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Magnetic Resonance Spectroscopy (2):
Recent article
Magnetic Resonance Spectroscopy
Abstract
To elucidate the biosynthetic pathways for all proteinogenic amino acids in Xanthomonas campestris pv. campestris, this study combines results obtained by in silico genome analysis and by (13)C-NMR-based isotopologue profiling to provide a panoramic view on a substantial section of bacterial metaboli...
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PMID: 21853248
PDF is available here.
PDF is available here.
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Ideggyogyaszati szemle (64)9-10 2011
Abstract
We can use an optimal imaging protocol. Cerebral structures can be evaluated on a microanatomical level on high-resolution images with thin slices. The three-dimensional (3D) sequence has high spatial resolution, properly distinguishes cerebral grey and white matter, provides the possibility of surf...
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PMID: 22059363
PDF is available here.
PDF is available here.
Abstract
Biomacromolecules (12)9 2011
Abstract
We investigated the properties of micellar siRNA delivery vehicles prepared with poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLL) comprising lysine amines modified to contain amidine and thiol functionality. Lysine modification was achieved using 2-iminothiolane (2-IT) [yielding PEG-b-PLL(N2IM...
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PMID: 21863796
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
We used noncrystalline poly(trimethylene carbonate) (PTMC) or poly(δ-valerolactone-co-ε-caprolactone) (PVLCL) macrodiols of different molecular weights as SSs that were reacted with 1,4-diisocyanatobutane and chain extended with 1,4-diaminobutane. Mechanical properties of the PUUs were characteriz...
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PMID: 21755999
PDF is available here.
PDF is available here.
Abstract
We determined the structure of Phytophthora capsici AVR3a4, a close homolog of P. infestans AVR3a. Our structural and functional analyses reveal that the effector domain of AVR3a contains a conserved, positively charged patch and that this region, rather than the RXLR domain, is required for binding...
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PMID: 21821794
PDF is available here.
PDF is available here.
Abstract
Dynamic nuclear polarization (DNP) is an emerging technique for dramatically increasing the sensitivity of magnetic resonance spectroscopy (MRS). This review evaluates the potential strengths and weaknesses of DNP-enhanced (13)C magnetic resonance spectroscopic imaging (DNP-MRSI) as a clinical imagin...
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PMID: 21849405
PDF is available here.
PDF is available here.
Abstract
Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via...
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PMID: 21887847
PDF is available here.
PDF is available here.
Abstract
To observe the clinical efficacy of electroacupuncture (EA) on mild cognitive impairment (MCI) for patients of Uygur and Han nationality and explore the national diversity among the patients with MCI.
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PMID: 21972616
PDF is available here.
PDF is available here.
Abstract
Antimicrobial properties of medicinal plants and plant parts such as flowers, roots, fruits, seeds and oils are being used to cure some chronic and acute diseases throughout the world. In the present study, an attempt has been made to isolate and identify the antibacterial compound p...
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PMID: 22013726
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)10 2011
Abstract
We therefore examined the interaction of peptides corresponding to either AS1 or AS2 of four different, well-characterized HAMP domains with several membrane model systems. The proteins included an Archaeoglobus fulgidus protein (Af1503), the Escherichia coli osmosensor EnvZ(Ec), the E. coli nitrate...
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PMID: 21763270
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)9 2011
Abstract
The asymmetric 3-ethyl-2-methylporphyrin iron complex was synthetized and inserted into apomyoglobin. UV-visible spectroscopic studies demonstrated the capacity of iron to coordinate different exogenous axial ligands in ferrous and ferric forms. The position of synthetic heme into th...
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PMID: 21600316
PDF is available here.
PDF is available here.
Abstract
Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this li...
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PMID: 21681959
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of eight days of oral antibiotic exposure (penicillin and streptomycin sulfate) on gut microbial composition and host metabolic phenotype in male Han-Wistar rats (n = 6) compared to matched controls. Early recolonization was assessed in a third group exposed to antibiotic...
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PMID: 21591676
PDF is available here.
PDF is available here.
Abstract
CCL5 (RANTES) is a proinflammatory chemokine known to activate leukocytes through its receptor, CCR5. Although the monomeric form of CCL5 is sufficient to cause cell migration in vitro, CCL5's propensity for aggregation is essential for migration in vivo, T cell activation and apo...
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PMID: 21827949
PDF is available here.
PDF is available here.
Abstract
One of the central challenges to metabolomics is metabolite identification. Regardless of whether one uses so-called 'targeted' or 'untargeted' metabolomics, eventually all paths lead to the requirement of identifying (and quantifying) certain key metabolites. Indeed, without metabol...
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PMID: 21827274
PDF is available here.
PDF is available here.
Abstract
We demonstrated that M. confluentis contains α-mycolates (type I) and epoxymycolates (type V mycolic acids).
Copyright © 2011 Elsevier B.V. All rights reserved....
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PMID: 21871846
PDF is available here.
PDF is available here.
Abstract
Phospholipids bearing tetrafluorophenylazido chromophores were synthesized with perfectly conserved amphiphilicity and photochemical activity. Interestingly however, those phospholipids harboring the amine-linked chromophores exhibited unusual (19)F NMR signals which depended on the...
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PMID: 21766799
PDF is available here.
PDF is available here.
Abstract
A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum in vitro, was isolated from the flowers of Cassia siamea, and its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employi...
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PMID: 21755916
PDF is available here.
PDF is available here.
Abstract
In-situ observation of the temporal evolution of the absorption of PbSe nanocrystals (NCs) via a low-temperature noninjection approach is presented. Based on a model reaction of lead oleate (Pb(OA)(2) ) and n-trioctylphosphine selenide (TOPSe) in 1-octadecene at 35-80 °C, the use of...
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PMID: 21735546
PDF is available here.
PDF is available here.
Abstract
31-Phosphorus-magnetic resonance spectroscopy may provide pathophysiological insights into the high-energy phosphate metabolism of the myocardium as measured by phosphocreatine to adenosine triphosphate (PCr/ATP) ratio. Aim of the present study was to determine in vivo the relation between cardiac PC...
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PMID: 21742100
PDF is available here.
PDF is available here.
Abstract
Abstract
We have examined in a cross-sectional study the interrelationships among IMCL, insulin sensitivity, and adiposity in European Americans (EAs) and African Americans (AAs). In 43 EA and 43 AA subjects, we measured soleus IMCL content with proton-magnetic resonance spectroscopy, insulin sensitivity wit...
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PMID: 21436797
PDF is available here.
PDF is available here.
Abstract
We measured T-helper (Th) cytokine production, i.e., interleukin-2 (IL-2), IL-4, IL-5, and interferon-gamma (IFN- γ), in cultured Peyer's patch (PP) cells from mice orally treated with a methanol extract of melinjo fruit. Oral administration of the 50 % ethanol extract at 100 mg/kg/day significantl...
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PMID: 21267811
PDF is available here.
PDF is available here.
Abstract
A stereospecific multicomponent reaction among isocyanides, syn-chlorooximes, and carboxylic acids provides an efficient synthesis of biologically relevant syn-α-oximinoamides.
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PMID: 21667987
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
We conducted a series of regioselective protection-deprotections of curdlan involving triphenylmethylation at C-6, phenylcarbamoylation at C-2 and C-4, and detriphenylmethylation. Subsequent glycosylation with a d-glucosamine-derived oxazoline, followed by deprotection gave rise to the branched curd...
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PMID: 21526779
PDF is available here.
PDF is available here.
Abstract
We propose using the levels of the four metabolites for diagnosing NAFLD at various stages. Furthermore, the probability of developing NAFLD at a particular stage was assessed by multinomial logistic regression (MLR) based on the clinical results of the four serum metabolites....
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PMID: 21563774
PDF is available here.
PDF is available here.
Abstract
We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues requi...
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PMID: 21623357
PDF is available here.
PDF is available here.
Abstract
Density functional theoretical calculations have been utilized to investigate the interaction of the amino acid arginine with the (100) surface of anatase and the reproduction of experimentally measured (49)Ti NMR chemical shifts of anatase. Significant binding of arginine through el...
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PMID: 20853182
PDF is available here.
PDF is available here.
Abstract
We report the isolation of N-aryl peptoid oligomers that adopt chiral folds, despite the absence of chiral centers. Peptoid monomers incorporating ortho-substituted N-aryl side chains are identified that exhibit axial chirality. We observe significant energy barriers to rotation about the stereogeni...
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PMID: 21634437
PDF is available here.
PDF is available here.
Abstract
Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyse...
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PMID: 21674790
PDF is available here.
PDF is available here.
Abstract
We used the new HRMAS-NMR DOSY technique to study the diffusive motions of sodium fluorescein, a drug mimetic small chromophoric molecule, loaded in a promising hydrogel developed for tissue engineering. While fluorescein behavior in water was as expected, also showing aggregation from mid concentra...
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PMID: 21830493
PDF is available here.
PDF is available here.
Abstract
We determine the systemic and hepatic effects of long-term administration of a very low-carbohydrate, low-protein, and high-fat ketogenic diet, serially comparing these effects to a high-simple-carbohydrate, high-fat Western diet and a low-fat, polysaccharide-rich control chow diet in C57BL/6J mice....
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PMID: 21454445
PDF is available here.
PDF is available here.
Abstract
Two new proanthocyanidins, epigallocatechin-3-O-p-hydroxybenzoate-(4beta-->8)-epigallocatechin (1) and epigallocatechin-3-O-p-hydroxybenzoate-(4beta-->8)-epigallocatechin-3-O-gallate (2) in addition to the known compound epigallocatechin-(4beta-->6)-epigallocatechin-3-O-gallate (3), were isolated fro...
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PMID: 21699087
PDF is available here.
PDF is available here.
Abstract
The biotransformation of digitoxin and some of its derivatives extracted from Digitalis lanata by Streptomyces isolated species was investigated. Cultures of a Streptomyces strain designated EUSA2003B, isolated from an Egyptian soil sample, efficiently induced selective 12beta-hydroxylation of the st...
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PMID: 21699088
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
We assessed ΔG'(ATP) hydrolysis, cytosolic [ADP], and the rate of phosphocreatine recovery using Phosphorus Magnetic Resonance Spectroscopy in the calf muscle of a group of patients affected by glycogen myo-phosphorylase deficiency (McArdle disease). The goal was to ascertain whether and to what ex...
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PMID: 21722623
PDF is available here.
PDF is available here.
Abstract
A theoretical study of the 1:1 and 2:1 complexes of XOOX' (X, X' = H, CH(3)) with the lithium cation has been carried out by means of ab initio computational methods up to the MP2/aug-cc-pVTZ level. The optical rotatory power and NMR parameters (absolute chemical shielding and indirect coupling const...
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PMID: 21604681
PDF is available here.
PDF is available here.
Abstract
The superacid-promoted reactions of vinyl-substituted N-heterocycles have been studied. Diprotonated pyrimidines, quinoxalines, and quinazolines exhibit an unusual regioelectronic effect that controls the type of addition reaction observed. Depending on the ring position of the vinyl substituent, eit...
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PMID: 21548654
PDF is available here.
PDF is available here.
Abstract
The torquoselectivity of the 4π electrocyclic ring-opening reaction of 2-azetines can be controlled by the Brønsted acidity of the catalyst and the polarity of the solvent. DFT calculations provided insight into the mechanism of this remarkable switch. Anti and syn stereoisomers of α,β-unsaturate...
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PMID: 21557577
PDF is available here.
PDF is available here.
Abstract
The designed synthesis and structural characterization of two metal cluster-centered metallosupramolecular architectures are reported. In complex [(CF(3)SO(3))Ag(4)((t)BuC≡C)(Py8)](CF(3)SO(3))(2) (1) and [(CF(3)SO(3))Ag(4){C≡C-(m-C(6)H(4))-C≡C-(m-C(6)H(4))-C≡C-(m-C(6)H(4))-C≡C}Ag(4)(CF(3)SO...
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PMID: 21561074
PDF is available here.
PDF is available here.
Abstract
We are developing solid-state NMR (SSNMR) to probe the flavin electronic structure, via the (15)N chemical shift tensor principal values (δ(ii)). We find that SSNMR has superior responsiveness to H-bonds, compared to solution NMR. H-bonding to a model of the flavodoxin active site produced an incre...
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PMID: 21619002
PDF is available here.
PDF is available here.
Abstract
We have determined the value of the glass transition temperature (T_{g}) as well as the steepness index (m_{P}) at various T-P conditions....
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PMID: 21728535
PDF is available here.
PDF is available here.
Abstract
We suggest that both changes contribute to the observed fatigue. A likely cause of the decline in tetanic myoplasmic calcium is precipitation of calcium phosphate in the SR....
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PMID: 21512148
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Majority of protein drugs in development today are glycoproteins e.g. recombinant antibodies expressed in various cell lines. Oligosaccharides through conformational changes can modulate therapeutic value (potency) of glycoproteins e.g. complement dependent cell cytotoxicity (CDCC) and antibody-depe...
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PMID: 18373267
PDF is available here.
PDF is available here.
Abstract
To study the polysaccharides contents and monosaccharide compositions in parent root, daughter root and rootlet of Aconitum carmichaeli.
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PMID: 21842639
PDF is available here.
PDF is available here.
Abstract
To investigate the chemical constituents of the branches and leaves of Uvaria kurzii.
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PMID: 21842647
PDF is available here.
PDF is available here.
Abstract
To study the chemical constituents of the roots of Helicteres angustifolia.
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PMID: 21842648
PDF is available here.
PDF is available here.
Abstract
Abstract
Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7),...
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PMID: 21656354
PDF is available here.
PDF is available here.
Abstract
A new coumarin, 7-[(E)-3',7'-Dimethyl-6'-oxo-2',7'-octadienyl]oxy coumarin (1), together with three known compounds, schinilenol (2), schinindiol (3) and 7-[(E)-7'-hydroxy-3',7'-dimethylocta-2',5'-dienyloxy]-coumarin (4) were isolated from the methylene chloride fraction of Z. schinifolium by normal...
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PMID: 21656356
PDF is available here.
PDF is available here.
Abstract
In the course of searching for cholesteryl ester transfer protein (CETP) inhibitors from natural sources, a new type of CETP inhibitor, [10]-dehydrogingerdione (1), was isolated from the extract of rhizomes of Zingiber officinale Roscoe. By NMR spectroscopic analysis of its (1)HNMR, (13)C-NMR, and (1...
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PMID: 21656357
PDF is available here.
PDF is available here.
Abstract
In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The...
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PMID: 21656355
PDF is available here.
PDF is available here.
Abstract
We show that such effects alter the magnetic relaxation response of local water in ways that may enable oligomer detection. By using water proton magnetic resonance spectroscopy, we measured significantly longer transverse magnetic relaxation (T(2)) times in mixtures of serum and amyloidogenic Aβ(1...
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PMID: 21539800
PDF is available here.
PDF is available here.
Abstract
Abstract
This article describes the rational design of first generation systems for oxidatively induced Aryl-CF(3) bond-forming reductive elimination from Pd(II). Treatment of (dtbpy)Pd(II)(Aryl)(CF(3)) (dtbpy = di-tert-butylbipyridine) with NFTPT (N-fluoro-1,3,5-trimethylpyridinium triflate) afforded the iso...
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PMID: 21513271
PDF is available here.
PDF is available here.
Abstract
We present the first direct evidence that chaotropic anions have an affinity for hydrophobic concavity and that it is competition between a convex hydrophobe and the anion for a binding site that leads to the apparent weakening of the hydrophobic effect by chaotropes. In combination, these results s...
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PMID: 21524086
PDF is available here.
PDF is available here.
Abstract
Thuricin CD is an antimicrobial factor that consists of two peptides, Trn-α and Trn-β, that exhibit synergistic activity against drug resistant strains of Clostridium difficile. Trn-α and Trn-β each possess three sulfur to α-carbon thioether bridges for which the stereochemistry is unknown. This...
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PMID: 21526839
PDF is available here.
PDF is available here.
Abstract
We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in the hippo...
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PMID: 21521612
PDF is available here.
PDF is available here.
Abstract
Water absorption of atmospheric carbon dioxide lowers the solution pH due to carbonic acid formation. Bulk water acidification by CO(2) is well documented, but significantly less is known about its effect on water in confined spaces. Considering its prominence as a greenhouse gas, th...
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PMID: 21506532
PDF is available here.
PDF is available here.
Abstract
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay syst...
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PMID: 21500849
PDF is available here.
PDF is available here.