Abstract
Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-...
|
PMID: 21505471
PDF is available here.
Abstract
We reevaluated the structure of the different SGL acyl (di-, tri-, and tetra-acylated) forms of the reference strain Mycobacterium tuberculosis H37Rv, as well as those produced by the mmpL8 knockout strains previously described to intracellularly accumulate di-acylated SGL. We report here the identi...
|
PMID: 21482713
PDF is available here.
Abstract
The advent of metabonomics has seen a proliferation of biofluid profiling studies of patients with hepatocellular carcinoma. The majority of these studies have been conducted in single indigenous populations making the widespread applicability of candidate metabolite biomarkers difficult. Presented h...
|
PMID: 21275434
PDF is available here.
Abstract
We examined pharmacological activities of these compounds in vitro (binding studies) and in vivo (MES test). Pharmacological evaluations revealed one of the compounds, 5a, to be a good lead, exhibiting moderate binding at NMDA receptors (IC(50) = 7.86 μM; K(i) = 5.28 μM), MES neuroprotection activ...
|
PMID: 21496213
PDF is available here.
Abstract
We present a structural and genetic analysis of the Y. pseudotuberculosis serotype O:1c OPS. Our results showed that this OPS has the same backbone as Y. pseudotuberculosis O:2b, but with a 3,6-dideoxy-D-ribo-hexofuranose (paratofuranose, Parf) side-branch instead of a 3,6-dideoxy-D-xylo-hexopyranos...
|
PMID: 20418261
PDF is available here.
Abstract
The present paper deals with a complex spectral and physicochemical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-isopropylammonium]fumarate, a potential ultrashort acting beta1-blocker. The identity of the substance under study (labelled as UPB-1) was confirmed by 1H- and 13C-...
|
PMID: 21650011
PDF is available here.
Abstract
We present an overview of the effect that structural diversity intrinsic to protein ensembles has on scattering data. We then demonstrate the observation of these effects in scattering from four molecular systems; myoglobin; ubiquitin; alcohol dehydrogenase; and HIV protease; and demonstrate the mod...
|
PMID: 21462170
PDF is available here.
Abstract
A six-coordinate oxovanadium(V) thiolate complex and an eight-coordinate non-oxovanadium thiolate complex, [PPh(4)][VO(PS3'')(OCH(3))] (1) and [NEt(4)][V(PS3'')(2)] (2) (PS3'' = P(C(6)H(3)-3-Me(3)Si-2-S)(3)(3-)), respectively, have been isolated and structurally characterized. The former belongs to a...
|
PMID: 21438583
PDF is available here.
Abstract
The reaction of the phosphonium alkylidene [(H(2)IMes)RuCl(2)═CHP(Cy)(3))](+) BF(4)(-) with propene, 1-butene, and 1-hexene at -45 °C affords various substituted, metathesis-active ruthenacycles. These metallacycles were found to equilibrate over extended reaction times in response to decreases in...
|
PMID: 21452876
PDF is available here.
Abstract
We have explored a new class of organometallic "piano-stool" Ru(II) and Os(II) arene anticancer complexes of the type [(η(6)-arene)Ru/Os(XY)Cl](+). Here XY is, for example, ethylenediamine (en), and the arene ligand can take many forms, including tetrahydroanthracene, biphenyl, or p-cymene. Arene-n...
|
PMID: 21446672
PDF is available here.
Abstract
Chronic marijuana (MRJ) use is associated with altered cognition and mood state, altered brain metabolites, and functional and structural brain changes. The objective of this study was to apply proton magnetic resonance spectroscopic imaging (MRSI) to compare proton metabolite levels in 15 young men...
|
PMID: 21334181
PDF is available here.
Abstract
To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure (ALF).
|
PMID: 21472104
PDF is available here.
Abstract
The homo-Reformatsky reaction, in which a metal homoenolate of an ester is added to an aldehyde, was adapted to produce γ-lactones from unsaturated, enolizable aldehydes. By use of titanium homoenolate, 11 different γ-lactones were synthesized in one step with moderate to good yields from readily a...
|
PMID: 21395335
PDF is available here.
Abstract
The screening for insecticidal principles from several Chinese medicinal herbs showed that the ethanol extract of Aconitum episcopale roots possessed significant feeding deterrence against the red flour beetle, Tribolium castaneum . From the ethanol extract, six feeding deterrents were isolated by bi...
|
PMID: 21417277
PDF is available here.
Abstract
We have previously observed that VIP-G (glycine-extended VIP) is unstructured in solution, as evidenced by the limited NMR chemical shift dispersion. In this study, we determined the three-dimensional structures of VIP-G in two distinct membrane-mimicking environments. Although these are basically s...
|
PMID: 21439408
PDF is available here.
Abstract
We propose the unusual electronic structure of the described high-spin iron imido complexes contributes to the observed catalytic reactivity....
|
PMID: 21405138
PDF is available here.
Abstract
Approximately 1100 genebank accessions of okra (Abelmoschus esculentus) and 540 additional accessions that included six of its related species-A. caillei, A. crinitis, A. esculentus, A. ficulneus, A. manihot, A. moschatus and A. tuberculatus-were evaluated for seed oil content using time domain NMR (...
|
PMID: 21413797
PDF is available here.
Abstract
Consumption of improperly ripened ackee ( Blighia sapida K.D. Koenig) often results in fatalities. The causal toxin, hypoglycin A, decreases in the edible arilli upon maturity; regulation of hypoglycin A in the arilli is thus critical. Hypoglycin B, also toxic, is confined to the seeds. Hypoglycins A...
|
PMID: 21410289
PDF is available here.
Abstract
These results are in accordance with the metabolic pathway proposed for the fermentation of L-ascorbate by E. coli....
|
PMID: 21401096
PDF is available here.
Abstract
Potatoes, tomatoes, and aubergines are all species of the Solanum genus and contain a vast array of secondary metabolites including calystegine alkaloids, phenolic compounds, lectins, and glycoalkaloids. Glycoalkaloids have been the subject of many literature papers, occur widely in the human diet, a...
|
PMID: 21401040
PDF is available here.
Elsa E Valero,
Stefano S Tambalo,
Pasquina P Marzola,
Mariano M Ortega-Muñoz,
F Javier FJ López-Jaramillo,
Francisco F Santoyo-González,
Juan J de Dios López,
Juan J JJ Delgado,
José J JJ Calvino,
Rafael R Cuesta,
José M JM Domínguez-Vera and
Natividad N Gálvez
Abstract
We show that the pH-driven assembly-disassembly natural process that occurs in apoferritin protein is effective for the encapsulation of maghemite nanoparticles of different sizes: 4 and 6 nm. In a second step, we demonstrate that the presence of functional amine groups in the outer shell of apoferr...
|
PMID: 21384882
PDF is available here.
Abstract
Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE(2) by LPS. An (18)F-FDG microPET imaging system was used to evaluate the anti-inflammato...
|
PMID: 21391605
PDF is available here.
Abstract
Narcissus bulbs contain the biologically active alkaloid galanthamine, and Narcissus is being developed as a natural source of the molecule for the pharmaceutical industry. The effect of fertilizer on galanthamine production was investigated in a field study using a (1)H nuclear magnetic resonance (N...
|
PMID: 21375239
PDF is available here.
Abstract
This paper describes the preparation of a new type of branched vegetable oil and its methyl ester that involves the formation of acetonides. A facile and environmentally friendly synthesis has been found to produce acetonides that entails the use of ferric chloride as a catalyst and is conducted at r...
|
PMID: 21375297
PDF is available here.