Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Controlled Clinical Trials as Topic (1):
Recent article
Controlled Clinical Trials as Topic
MMW Fortschritte der Medizin (153)19 2011
Abstract
| < More recent | Older article > |
Abstract
The therapeutic gain with PPIs over placebo or comparator agents for the relief of regurgitation is modest, and considerably lower than for heartburn. Thus, regurgitation is likely to be an important factor for determining incomplete response to PPI treatment in GERD. Future trials would benefit from...
|
PMID: 21537361
PDF is available here.
PDF is available here.
Pflege Zeitschrift (64)4 2011
Abstract
Abstract
Abstract
To evaluate the scientific evidence regarding laser technology for removal of carious tissue.
|
PMID: 21319941
PDF is available here.
PDF is available here.
Abstract
We performed a retrospective review of patients undergoing vertebroplasties and those patients who were referred for but did not receive vertebroplasties before and after the recently published placebo-controlled vertebroplasty trials....
|
PMID: 21349971
PDF is available here.
PDF is available here.
Abstract
We explored whether remission from depression was associated with better survival and aimed to characterize participants who remitted during the trial. Based on depression response during the 12-week treatment phase, SADHART-CHF participants were divided into 2 groups: (1) remission, defined as part...
|
PMID: 21295172
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Revue Neurologique (167)1 2011
Abstract
Botulinum toxin type A (BTX-A) is a potent neurotoxin that blocks acetylcholine release from presynaptic nerve terminals by cleaving the SNARE complex. BTX-A has been reported to have analgesic effects independent of its action on muscle tone. The most robust results have been observed in patients wi...
|
PMID: 21194720
PDF is available here.
PDF is available here.
Abstract
Molecular targeted agents represent a major breakthrough in the treatment of non-small cell lung cancer. Among these agents, Epidermal Growth Factor Receptor (EGFR) inhibitors are probably the more important so far. Whether inhibition is obtained by targeting the tyrosine kinase of the receptor (gefi...
|
PMID: 21167447
PDF is available here.
PDF is available here.
Abstract
In this nonrandomized comparison, outcomes after thrombolysis were significantly better than in untreated comparators across baseline NIHSS 5 to 24. The significant association was lost only at extremes of baseline NIHSS when sample sizes were small and confidence limits were wide....
|
PMID: 20947852
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)40 2010
Abstract
Abstract
In total, 162 studies were analyzed (136 nRCTs and 26 RCTs). Significant discrepancies between RCT- and nRCT-based results were revealed for 3 of 15 variables: overall complications (P<0.021), wound infections (P<0.014), and length of hospital stay (P<0.005). In RCTs and in nRCTs, length of hospital...
|
PMID: 20346627
PDF is available here.
PDF is available here.
Abstract
We provide the rationale, design, and preliminary data from 3 ongoing clinical trials of mobile interventions developed for bipolar disorder or schizophrenia. Project 1 used a personal digital assistant to prompt engagement in personalized self-management behaviors based on real-time data. Project 2...
|
PMID: 20921861
PDF is available here.
PDF is available here.
Abstract
Oral Diseases (16)7 2010
Abstract
To provide readers with information about the Cochrane Oral Health Group and how the reviews on oral diseases have contributed to guideline developments and the commissioning of trials.
Examples have been selected from the reviews published on The Cochrane Library. Descriptions are given of how t...
|
PMID: 20846149
PDF is available here.
PDF is available here.
La Revue du praticien (60)7 2010
Abstract
MMW Fortschritte der Medizin (152)37 2010
Abstract
MMW Fortschritte der Medizin (152)37 2010
Abstract
Abstract
Treatment with low-dose methotrexate (MTX) is an important element in the therapy of juvenile idiopathic arthritis (JIA). It could be demonstrated in placebo-controlled trials that MTX is a safe and effective drug which is generally well tolerated by children and adolescents. MTX is usually used at...
|
PMID: 20632181
PDF is available here.
PDF is available here.
Bioanalysis (2)8 2010
Abstract
Dried blood spots (DBS) sampling is a well-known technology for qualitative determination such as DNA analysis and screening of newborn metabolic disorders. The scientific community has recently expressed interest in applying the DBS technique for quantitative determination of drugs...
|
PMID: 21083350
PDF is available here.
PDF is available here.
Genetics in Medicine (12)8 2010
Abstract
These results suggest that strategies to encourage African Americans' participation in genetics research would do well to inform potential participants of how their involvement might be used to better understand important environmental factors that affect health disparities....
|
PMID: 20613544
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
Abstract
The neurological practice suffered considerable changes during the last twenty years. The recent therapeutic methods and the acceptance of the ideology of evidence based medicine, which is based on confidence in statistics, changed the reasoning of the neurologists. Therapy protocols intrude into the...
|
PMID: 20648778
PDF is available here.
PDF is available here.
Journal of Rheumatology (37)6 2010
Abstract
Abstract
Abstract
Audio, Transactions of the IRE Professional Group on (101 Suppl 1) 2010
Abstract
We are going to make a systematic review of the principal studies available on etanercept for the treatment of PA....
|
PMID: 20492877
PDF is available here.
PDF is available here.
Der Orthopäde (39)4 2010
Abstract
Even in times of kyphoplasty and vertebroplasty, braces remain an efficient option in the treatment of osteoporotic hyperkyphosis due to imminent or manifest vertebral wedging with the obligatory pain and fracture risk of adjacent vertebraes. In the same fashion, acute osteoporotic fractures with co...
|
PMID: 20358323
PDF is available here.
PDF is available here.
Abstract
We report the design, implementation, and outcome of an innovative Bayesian, response-adaptive, dose-ranging trial of an investigational drug in patients with diabetes, incorporating a dose expansion approach to flexibly address both efficacy and safety.
The design was developed to a...
|
PMID: 20338905
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Only baseline severity moderated treatment response: Higher severity showed greater improvement for risperidone but not for placebo. Weight gain mediated treatment response negatively: those who gained more weight improved less with risperidone and more with placebo. Compliance correlated with outco...
|
PMID: 20415603
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)10 2010
Abstract
Abstract
We review a body of placebo-controlled studies as well as meta-analyses on the cholinesterase (ChE) inhibitor galantamine, one of only four drugs currently approved for anti-dementia therapy in AD. WHAT THE READER WILL GAIN: The scope of this article is to concisely review the rationale of cholinerg...
|
PMID: 20113148
PDF is available here.
PDF is available here.
Abstract
Meta-analysis shows that Bevacizumab has equal efficacy and safety to Ranibizumab in treatment of ocular neovascularization. However, a high quality perspective study is still required for further analysis....
|
PMID: 20450674
PDF is available here.
PDF is available here.
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft fur Sozialpadiatrie und Deutsche Gesellschaft fur Kinderheilkunde (29)2 2010
Abstract
Abstract
Although many of the data regarding this approach are positive, not all the studies have demonstrated efficacy. It is hoped that future non-pharmaceutical company-sponsored research will clarify this issue and, should efficacy be confirmed, shed light on the mechanism of action....
|
PMID: 20306813
PDF is available here.
PDF is available here.
Modern Rheumatology (20)1 2010
Abstract
In recent years, large controlled trials have tested several new agents for systemic lupus erythematosus (SLE). Unfortunately, none of these trials has met its primary outcome. This does not mean progress has not been made. In fact, a great deal has been learned about doing clinical trials in lupus...
|
PMID: 19669389
PDF is available here.
PDF is available here.
Reumatismo (62)1 2010
Abstract
A set of 15 national recommendations for the use of MTX in daily clinical practice was developed. These recommendations are evidence-based and integrate the expertise of a large panel of Italian rheumatologists....
|
PMID: 20390116
PDF is available here.
PDF is available here.
Abstract
Whenever possible, standard methodological approaches should be applied in the design and analysis of a clinical trial that warrant adequate informative value. However, there are circumstances when the number of experimental subjects is unavoidably small. In such circumstances it is justified to con...
|
PMID: 20824446
PDF is available here.
PDF is available here.
Abstract
Twenty-four sequential trials, published between 1963 and 2005, were found. In nine studies, the information about the assumptions was sufficient to calculate a fixed sample size. The median reduction in included sample size in these trials compared with the fixed sample size calculation was 52 subj...
|
PMID: 19788954
PDF is available here.
PDF is available here.
Kardiologiia (50)2 2010
Abstract
Abstract
Cognitive intervention involves training, stimulation and rehabilitation of higher brain functions, and stands as a non pharmacological treatment option for patients with cognitive symptoms and dementia. Mild Cognitive Impairment is a syndrome that appears to capture a group of individuals in a tran...
|
PMID: 21188312
PDF is available here.
PDF is available here.
Medical Teacher (32)4 2010
Abstract
Abstract
There is substantial evidence that omega-3 fatty acids reduce blood pressure, with a greater effect in hypertensive patients and those with high-normal blood pressure. The dose of omega-3 fatty acids required to achieve a blood pressure reduction is likely to be at least 3-4 g/day. However, the magn...
|
PMID: 20196972
PDF is available here.
PDF is available here.
Abstract
There is actually only one ongoing European randomized study evaluating surgery of residual disease in patients with metastatic gastrointestinal stromal tumors responding to imatinib mesylate. Imatinib mesylate represents the standard treatment as preoperative supplement for locally unresectable and...
|
PMID: 20845798
PDF is available here.
PDF is available here.
Psychological Medicine (40)1 2010
Abstract
CBT is no better than non-specific control interventions in the treatment of schizophrenia and does not reduce relapse rates. It is effective in major depression but the size of the effect is small in treatment studies. On present evidence CBT is not an effective treatment strategy for prevention of...
|
PMID: 19476688
PDF is available here.
PDF is available here.
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft fur Sozialpadiatrie und Deutsche Gesellschaft fur Kinderheilkunde (29)1 2010
Abstract
Abstract
We found an association between participation in the German diabetes DMP and reduced mortality. This reduced mortality cannot be attributed directly to the DMP. However, further research should evaluate whether a primary care-based DMP contributes to increased life expectancy in patients with diabet...
|
PMID: 20148605
PDF is available here.
PDF is available here.
Abstract
Presently, no clinical recommendations can be made with regard to RLX and its effects on breast density. To determine the effect of RLX on breast density, larger studies need to be conducted in postmenopausal women with high breast density at baseline who are at high risk for BC, with a standardized...
|
PMID: 20032799
PDF is available here.
PDF is available here.
Abstract
After 8 weeks, the trial-based analysis showed that treatment with olmesartan versus losartan, valsartan, and irbesartan resulted in a significantly larger decrease in BP (11.5 vs 8.2, 7.9 and 9.9 mmHg [p < 0.05], respectively) and consequently more complications averted. Cost effectiveness for olme...
|
PMID: 20104934
PDF is available here.
PDF is available here.
Abstract
The antipsychotic treatment of schizophrenia is still marked by poor compliance, and drug discontinuation; the development of more effective and safer drugs still remains a challenge. Sertindole is a second-generation antipsychotic with high affinity for dopamine D(2), serotonin 5-HT(2A), 5-HT(2C),...
|
PMID: 20856845
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)46 2009
Abstract
There were 2121 patients (1062 cases in treatment group and 1059 cases in control group) from 16 controlled clinical trials were enrolled. Response rate increased (46.3% vs 40.6%, OR = 1.28, P = 0.006) and 1-year survival rate increased (44.6% vs 39.3%, OR = 1.25, P = 0.04) in treatment group than t...
|
PMID: 20193364
PDF is available here.
PDF is available here.
Abstract