Abstract
The aims of the study were to develop and test multi-phase glaze coatings for zirconia restorations, so that the surface could be etched and adhesively bonded.
Zirconia disc specimens (n=125, 16 mm x 1 mm) were cut from cylinders of Y-TZP (yttria-stabilized tetragonal zirconia polycrystals) ZS-Blank...
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PMID: 20600558
PDF is available here.
Abstract
This is a short overview focusing on the biochemical interactions underlying the protective effects of lithium at the neuronal level. These include lithium modulation of autophagy, growth factors, excitotoxicity, and a variety of mechanisms underlying cell death, neurogenesis, and neuronal different...
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PMID: 20700048
PDF is available here.
Abstract
We discuss the evidence in light of the complexity inherent in the connection between cognitive deficits and neurological abnormalities in BD. This article also addresses issues related to etiology, advancing an integration of neurological, clinical, cognitive, and psychosocial factors into a model...
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PMID: 20675966
PDF is available here.
Abstract
Depressive phases are the most prevalent component of bipolar disorders, even with modern treatment. Bipolar depressive morbidity is often misdiagnosed and is limited in response to available treatments. These conditions are especially debilitating and are associated with psychiatric comorbidity, su...
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PMID: 20415631
PDF is available here.
Abstract
A total of 79 lithium patients and 85 nonlithium patients were included. The prevalence of hypothyroidism (subclinical and clinical) was 35.4% among the lithium patients, with women having a prevalence as high as 41.3% and men 12.6%. In the nonlithium patients, the prevalence was 7.1%; very close to...
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PMID: 20429083
PDF is available here.
Abstract
A study by molecular dynamics (MD) simulation of the acetonitrile diffusion into a polypyrrole film was carried out with atomic detail in a 0.1N lithium perchlorate solution. From the simulated trajectories, the acetonitrile behavior was estimated from bulk solution to the interior of the polypyrrol...
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PMID: 20406005
PDF is available here.
Abstract
A novel, totally regioselective transformation of aromatic N-4-methoxyphenylaziridine 2-carboxamides into 2-aminoamides promoted by active manganese (Mn*) is reported. alpha-Amino ketones can be readily obtained by reaction of morpholine-derived 2-aminoamides with organolithium compounds.
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PMID: 20196575
PDF is available here.
Abstract
We report that both drugs significantly reduced (1) spatial memory impairment induced by amyloid burden; (2) Abeta aggregates and Abeta oligomers; and (3) astrocytic and microglia activation. They also prevented changes in presynaptic and postsynaptic marker proteins. Finally, both drugs activate Wn...
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PMID: 19621015
PDF is available here.
Abstract
We examined the effects of atovaquone on cellular respiration and in vitro growth of C. albicans to explore a new therapeutic possibility for fungal infections. Atovaquone strongly inhibited glucose-dependent cellular respiration similarly to antimycin A, stigmatellin, and myxothiazol, specific bc(1...
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PMID: 20118649
PDF is available here.
Abstract
We evaluated prospectively and systematically acquired data from consenting adults with major affective disorders treated with lithium for an average of 5.4 years to compare, within-subjects, estimated long-term morbidity versus the first-wellness interval after clinical remission of a treated index...
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PMID: 20075652
PDF is available here.
Abstract
Ziprasidone is an effective, safe, and well-tolerated adjunctive treatment with a mood stabilizer for long-term maintenance treatment of bipolar mania. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00280566.
Copyright 2010 Physicians Postgraduate Press, Inc....
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PMID: 20122373
PDF is available here.
Glenn E Smith,
Keith G Rasmussen,
C Munro Cullum,
M Donna Felmlee-Devine,
Georgios Petrides,
Teresa A Rummans,
Mustafa M Husain,
Martina Mueller,
Hilary J Bernstein,
Rebecca G Knapp,
M Kevin O'Connor,
Max Fink,
Shirlene Sampson,
Samuel H Bailine,
Charles H Kellner and
CORE Investigators
Abstract
The finding of no memory outcome differences between unrelapsed recipients of C-ECT and C-PHARM is consistent with clinical experience. Memory effects have only a small role in the choice between C-ECT and C-PHARM.
Copyright 2010 Physicians Postgraduate Press, Inc....
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PMID: 20193646
PDF is available here.
Abstract
Quetiapine (300 or 600 mg/d) was more effective than placebo for the treatment of episodes of acute depression in bipolar disorder. Lithium did not significantly differ from placebo on the main measures of efficacy. Both treatments were generally well tolerated. TRIAL REGISTRATION: clinicaltrials.go...
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PMID: 20122369
PDF is available here.
Abstract
We describe a most unusual case of a patient with a history of bipolar disorder who developed ataxic gait, imbalance, and intention tremor after lithium-and-carbamazepine combination treatment with therapeutic serum levels of both drugs; he recovered completely when carbamazepine was discontinued. W...
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PMID: 20375657
PDF is available here.
Abstract
Lithium overdoses causing cardiotoxicity are uncommon and electrocardiographic changes suggesting myocardial ischemia are rare. However, some authors have specifically reported the occurrence of ischemic electrocardiography changes due to a lithium overdose. This paper describes a case where electro...
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PMID: 20690099
PDF is available here.
Abstract
We will describe a turn-on fluorescent sensor for the pharmacologically important lithium ion. The sensor can be used in purely aqueous solution, and it displays a very high selectivity for lithium over sodium and magnesium ions. It is based on a metallacrown receptor unit, which can be assembled in...
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PMID: 21140908
PDF is available here.
Abstract
A 57-year-old woman with a bipolar disorder presented with decreasing renal function caused by lithium-induced nephropathy.
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PMID: 20456791
PDF is available here.
Abstract
We present a case report of an atypical presentation of compartment syndrome of the leg in which a patient taking lithium for bipolar disorder did not report pain out of proportion to the injury mechanism. Lithium has been implicated in altering pain perception and increasing the tolerance and thres...
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PMID: 20305839
PDF is available here.
Abstract
The aim of this research was to evaluate the fatigue behavior and reliability of monolithic computer-aided design/computer-assisted manufacture (CAD/CAM) lithium disilicate and hand-layer-veneered zirconia all-ceramic crowns.
A CAD-based mandibular molar crown preparation, fabricated using rapid pro...
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PMID: 20859559
PDF is available here.
Abstract
The aim of this study was to investigate the effect of different resin cement film thicknesses on the shear bond strength of resin core materials to lithium disilicate ceramics. Forty IPS Empress 2 ceramic disks were bonded to the core materials (Bis-core and Smile) with resin cement film thicknesse...
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PMID: 20859565
PDF is available here.
Abstract
The present study was designed to examine the protective potential of lithium if any in ameliorating the alterations induced by aluminium (Al) on behavioral and neurochemical indices. Al was given orally (100mg/kg b.wt./day) whereas lithium was administered through diet (1.1g/kg diet) to rats for a...
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PMID: 19895864
PDF is available here.
Abstract
As dentistry continues to evolve, new technologies and materials are continually being offered to the dental profession. Throughout the years restorative trends and techniques have come and gone. Some material developments have transformed the face of esthetic dentistry, while other initial concepts...
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PMID: 21197940
PDF is available here.
Abstract
We stopped her lithium and tried alternatives but this was not successful and resulted in poor quality of life for the patient including long hospital admissions. We respected patient's wish and capacity to make decision and retried lithium. This case report gives key points in managing such cases....
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PMID: 20430244
PDF is available here.
Abstract
Zirconia oral implants are a new topic in implant dentistry. So far, no data are available on the biomechanical behavior of two-piece zirconia implants. Therefore, the purpose of this pilot investigation was to test in vitro the fracture strength of two-piece cylindrical zirconia imp...
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PMID: 18783418
PDF is available here.
Abstract
A 38-year-old man was brought by emergency medical service after resuscitation following cardiac arrest. The patient was found pulseless with a wide complex tachycardia. The patient had bipolar disorder and was on lithium, lamotrigine, and ziprasidone. His electrolytes and lithium levels were normal...
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PMID: 20016437
PDF is available here.
Abstract
I evidence, but its clinical use has to be tempered against potential side-effects and the need for ongoing monitoring. In practice, lithium should be considered a first-line option in bipolar disorder, especially in prophylaxis and when onset of action is not an imperative. Lithium has been in use...
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PMID: 20001408
PDF is available here.
Georgios Petrides,
Raphael J Braga,
Max Fink,
Martina Mueller,
Rebecca Knapp,
Mustafa Husain,
Teresa Rummans,
Samuel Bailine,
Chitra Malur,
Kevin O'Connor,
Charles Kellner and
CORE (Consortium for Research in ECT) Group
Abstract
We sought to examine the relationship of seizure threshold (ST) to age and other demographic characteristics in a large sample where ST was determined by the dose titration (DT) method. We also compared the resulting stimulation levels to estimates predicted by an age-based formula, the half-age (HA...
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PMID: 19972637
PDF is available here.
Abstract
We describe a set of simple behaviours in mice that are robustly affected by chronic lithium treatment and are similarly affected by structurally diverse GSK3 inhibitors and by removing one copy of the Gsk3b gene. These observations, from several independent laboratories, support a central role for...
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PMID: 19754466
PDF is available here.
Abstract
The aim of this prospective randomized controlled clinical trial was to evaluate the 2-year clinical performance of a self-adhesive resin cement, RelyX Unicem (3M ESPE), used for cementation of ceramic inlays. In addition, the influence of selectively acid etching enamel prior to luting on marginal i...
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PMID: 20157666
PDF is available here.
Abstract
We discuss evidence that Li(+) has a substantial effect on PtdIns(3,4,5)P(3), an important signal molecule within the nervous system. As seen for Ins(1,4,5)P(3) signalling, suppression of PtdIns(3,4,5)P(3) signalling also occurs via an inositol-depletion mechanism. This has implications for the cell...
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PMID: 19754462
PDF is available here.
Abstract
Prs [PRPP (phosphoribosyl pyrophosphate) synthetase] catalyses the transfer of pyrophosphate from ATP to ribose 5-phosphate, thereby activating the pentose sugar for incorporation into purine and pyrimidine nucleotides. The Saccharomyces cerevisiae genome contains five genes, PRS1-PRS5, whose produc...
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PMID: 19754463
PDF is available here.
Abstract
We studied Impa1 (encoding IMPase) and Smit1 (sodium-myo-inositol transporter 1)-knockout mice. In brains of adult homozygous Impa1-knockout mice, IMPase activity was found to be decreased; however, inositol levels were not found to be altered. Behavioural analysis indicated decreased immobility in...
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PMID: 19754464
PDF is available here.
Abstract
The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inosi...
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PMID: 19754460
PDF is available here.
Abstract
I review studies in unanaesthetized rats using a neuropharmacological approach, combined with kinetic, biochemical and molecular biology techniques, demonstrating that chronic administration of three commonly used mood stabilizers (lithium, valproic acid and carbamazepine), at therapeutically releva...
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PMID: 19754461
PDF is available here.
Abstract
Phosphoinositide signalling regulates a series of important neuronal processes that are thought to be altered in mood disorders. Furthermore, mood-stabilizing drugs inhibit key enzymes that regulate phosphoinositide production and alter neuronal growth cone morphology in an inositol-reversible manne...
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PMID: 19754467
PDF is available here.
Abstract
We have recently conducted a microarray study of rat frontal cortex following chronic treatment (21 days) with lithium. Chronic treatment with lithium led to a significant (at least 1.5-fold) down-regulation of 151 genes and up-regulation of 57 genes. We discuss our results in the context of previou...
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PMID: 19754458
PDF is available here.
Abstract
I disorder. Placebo-controlled studies have been conducted with lithium, anticonvulsants, and atypical antipsychotics, but more research is needed, especially in areas other than acute manic and mixed episodes. Additional studies are needed to determine the safest and most effective agents for treat...
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PMID: 19818240
PDF is available here.
Abstract
Treatment with mood stabilizers may be associated with specific neuropsychological impairments. Cognitive side effects may need to be considered in selecting particular psychopharmacologic treatments for children with bipolar disorder.
2009 Physicians Postgraduate Press, Inc....
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PMID: 19573494
PDF is available here.
Abstract
We discuss the controversies about the relationship between drugs and psoriasis and report our own experience at the Section of Dermatology, University of Genoa....
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PMID: 19661544
PDF is available here.
Abstract
We used chemicals that can cleave phosphodiester bonds of RNA and assessed their effects on the infectious agent. Lithium aluminum hydride, a reducing agent that can induce reductive cleavage of oxidized molecules such as carbonyls, carboxyl acids, esters, and phosphodiester bonds, did not affect ce...
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PMID: 19606066
PDF is available here.
Abstract
Bipolar disorder is an illness with complex symptomatology that encompasses severe symptoms of mood and thought disorder and can limit the cognitive range of human brain functioning. The Diagnostic and Statistical Manual, 4th edition and International Classification of Mental Disorder recommend subg...
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PMID: 19606936
PDF is available here.
Giovanni Schifitto,
Jianhui Zhong,
David Gill,
Derick R Peterson,
Michelle D Gaugh,
Tong Zhu,
Madalina Tivarus,
Kim Cruttenden,
Sanjay B Maggirwar,
Howard E Gendelman,
Stephen Dewhurst and
Harris A Gelbard
Abstract
These results suggest that lithium can be used safely in HIV-infected individuals with cognitive impairment. Furthermore, the neuroimaging results suggest that lithium may improve HIV-associated central nervous system (CNS) injury; thus, further investigations of lithium as an adjunctive treatment f...
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PMID: 19306230
PDF is available here.
Abstract
Borderline Personality Disorder (BPD) constitutes a profound instability with dysfunction in three psychopathological dimensions as cognitive-perceptual symptoms, affective dysregulation and behavioral impulsivity. Psychopharmacotherapy has a crucial role in the treatment of this complex disorder an...
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PMID: 19455483
PDF is available here.
Abstract
Every patient enrolled into this study had at least 1 medical illness (most commonly respiratory, 72%) and on average had 4.9 different medical conditions. Over half of patients (52%) exhibited illnesses across four or more different organ systems, 24% had uncontrollable medical illnesses, and the m...
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PMID: 19100627
PDF is available here.
Abstract
Chronic administration of lithium led to clinically significant increases in serum creatinine levels and decreases in creatinine clearance in lithium-treated intellectually disabled individuals....
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PMID: 19440087
PDF is available here.
Abstract
We show that the addition of carbon nanostructure C60 to LiBH4 has a remarkable catalytic effect, enhancing the uptake and release of hydrogen. A fullerene-LiBH4 composite demonstrates catalytic properties with not only lowered hydrogen desorption temperatures but also regenerative rehydrogenation a...
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PMID: 19420670
PDF is available here.
Abstract
The local bonding and atomic environments in the Ni-catalyzed destabilized system LiBH4/MgH2 and the quaternary borohydride-amide phase Li3BN2H8, were studied by x-ray absorption spectroscopy. In both cases the Ni catalyst was introduced as NiCl2 and a qualitative comparison of the Ni K-edge near-ed...
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PMID: 19420655
PDF is available here.