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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neuromuscular Blockade (0):
Recent article
Neuromuscular Blockade
Lijecnicki vjesnik (133)3-4 2011
Abstract
Sugammadex is a new pharmacological agent for neuromuscular block reversion. It is a cyclic oligosaccharide, a gamma cyclodextrin with lipophylic inner coat that enables forming of stable complexes with steroidal neuromuscular blocking drugs, especially with rocuronium. A physical en...
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PMID: 21612107
PDF is available here.
PDF is available here.
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Anesthesiology (113)6 2010
Abstract
We hypothesized that neostigmine administered after recovery of the train-of-four (TOF) ratio impairs upper airway integrity and genioglossus muscle function.
We measured, in 10 healthy male volunteers, epiglottic and nasal mask pressures, genioglossus electromyogram, air flow, respiratory timing, a...
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PMID: 20980910
PDF is available here.
PDF is available here.
Anesthesiology (113)4 2010
Abstract
None experienced airway obstruction or arterial oxygen desaturation, even at normalized TOF ratio less than 0.4. Functional residual capacity remained unchanged whereas vital capacity decreased linearly with decreasing TOF ratio. The ability to protrude the tongue was preserved at all times. The abi...
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PMID: 20808216
PDF is available here.
PDF is available here.
The Lancet (376)9735 2010
Abstract
Abstract
40 CMAPs from 5LVB and 60 CMAPs from 6LVB patients were compared with each other within L3 to S levels. First, there was no difference between groups in the pattern of radicular pain and myotomal innervation at the level L3/4 and L4/5 (p=0.39-1.0). Second, the nerve root stimulated at the L5/6 level...
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PMID: 20581139
PDF is available here.
PDF is available here.
Abstract
Anesthesiology (113)1 2010
Abstract
L-cysteine adduction occurs at different rates by design in olefinic isoquinolinium diester neuromuscular blockers, yielding corresponding durations of action. Antagonism by exogenous L-cysteine is superior to anticholinesterases, inducing inactivation of the active molecules to restore function rap...
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PMID: 20526187
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)1 2010
Abstract
Our results suggest a lack of agreement among anesthesia providers about the best way to monitor neuromuscular function. Efforts to improve awareness by developing formal training programs and/or publishing official guidelines on best practices to reduce the incidence of postoperative neuromuscular...
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PMID: 19910616
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)1 2010
Abstract
Anesthesia & Analgesia (111)1 2010
Monitoring and pharmacologic reversal of a nondepolarizing neuromuscular blockade should be routine.
Abstract
Anesthesia & Analgesia (111)1 2010
Abstract
Anesthesia & Analgesia (111)1 2010
Abstract
Anesthesia & Analgesia (111)1 2010
Abstract
Anesthesia & Analgesia (111)1 2010
Abstract
The aim of the second part of this review is to examine optimal neuromuscular management strategies that can be used by clinicians to reduce the risk of residual paralysis in the early postoperative period. Current evidence has demonstrated that frequently used clinical tests of neuromuscular functi...
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PMID: 20442261
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)1 2010
Abstract
We summarize the clinical implications of residual neuromuscular block. Data suggest that residual neuromuscular block is a common complication in the postanesthesia care unit, with approximately 40% of patients exhibiting a train-of-four ratio <0.9. Volunteer studies have demonstrated that small de...
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PMID: 20442260
PDF is available here.
PDF is available here.
Abstract
Abstract
Emergency physicians perform tracheal intubation and initiate mechanical ventilation for critically ill patients on a daily basis. With the current national challenges of intensive care unit bed availability, intubated patients now often remain in the emergency department (ED) for exceedingly long pe...
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PMID: 20363578
PDF is available here.
PDF is available here.
Abstract
Abstract
We administered sugammadex to a patient with myasthenia gravis to reverse a rocuronium-induced profound NMB. NMBDs predispose such patients to severe postoperative residual paralysis and respiratory complications. Sugammadex binds steroidal NMBDs and, therefore reverses a rocuronium or vecuronium-in...
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PMID: 20422852
PDF is available here.
PDF is available here.
Abstract
Many recent studies have underlined the importance of quantitative neuromuscular monitoring and the high incidence of residual block in clinical practice in spite of the use of nondepolarizing neuromuscular blockers of intermediate duration. Neuromuscular monitoring facilitates the tailoring of the...
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PMID: 20422848
PDF is available here.
PDF is available here.
Medicina Intensiva (34)2 2010
Abstract
We have achieved a return to spontaneous circulation in a growing proportion of patients with cardiac arrest. Nevertheless, most of these patients die in the first few days after admission to the intensive care unit (ICU), and this situation has not improved over the years. Mortality in these patien...
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PMID: 19931943
PDF is available here.
PDF is available here.
Abstract
Abstract
We review the literature on sugammadex published to date....
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PMID: 20337001
PDF is available here.
PDF is available here.
Abstract
Abstract
We managed 10 cases of propofol anesthesia with rocuronium, and recorded the time course of the neuromuscular blockade evaluated through accelerometry, as well as the estimated blood concentrations of rocuronium calculated from the administration history with a pharmacokinetic simulation analysis. R...
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PMID: 20077775
PDF is available here.
PDF is available here.
Abstract
The review covers the history of neuromuscular block reversal. It states that indications for decurarization have been changed due to the extremely high rate of residual curarization even after the use of average-acting myorelaxants. The paper provides the pharmacological characteristics of sugammad...
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PMID: 20524330
PDF is available here.
PDF is available here.
Abstract
We conducted a prospective observational study to assess the incidence of residual neuromuscular blockade (RNMB) in a post-anaesthetic care unit (PACU) of a tertiary hospital. The subjects were 102 patients undergoing general anaesthesia with neuromuscular blockade (NMB). The procedural anaesthetist...
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PMID: 20191783
PDF is available here.
PDF is available here.
Anesthesiology (112)1 2010
Abstract
When given at a TOF ratio of either 0.4 or 0.6, time to 0.9 and 1.0 TOF ratio was significantly shorter with any dose of neostigmine than without. The probability of successful reversal after 20 microg/kg neostigmine was 100% when a TOF ratio of 0.9 was the target; for a TOF ratio of 1.0, the probab...
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PMID: 19952724
PDF is available here.
PDF is available here.
Anesthesiology (112)1 2010
Abstract
Abstract
We investigated the differences between males and females in the reversal effect of neostigmine on neuromuscular blockade. Thirty male and 30 female patients undergoing elective general anesthesia were studied. Vecuronium was given in all patients anesthetized with nitrous oxide, oxygen, and sevoflu...
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PMID: 20608096
PDF is available here.
PDF is available here.
Abstract
Medical Science Monitor (15)11 2009
Abstract
Memantine inhibits neuromuscular transmission in vitro and with in vivo treatment. LD/CD treatment enhances neuromuscular transmission. Clinical implications need further investigation....
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PMID: 19865051
PDF is available here.
PDF is available here.
Abstract
We suggest that monitoring neuromuscular function may be necessary to detect subtle residual neuromuscular blockade when rocuronium is used in a patient with CMTD and liver dysfunction....
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PMID: 19860243
PDF is available here.
PDF is available here.
Abstract
There were no significant differences between groups in terms of QTc (Fridericia) interval. Three serious adverse events, one in each treatment group, considered to be possibly drug-related according to the investigator, were cases of mild QTc (Bazett) interval prolongation. Blood pressure and heart...
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PMID: 19455040
PDF is available here.
PDF is available here.
Abstract
We set out to describe ventilation practice, the use of lung-protective ventilation strategies, administration of sedation and neuromuscular blockade, and related critical events during out-of-hospital transport of ventilated patients. Methods. We conducted a population-based retrospective co...
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PMID: 19499467
PDF is available here.
PDF is available here.
Anaesthesist (58)7 2009
Abstract
The management of general anaesthesia in patients with neuromuscular disorders remains challenging. The underlying causes and clinical presentations of these rare heterogeneous diseases are highly variable and the only common feature is usually skeletal muscle weakness. The appropriate choice and do...
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PMID: 19590832
PDF is available here.
PDF is available here.
Pediatric Emergency Care (25)6 2009
Abstract
A significant proportion of pediatric patients receiving etomidate and rocuronium or vecuronium during endotracheal intubation are likely experiencing ongoing paralysis without adequate sedation. Emergency medicine physicians should be cognizant of this when using these medications for facilitating...
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PMID: 19458564
PDF is available here.
PDF is available here.
Abstract
Sub-Tenon's anaesthesia, a versatile and technically easy procedure to master, has gained popularity with both ophthalmic surgeons and anaesthetists. This block is achieving repute as the block of choice, providing anaesthesia as well as akinesia during ophthalmic surgery. As the technique has furth...
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PMID: 19367161
PDF is available here.
PDF is available here.
Abstract
Neostigmine, the currently used agent for reversal of neuromuscular block, has several drawbacks, such as a slow onset of peak effect, inability to reverse deep block and the occurrence of widespread muscarinic effects. Sugammadex is a new class of reversal agent that acts by encapsulating the molec...
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PMID: 19402771
PDF is available here.
PDF is available here.
Abstract
Ugeskrift for laeger (171)13 2009
Abstract
Anaesthesia (64 Suppl 1) 2009
Abstract
Sugammadex is a cyclodextrin molecule that encapsulates and inactivates rocuronium and vecuronium. As a result, any degree of neuromuscular block produced by rocuronium or vecuronium can be rapidly and completely reversed without autonomic effects. Because sugammadex is optimised for reversing rocur...
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PMID: 19222433
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
These results offer support for the further development of sugammadex for clinical use in humans....
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PMID: 19222430
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
The availability of sugammadex allows greater flexibility in the use of rocuronium and vecuronium during anaesthesia and surgery. The neuromuscular block induced by both drugs can be reversed from both superficial and deep levels of block by adjusting the dose of sugammadex. The dose of sugammadex f...
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PMID: 19222431
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
Residual paralysis, with its subsequent postoperative pulmonary sequelae, is one of the major complications of anaesthesia, and was recognised shortly after the introduction of neuromuscular blocking drugs into routine clinical practice. Although its incidence decreased with the introduction of inte...
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PMID: 19222429
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
Anaesthesia (64 Suppl 1) 2009
Abstract
There is now mounting evidence that even small degrees of postoperative residual neuromuscular block increases the incidence of adverse respiratory events in the Post Anaesthesia Care Unit and may increase longer-term morbidity as well. In the absence of quantitative neuromuscular monitoring, residu...
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PMID: 19222428
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
The first part of this article presents an update of the basic considerations of neuromuscular monitoring. It emphasises the need to assure supramaximal stimulation, to place the stimulating electrodes correctly and to use appropriate sites for nerve stimulation as well as appropriate stimulation pa...
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PMID: 19222435
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
No drugs in anaesthesia are more problematic than suxamethonium. Yet, no drugs have survived as suxamethonium does in spite of crisis after crisis, and attempt after attempt at its replacement. For decades, suxamethonium has taught us neuromuscular pharmacology and provided us with an encyclopaedia...
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PMID: 19222434
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
The pharmacodynamics and pharmacokinetics of the currently available neuromuscular blocking and reversal drugs may be altered by organ disease. Adverse effects such as prolonged neuromuscular block, postoperative residual curarisation, recurarisation, the muscarinic effects of the anticholinesterase...
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PMID: 19222432
PDF is available here.
PDF is available here.
Anaesthesia (64 Suppl 1) 2009
Abstract
Neuromuscular blocking drugs are designed to bind to the nicotinic receptor at the neuromuscular junction. However, they also interact with other acetylcholine receptors in the body. Binding to these receptors causes adverse effects that vary with the specificity for the cholinergic receptor in ques...
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PMID: 19222427
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)3 2009
Abstract
The facial nerve monitoring via facial electromyographic responses can be obtained when an intraoperative partial neuromuscular blockade is induced to provide an adequate immobilization of the patient. The 50% NMB should be considered as the choice of anesthetic management for facial nerve monitorin...
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PMID: 19236810
PDF is available here.
PDF is available here.
Abstract
We concluded that the 10 cmH2O of PEEP attenuates the effects of PnP in respiratory mechanics, lowering R(RS), E(P), and E(RS). These effects may be useful in the ventilatory approach for patients experiencing a non-physiological increase in IAP owing to PnP in laparoscopic procedures....
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PMID: 19175578
PDF is available here.
PDF is available here.
Abstract
Increased RE is followed by increased SE at nociceptive stimuli in patients not receiving neuromuscular blockers. Owing to their overlapping power spectra, the contribution of EMG and EEG cannot be accurately separated with frequency analysis in the range of 10-40 Hz....
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PMID: 19112059
PDF is available here.
PDF is available here.
Abstract
Depression ofT1/T0 was enhanced under sevoflurane compared to TIVA. ED50 and ED95 values of both drugs were significantly lower under sevoflurane more than TIVA. Recovery index 25-75% and time to a TOF ration of 0.70 were prolonged significantly by sevoflurane compared to TIVA. Hemodynamically, rocu...
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PMID: 19266825
PDF is available here.
PDF is available here.
Abstract
Administration of rocuronium at dose of 0.25 to 0.5 mg/kg IM is a safe and effective adjunct to clinical proceedings or pre-anesthetics in P. expansa. Because rocuronium does not provide any analgesic or sedative effects, the duration of neuromuscular blockade without anesthesia should be minimized...
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PMID: 19705031
PDF is available here.
PDF is available here.
Abstract
Abstract
Sugammadex effectively and safely reverses a rocuronium-induced neuromuscular blockade in less than 2 minutes in long-duration surgery performed under both inhaled and intravenous anesthesia. The interaction of neuromuscular blocking agents with sevoflurane appears not to affect the reversal time of...
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PMID: 19725342
PDF is available here.
PDF is available here.
Abstract
Local anesthetics caused a potentiation of the neuromuscular blockade produced by rocuronium. The results showed pre- and post-synaptic effects....
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PMID: 20011862
PDF is available here.
PDF is available here.
Abstract
I presented to otolaryngology clinic with important complaints of stridor and dyspnoea. There was no comorbidity. Routine investigations were normal. Indirect laryngoscopic examination revealed pedunculated mass (polyp) arising from subglottic region, with a size of 0.7 x 0.5 cm and its pedicle was...
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PMID: 20187489
PDF is available here.
PDF is available here.