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Whole-Body Irradiation (0):
Recent article
Whole-Body Irradiation
Abstract
A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematologic malignancies who are older or have comorbid conditions.
To describe outcomes of patients 60 years or older afte...
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PMID: 22045765
PDF is available here.
PDF is available here.
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Abstract
The effects of aqueous (PnAq) and alcoholic (PnA1 extract (50-250 mg/kg) of P. niruri on in vivo gamma radiation induced chromosome aberration and in vitro antioxidant activity (50-500 microg/ml) were studied. The antioxidant activity was studied by measuring inhibition of hydroxyl r...
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PMID: 21941945
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We targeted myeloid cell subsets from different compartments and examined disease pathogenesis in three different mouse models of AD (APP(swe/PS1), APP(swe), and APP23 mice). We identified chemokine receptor 2 (CCR2)-expressing myeloid cells as the population that was preferentially recruited to β-...
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PMID: 21813677
PDF is available here.
PDF is available here.
Oral Oncology (47)9 2011
Abstract
To study salivary secretion rates and symptoms of xerostomia in children and adolescents conditioned with either radiation therapy or with chemotherapy only in the setting of hematopoietic stem cell transplantation (HSCT). Thirty patients conditioned with 10 Gy single dose TBI (sTBI) and cyclophospha...
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PMID: 21784697
PDF is available here.
PDF is available here.
Abstract
To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields.
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PMID: 21294690
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We analyzed altered protein expressions in various tissues, namely, brain, lung, spleen, and intestine, from 1 Gy-irradiated mice by employing 2-DE analysis. MALDI-TOF MS and peptide mapping identified 25 proteins that showed greater than twofold expressional changes. In order to confirm signific...
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PMID: 21319302
PDF is available here.
PDF is available here.
Mutation Research (722)1 2011
Abstract
α-Asarone (1-propenyl-2,4,5-methoxybenzol), one of the active components of Acorus calamus extract, was examined for its efficacy as a radioprotector in mice exposed to lethal and sublethal whole-body γ-radiation. Oral administration of α-asarone 1h prior to the radiation exposure reduced radiatio...
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PMID: 21440084
PDF is available here.
PDF is available here.
Abstract
We examined their oxidation potentials and radical scavenging properties in comparison to other semicarbazone and pyrazole curcumin derivatives with less effective DMFs. Comparisons between D12, D13, D56, and D68 and other semicarbazone and pyrazole derivatives of curcumin did not show a sufficient...
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PMID: 21445800
PDF is available here.
PDF is available here.
Abstract
This study aimed to describe the Rarebit (RB) visual field and optic nerve size/morphology in patients treated with allogeneic stem-cell transplantation (SCT) in childhood, and to determine the impact of ocular status and conditioning regimens such as total body irradiation (TBI), ch...
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PMID: 20064124
PDF is available here.
PDF is available here.
Abstract
We previously showed that this ratio increases dramatically in murine small bowel within 48 hours following whole body irradiation. We now report that those levels continue to rise for four days and remain elevated at close to that level beyond 30 days after 5 Gy of irradiation.We further demonstrat...
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PMID: 21445788
PDF is available here.
PDF is available here.
Abstract
One major objective of total body irradiation (TBI) treatments is to deliver a uniform dose in the entire body of the patient. Looking at 3D dose distributions for constant speed (CstSpeed) and variable speed (VarSpeed) translating couch TBI treatments, dose uniformity and the effect...
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PMID: 21844851
PDF is available here.
PDF is available here.
Abstract
We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by overall survival (OS) and disease-free survival (DFS). Acute and late toxicity were secondary endpoints. Meta-an...
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PMID: 21460603
PDF is available here.
PDF is available here.
Abstract
Treatment with rapamycin (RAPA) favorably affects regulatory T cells (Treg) in vivo, and RAPA induces the de novo expression of FOXP3 in murine alloantigen-specific T cells. Whether RAPA acts independently or with transforming growth factor beta (TGF-β) to produce ex vivo-induced Tr...
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PMID: 21147213
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
We observed increased ATP concentrations in the peritoneal fluid after total body irradiation, and during the development of GVHD in mice and in humans. Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of...
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PMID: 21102458
PDF is available here.
PDF is available here.
Abstract
Of 73 patients, 26 received CY/E/TBI and 47 received BEAM. The median follow-up for the CY/E/TBI group was 12.0 years and for the BEAM group was 7.3 years. After PBSCT, no differences in acute toxicity were seen between the two groups. The 5-year disease relapse-free survival rate was 50.0% and 50.7...
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PMID: 20137862
PDF is available here.
PDF is available here.
Abstract
We report the case of a 42-year-old woman who presented with multiple pulmonary nodules. Surgical resection of 3 nodules revealed differentiated thyroid carcinoma. Thyroid and neck ultrasound was normal. A review of her history revealed that this patient underwent an ovarian cyst resection 15 years...
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PMID: 20706043
PDF is available here.
PDF is available here.
Abstract
Our retrospective study assessed the utility of bone scans as a diagnostic tool to identify candidate vertebral levels for vertebroplasty and determined that bone scans were positive in 78.3% of all fractures that subsequently underwent vertebral augmentation procedures. Although no significant diff...
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PMID: 20706042
PDF is available here.
PDF is available here.
Clinical Immunology (136)2 2010
Abstract
Clinical Immunology (136)2 2010
Abstract
We describe a novel approach that uses delivery of alloantigen by mature T cells to induce tolerance to fully allogeneic cardiac grafts. Adoptive transfer of mature alloantigen-expressing T cells into myeloablatively conditioned mice results in long-term acceptance of fully allogeneic heart transpla...
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PMID: 20452826
PDF is available here.
PDF is available here.
British Journal of Radiology (83)992 2010
Abstract
We have therefore developed a new biodosimetric technique targeting circulating B1 DNA in mouse plasma by branched DNA signal amplification for rapid quantification of plasma DNA. This technology targets repetitive elements of the B1 retrotransposon in the mouse genome, followed by signal amplificat...
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PMID: 20675464
PDF is available here.
PDF is available here.
Abstract
The findings suggest the ability of IB-MECA to stimulate hematopoiesis and to support the hematopoiesis-stimulating effects of G-CSF in sublethally irradiated mice....
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PMID: 20586541
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that ionizing radiation can induce endothelial dysfunction, which contributes to increased vascular stiffness. In this study, we demonstrate that gamma radiation exposure reduced endothelial cell viability or proliferative capacity using an in vitro aortic angiogenesi...
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PMID: 20401726
PDF is available here.
PDF is available here.
Abstract
We investigated in vivo differential effects of gamma-rays and HZE ions on intestinal tumorigenesis using two different murine models, ApcMin/+ and Apc1638N/+. We showed that gamma- and/or HZE exposure significantly enhances development and progression of intestinal tumors in a mutant-line-specific...
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PMID: 20490531
PDF is available here.
PDF is available here.
Abstract
Using D2-40, our results demonstrated a significantly greater detection rate (p = .031) of LVI compared with routine HE staining. LVI was correctly identified by D2-40 (D2-40-positive LVI) in 10 (13.5%) of 74 tumors. On routine HE staining, 4 tumors (5.4%) were classified as HE-positive LVI. Doubles...
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PMID: 20133078
PDF is available here.
PDF is available here.
Abstract
Cancer Research (70)12 2010
Abstract
We aimed to develop a mouse model of pulmonary metastasis that can be assayed in multiple inbred mouse strains for further use in identification of host genetic variants that influence metastasis. We used i.v. injection of Sarcoma 180 (S180) cells, which can be tracked and quantified by bioluminesce...
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PMID: 20501835
PDF is available here.
PDF is available here.
Inflammation Research (59)6 2010
Abstract
The absence of histamine adversely affects splenic hematopoiesis via direct and indirect mechanisms....
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PMID: 19921486
PDF is available here.
PDF is available here.
Journal of Immunological Methods (357)1-2 2010
Abstract
We describe a model whereby lead shields protect resident cell populations in the lungs from radiation during bone marrow transplantation but permit full bone marrow engraftment. This system may be applicable to other organ systems in which protection from radiation during bone marrow transplantatio...
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PMID: 20347833
PDF is available here.
PDF is available here.
Health Physics (98)6 2010
Abstract
The 1986 Chernobyl Nuclear Power Plant accident that occurred is known as the most severe nuclear disaster in the history of humankind. Acute radiation syndrome (ARS) was diagnosed in 237 persons but only 134 of those were confirmed, including 28 patients who died due to lethal total-body gamma-irra...
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PMID: 20445398
PDF is available here.
PDF is available here.
Health Physics (98)5 2010
Abstract
I activity added to a large NaOH-filled rectangular phantom. The desired dose rate is maintained at essentially constant levels by weekly additions of I to compensate for decay. Dosimetry results for long-term animal irradiation at targeted dose rates of 0.00021 and 0.0021 cGy min are presented....
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PMID: 20386202
PDF is available here.
PDF is available here.
Oncology Reports (23)5 2010
Abstract
Experiments were conducted to assay whether monoenergetic neutron-induced genetic damage in parental germline cells can give rise to development of cancer in the offspring. Seven-week-old C3H male mice were irradiated with monoenergetic neutrons with energy levels of 0.2 or 0.6 MeV at doses of 0, 50...
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PMID: 20372851
PDF is available here.
PDF is available here.
Abstract
Stereotactic body radiation therapy (SBRT) has emerged as a novel treatment modality for spinal metastases. Due to advances in radiation delivery technologies, it is now possible to deliver ablative doses to spinal metastases safely and effectively, and in particular high-dose re-irradiation. Data f...
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PMID: 20423672
PDF is available here.
PDF is available here.
Abstract
We present a child with Down syndrome who had received previous chemotherapy, cranial radiation, and a stem cell transplant with total body irradiation for her acute lymphoblastic leukemia. She subsequently relapsed and was treated with clofarabine. After her third course, she had a stroke that was...
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PMID: 20216234
PDF is available here.
PDF is available here.
Abstract
Histamine reduces ionising radiation toxicity on bone marrow cells being a suitable candidate for use as radioprotector, especially for patients undergoing radiotherapy who are at the risk of bone marrow or small intestine damage....
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PMID: 20353338
PDF is available here.
PDF is available here.
Abstract
The results suggest that irradiation-evoked inhibition of the BK(Ca) current in aortic VSMC is mediated by PKC. Taken together, our data indicate that one of the mechanisms leading to elevation of vascular tone and related arterial hypertension development under ionising irradiation impact is a PKC-...
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PMID: 20353339
PDF is available here.
PDF is available here.
Abstract
We reasoned that deficiency of p19 in the allogeneic donor transplant might reduce the inflammation caused by acute GVHD (aGVHD). The major histocompatibility complex-2 (H2(d)) BALB/c mice were subjected to 8.5 Gy TBI, followed by transplantation with 10 x 10(6) BM and 2.5 x 10(6) spleen cells from...
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PMID: 19718070
PDF is available here.
PDF is available here.
Radiation Research (173)4 2010
Abstract
We analyzed cytokine expression after irradiation. Adult mice were studied after whole-lung or total-body irradiation. Mouse pups of different ages were also investigated after total-body irradiation. mRNA abundance was analyzed in tissue and plasma, and pathological changes were assessed. In lung t...
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PMID: 20334525
PDF is available here.
PDF is available here.
Radiation Research (173)4 2010
Abstract
We report the unexpected finding that antioxidant supplementation starting 24 h after total-body irradiation resulted in better survival than antioxidant supplementation started soon after the irradiation. The antioxidant dietary supplement was l-selenomethionine, sodium ascorbate, N-acetyl cysteine...
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PMID: 20334518
PDF is available here.
PDF is available here.
Radiation Research (173)4 2010
Abstract
We explored the potential of mitochondrial SOD (MnSOD) gene therapy to protect esophageal, pancreatic and bone marrow cells from radiation-induced genomic instability. Specifically, we measured the frequency of homologous recombination (HR) at an integrated transgene in the Fluorescent Yellow Direct...
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PMID: 20334517
PDF is available here.
PDF is available here.
Radiation Research (173)4 2010
Abstract
We conclude that the intestinal immune system undergoes profound changes after sublethal TBI and that these changes likely contribute to postirradiation pathophysiological manifestations....
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PMID: 20334519
PDF is available here.
PDF is available here.
Radiation Research (173)4 2010
Abstract
Thoracic cavity radiotherapy is limited by the development of alveolitis and fibrosis in susceptible patients. To define the response to 18 Gy pulmonary irradiation in mice at the gene expression level and to identify pathways that may influence the alveolitis and fibrosis phenotypes, expression pro...
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PMID: 20334524
PDF is available here.
PDF is available here.
Radiation Research (173)4 2010
Abstract
Space travel and prolonged bed rest cause bone loss due to musculoskeletal disuse. In space, radiation fields may also have detrimental consequences because charged particles traversing the tissues of the body can elicit a wide range of cytotoxic and genotoxic lesions. The effects of heavy-ion radia...
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PMID: 20334522
PDF is available here.
PDF is available here.
Abstract
The effect of intravenous administration of human mesenchymal stromal stem cells (hMSC) has been evaluated by means of large-conductance calcium-dependent potassium channel (BK(Ca)) activity measurements in thoracic aorta smooth muscle cells (SMC) obtained from non-fatal whole-body irradiated rats,...
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PMID: 20052569
PDF is available here.
PDF is available here.
Abstract
The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demons...
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PMID: 20179347
PDF is available here.
PDF is available here.
Abstract
We extended HCT to recipients of HLA class I-mismatched grafts to investigate whether NMA conditioning can establish stable donor engraftment. Fifty-nine patients were conditioned with fludarabine (Flu) 90 mg/m(2) and 2 Gy total body irradiation (TBI), followed by immunosuppression with cyclosporine...
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PMID: 19900571
PDF is available here.
PDF is available here.
Health Physics (98)2 2010
Abstract
Victims of nuclear accidents or radiological terrorism are likely to receive varying doses of ionizing radiation inhomogeneously distributed over the body. Early biomarkers may be useful in determining organ-specific doses due to total body irradiation (TBI) or partial body irradiation. The authors...
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PMID: 20065682
PDF is available here.
PDF is available here.
Abstract
Human tumour xenografts in a nude rat model have consistently been used as an essential part of preclinical studies for anticancer drugs activity in human. Commonly, these animals receive whole body irradiation to assure immunosuppression. But whole body dose delivery might be inhomogeneous and the...
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PMID: 20368799
PDF is available here.
PDF is available here.
Mutation Research (695)1-2 2010
Abstract
Our extended animal studies suggest that oral administration of silibinin (70mg/kg for 3 days) to mice prior to whole-body gamma-exposure (7.5Gy) resulted in significant protection to radiation-induced mortality and DNA damage in blood leukocytes. However, silibinin treatment after irradiation was n...
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PMID: 19945544
PDF is available here.
PDF is available here.
Journal of Immunotherapy (33)1 2010
Abstract
We observed a strong correlation between the intensity of the conditioning regimen and the efficacy of ACT-based treatments using linear regression analysis. This was the case for preparative total body irradiation administered either as a single dose (R=0.97, P<0.001) or in fractionated doses (R=0....
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PMID: 19952961
PDF is available here.
PDF is available here.
Abstract
Little is known regarding long-term bone deficit in relationship with the modalities of cancer therapy among survivors of childhood malignancy.
Bone mineral density (BMD) was evaluated at lumbar spine (LS), total hip and femoral neck in 89 patients (44 men) more than...
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PMID: 20395671
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (51)1 2010
Abstract
We electronically searched the Cochrane Central Register of Controlled Trials, Medline, Embase, CIBMTR and critically appraised all relevant articles (1990.01-2009.04). Comparative studies were evaluated on clinical therapeutic effects of TBI/CY and busulphan BU/CY regimens with assessement of engra...
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PMID: 20055658
PDF is available here.
PDF is available here.
Abstract
The frequency of translocations, detected by FISH in lymphocytes of control donors increased with increasing age as quadratic function. This process is elevated in persons exposed to radiation at low-doses. It means that the level of translocations could be used as an indicator of biological age. Mo...
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PMID: 20734795
PDF is available here.
PDF is available here.
Abstract
Four randomized groups of male mice F1 (C57Black/CBA) were investigated: a) UV-irraidated (UV-A, 15 min daily during 9 months, dose 5.6 + 1.2 W/m2), b) gamma-rays irradiated (2 Gy), single, c) influence for combination of UV- and gamma-rays treatment, d) aging. The lens opacities were measured on 7t...
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PMID: 20734799
PDF is available here.
PDF is available here.
Abstract
We found that pre-administration of heat-killed Lactobacillus casei (HLC) to mice increases the level of interleukin (IL)-1 beta in circulation as well as the survival rate following lethal dose of radiation. Since HLC stimulates early immune responses, effects by drugs to modify inflammation were s...
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PMID: 19851041
PDF is available here.
PDF is available here.
Abstract
We have studied the properties of volatile secretions induced in laboratory mice, separately or combined influence of ionizing radiation and cyclophosphamide. The reaction of preference-avoidance response in the T-maze revealed that the urine samples of mice in the early period after exposure to ion...
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PMID: 20297684
PDF is available here.
PDF is available here.
Abstract
Our results suggest that transplanted MSCs may play an important role in preventing radiation-induced injury and may offer a novel method to treat radiation-induced intestinal injury....
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PMID: 19851042
PDF is available here.
PDF is available here.
Abstract
The dose-response of unstable chromosome exchanges (UCE) in lymphocytes of 4 cancer patients undergone whole-body fractionated gamma-rays exposure (at the daily dose of 0.115 Gy up to the total dose 1.15 Gy) was compared with corresponding dose-response for lymphocytes of the same patients, irradiat...
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PMID: 20464960
PDF is available here.
PDF is available here.
Biomedical Research (31)1 2010
Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
Abstract
We identified the contiguous gene deletion of Ptprk and Themis genes in the thid locus that causes the simultaneous loss of expression of both genes, and the exogenous Ptprk expression partially rescued this phenotype. To determine whether the deletion of Themis influences thid phenotype, bone marro...
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PMID: 20203423
PDF is available here.
PDF is available here.
Abstract
We report that the E2F family member E2F3a can be induced by DNA damage through transcriptional and posttranslational mechanisms. We demonstrate that the posttranslational induction of human E2F3a is dependent on the checkpoint kinases. Moreover, we show that human E2F3a is a substrate for the check...
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PMID: 19917728
PDF is available here.
PDF is available here.
Abstract
Our study confirms the safety of radiotherapy for patients implanted with pacemakers or implantable cardioverter-defibrillators but suggests that chemoradiation represents a probable risk factor for cardiac toxicity. Furthermore, all cardiac events were observed in patients treated in the head and'n...
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PMID: 20437862
PDF is available here.
PDF is available here.