quantitation of acrolein in fats and oils using [(13)C(3)]-acrolein as the internal standard. First, a direct GC-MS headspace method, followed by an indirect GC-MS method using derivatization with pentafluorophenyl hydrazine, was established....
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PMID: 21401209
PDF is available here.
PDF is available here.
Abstract
We have for the first time detected the structural coupling of CP43-Arg357 with the Mn(4)Ca cluster by means of isotope-edited Fourier transform infrared (FTIR) spectroscopy. Light-induced FTIR difference spectra upon the S(1)→S(2) transition (S(2)/S(1) difference spectra) of the Mn(4)Ca cluster w...
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PMID: 21348470
PDF is available here.
PDF is available here.
Abstract
We have measured the mass-specific vibronic spectra of the centrosymmetric H-bonded dimers (2-pyridone)2 and (2-aminopyridine)2 that are supersonically cooled to a few K and isolated in molecular beams, using two-color resonant two-photon ionization spectroscopy. Comparison of the all-12C- and 13C-...
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PMID: 21678767
PDF is available here.
PDF is available here.
Abstract
We collected drip water samples from three adjacent caves in northwestern Germany during several campaigns. The noble gas data were evaluated by inverse modelling to obtain recharge temperature and excess air, supporting the calculation of the tritiogenic (3)He and hence the (3)H-(3)He age. Although...
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PMID: 20812118
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
We applied the chlorofluorocarbons CFC-113, CFC-12, sulphur hexafluoride (SF(6)) and tritium to identify potential recharge, and found indications for some advective transport of the CFCs and SF(6), which we accounted for as constituting potential active localised recharge. In our contribution, we s...
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PMID: 20812119
PDF is available here.
PDF is available here.
Abstract
We employed environmental tracers ((3)H-(3)He, SF(6)) in a study investigating the groundwater recharge in the North China Plain (NCP), a sedimentary aquifer system consisting of fluvial and alluvial river deposits near the city of Shijiazhuang. The (3)H-(3)He dating method revealed reasonable resul...
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PMID: 20603738
PDF is available here.
PDF is available here.
Abstract
This study presents selected results, applying environmental tracers to investigate lake water-groundwater interactions at two study sites located in Lusatia, Germany. The focus of the investigations were two meromictic pit lakes and their adjacent aquifers. In order to follow hydrodynamic processes...
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PMID: 20645204
PDF is available here.
PDF is available here.
Abstract
We also discuss areas where additional research is required to improve ease of use and extend quantitative interpretations of tracer results....
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PMID: 20845177
PDF is available here.
PDF is available here.
Abstract
We present QTIPS, Quantification by Total Identified Peptides for SILAC, a straightforward, accurate method to determine the level of heavy amino acid incorporation throughout a population of peptides detected by mass spectrometry. Using QTIPS, we show that the incorporation of heavy amino acids in...
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PMID: 20451407
PDF is available here.
PDF is available here.
Abstract
We have tested near-infrared laser optical spectrometry and compared it with conventional continuous-flow isotope ratio mass spectrometry (CF-IRMS) using several methane carbon isotope standards and a large number of biogas samples from batch anaerobic reactors. Results from measurements on these sa...
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PMID: 20540538
PDF is available here.
PDF is available here.
Abstract
Perchlorate (ClO(4)(-)) has been detected widely in groundwater and soils of the southwestern United States. Much of this ClO(4)(-) appears to be natural, and it may have accumulated largely through wet and dry atmospheric deposition. This study evaluates the isotopic composition of natural ClO(4)(-...
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PMID: 20521813
PDF is available here.
PDF is available here.
Abstract
Numerous halogenated organic compounds have been identified as pollutants of concern. Those with high persistence and hydrophobicity may concentrate in biota, sediments, and wastewater sludge. Nonetheless, the release to the environment of many remains largely unrecognized. Stabilized sewage sludge...
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PMID: 20486701
PDF is available here.
PDF is available here.
Abstract
We find that the blood lead level of children strongly correlates with the lead concentration in atmospheric particles, and the latter correlates with the coal consumption instead of leaded gasoline. Combined with the (207)Pb/(206)Pb ratio measurements, we find that the coal consumption fly ash is a...
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PMID: 20536267
PDF is available here.
PDF is available here.
Analytical Biochemistry (401)2 2010
Abstract
Interassay variation of antibody-based routine tests hampers comparability of measurement results for growth hormone (GH) between different laboratories and decision making in clinical practice. Here it is demonstrated that quantification of GH by isotope dilution mass spectrometry (IDMS) constitute...
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PMID: 20226156
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)12 2010
Abstract
The objective was to quantify the vitamin A equivalency of beta-carotene in two diets using a dual-isotope dilution technique and the apparent beta-carotene absorption as measured by the oral-faecal balance technique. Seventeen healthy adults with an ileostomy completed the 4-week diet-controlled, c...
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PMID: 20132586
PDF is available here.
PDF is available here.
Phytochemistry (71)8-9 2010
Abstract
We developed a sensitive assay suitable for plant extracts that is based on the decarboxylation of labeled pyruvate (1-(13)C)-PYR and detection of (13)CO(2) by isotope ratio mass spectrometry. We tested our method investigating the DXS activity in poplar leaves. Apparent DXS activity showed Michaeli...
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PMID: 20303132
PDF is available here.
PDF is available here.
Abstract
We report experimental and computational results on equilibrium Hg isotope fractionation between dissolved Hg(II) species and thiol-bound Hg. Hg(II) chloride and nitrate solutions were equilibrated in parallel batches with varying amounts of thiol resin resulting in different fractions of thiol-boun...
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PMID: 20443581
PDF is available here.
PDF is available here.
Abstract
The mechanism of decarboxylations in water and the catalysis of mandelylthiamin (MTh) decarboxylation by pyridinium ions is explored. It has been recently proposed that a decarboxylation step forming an intermediate molecule/CO(2) pair is reversible and that pyridinium ions catalyze the MTh decarboxy...
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PMID: 20433168
PDF is available here.
PDF is available here.
Abstract
We reported that 4-hydroxyacids are catabolized through two parallel pathways. In this report we detail two isotopic tools that have allowed the dissection of this catabolic process and illustrate how these tools can be used to quantify the relative flux down each pathway. We found that 4-hydroxynon...
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PMID: 20408520
PDF is available here.
PDF is available here.
Abstract
We describe how the path integral formalism can be used to describe rigorously the nuclear quantum effects on equilibrium and kinetic properties of molecules. Specifically, we explain how path integrals can be employed to evaluate the equilibrium (EIE) and kinetic (KIE) isotope effects, and the temp...
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PMID: 20432050
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (114)16 2010
Abstract
The performance of four basis sets (6-311+G(2d,p), IGLO-III, cc-PVTZ, and 6-31G) is evaluated in order to find a quantum mechanical technique that can be used to accurately estimate (29)Si-(1)H spin-spin coupling constants in organoalkoxysilanes. The 6-31G basis set with the B3LYP functional is foun...
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PMID: 20361771
PDF is available here.
PDF is available here.
Abstract
We examined this for the retreat-building sedentary larvae of the caddis Tinodes waeneri, which are often dominant in the littoral of lakes. We hypothesised that T. waeneri gardens by fertilising its retreat (a fixed 'gallery' on which algae and other microorganisms grow), and that gardening would b...
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PMID: 20072787
PDF is available here.
PDF is available here.
Abstract
The non-heme iron enzyme phenylalanine hydroxylase from Chromobacterium violaceum has previously been shown to catalyze the hydroxylation of benzylic and aliphatic carbons in addition to the normal aromatic hydroxylation reaction. The intrinsic isotope effect for hydroxylation of 3-cyclochexylalanine...
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PMID: 20355730
PDF is available here.
PDF is available here.
Abstract
A rapid method for quantification of 25-hydroxy vitamin D3 in different swine tissues based on isotope dilution HPLC-MS has been developed and validated. Six times deuterated analyte is used as internal standard. The method is fast and can be performed with only 1g sample. Sample preparation for kid...
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PMID: 20299291
PDF is available here.
PDF is available here.
Journal of Proteomics (73)6 2010
Abstract
We have investigated the stability of human plasma samples by spiking stable isotope-labeled peptides into the plasma and monitoring their degradation under different storage conditions. FPA-1, C4A and C3f were synthesized with isotopically labeled amino acids, and used as reference peptides. The mi...
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PMID: 20176153
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated the feasibility of performing baboon brain imaging on a dedicated small animal PET scanner provided that the data are accurately corrected for degrading physical effects such as photon attenuation in the body. In this study, we investigated factors affecting the accuracy a...
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PMID: 20360636
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (Chapter 30) 2010
Abstract
Along with genes and proteins, metabolites play important roles in sustaining life. Their functions include "primary" functions in metabolism and energy storage, as well as "secondary" functions in cell-to-cell signaling, metal acquisition, and virulence. There remains much to be learned about the i...
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PMID: 20373502
PDF is available here.
PDF is available here.
Abstract
In choroidal melanomas the chance of local tumour control and preservation of the globe decreases with increase of the tumour prominence. In small choroidal melanomas with posterior location local tumour control was achieved significantly faster after TTT than after RB.
Copyright Georg Thieme Verlag...
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PMID: 20408070
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)7 2010
Abstract
We measured the bioavailability of Fe and Zn from Thriposha formula at two different molar ratios of Zn:Fe in order to determine the effect on Fe and Zn absorption. Children 4-7 years (n 53) were given a meal prepared with 50 g Thriposha containing 1.5 mg Zn as zinc sulphate and either 9 mg (high Fe...
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PMID: 19889243
PDF is available here.
PDF is available here.
Abstract
Ventilation defects were found in all patients (mean VDI, 5.1 +/- 1.9; mean global VF, 78.5% +/- 12.3; and mean peripheral VF, 75.5% +/- 17.1) despite normal spirometric results. After CPT, disparate changes in the distribution of ventilation defects were observed but the average VDI and VF did not...
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PMID: 20308459
PDF is available here.
PDF is available here.
Abstract
To investigate the influence of different types of fertilizers on quality parameters, N-containing compounds, and the delta(15)N, delta(13)C, delta(2)H, delta (34)S, and delta(18)O values of citrus fruit, a study was performed on the orange fruit cv. 'Valencia late' (Citrus sinensis L. Osbeck), whic...
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PMID: 20184327
PDF is available here.
PDF is available here.
Abstract
The role of vitamin A and its metabolites in the life processes starting with the historical background and its up to date information is discussed in the introduction. Also the role of 11Z-retinal in vision and retinoic acid in the biological processes is elucidated. The essential role of isotopica...
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PMID: 20336016
PDF is available here.
PDF is available here.
Abstract
Our experimental and theoretical results, especially the Cr isotope shifts, clearly demonstrate that the potential energy of the Cr-Cr stretching coordinate is distributed among several normal modes having both Cr-Cr and Cr-ligand character. The general significance of these results in interpreting...
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PMID: 20092271
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (127)3 2010
Abstract
We observed significant growth inhibitory activity of the CP extract on tumor cell lines. In PBMC, the production of IL-2 and IL-4 was reduced following the addition of CP extract, whereas that of IL-12p40, IL-12p70, IFN-gamma and TNF-alpha was enhanced without growth inhibition. In addition, cytoto...
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PMID: 19961915
PDF is available here.
PDF is available here.
Abstract
Comparability of obtained results confirmed the applicability of recently recommended "common" reference intervals to the Croatian population for all laboratories measuring serum creatinine concentrations using enzymatic methods traceable to the IDMS method and NIST SRM 967....
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PMID: 19943808
PDF is available here.
PDF is available here.
Abstract
We previously observed that CLA (a mixture of isomers) and t10c12 decreased the growth of TSU-Pr1 cells, whereas linoleic acid and c9t11 exerted no effects. In the current study, the mechanisms underlying the t10c12-mediated regulation of the growth of these bladder cancer cells were evaluated. TSU-...
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PMID: 20136431
PDF is available here.
PDF is available here.
Abstract
The present report discusses targeted and non-targeted approaches to monitor single nutrients and global metabolite profiles in nutritional research. Non-targeted approaches such as metabolomics allow for the global description of metabolites in a biological sample and combine an analytical platform...
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PMID: 19954566
PDF is available here.
PDF is available here.
Abstract
Diabetic neuropathy (DN) is a debilitating disorder occurring in most diabetic patients without a viable treatment yet. The present work examined the protective effect of (25)Mg-PMC(16) nanoparticle (porphyrin adducts of cyclohexil fullerene-C60) in a rat model of streptozotocin (STZ)-induced DN. (2...
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PMID: 20957114
PDF is available here.
PDF is available here.
Medical Physics (37)1 2010
Abstract
Hyperpolarized 3He MRI was well tolerated in all subjects with moderate to severe RILI. Functional improvements and microstructural changes were observed in the contralateral lung, while the ipsilateral lung remained stable, suggesting that functional compensatory changes may have occurred in the co...
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PMID: 20175462
PDF is available here.
PDF is available here.
Phytochemistry (71)1 2010
Abstract
The metabolic fate of [carbonyl-14C]nicotinamide was surveyed in leaf disks of seven mangrove species, Bruguiera gymnorrhiza, Rhizophora stylosa, Kandeliaobovata, Sonneratia alba, Pemphis acidula, Lumnitzera racemosa and Avicennia marina, with and without 250 mM NaCl. Uptake of [14C]nicotinamide by...
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PMID: 19913262
PDF is available here.
PDF is available here.
Abstract
We also investigated the mechanism of the antiproliferative effects of BST406 in PDGF-BB-stimulated VSMCs. In Western blot analysis, PDGF-BB-stimulated (25 ng/ml) phospholipase-C (PLC)gamma1 and Akt phosphorylation was inhibited by BST406 (0-10microM). However, BST406 did not inhibit the PDGF-recept...
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PMID: 20460774
PDF is available here.
PDF is available here.
Abstract
We recently showed that SAA deficiency significantly suppresses intestinal mucosal growth and reduces intestinal epithelial cell proliferation, and increases intestinal oxidant stress in piglets. These recent findings indicate that intestinal metabolism of dietary methionine and cysteine is nutritio...
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PMID: 19835653
PDF is available here.
PDF is available here.
Analytical Biochemistry (398)2 2009
Abstract
New stable isotope dilution assays were developed for the simultaneous quantitation of the folates 5-methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid, tetrahydrofolic acid, 10-formylfolic acid and folic acid as well as for their catabolites para-aminobenzoylglutamate (pABG) a...
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PMID: 19903444
PDF is available here.
PDF is available here.
Abstract
In 4.5 seconds of free collapse, volume decreased by 6% +/- 2 (standard error) and 53% +/- 3, respectively, in trapped-gas lobes and in unobstructed regions (P < .0001). Specific gas volume changed by 6% +/- 2 in areas of trapped gas and decreased by 56% +/- 3 in unobstructed regions, from 3.4 mL/g...
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PMID: 19703847
PDF is available here.
PDF is available here.
Radiation Research (172)4 2009
Abstract
In boron neutron capture therapy, the absorbed dose from the (10)B(n,alpha)(7)Li reaction depends on the (10)B concentration and (10)B distribution in the irradiated volume. Thus compounds used in BNCT should have tumor-specific uptake and low accumulation in normal tissues. This study compares in a...
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PMID: 19772470
PDF is available here.
PDF is available here.
Health Physics (97)4 2009
Abstract
The aim of this paper is to evaluate the risks and doses for the internal contamination of the radiochemistry staff in a high workload medical cyclotron facility. The doses from internal contamination derive from the inhalation of radioactive gas leakage from the cells by personnel involved in the s...
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PMID: 19741360
PDF is available here.
PDF is available here.
Abstract
There is increasing interest in combined carbon-chlorine compound-specific isotope analysis (CSIA)to differentiate between contaminant sources and to assess transformation processes. However, the significant abundance of polychlorinated molecules with several heavy chlorine isotopes complicates the...
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PMID: 19764245
PDF is available here.
PDF is available here.
Abstract
Abstract
Der Radiologe (49)8 2009
Abstract
Pulmonary diseases have a high health-related and economic significance. (3)He-MRI is an alternative imaging method which can detect ventilatory disturbances with a high sensitivity. The application of different pulse sequences allows static and dynamic assessment of ventilation and bronchial gas fl...
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PMID: 19636524
PDF is available here.
PDF is available here.
Abstract
We investigated the capacity of the indigenous microbial community of a eutrophic river sediment to biodegrade chlorinated aliphatic hydrocarbons (CAHs) originating from discharging, polluted groundwater using a compound-specific isotope approach. We specifically targeted the site's major pollutants...
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PMID: 19708351
PDF is available here.
PDF is available here.
Abstract
We compared these effects for chromosome and plasmid encoding strategies for bait proteins in two microbes: Escherichia coli and Rhodopseudomonas palustris. Differential metabolic labeling of strains expressing bait protein relative to the wild-type strain in each species allowed comparison by liqui...
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PMID: 19459691
PDF is available here.
PDF is available here.
Abstract
We characterized dietborne copper, nickel, and cadmium influxes in a freshwater gastropod exposed to diatoms labeled with enriched stable metal isotopes. Metal influxes in Lymnaea stagnalis correlated linearly with dietborne metal concentrations over a range encompassing most environmental exposures...
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PMID: 19673285
PDF is available here.
PDF is available here.
Modern Healthcare (39)22 2009
Abstract
Journal of Perinatology (29 Suppl 2) 2009
Abstract
We describe a series of studies conducted by applying two recently developed methods to measure surfactant kinetics. In the first set of studies, namely 'endogenous studies', which used stable isotope-labeled intravenous surfactant precursors, we have shown the feasibility of measuring surfactant sy...
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PMID: 19399007
PDF is available here.
PDF is available here.
Abstract
We describe our development of a platform for MS data evaluation in glycomics that demands only a low human intervention. The proposed platform named SysBioWare is constructed to allow import of the raw MS data to the spectrum browser and to perform isotopic grouping of detected peaks after de-noisi...
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PMID: 19341273
PDF is available here.
PDF is available here.