Angeliki Asimaki,
Harikrishna Tandri,
Elizabeth R Duffy,
Jeffrey R Winterfield,
Shannon Mackey-Bojack,
Maria M Picken,
Leslie T Cooper,
David J Wilber,
Frank I Marcus,
Cristina Basso,
Gaetano Thiene,
Adalena Tsatsopoulou,
Nikos Protonotarios,
William G Stevenson,
William J McKenna,
Shiva Gautam,
Daniel G Remick,
Hugh Calkins and
Jeffrey E Saffitz
Abstract
We observed a false-positive case in which plakoglobin signal was reduced in a patient initially believed to have ARVC but who actually had cardiac sarcoidosis. Sarcoidosis can masquerade clinically as ARVC but has not been previously associated with altered desmosomal proteins.
We o...
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PMID: 21859801
PDF is available here.
Abstract
We analyzed the clinical and pathologic data from 141 consecutive autopsies of individuals with sudden death due to AoDs in Harris County, TX, from 2003 to 2010, which represented 20% (107/534) of all deaths attributed to AoDs during this period by the Texas Department of Health. Multivariate Cox re...
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PMID: 21884863
PDF is available here.
Abstract
We found 35 brains with deposits of 3 proteins (tau, β-amyloid, and α-synuclein). In these two series of brains, the high incidence of deposition of multiple proteins in neurodegenerative disorders is shown. Our results are in agreement with previous findings showing that tau, β-amyloid, and α-s...
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PMID: 21618706
PDF is available here.
Abstract
We suspected diffuse alveolar hemorrhage due to vasculitis. Steroid pulse therapy was given, and his fever and chest X-ray findings completely improved. However, 1 week later, he again suffered a high fever and bloody sputum, and a chest X-ray film showed granular shadows in bilateral lung fields. H...
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PMID: 21842695
PDF is available here.
Abstract
Clinical and morphologic features are described in 20 adults (15 men) aged 17 to 85 years (mean 56) who at necropsy were found to have ≥1 aneurysm in ≥1 of their 3 major (right, left anterior descending, and left circumflex) epicardial coronary arteries. Of the 34 coronary aneury...
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PMID: 21791334
PDF is available here.
Abstract
Idiopathic spontaneous hemoperitoneum has never been reported in patients with associated orthopedic injury. The present report aimed to demonstrate a case of this life-threatening condition concomitant with cervical spine injury.
A 50-year-old male was an illegal imm...
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PMID: 21774298
PDF is available here.
Abstract
An individual case review of diving-related deaths reported as occurring in Australia in 2006 was conducted as part of the Divers Alert Network Asia-Pacific (DAN AP) dive fatality reporting project.
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PMID: 21848110
PDF is available here.
Abstract
Worldwide, the prevalence of cardiovascular diseases such as atherosclerosis is on the increase. Younger people may be especially vulnerable owing to their exposure to risk factors such as drug abuse and HIV.
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PMID: 21920077
PDF is available here.
Abstract
We speculated that an elderly, tumor-bearing condition combined with chemotherapy led to prolonged immobility, a poor nutritional state, and rapid weight loss, which could be influential on the bowel necrosis....
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PMID: 21677492
PDF is available here.
Abstract
To our knowledge, no study in humans had studied the effect of tobacco smoking on pancreatic tissue. We have demonstrated for the first time that current cigarette smoking is associated with total PF-specifically, intralobular PF-as compared with nonsmokers.Am J Gastroenterol advance online publicati...
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PMID: 21577244
PDF is available here.
Abstract
A 24-year-old woman was strangulated by her husband using his wife's own 60-cm long artificial head hair integrations. During a domestic conflict, she was strangulated while lying in bed in a prone position. Her husband wrapped her hair around her neck and pulled it with one hand while fixing her hea...
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PMID: 21107595
PDF is available here.
Abstract
We retrospectively examined 50 victims of blunt trauma with regard to grade and extent of fractures and crushing of subcutaneous fatty tissue and presence and severity of PFE. Our results indicate that PFE can arise due to mere crushing of subcutaneous fat and that the fracture grade correlated well...
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PMID: 21424264
PDF is available here.
Abstract
The common hepatic artery was divided at the foot of the hepatic pedicle into a gastro duodenal artery and into a proper hepatic artery in 94% of the cases. In 6% of the cases, we noticed a threelevel change, a branching of the average hepatic artery into a gastro duodenal artery, a right hepatic ar...
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PMID: 21557182
PDF is available here.
Abstract
We reported significant alterations in the transcription of nuclear-encoded electron transport chain genes in MS and confirmed translational alterations for components of Complexes I and III that resulted in reductions in their activity. To more thoroughly and efficiently elucidate potential alterat...
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PMID: 21295140
PDF is available here.
Rohit R Mehra,
Chandan C Kumar-Sinha,
Sunita S Shankar,
Robert J RJ Lonigro,
Xiaojun X Jing,
Neena E NE Philips,
Javed J Siddiqui,
Bo B Han,
Xuhong X Cao,
David C DC Smith,
Rajal B RB Shah,
Arul M AM Chinnaiyan and
Kenneth J KJ Pienta
Abstract
We present here the discovery of non-ossified bone metastases from multiple patients with advanced prostate cancer and their subsequent characterization and comparison to non-osseous metastases from the same patients CONCLUSION: This represents a versatile and practical approach that may be employed...
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PMID: 21555375
PDF is available here.
Abstract
We were unable to differentiate between lung cancer and malignant pleural tumor using either transbronchial lung biopsy or computed tomography (CT)-guided needle biopsy. After 3 months the patient died from rapid disease progression despite radiation therapy, drainage of large quantities of the pleu...
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PMID: 21591456
PDF is available here.
Abstract
We present a case of AEF formation secondary to a Stanford B aortic dissection, along with a review of literature and terminology involved in describing such pathology....
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PMID: 21560995
PDF is available here.
Abstract
A 90-year-old woman was admitted to our hospital with dyspnea and palpitation. A chest X-ray film showed an enlarged cardiac outline. An enhanced chest CT scan showed a 35-mm tumor in the superior portion of the mediastinum, a large amount of pericardial effusion, and bilateral lung...
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PMID: 21485160
PDF is available here.
Ryan R Vass,
Emily E Ashbridge,
Felix F Geser,
William T WT Hu,
Murray M Grossman,
Dana D Clay-Falcone,
Lauren L Elman,
Leo L McCluskey,
Virginia M Y VM Lee,
Vivianna M VM Van Deerlin,
John Q JQ Trojanowski and
Alice S AS Chen-Plotkin
Abstract
We therefore investigated whether FTLD-TDP-associated risk genotypes at TMEM106B (1) contribute to risk of developing ALS or (2) modify the clinical presentation in ALS. Detailed clinical and pathological information from 61 postmortem ALS patients was collected by database query, retrospective char...
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PMID: 21104415
PDF is available here.
Abstract
We report a case of cystic medial necrosis Erdheim Gsell as a reason for fatal spontaneous rupture of the ascending aorta....
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PMID: 21500180
PDF is available here.
Abstract
Hypothermia is a rare cause of death in Israel, and usually occurs among risk groups such as elderly people, homeless persons, psychiatric patients and persons who function in cold environments or are unintentionally exposed to such conditions. Death due to hypothermia generally occurs in extremely c...
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PMID: 21574352
PDF is available here.
Abstract
We present the case of a 48-year-old woman suffering from fatal familial insomnia (FFI)--a rare prion disease--who developed Biot's breathing and secondary respiratory failure during the early stages of the illness. Once hypercapnia was detected a trial of nocturnal noninvasive ventilation (NIV) was...
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PMID: 21344052
PDF is available here.
Abstract
Studies of pituitary-related disorders would be facilitated by enhanced knowledge of the pituitary proteome. To construct a data set of human pituitary proteins, separate protein extracts were prepared from 15 post-mortem pituitaries and analyzed by data independent label-free nanofl...
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PMID: 21268279
PDF is available here.
Abstract
Most patients with acute fatal PE have a subclinical history of recurrent PE. The frequency of their untreated PE is suspected to correlate with specific risk factors for venous thromboembolism and their clinical course.
Copyright © 2011 International Society on Thrombosis and Haemo...
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PMID: 21294826
PDF is available here.
Abstract
We report an autoptic case. The patient was a male preterm infant. At 14 weeks of gestation, a routine ultrasonography showed severe craniofacial anomalies and a close contiguity of the foetal head with the amnios. The neonate survived three days, after which an autopsy was carried out. The infant h...
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PMID: 21837919
PDF is available here.
Abstract
We analyzed the expression of C1q, the initial recognition subcomponent of the classic complement cascade, in the substantia nigra pars compacta (SNc) in Parkinson disease (PD) and control cases using immunohistochemistry and in situ hybridization. Microglia were determined to be the only cells that...
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PMID: 21343881
PDF is available here.
Abstract
Necropsy is a major step of most studies using laboratory animals. During necropsy, tissue and organ changes noticeable grossly can be recorded, and important tissue samples can be stored for subsequent evaluation. It is therefore important that the personnel in charge of this key experimentation st...
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PMID: 20972746
PDF is available here.
Abstract
We diagnosed this case as autoimmune cerebellar atrophy associated with gluten ataxia. All 3 autopsies previously reported on gluten ataxia have noted infiltration of inflammatory cells in the cerebellum.In this case, we postulated that the infiltration of inflammatory cells was not found because th...
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PMID: 21294863
PDF is available here.
Abstract
Treatment of coronary bifurcation lesions remains challenging, beyond the introduction of drug eluting stents. Dedicated stent systems are available to improve the technical approach to the treatment of these lesions. However dedicated stent systems have so far not reduced the incidence of stent rest...
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PMID: 21814552
PDF is available here.
Abstract
We histologically analyzed 14 tissue specimens from 14 autopsies of patients with CKD Stage 5D who underwent hemodialysis and 5 specimens from 5 patients with CKD Stage 2 - 3 (90 ml/min/1.73 m2 > estimated GFR >= 30 ml/min/1.73 m2). We performed immunohistochemical staining of osteopontin (OPN) as a...
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PMID: 21176745
PDF is available here.
Abstract
We report a 62-year-old woman with FGN who showed mild proteinuria without hematuria and developed rapidly progressive renal failure requiring hemodialysis. Renal biopsy showed severe tubulointerstitial injury associated with non-amyloidotic fibrillary deposits in the tubular basement membrane, inte...
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PMID: 21176754
PDF is available here.
Abstract
While rare, an obstetrician can encounter dissection of the aorta and other large vessels in the course of pregnancy. They can be experienced either separately or as part of different syndromes. In the latter situation, there is a chance to establish the diagnosis of this pathologica...
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PMID: 21712775
PDF is available here.
Abstract
We review the problems of the differential diagnosis of notochordal remnants apropos of a case of the incidental autopsy finding of EP in a 78-year-old man, who died due to heart infarction. The 6-mm asymptomatic gelatinous lesion was fixed to the basilar artery on its ventral aspect. Small EPs can...
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PMID: 21574122
PDF is available here.
Abstract
A 65-year-old-man complained of coughing and fever. The urine showed microscopic hematuria. The level of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) was 167 EU. Two months later, he was admitted to our hospital with pulmonary hemorrhage and progressive renal dysfunction. He was tr...
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PMID: 21688488
PDF is available here.
Abstract
We have analyzed content of chemical elements in left and right ventricular myocardium of patients with ischemic heart disease with progressing heart failure and have shown that during development and progression of heart failure metabolic processes have unidirectional character in myocardium of bot...
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PMID: 21942953
PDF is available here.
Abstract
The objective of this study was to identify the incidence and patterns of thoracic aortic injuries in a series of blunt traumatic deaths and describe their associated injuries.
All autopsies performed by the Los Angeles County Department of Coroner for blunt traumatic deaths in 2005 were retrospecti...
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PMID: 21217494
PDF is available here.
Abstract
The 2008 case presented here of tularaemia in a cat and its owner occurred in an urban setting and was associated with animal contact, a relatively rare mode of transmission in Minnesota in recent years. Response to this case exemplified a 'One Health' approach involving pre-existing...
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PMID: 20163576
PDF is available here.
Abstract
The Armanni-Ebstein phenomenon, which is found in the kidneys in diabetic ketoacidosis, has also been proposed as an independent diagnostic postmortem marker for hypothermia. A case is reported to demonstrate the possibility of a more complex inter-related etiology in certain instanc...
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PMID: 20632132
PDF is available here.
Abstract
Autolytic rupture of the stomach, so called gastromalacia, is a well recognized artifact at autopsy. A 50 year old Asian woman with a past history of alcoholism, head injury and posttraumatic epilepsy was found deceased at home following a 12 h period of feeling unwell, seizures and vomiting. Post...
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PMID: 20467840
PDF is available here.
Abstract
Results from toxicological analyses in death investigations are used to determine whether foreign substances were a cause of death, whether they contributed to death, or whether they caused impairment. Drug concentrations are likely to change during pre-terminal stages due to altered pharmacokinetic...
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PMID: 20204545
PDF is available here.
Abstract
Abstract Patterns of malformations seen in autopsies may contribute to the understanding of their pathogenetic mechanisms. Two entities, acardiac twins (ATs) and amniotic band disruption complex (ABDC), have distinct patterns, suggesting different mechanisms, namely vascular perfusio...
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PMID: 21105785
PDF is available here.
Abstract
We report a 65-year-old man with a 35-year history of occupational asbestos exposure. He presented at a nearby hospital with a complaint of dyspnea in 2002. Bilateral pleural effusion was revealed on a chest x-ray film. Chest CT revealed diffuse thickening of the pleura, bilateral pleural effusions...
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PMID: 21141060
PDF is available here.
Abstract
We report a 75-year-old man with pneumoconiosis, interstitial pneumonia and diabetes mellitus, who had carcinoma of the buccal mucosa. After resection of the carcinoma, he was given corticosteroids for the deterioration of interstitial pneumonia, but 38 days after initiating steroid therapy, he was...
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PMID: 21141065
PDF is available here.
Abstract
Developments in the molecular genetic studies of cardiomyopathy (CM) have led to discovery of a large number of mutations in the genes encoding the sarcomeric proteins. In this study, comprehensive screening of TNNI3 was performed in 36 consented autopsy cases diagnosed as CM, in order to evaluate t...
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PMID: 20817590
PDF is available here.
Abstract
We report here a sudden death case of a patient previously diagnosed as Marfan syndrome (MFS). The victim was dead on the wheel and the cause of death was diagnosed to be a rupture of the thoracic aorta by autopsy findings. MFS is an autosomal dominant disorder of the connective tissue and can be a...
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PMID: 20729124
PDF is available here.
Abstract
We examined the feasibility of using cross-sectional imaging with postmortem multi-slice computed tomography (MSCT) to detect lesions of the skeletal structures and internal organs. For this purpose, we used whole-body MSCT to examine 10 corpses that suffered fatal falls from great height while clim...
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PMID: 20728397
PDF is available here.
Abstract
This case report describes the incidental finding of a calcified ligamentum arteriosum during post-mortem CT examination. The calcification of the ligament was confirmed at autopsy. Subsequent histological examination revealed the presence of cartilage-like and bone-like tissue as well as extended c...
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PMID: 20822945
PDF is available here.
Abstract
Although postmortem imaging has gained prominence in the field of forensic medicine, evaluation of the postmortem lung remains problematic. Specifically, differentiation of normal postmortem changes and pathological pulmonary changes is challenging and at times impossible. In this study, five corpse...
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PMID: 20729123
PDF is available here.
Abstract
Blood aspiration may be fatal, even when caused by a minor hemorrhage, and then it is important to localize and identify the source of bleeding in order to determine its origin as traumatic, spontaneous or iatrogenic. The present case deals with the clinically unexpected sudden death of a 73-year-ol...
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PMID: 20729125
PDF is available here.
Abstract
Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected by GC-MS and determined by HPLC-DAD in the...
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PMID: 20870445
PDF is available here.
Abstract
A recent coronial inquest examined the death of a patient, 17 years of age, from fulminant diabetic ketoacidosis.1 The patient's presentation with diabetic ketoacidosis was the first manifestation of the onset of type 1 diabetes. This article examines the Coroner's findings and recommendations.
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PMID: 21301662
PDF is available here.
Abstract
The ADVANCED QUALITY One Step Multi-Drug Screen test is a new urine on-site immunoassay test that is designed to detect multiple drugs of abuse in one time (barbiturates, benzodiazepines, cocaine, methylenedioxymethamphetamine (MDMA), methamphetamine, and opiates group). Thus, the present research w...
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PMID: 21114210
PDF is available here.