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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Radiometry (7):
Recent article
Radiometry
Abstract
I study were to evaluate radiation dosimetry, biodistribution, human safety, tolerability, and early elimination of (18)F activity in urine after injection of a single dose of the tracer at rest in healthy subjects....
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PMID: 21849402
PDF is available here.
PDF is available here.
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Abstract
(18)F-fluoropaclitaxel is a radiolabeled form of paclitaxel, a widely used chemotherapy agent. Preclinical data suggest that (18)F-fluoropaclitaxel may be a reasonable surrogate for measuring the uptake of paclitaxel. As a substrate of P-glycoprotein, a drug efflux pump associated with multidrug resi...
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PMID: 21849404
PDF is available here.
PDF is available here.
Abstract
Preclinical studies have indicated that somatostatin receptor (sst)-expressing tumors demonstrate higher uptake of radiolabeled sst antagonists than of sst agonists. In this study, we evaluated whether imaging with sst antagonists was feasible in patients.
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PMID: 21852357
PDF is available here.
PDF is available here.
Medical Physics (38)7 2011
Abstract
A statistical projection restoration algorithm based on the penalized weighted least-squares (PWLS) criterion can substantially improve the image quality of low-dose CBCT images. The performance of PWLS is largely dependent on the choice of the penalty parameter. Previously, the pena...
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PMID: 21859005
PDF is available here.
PDF is available here.
Medical Physics (38)6 2011
Abstract
In the radiopharmaceutical therapy approach to the fight against cancer, in particular when it comes to translating laboratory results to the clinical setting, modeling has served as an invaluable tool for guidance and for understanding the processes operating at the cellular level and how these rela...
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PMID: 21815364
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)12 2011
Abstract
(111)In-hPAM4 showed normal biodistribution with radiation dose estimates to red marrow and solid organs acceptable for radioimmunotherapy and with tumor targeting in 12 patients. One patient withdrew before (90)Y-hPAM4; otherwise, 20 patients received (90)Y doses of 15 (N = 7), 20 (N = 9), and 25 m...
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PMID: 21527562
PDF is available here.
PDF is available here.
Minerva endocrinologica (36)2 2011
Abstract
The efficacy of low and high fixed dose radioactive iodine (RAI) therapy in patients with toxic nodular goiter was investigated.
Ninety-three patients (25 males, 68 females) were included into the study (32 patients with toxic adenoma, 61 patients with toxic multinodu...
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PMID: 21519320
PDF is available here.
PDF is available here.
Abstract
Digital radiography (DR) is one of several new products that have changed our work processes from hard copy to digital formats. The transition from analog screen-film radiography to DR requires thorough user education because of differences in image production, processing, storage and evaluation betw...
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PMID: 21491200
PDF is available here.
PDF is available here.
Abstract
Abstract
On Feb. 4, 2010, the Alliance for Radiation Safety in Pediatric Radiology held a Pediatric Digital Radiography Summit. The goal was for radiologists, radiologic technologists, medical physicists, and vendor representatives, including engineers, medical physicists and education specialists, to discuss...
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PMID: 21491196
PDF is available here.
PDF is available here.
Medical Physics (38)4 2011
Abstract
The aim of this work is the dosimetric validation of a deterministic radiation transport based treatment planning system (BRACHYVISION v. 8.8, referred to as TPS in the following) for multiple 192Ir source dwell position brachytherapy applications employing a shielded applicator in homogeneous water...
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PMID: 21626931
PDF is available here.
PDF is available here.
Medical Physics (38)4 2011
Abstract
The purpose of this study was to investigate whether or not a stem effect removal technique is necessary when performing Ir-192 HDR brachytherapy in vivo dosimetry using a scintillation detector.
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PMID: 21626951
PDF is available here.
PDF is available here.
Medical Physics (38)4 2011
Abstract
The dosimetric accuracy of the recently released Acuros XB advanced dose calculation algorithm (Varian Medical Systems, Palo Alto, CA) is investigated for single radiation fields incident on homogeneous and heterogeneous geometries, and a comparison is made to the analytical anisotropic algorithm (AA...
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PMID: 21626955
PDF is available here.
PDF is available here.
Medical Physics (38)4 2011
Water equivalent path length measurement in proton radiotherapy using time resolved diode dosimetry.
Abstract
To verify water equivalent path length (WEPL) before treatment in proton radiotherapy using time resolved in vivo diode dosimetry.
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PMID: 21626963
PDF is available here.
PDF is available here.
Medical Physics (38)4 2011
Abstract
MLC leaf gap consistency is critical for the accurate delivery of dynamic IMRT plans. It is estimated that a systematic MLC leaf gap change of 0.6 mm will result in a 2% change to the equivalent uniform dose to a clinical target volume for a typical head and neck sliding window (SW) IMRT plan. The ai...
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PMID: 21626959
PDF is available here.
PDF is available here.
Medical Physics (38)3 2011
Abstract
To evaluate the robustness of TG119-based quality assurance metrics for an IMRT system.
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PMID: 21520877
PDF is available here.
PDF is available here.
Medical Physics (38)3 2011
Abstract
Quality management for any use of medical x-ray imaging should include monitoring of radiation dose. Fluoroscopically guided interventional (FGI) procedures are inherently clinically variable and have the potential for inducing deterministic injuries in patients. The use of a conventional diagnostic...
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PMID: 21520873
PDF is available here.
PDF is available here.
Medical Physics (38)3 2011
Abstract
Medical Physics (38)3 2011
Abstract
Focused radiation therapy by direct intratumoral infusion of lipid nanoparticle (liposome)-carried beta-emitting radionuclides has shown promising results in animal model studies; however, little is known about the impact the intratumoral liposomal radionuclide distribution may have on tumor control....
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PMID: 21520844
PDF is available here.
PDF is available here.
Medical Physics (38)3 2011
Abstract
Dosimetric uncertainty in the surface and superficial regions is still a major concern for radiation therapy and becomes more important when using the inverse planning algorithm for IMRT. The purpose of this study was to measure dose distributions and to evaluate the calculation accuracy in the super...
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PMID: 21520855
PDF is available here.
PDF is available here.
Medical Physics (38)3 2011
Abstract
In the present era of cone-beam CT scanners, the use of the standardized CTDI100 as a surrogate of the idealized CTDI is strongly discouraged and, consequently, so should be the use of the dose-length product (DLP) as an estimate of the total energy imparted to the patient. However, the DLP is still...
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PMID: 21520859
PDF is available here.
PDF is available here.
Abstract
Abstract
Xenobiotics, including therapeutic agents, can produce a variety of beneficial, as well as adverse, effects in mammals. One potential source of drug-mediated toxicity stems from metabolic activation of the parent compound, typically catalyzed by one or more members of the cytochrome P450 family of e...
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PMID: 20972760
PDF is available here.
PDF is available here.
Abstract
One major objective of total body irradiation (TBI) treatments is to deliver a uniform dose in the entire body of the patient. Looking at 3D dose distributions for constant speed (CstSpeed) and variable speed (VarSpeed) translating couch TBI treatments, dose uniformity and the effect...
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PMID: 21844851
PDF is available here.
PDF is available here.
Abstract
We analyze the case of double dendrimer conjugation with pH-sensitive and pH-insensitive molecules leading to the realization of ratiometric pH sensors that are calibrated in vitro and in living cells. By tuning the physicochemical properties of the dendrimer scaffold sensors can be targeted to spec...
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PMID: 21141854
PDF is available here.
PDF is available here.
Abstract
To estimate the minimum dose needed at follow-up cranial computed tomography (CCT) to reliably determine ventricular width in children with hydrocephalus.
For the study, a phantom was created using the calvarium of an infant which was filled with gelatin and the shaped inner cones of two carrots ser...
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PMID: 20972937
PDF is available here.
PDF is available here.
Abstract
Besides photons and electrons, high-energy particles like protons, neutrons, ⁴He ions or heavier ions (C, Ne, etc) have been finding increasing applications in the treatment of radioresistant tumors and tumors located near critical structures. The main difference between photons and hadrons is the...
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PMID: 20395789
PDF is available here.
PDF is available here.
Abstract
Samarium-153 ethylenediamine tetramethylene phosphoric acid (153Sm-EDTMP) is a radiopharmaceutical that has been used to treat osteosarcoma. The authors conducted a phase 2 study to test safety and response of high-risk osteosarcoma to tandem doses of 153Sm-EDTMP and to determine cor...
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PMID: 20715156
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an (18)F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrati...
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PMID: 20862423
PDF is available here.
PDF is available here.
Abstract
Myocardial perfusion imaging (MPI) is the single medical test with the highest radiation burden to the US population. Although many patients undergoing MPI receive repeat MPI testing, or additional procedures involving ionizing radiation, no data are available characterizing their total longitudinal...
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PMID: 21078807
PDF is available here.
PDF is available here.
Abstract
Recently, ion beam radiotherapy (including protons as well as heavier ions) gained considerable interest. Although ion beam radiotherapy requires dose prescription in terms of iso-effective dose (referring to an iso-effective photon dose), absorbed dose is still required as an operative quantity to...
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PMID: 20952816
PDF is available here.
PDF is available here.
Health Physics (99)5 2010
Abstract
We studied a series of phantoms of varying complexity of geometry, with three radionuclides whose decay schemes varied from simple to complex. Four aqueous concentrations of ⁹⁹mTc, ¹³¹I, and ¹¹¹In (74, 185, 370, and 740 kBq mL⁻¹) were placed in spheres of four different sizes in a water...
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PMID: 20938240
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to verify the advanced inhomogeneous dose distribution produced by a volumetric arc therapy technique (RapidArc) using 3D gel measurements and Monte Carlo (MC) simulations. The TPS (treatment planning system)-calculated dose distribution was compared with gel measurements a...
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PMID: 20679702
PDF is available here.
PDF is available here.
Abstract
We are confident to be able to treat moderately moving targets on Gantry 2 using repainted pencil-beam spot scanning. Continuous line scanning seems to be the most elegant solution; it provides higher repainting rates and produces superior results but is probably more difficult to realize. For large...
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PMID: 20702927
PDF is available here.
PDF is available here.
Abstract
We present a spatiotemporal optimization method, which takes into account all phases of breathing via the corresponding 4D-CTs and provides a 4D-optimal plan that can be delivered throughout all breathing phases. Monte Carlo dose calculations are employed to warrant for highest dosimetric accuracy,...
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PMID: 20714043
PDF is available here.
PDF is available here.
Abstract
We present a graphics processing unit (GPU)-based simulation framework to calculate the delivered dose to a 3D moving lung tumor and its surrounding normal tissues, which are undergoing subject-specific lung deformations. The GPU-based simulation framework models the motion of the 3D volumetric lung...
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PMID: 20714041
PDF is available here.
PDF is available here.
Abstract
The frequency distribution of the lineal energy, y, of a 290 MeV/u carbon beam was measured to obtain the dose-weighted mean of y and compare it with the linear energy transfer (LET). In the experiment, a wall-less tissue-equivalent proportional counter (TEPC) in a cylindrical volume with a simulate...
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PMID: 20702924
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to develop an oscillating sweeping gap test for volumetric modulated arc therapy (VMAT) quality assurance (QA). A novel test was designed and used to simultaneously determine uncertainties associated with linac performance, dose calculation and dosimetric MLC paramete...
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PMID: 20702923
PDF is available here.
PDF is available here.
Abstract
In the recent past, computed tomography (CT) use has grown by approximately 10% per year, with 62 million examinations performed in the USA in 2006. While these studies make up only 15% of the total number of radiologic examinations, they contribute approximately half of the public exposure due to m...
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PMID: 20723832
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The bronchial tree has little effect on the global deformation and the accuracy of deformable image registration of lungs. Hence, the homogenous model is a reasonable assumption. Since there are some local deformation differences between nodes as the material properties of the bronchial tree change...
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PMID: 20964173
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
Dosimetry issues observed in a transverse linac-MR geometry such as changes to the depth dose distribution and tissue interface effects were significantly reduced or eliminated in a longitudinal geometry on a representative lung plan. Further, an increase in dose to the PTV, resulting from the magne...
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PMID: 20964190
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The uncertainty in measuring dose resulting from a kilovoltage beam used in IGRT is approximately 20%; this uncertainty is mainly due to the sensitivity dependence of the incident beam direction relative to the OneDose detector. The ease of use may allow the dosimeter to be suitable for estimating t...
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PMID: 20964206
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
When calibrated in 60Co or MV photon beams, corrections for the photon energy dependence of detector response are needed to achieve the highest accuracy when using lithium formate EPR dosimeters for measuring absorbed doses around brachytherapy sources emitting photons in the energy range of 20-150...
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PMID: 20964214
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The authors conclude that a combination of MCS algorithms is required to accurately reproduce experimental data of single pencil beams and 3-D dose distributions for the scanning beam nozzle. In addition, the MC simulations showed that because of the low-dose envelope, ionization chambers with radii...
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PMID: 20964215
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
This study demonstrated that MHI-TM2000 has the capability for high leaf position accuracy and low leakage, leading to highly accurate intensity-modulated radiotherapy delivery. Furthermore, substantial changes in the dosimetric data on field characteristics and leaf position accuracy were not obser...
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PMID: 20964187
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The GEANT4-DNA physics models available in the GEANT4 toolkit have been compared in this article to available experimental data in the water vapor phase as well as to several published recommendations on the mass stopping power. These models represent a first step in the extension of the GEANT4 Mont...
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PMID: 20964188
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The results suggest that %deltaD near the cable region is larger than previously estimated. The spatial distribution of the dose deviation is highly dependent on the reference TG-43 data used to compare to GBBS. The differences observed, while important to realize, should not have an impact on clini...
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PMID: 20964191
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The films demonstrated a lower sensitivity to absorbed dose measurements due to the geometric inefficiency of measuring dose from a beam situated end-on to the film. Once corrected, the film demonstrated equivalent dose measurement accuracy as TLD detectors with the added advantage of relatively sim...
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PMID: 20964198
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
Helical tomotherapy is a relatively new modality with integrated treatment planning and delivery hardware for radiation therapy treatments. In view of the uniqueness of the hardware design of the helical tomotherapy unit and its implications in routine quality assurance, the Therapy Physics Committe...
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PMID: 20964201
PDF is available here.
PDF is available here.
Medical Physics (37)9 2010
Abstract
The compensator-based field and both types of MLC-based fields have MatriXX results that are within the clinically acceptable tolerance of 3% dose difference and 2 mm DTA. However, when the criteria are tightened, it becomes evident that the compensators have a definite advantage over their comparab...
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PMID: 20964202
PDF is available here.
PDF is available here.
Abstract
We measured the tissue and organ doses by test site in 4-row, 16-row, and 64-row multi detector CT by using an anthropomorphic phantom and fluorescent glass dosimeters. Furthermore, we calculated the effective dose by using the tissue weighting factor recommended by the ICRP in 2007. The effective d...
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PMID: 20953106
PDF is available here.
PDF is available here.
Abstract
We formulated a basic equation by mathematically representing all factors that influence imaging conditions. Using the basic equation, we succeeded in determining the optimal exposure condition for a patient's body thickness by calculation. Even if another equipment, grid, added filter, etc., is use...
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PMID: 20953104
PDF is available here.
PDF is available here.
Abstract
This work investigated the accuracy of Monte Carlo (MC) simulations of amorphous silicon (a-Si) electronic portal imaging devices (EPIDs) for the dosimetric verification of intensity-modulated radiotherapy (IMRT). In particular, the suitability of the method for verification of head and neck IMRT wi...
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PMID: 20668335
PDF is available here.
PDF is available here.
Abstract
The purpose of this study is to determine whether dose to medium, D(m), or dose to water, D(w), provides a better estimate of the dose to the radiosensitive red bone marrow (RBM) and bone surface cells (BSC) in spongiosa, or cancellous bone. This is addressed in the larger context of the ongoing deb...
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PMID: 20668336
PDF is available here.
PDF is available here.
Abstract
Modern cancer treatment techniques, such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), have greatly increased the demand for more accurate treatment planning (structure definition, dose calculation, etc) and dose delivery. The ability to use fast and...
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PMID: 20668343
PDF is available here.
PDF is available here.
Abstract
A model of irradiated cell survival based on rigorous accounting of microdosimetric effects is developed. The model does not assume that the distribution of lesions is Poisson and is applicable to low, intermediate and high acute doses of low or high LET radiation. For small doses, the model produce...
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PMID: 20671352
PDF is available here.
PDF is available here.
Investigation of systematic uncertainties in Monte Carlo-calculated beam quality correction factors.
Abstract
I in the electron stopping powers are varied. The corresponding sensitivities are subsequently applied with information of standard uncertainties for the cross section data found in the literature. It turns out that the calculation of k(Q) factors with EGSnrc is mostly insensitive to transport setti...
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PMID: 20668340
PDF is available here.
PDF is available here.
Abstract
We investigate the effect of varying the glandular/adipose proportion of the breast tissue on dose distributions. The dose to the PTV (skin) decreases (increases) with the increasing adipose proportion inside the breast. In a complete geometry and compared to a TG43-like situation, the average PTV D...
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PMID: 20668347
PDF is available here.
PDF is available here.
Abstract
We are planning to implement MC calculations for head and neck and lung cancer patients....
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PMID: 20668337
PDF is available here.
PDF is available here.
Abstract
The effective doses of (11)C-MePPEP and (18)F-FMPEP-d (2) are 4.6 and 19.7 muSv/MBq, respectively. Both radioligands demonstrated high uptake of radioactivity in liver, lung, and brain shortly after injection and accumulated radioactivity in bone marrow towards the end of the scan. After injection o...
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PMID: 20333514
PDF is available here.
PDF is available here.