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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Animal Experimentation (3):
Recent article
Animal Experimentation
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In the current paper a role of the serotinergic system in organization of impulsive behaviour in animals was considered. The results of influence of antagonists and agonists of the different types and subtypes of 5-HT receptors (1A, B; 2A, B, C; 7) and the effects of the dorsal raphe nuclei lesions o...
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PMID: 21861382
PDF is available here.
PDF is available here.
American Surgeon (11) 2011
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Parazitologiya (45)1 2011
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The paper describes the techniques of the actinospores investigation under field and laboratory conditions. The methylene blue solution for staining of actinospore processes and estimating of daughter cells of sporoplasm is proposed.
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PMID: 21598670
PDF is available here.
PDF is available here.
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The European Union has passed new laws for the protection of laboratory animals according to the 'three Rs' concept.
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PMID: 20959796
PDF is available here.
PDF is available here.
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We pose that it is essential that the goal of the specific experiment conducted is clearly defined and that the decision to balance between standardization and generalization must be made based on the specific needs to meet the intended goal. In this light, we discuss a multi-tiered approach to anim...
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PMID: 20662940
PDF is available here.
PDF is available here.
Prescrire international (19)109 2010
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Molecular Interventions (10)5 2010
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Theory in Biosciences (129)2-3 2010
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We celebrate Charles Darwin's second centenary, and 150 years since the publication of 'The Origin of Species'. After so many years, what has changed in the way we understand Evolution? Obviously we have now a full understanding of the mechanisms underlying heritability. Many molecular tools are ava...
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PMID: 20502983
PDF is available here.
PDF is available here.
Theory in Biosciences (129)2-3 2010
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Adaptation to a new environment (as well as its underlying mechanisms) is one of the most important topics in Evolutionary Biology. Understanding the adaptive process of natural populations to captivity is essential not only in general evolutionary studies but also in conservation programmes. Since...
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PMID: 20532673
PDF is available here.
PDF is available here.
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We can expect to be confronted with new ethical challenges. To be able to respond adequately and timely to current and possible future ethical issues, a prospective and anticipatory ethical analysis is essential. To obtain a first survey of ethical issues that might arise during the different phases...
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PMID: 20163208
PDF is available here.
PDF is available here.
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Turkey and Iran are two Near East countries that are developing ethical regulation systems for animal experiments, following significant developments in this field in neighbouring Europe. In Turkey, legislation was passed between 2004 and 2006 to mandate ethical review of experiments which involve t...
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PMID: 20822325
PDF is available here.
PDF is available here.
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Lab Animal (39)6 2010
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Lab Animal (39)6 2010
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Lab Animal (39)6 2010
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Lab Animal (39)6 2010
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British Journal of Cancer (102)11 2010
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We provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pil...
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PMID: 20502460
PDF is available here.
PDF is available here.
British Journal of Cancer (102)11 2010
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Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft fur Sozialpadiatrie und Deutsche Gesellschaft fur Kinderheilkunde (29)5 2010
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These results suggest that Brazil is important in the context of worldwide animal use for research, in terms of both the total numbers of animals and the numbers of vertebrates used. Bibliographical sampling is a useful method for estimating the extent of animal use in experiments in Brazil. However...
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PMID: 20377302
PDF is available here.
PDF is available here.
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We summarize recent events and suggest steps that researchers can take to educate the public on the value of animal research both for people and animals....
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PMID: 20098845
PDF is available here.
PDF is available here.
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We are attempting to develop a test for predicting the respiratory sensitization of chemicals. In the evaluation of skin sensitization of chemicals, the mostly used predictive tests are the guinea pig maximization test, Buehler test, and mouse local lymph node assay (LLNA). However, only LLNA has be...
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PMID: 20134104
PDF is available here.
PDF is available here.
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Congenital toxoplasmosis was diagnosed in 28 of the 102 cases. A prenatal diagnosis was obtained in only 16 cases. Specific IgM was detected in 57% of the babies at birth. A positive placental examination by PCR and mouse inoculation was the only evidence of infection in 3 neonates (11%) who were as...
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PMID: 19858771
PDF is available here.
PDF is available here.
IARC monographs on the evaluation of carcinogenic risks to humans / World Health Organization, International Agency for Research on Cancer (94) 2010
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Perception (39)3 2010
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The present study can contribute, supplying subsidies for adoption of future editorials policies regarding the publication of animal research papers in Brazilian Journal of Cardiovascular Surgery....
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PMID: 20305924
PDF is available here.
PDF is available here.
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This study evaluates the editorial policies of a randomized sample of English language peer-reviewed journals that publish original research involving the use of animals. The aim is to identify whether journals have editorial policies relating to the use of animals in the research that they are prep...
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PMID: 20013503
PDF is available here.
PDF is available here.
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Alternatives to Laboratory Animals (37 Suppl 2) 2009
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At the opening of a meeting to celebrate the 50th anniversary of the publication of The Principles of Humane Experimental Technique, by W.M.S. Russell and R.L. Burch, and the 40th anniversary of the establishment of FRAME, some comments on the early days of the Charity are made, with particular refe...
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PMID: 20105003
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
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The article reviews the early history of FRAME from the perspective of its first "Scientific Administrator". The roles of Mrs Hegarty the founder, and other early contributors to FRAME's development are described. In addition, the article discusses FRAME's strategic approach to the subject and how M...
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PMID: 20105004
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
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I feel well placed to speak of the contributions made by FRAME over the last 40 years. FRAME has promoted the development and use of alternatives by presenting the "better science" arguments to scientists, promoting informed discussion, changing opinions and changing behaviours. FRAME has also contr...
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PMID: 20105005
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
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FRAME has more than any other institution contributed to the implementation of the Three Rs concept in Europe. The first step was achieved by establishing the European Research Group on Alternatives to Toxicity Testing (ERGATT), in which individual scientists in several European countries began to c...
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PMID: 20105007
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
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I was stimulated to find an original edition by my first visits to FRAME and its Chairman, Michael Balls. The search continued for several years, until I was able to find an edition suitable for presentation to him. During this hunt, I was able to learn a great deal about the Three Rs of Replacement...
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PMID: 20105009
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
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We can find the strength and motivation to pursue our goal of scientific research and testing that no longer relies on animal-based techniques.
2009 FRAME....
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PMID: 20105010
PDF is available here.
PDF is available here.
Alternatives to Laboratory Animals (37 Suppl 2) 2009
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We could see the pursuit of the Three Rs degenerate into a formulaic process, leading to imperfect animal models being replaced by imperfect alternatives which would not serve to improve our science. We must not lose sight of the ultimate goal of conducting good science without the need to use anima...
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PMID: 20105013
PDF is available here.
PDF is available here.
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In the 1970s, under pressure from certain sections of society and thanks to initiatives by several scientific research teams, committees charged with improving the conditions of laboratory animals started to be created, first in the United States and subsequently in Europe. This led to the developme...
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PMID: 20669538
PDF is available here.
PDF is available here.
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We live in a digital world In medicine, computers are providing new tools for data collection, imaging, and treatment. During research and development of complex technologies and devices such as artificial hearts, computer simulation can provide more reliable information than experimentation on larg...
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PMID: 20669539
PDF is available here.
PDF is available here.
Abstract
Animal experimentation is of considerable importance in pharmacology and cannot yet be avoided when studying complex, highly integrated physiological functions. The use of animals has been drastically reduced in the classical phases of pharmacological research, for example when comparing several com...
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PMID: 20669540
PDF is available here.
PDF is available here.
Abstract
Transgenic mice bear stable, artificially induced genetic modifications that are transmitted to their offspring. They are prepared from cultured embryonic stem cells isolated from blastocysts. The stem cells are then transfected with a vector comprising a selection cassette and the sequence to be in...
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PMID: 20669542
PDF is available here.
PDF is available here.
Abstract
EC Directive 86/609, governing the protection of animals used for scientific purposes, is currently under review. The new text remains to be finalized but will likely include the following measures:--prior authorization will be required for all scientific projects,--authorization will include on an...
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PMID: 20669544
PDF is available here.
PDF is available here.
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Since 1959, when Russel and Burch formulated the 3Rs principle (Reduce, Replace, Refine), the scientific community has been attempting to reduce the use of laboratory animals for research purposes. Current regulatory guidelines take this principle into account. Thanks to scientific and technical pro...
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PMID: 20669541
PDF is available here.
PDF is available here.
Abstract
The use of alternative methods to animal testing are an integral part of the 3Rs concept (refine, reduce, replace) defined by Russel & Burch in 1959. These approaches include in silico methods (databases and computer models), in vitro physicochemical analysis, biological methods using bacteria or is...
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PMID: 20669543
PDF is available here.
PDF is available here.