Abstract
We used two-photon RuBi-Glutamate uncaging to optically map how the largest population of cortical interneurons, the parvalbumin-positive cells (PV+), are connected to pyramidal cells (PCs) in mouse neocortex. We found locally dense connectivity from PV+ interneurons onto PCs across cortical areas a...
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PMID: 21917809
PDF is available here.
Abstract
We contrasted the connection patterns of parvalbumin-immunoreactive cells in two functionally distinct cortical regions: the tonotopic, narrowly frequency-tuned module [central narrow band (cNB)] of cat central primary auditory cortex (AI) and the nontonotopic, broadly tuned second auditory field (A...
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PMID: 21917816
PDF is available here.
Abstract
We recorded single-unit activity and local field potential from three MTL areas (hippocampus and entorhinal and perirhinal cortex) and visual area TE as monkeys performed a temporal-order memory task. Hippocampus provided incremental timing signals from one item presentation to the next, whereas per...
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PMID: 21817056
PDF is available here.
Abstract
These results are discussed in terms of selection mechanisms and object/group representations.
Copyright © 2011 Elsevier B.V. All rights reserved....
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PMID: 21652032
PDF is available here.
Abstract
We designed a functional MRI task capable of imaging FL activity in individuals, including the SGC region, using a transient sadness paradigm. We sought to develop a method that may better detect individual differences of FL subregions related to sadness, since this region has been implicated to sho...
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PMID: 21720734
PDF is available here.
Abstract
We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents wit...
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PMID: 21778039
PDF is available here.
Abstract
The discovery of the period gene mutants in 1971 provided the first evidence that daily rhythms in the sleep-wake cycle of a multicellular organism, the fruit fly Drosophila melanogaster, had an underlying genetic basis. Subsequent research has established that the biological clock mechanism in flies...
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PMID: 21819382
PDF is available here.
Abstract
We investigated 53 healthy individuals aged 18 to 89 years and assessed MEG during a resting condition. Generators of focal magnetic slow waves were localized. Results showed a significant influence of age: dipole density decreases with increasing age. The relationship between cognitive performance...
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PMID: 21698438
PDF is available here.
Abstract
Attention-deficit/hyperactivity disorder (ADHD) and conduct disorder overlap behaviorally, clinically, and cognitively. An important question of potential future clinical relevance is whether these two overlapping disorders are mediated by similar or distinct underlying brain substra...
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PMID: 21094938
PDF is available here.
Abstract
We use in vivo magnetic resonance imaging (MRI) and advanced image processing using surface rendering to visualize and characterize myeloarchitecture in a small nonhuman primate, the common marmoset (Callithrix jacchus). Through images made in four female adult marmosets, we produce a representative...
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PMID: 21599695
PDF is available here.
Abstract
We present the first neuroimaging investigation to our knowledge to characterize brain function and anatomy in chronic prostatitis/chronic pelvic pain syndrome....
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PMID: 21571326
PDF is available here.
Abstract
We used functional magnetic resonance imaging to determine brain activity during slow and fast pelvic floor contractions....
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PMID: 21575960
PDF is available here.
Abstract
We examined the relationship between brain activation and history of media violence exposure in adolescents, using functional magnetic resonance imaging (fMRI). Samples of adolescents with no psychiatric diagnosis or with disruptive behavior disorder (DBD) with aggression were compared to investigat...
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PMID: 21376543
PDF is available here.
Abstract
We hypothesized that the frontal lobe associated with social interaction was being stimulated. To test this hypothesis, we studied 24 patients with vascular dementia. In addition to conventional care, a 1-h session of GRA with RO was provided once a week for 3 months in the GRA-RO arm (n=12). Only s...
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PMID: 21543189
PDF is available here.
Abstract
We conclude that CRT leads to measurable physiological adaptation associated with improved cognitive ability. Trial name: Cognitive Remediation Theraphy and Schizophrenia. http://clinicaltrials.gov/ct2/show/NCT01078129. Registration number: NCT01078129....
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PMID: 21543191
PDF is available here.
Abstract
Our data demonstrate a diffuse reduction of WM together with focal areas of GM atrophy in AN. The finding of a hypothalamic focal atrophy points to hormonal dysfunction and opens the possibility for a central dysregulation of homeostasis. The involvement of temporoparietal areas could account for bo...
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PMID: 21546219
PDF is available here.
Abstract
We investigated the relationship between pretreatment EEG and early improvement in predicting clinical outcome in 72 MDD subjects across three placebo-controlled treatment trials. Subjects were randomized to receive fluoxetine, venlafaxine, or placebo. Theta current density in the rACC and mOFC was...
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PMID: 21546222
PDF is available here.
Andrea A Jackowski,
Tarique D TD Perera,
Chadi G CG Abdallah,
Griselda G Garrido,
Cheuk Y CY Tang,
Jose J Martinez,
Sanjay J SJ Mathew,
Jack M JM Gorman,
Leonard A LA Rosenblum,
Eric L P EL Smith,
Andrew J AJ Dwork,
Dikoma C DC Shungu,
Arie A Kaffman,
Joel J Gelernter,
Jeremy D JD Coplan and
Joan J Kaufman
Abstract
Male bonnet monkeys (Macaca radiata) were subjected to the variable foraging demand (VFD) early stress paradigm as infants, MRI scans were completed an average of 4 years later, and behavioral assessments of anxiety and ex-vivo corpus callosum (CC) measurements were made when animals were fully matur...
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PMID: 21377844
PDF is available here.
Abstract
1) association of the DAT1 9R allele with adult ADHD, 2) marginal DAT1 association with task-related suppression in left medial PFC, 3) marginal genotype×diagnosis interaction in the dorsal anterior cingulate cortex, and 4) correlation of DMN suppression to ADHD symptoms. These findings replicate t...
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PMID: 21596533
PDF is available here.
Abstract
We aimed to assess the association between core cerebrospinal fluid (CSF) biomarkers, regional brain atrophy and clinical severity in the Alzheimer's disease (AD) continuum, as well as to investigate how cognitive reserve (CR) may modulate these putative associations. Forty-nine subjects (11 controls...
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PMID: 21546220
PDF is available here.
Abstract
Cocaine use is associated with poorer HIV clinical outcomes and may contribute to neurobiological impairments associated with impulsive decision making. This study examined the effect of cocaine dependence on brain activation during a delay discounting task involving choices between smaller immediate...
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PMID: 21546221
PDF is available here.
Abstract
Brain metabolite concentrations have recently been assessed in different cerebral regions presumably targeted in patients with obsessive-compulsive disorder (OCD) using magnetic resonance spectroscopy (MRS). However, results have been divergent. Possible confounding variables, such as the cerebral lo...
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PMID: 21377338
PDF is available here.
Abstract
We used the midsagittal area and thickness to assess the morphology of the corpus callosum (CC), the largest connecting fiber tract in the human brain. Midsagittal magnetic resonance images of the CC were acquired from 69 adult patients with OCD and 69 matched normal controls. We calculated and comp...
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PMID: 21543190
PDF is available here.
Abstract
We achieved specific bodily conflicts and induced predictable changes in a fundamental aspect of self-consciousness by altering where healthy subjects experienced themselves to be (self-location). Functional magnetic resonance imaging revealed that temporo-parietal junction (TPJ) activity reflected...
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PMID: 21521620
PDF is available here.
Abstract
Our study suggests that the gray matter volume and density of limbic structure decreased in recent onset PTSD patients who were exposed to extreme trauma. PTSD symptom severity was associated with gray matter density in calcarine cortex and hippocampus....
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PMID: 21498053
PDF is available here.
Abstract
We therefore investigated the cerebral correlates of NSS by using magnetic resonance imaging (MRI) in 102 patients with first episode schizophrenia. NSS were assessed after remission of acute psychotic symptoms using the Heidelberg scale (HS), which consists of five NSS subscales ("motor coordinatio...
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PMID: 21498055
PDF is available here.
Abstract
We wanted to test whether brain white matter (WM) integrity is altered in AN, and related to heightened anxiety. Sixteen adult women with AN (mean age 24 ± 7 years) and 17 healthy control women (CW, mean age 25 ± 4 years) underwent diffusion tensor imaging (DTI) of the brain. The DTI brain images...
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PMID: 21498054
PDF is available here.
Abstract
We assessed the relationship between clinically assessed premorbid function, and cortico-striatal activity during sustained attention in controls (HC: with no family history of psychosis) and SCZ-Off. Subjects (n=39) were assessed using the Structured Interview for Prodromal Syndromes and the Scale...
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PMID: 21497490
PDF is available here.
Abstract
We investigated the mechanisms that underpin the modulation of affect in bipolar disorder to examine the contributions of cortico-limbic brain networks in the processing of affect. We employed a simultaneous functional magnetic resonance imaging and galvanic skin response methodology to investigate...
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PMID: 21493046
PDF is available here.
Abstract
We aimed to develop, pilot, and test a novel visuocognitive prototype test battery which addressed these issues, suitable for both clinical and functional imaging use....
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PMID: 21471555
PDF is available here.
Julien J Doyon,
Pierre P Orban,
Marc M Barakat,
Karen K Debas,
Ovidiu O Lungu,
Geneviève G Albouy,
Stuart S Fogel,
Sébastien S Proulx,
Samuel S Laventure,
Jonathan J Deslauriers,
Catherine C Duchesne,
Julie J Carrier and
Habib H Benali
Abstract
We then describe the functional changes that occur at the different (rapid, slow, automatization) acquisition phases, and propose specific roles that the putamen, the cerebellum and their motor-related cortical areas, play in this form of motor behavior. Finally, we put forward evidence that post-tr...
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PMID: 21524407
PDF is available here.
Abstract
We investigated different modes of visual search (serial vs. parallel) and demonstrated that the attentional set induced by the type of search greatly influences these attentional effects. IOR was linked to serial search while facilitation followed parallel search. Event related potentials and LORET...
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PMID: 21458425
PDF is available here.
Abstract
Our findings are in line with earlier results which showed that VNS increases rCBF in the left dorsolateral prefrontal cortex. The modulation of the activity in this region could be associated with the antidepressant efficacy of VNS....
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PMID: 21306877
PDF is available here.
Abstract
Chronic marijuana (MRJ) use is associated with altered cognition and mood state, altered brain metabolites, and functional and structural brain changes. The objective of this study was to apply proton magnetic resonance spectroscopic imaging (MRSI) to compare proton metabolite levels in 15 young men...
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PMID: 21334181
PDF is available here.
Abstract
We reported smaller volume and width of the outer cortex (layers I-III), especially in the left hemisphere, among subjects with schizophrenia. In the present study, we measured neuron density and size in the same PT samples, and also in prefrontal area 9 of the same brains. In the PT, separate stere...
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PMID: 21377842
PDF is available here.
Abstract
We hypothesized the antidepressant action of fluoxetine would produce adaptations in mesolimbic regions after two weeks of treatment. We used Holtzman rats, a genetic strain showing susceptibility to novelty-evoked hyperactivity and stress-evoked helplessness, to map regional brain metabolic effects...
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PMID: 21376019
PDF is available here.
Abstract
The hippocampal atrophy of MDD has been known, but the region shape contractions of the hippocampus in MDD were inconsistent. Spheric harmonic shape analysis was applied to the hippocampus in female patients with unremitting MDD to evaluate morphometric changes of the hippocampus.
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PMID: 21372170
PDF is available here.
Goultchira G Chakirova,
Heather C HC Whalley,
Pippa A PA Thomson,
William W Hennah,
Thomas W J TW Moorhead,
Killian A KA Welch,
Stephen S Giles,
Jeremy J Hall,
Eve C EC Johnstone,
Stephen M SM Lawrie,
David J DJ Porteous,
Verity J VJ Brown and
Andrew M AM McIntosh
Abstract
We examined the effects of these risk variants on brain activation during functional magnetic resonance imaging (fMRI) of the Hayling Sentence Completion Task (HSCT) in healthy volunteers (n=33), patients with schizophrenia (n=20) and patients with bipolar disorder (n=36). In the healthy controls th...
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PMID: 21376542
PDF is available here.
Abstract
We propose a fusion method comprising innovation approach in time series analysis and statistical test. Autoregressive (AR) models were fitted to time series data of each pixel for the range sufficiently before or after the state transition. Then, the remaining time series data were filtered using t...
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PMID: 21224173
PDF is available here.
Abstract
Epilepsy surgery concerns any patient with pharmacoresistant partial epilepsy, responsible for disability. Children and adult patients can be candidates for epilepsy surgery. A presurgical evaluation, adapted to each patient, must identify the most precisely the cortical area, where the seizures orig...
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PMID: 21310584
PDF is available here.
Abstract
We assessed the evolution of changes in sensory processing and neglect symptoms over a 6 month follow-up period. Twenty-one stroke subjects with hemispatial neglect were studied at baseline, 3 weeks later and at 6 months follow-up. At enrollment, 12 patients were in Acute/subacute and 9 were in the...
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PMID: 21092746
PDF is available here.
Abstract
We investigated the neural correlates of autonomic control by measuring both HRV and associated brain activity during the performance of mildly stressful tasks. Medically healthy female subjects with MDD (N=10) and healthy controls (N=7) underwent H(2)(15)O-positron emission tomography (PET) and ele...
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PMID: 21129936
PDF is available here.
Abstract
We demonstrated that the width of the third ventricle, as a marker of brain atrophy can reliably be monitored by using TCS as a non-invasive, time- and cost-effective method. We provide evidence that the assessed width of the third ventricle can differentiate between subjects with a normal cognitive...
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PMID: 21288698
PDF is available here.
Abstract
We combine measures of functional activity, grey matter integrity and performance in patients with left hemisphere damage and healthy participants to ask whether the left inferior frontal gyrus is essential for syntactic processing. In a functional neuroimaging study, participants listened to spoken...
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PMID: 21278407
PDF is available here.
Abstract
To observe the characteristics of needling sensation of "Deqi" (feelings of soreness, numbness, distending and heaviness, SNDH) by using positron emission tomography (PET) based on changes of glucose metabolism in different functional brain areas.
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PMID: 21585059
PDF is available here.
Abstract
We used graph theoretic analysis to construct weighted cortical functional networks from hemodynamic (functional MRI) responses in 12 younger and 12 older adults during a speech perception task performed in both quiet and noisy listening conditions. Functional networks were constructed for each subj...
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PMID: 21304991
PDF is available here.
Abstract
We expected this response-focused emotion regulation strategy to be associated with increased grey matter volume in the dorsomedial prefrontal cortex (dmPFC). On high-resolution MRI scans of 42 college-aged healthy adults we computed optimized voxel-based-morphometry (VBM) to explore the correlation...
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PMID: 21298057
PDF is available here.
Abstract
The default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampus are impaired in drug addiction and meanwhile are parts of t...
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PMID: 21298074
PDF is available here.
Abstract
In the search for neurobiological correlates of depression, a major finding is hyperactivity in limbic-paralimbic regions. However, results so far have been inconsistent, and the stimuli used are often unspecific to depression. This study explored hemodynamic responses of the brain in patients with d...
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PMID: 21283580
PDF is available here.
Abstract
We have elucidated the mechanism of the "top-down" modulation of taste perception in humans using functional magnetic resonance imaging (fMRI) and demonstrated that gustatory imagery is mediated by the prefrontal (PFC) and insular cortices (IC). However, the temporal order of activation of these bra...
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PMID: 21760903
PDF is available here.
Abstract
We introduced a two-choice condition (between either the smaller/lower or the larger/higher of two digits) and examined its effect on brain activity by fMRI. We observed longer response times and greater activity with the choice of smaller numbers ("choice effect") in several brain regions including...
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PMID: 21738777
PDF is available here.
Abstract
We specifically compared Chinese with Korean script, with Korean script serving as a good example of alphabetic writing system, but matched to Chinese in the overall square shape. Sixteen proficient early Chinese-Korean bilinguals took part in the fMRI experiment. Four types of stimuli (Chinese char...
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PMID: 21818386
PDF is available here.
Abstract
We hypothesized that the degree of negative expectation depends on state (dread) and trait (pessimism) sensitivity. Of the brain regions that are involved in mediating pleasure, the nucleus accumbens also signals unexpected reward and positive prediction error. We hypothesized that accumbens activit...
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PMID: 21490964
PDF is available here.
Abstract
We investigated this question in an fMRI paradigm in which LTM for reward-predicting and neutral cues was compared to LTM for items presented during consumption of reliably predictable as compared to less predictable rewards. We observed activation of the ventral striatum and enhanced memory formati...
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PMID: 21326612
PDF is available here.
Abstract
These results raise the possibility that certain forms of synaptic plasticity may occur within the cortex while synaptic potentiation takes place within synapses in the hippocampus and amygdala. This hypothesis is supported by electrophysiological evidence obtained from freely moving animals that ne...
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PMID: 21912749
PDF is available here.
Abstract
We will review current human data on possible neurobiological mechanisms of repetitive (r) TMS implicated in the deregulated neurocircuitry present in unipolar depression. Furthermore, as the rTMS application can be considered as a "top-down" neuronal intervention, we will focus on the neuronal path...
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PMID: 21485753
PDF is available here.
Abstract
Chronic exposure to adverse interpersonal environment in schizophrenia is associated with vulnerability to relapse. The construct of expressed emotion (EE) measures the quality of interpersonal environment, of which criticism is a main component. To use functional magnetic resonance imaging and to i...
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PMID: 21206243
PDF is available here.