Abstract
We conclude that improvements in lung mechanics, gas exchange, and changes in CBF are comparable for a porcine-derived and peptide-containing synthetic surfactant, despite instilled volumes differing by 2-fold. Intrapulmonary distribution of surfactant is more uniform after a larger volume is instil...
|
PMID: 20531255
PDF is available here.
Abstract
We detected several long chain aliphatic alcohols ranging from C18-C32 in honey bees and the level of these alcohols varied in each body segment. C18:0Alc and C20:0Alc are more pronounced in the head, whereas C22:0Alc to C32Alc are abundant in the abdomen. One of the cDNAs coding for a fatty acyl-Co...
|
PMID: 20542116
PDF is available here.
Abstract
We describe the discovery of an alkane biosynthesis pathway from cyanobacteria. The pathway consists of an acyl-acyl carrier protein reductase and an aldehyde decarbonylase, which together convert intermediates of fatty acid metabolism to alkanes and alkenes. The aldehyde decarbonylase is related to...
|
PMID: 20671186
PDF is available here.
Abstract
The hydrogenation of biodiesel was investigated in presence of thermoregulated phase-transfer catalysts to produce fatty alcohols. The thermoregulated catalytic system Pd/IV (IV: P-ligand, tri-(methoxyl polyethylene glycol)-phosphite) exhibited an efficient catalytic performance for the hydrogenatio...
|
PMID: 20338750
PDF is available here.
Abstract
Maintenance of sex-specific germ cells requires balanced activation and repression of genetic hierarchies to ensure gender-appropriate development in mammals. Figla (factor in the germ line, alpha) encodes a germ cell-specific basic helix-loop-helix transcription factor first identified as an activa...
|
PMID: 20479125
PDF is available here.
Abstract
We serendipitously discovered that an endogenous OR in the fruit fly, Drosophila melanogaster, is highly sensitive to the sex pheromone of the silkworm moth, bombykol. Intriguingly, the fruit fly detectors are more sensitive than the receptors of the silkworm moth, although its ecological significan...
|
PMID: 20439725
PDF is available here.
Abstract
Two different mixture synthesis routes have been used to make the four stereoisomers of petrocortyne A. A first quick and dirty route provided a mixture of the four isomers in nonselective fashion. Mosher and 2-naphthylmethoxyacetic acid (NMA) ester methods were developed to identify the components,...
|
PMID: 20394446
PDF is available here.
Abstract
Sodium cetearyl sulfate is the sodium salt of a mixture of cetyl and stearyl sulfate. The other ingredients in this safety assessment are also alkyl salts, including ammonium coco-sulfate, ammonium myristyl sulfate, magnesium coco-sulfate, sodium cetyl sulfate, sodium coco/hydrogenated tallow sulfat...
|
PMID: 20448271
PDF is available here.
Abstract
The effect of surfactant administration for respiratory distress syndrome (RDS) on indomethacin (INDO) pharmacodynamics and dosing requirements for patent ductus arteriosus (PDA) closure and renal toxicity was evaluated. A 22-year prospective cohort study including 442 INDO-treated patients given 46...
|
PMID: 20063159
PDF is available here.
Abstract
Neutrophils are important in the host response against invading pathogens. One chemical defense mechanism employed by neutrophils involves the production of myeloperoxidase (MPO)-derived HOCl. 2-Chlorohexadecanal (2-ClHDA) is a naturally occurring lipid product of HOCl targeting the vinyl ether bond...
|
PMID: 20019386
PDF is available here.
Abstract
OBJECTIVE: To evaluate the effect of panaxynol (PAN) on delayed type hypersensitivity and possible mechanism. METHOD: Allergic contact dermatitis (ACD) was induced by DNCB as a delayed type hypersensitivity (DTH) model to observe effect of PAN on auricle inflammation including pathological injury. P...
|
PMID: 20617688
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Recurrent herpes labialis (RHL) is a significant disorder with social and health consequences that affects upwards of 20 - 40% of the adult population. Docosanol is the only FDA-approved topical agent that is available over the counter for management of RHL. Its mechanism of...
|
PMID: 20210688
PDF is available here.
Abstract
Minimal inhibitory concentration (MIC) of MUC5AC expression of each polyphenol was found as follows: [6]-gingerol, 1 microM; EGCG, 20 microM; quercetin, 40 microM; and curcumin, 10 microM. No polyphenol influenced cell proliferation at this MIC. CBF was not affected by [6]-gingerol, quercetin, or EG...
|
PMID: 20338103
PDF is available here.
Abstract
On the basis of the results we conclude that [6]-gingerol possesses apoptotic potential in mouse skin tumors as mechanism of chemoprevention hence deserves further investigation....
|
PMID: 19629484
PDF is available here.
Abstract
We have characterized some of the key molecules involved in the biosynthesis of the sex pheromone bombykol in the silkmoth, Bombyx mori. Characterization of these molecules has facilitated our understanding of the precise mechanisms underlying lepidopteran sex pheromone production....
|
PMID: 20139627
PDF is available here.
Abstract
Gingerol has good activity against cisplatin-induced emesis in minks possibly by inhibiting central or peripheral increase of substance P and NK(1) receptors....
|
PMID: 20193490
PDF is available here.
Abstract
New terbium complex of 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,2-dihydro-3H- 1,4-benzdiazepin-2-one (lorazepam, L), which is highly luminescent and do not require luminescence enhancers, is reported. The luminescence intensity of the Tb-L complex was enhanced by the addition of Tergitol 7 in water s...
|
PMID: 20873413
PDF is available here.
Abstract
The kinetics of wax ester synthesis from oleic acid and oleyl alcohol using immobilized lipase from Candida antartica as catalyst was studied with different types of impeller (Rushton turbine and AL-hydrofoil) to create different mixing conditions in 2l stirred tank reactor. The effects of catalyst...
|
PMID: 20124754
PDF is available here.
Abstract
LTB4 administered via i.c.v down-regulates the airway contraction response and inflammation through activation of the HPA axis via its BLT1 receptor. This study expands our concept of the regulatory role of intracranial inflammatory mediators in inflammatory diseases including asthma. The favourable...
|
PMID: 20403205
PDF is available here.
Abstract
The purpose of this work was to develop a novel polyurethane hydrogel system for sustained drug release, which could be used as a vaginal drug-delivery vehicle. The blank polyurethane hydrogels were synthesized by a polyol oligomeric, a diisocyanate and a triol (used as cross-linking agent). In orde...
|
PMID: 20233505
PDF is available here.
A A Mavridou,
E E Smeti,
G G Mandilara,
G G Mandilara,
P P Boufa,
M M Vagiona-Arvanitidou,
A A Vantarakis,
G G Vassilandonopoulou,
O O Pappa,
V V Roussia,
A A Tzouanopoulos,
M M Livadara,
I I Aisopou,
V V Maraka,
E E Nikolaou and
G G Mandilara
Abstract
In this study ten laboratories in Greece compared the performance of reference method TTC Tergitol 7 Agar (with the additional test of beta-glucuronidase production) with five alternative methods, to detect E. coli in water, in line with European Water Directive recommendations. The samples were pre...
|
PMID: 20057092
PDF is available here.
Abstract
We identified the genes for depudecin biosynthesis and created depudecin-minus mutants. The depudecin gene cluster contains six genes (DEP1 to DEP6), which are predicted to encode a polyketide synthase (AbPKS9 or DEP5), a transcription factor (DEP6), two monooxygenases (DEP2 and DEP4), a transporter...
|
PMID: 19737099
PDF is available here.
Abstract
Supplementation with O3 + P may be effective in improving mood state and reactivity. The reaction time reduction appears to be due to a central nervous system effect, as shown by the reduced latency of movement-related brain macropotentials and EMG activation. These results are in line with previous...
|
PMID: 20234035
PDF is available here.
Abstract
The aerial parts of Pamburus missionis (Wight) Swingle (Rutaceae) are traditionally used in the treatment of swelling, chronic rheumatism, paralysis, and puerperal diseases.The aim of this work was to investigate the chemical composition and antibacterial activity of essential oil of...
|
PMID: 19375495
PDF is available here.
Abstract
P. gingivalis application resulted in periodontal disease with gingival inflammation and bone loss (30% compared to baseline) at 6 weeks. Treatment with 1-TDC stopped the progression of the disease and resulted in a significant reduction in the macroscopic periodontal inflammation, attachment, and b...
|
PMID: 19563290
PDF is available here.
Author(s) unavailable
Abstract
(1) Herpes is a contagious, recurrent viral infection of the skin and mucous membranes. In immunocompetent patients the recurrences can be troublesome but they heal spontaneously. Management is mainly based on lifestyle measures. Local application of an antiviral drug such as aciclovir has modest ef...
|
PMID: 19637417
PDF is available here.
Abstract
An investigation of Oenanthe fistulosa from Sardinia afforded oenanthotoxin (1a) and dihydrooenanthotoxin (1b) from the roots and the diacetylenic epoxydiol 2 from the seeds. The absolute configuration of 1a and 1b was established as R by the modified Mosher's method, and the structure of 2 by chemi...
|
PMID: 19245244
PDF is available here.
Abstract
Using switchgrass ( Panicum virgatum L.) as a cellulosic feedstock for the production of ethanol could lead to the extraction of co-products prior to the pretreatment step, thereby adding value to the ethanol conversion process. Policosanols, registered as 142583-61-7, are present in Poaceae and are...
|
PMID: 19415924
PDF is available here.
Abstract
Nonpareil almonds, Prunus dulcis , account for the largest percentage of almond varieties grown in the Central Valley of California. Several studies have investigated the various nonvolatile and volatile components of various plant parts; however, the volatile organic compound (VOC) emission of almo...
|
PMID: 19344182
PDF is available here.
Abstract
The benefits of exogenous synthetic or animal-derived surfactants for prevention or treatment of respiratory distress syndrome (RDS) are well established. Data from head-to-head trials comparing animal-derived surfactants primarily with the synthetic surfactant colfosceril suggest that the major cli...
|
PMID: 19399006
PDF is available here.
Abstract
These results are in good agreement with previous studies on the interaction of GMO-based CPNPs with planar bilayers using neutron reflectivity, where the diffraction peak shifted with time upon mixing. The structural changes are much less prominent for the PtOH-based CPNPs and the HPNPs upon mixing...
|
PMID: 19714888
PDF is available here.
Abstract
To develop microbial production method for prenyl alcohols (e.g., (E,E)-farnesol (FOH), (E)-nerolidol (NOH), and (E,E,E)-geranylgeraniol (GGOH)), the genes encoding enzymes in the mevalonate and prenyl diphosphate pathways were overexpressed in Saccharomyces cerevisiae, and the resultant transforman...
|
PMID: 19083230
PDF is available here.
Abstract
OBJECTIVE: To investigate the antiemetic effect of gingerol and its multi-targets effective mechanism on 5-hydroxytryptamine (5-HT), dopamine (DA) and substance P (SP). The antiemetic effect of gingerol was investigated on a vomiting model of mink induced by cisplatin (7.5 mg . kg(-1), i.p.) in 6 h...
|
PMID: 19407975
PDF is available here.
Abstract
OBJECTIVE: To establish the quality standards of roasted ginger and charry ginger prepared from dried ginger. METHOD: The basic quality information of roasted ginger and charry ginger investigated by analysis of marketed samples. Ten batches of two roasted ginger and charry ginger were prepared in m...
|
PMID: 19526783
PDF is available here.
Abstract
Bioactivity-guided fractionation of Zingiber Officinale (zingiberaceae) led us to isolate 14 compounds, -gingerol ( 1), -gingerol ( 2), -gingerol ( 3), -gingerol ( 4), -paradol ( 5), -shogaol ( 6), -shogaol ( 7), 1-dehydro- -gingerdione ( 8), -gingerdione ( 9), hexahydrocurcumin ( 10), tetrahydrocur...
|
PMID: 19031369
PDF is available here.
Abstract
The lipophilization of polar antioxidants such as phenolics is an efficient way to enhance their solubility in apolar media. Thus, in emulsified systems, lipophilized antioxidants are supposed to locate at the lipid/aqueous phase interface and to lead to a better protection of unsaturated lipids. He...
|
PMID: 19143487
PDF is available here.
Abstract
End-product conversion, low product concentration and large volumes of fermentation broth, the requirements for large bioreactors, in addition to the high cost involved in generating the steam required to distil fermentation products from the broth largely contributed to the decline in fermentative...
|
PMID: 19037672
PDF is available here.
Abstract
We analyzed the sex pheromone of the pear fruit moth, Acrobasis pyrivorella, by means of gas chromatography-electroantennographic detection (GC-EAD) and GC-mass spectrometry. Two EAD-active compounds were detected in the pheromone gland extract of females. They were identified as (Z)-9-pentadecenyl...
|
PMID: 19189185
PDF is available here.
Abstract
We describe a detailed protocol for the separation of proteins by 16-BAC/SDS-PAGE....
|
PMID: 19153699
PDF is available here.
Abstract
We investigated the protective role of PND in SCs through immunocytochemistry and ELISA assay. PND promoted the expression and secretion of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) by SCs in a dose-dependent manner at doses of 2.5-20 and 5.0-20 microM, respectively. The...
|
PMID: 18805406
PDF is available here.
Abstract
We investigated the effect of phenolic compounds (PCs) and policosanol of Kokuto, Okinawan noncentrifugal cane sugar, on the development of atherosclerosis. A total of 67 male Japanese quail were divided into eight dietary groups in trial 1. The dietary groups were fed the atherosclerotic diet (AD)...
|
PMID: 19072226
PDF is available here.
Abstract
Positron annihilation lifetime spectroscopy (PALS) has potential as a novel rapid characterization method for self-assembly amphiphile systems; however, a lack of systematic correlation of PALS parameters with structural attributes has limited its more widespread application. In this study, using th...
|
PMID: 19086790
PDF is available here.
Abstract
We investigate the differentiation-inducing activity of compound 1 using the human promyelocytic leukemia HL-60 cell line. The effect of compound 1 on HL-60 cell viability and proliferation was determined at different treatment times using the 3-(4,5-dimethythiazol-2-yl)-2,5-diohenyl-2 H-tetrazolium...
|
PMID: 19031365
PDF is available here.
Abstract
We show that: (i) blocking [Ca2+]i increase during multiple-trial conditioning selectively impairs long-term memory performance; (ii) conversely, increasing [Ca2+]i during single-trial conditioning triggers long-term memory formation; and finally, (iii) as was the case for long-term memory produced...
|
PMID: 19531205
PDF is available here.
Abstract
Tadenan, a drug of plant origin, was given to 27 patients with documented prostatic adenoma for 3-12 months. Home uroflowmonitoring for 1, 3, 6 and 12 months registered positive changes in urinary flow rate and urination volume. Side effects were absent. IPSS and QoL parameters were also assessed....
|
PMID: 19526878
PDF is available here.
Abstract
We report that phthoxazolin A and its analog inthomycin B inhibit the growth of human prostate cancer DU-145 cells by modulating tumor-stromal cell interactions. Using an in vitro coculture system, in which prostate cancer cell growth is upregulated by prostate stromal cells (PrSC), we found that ph...
|
PMID: 19018764
PDF is available here.
Abstract
Egyptian jojoba seeds newly cultivated in Ismailia desert in Egypt promoted us to determine its lipid components. Fatty alcohols, fatty acids, wax esters and sterols patterns were determined by capillary GLC whereas, tocopherols profile, isopropenoid alcohols and sterylglycosides were determined by...
|
PMID: 19844068
PDF is available here.
Abstract
The effect of [10]-gingerol on cytosol free Ca(2+) concentration ([Ca(2+)](i)) and viability is large unknown. This study examines the early signaling effects of [10]-gingerol on human colorectal cancer cells. It was found that this compound caused a slow and sustained rise of [Ca(2+)](i) in a conce...
|
PMID: 19255554
PDF is available here.
Abstract
We previously reported that alpha-trifluoromethyl acyloins (TFs) induced various types of cell death, depending on the target cancer cell line. We investigated here what type of cell death is induced by a-trifluoromethyl acyloins in two human oral squamous cell carcinoma cell lines (HSC-2, HSC-4). T...
|
PMID: 19331148
PDF is available here.
Abstract
Solid lipid particles were evaluated for their potential as a thermo-activated drug delivery system. Submicron-sized diphenylhexatriene (DPH)/myristyl alcohol particles were produced by an atomization/drying process and the release rate of DPH into sodium dodecyl sulfate (SDS) micellar solutions was...
|
PMID: 18651283
PDF is available here.
Abstract
A high-performance thin layer chromatographic method has been established for the identification and standardization of Stereospermum suaveolens extracts using two active biomarkers viz. triacontanol and p-coumaric acid in root samples collected from different geographical locations of India. These...
|
PMID: 19930809
PDF is available here.
Abstract
We report calculations dedicated to estimate the selectivity of the Bombyx mori pheromone binding protein towards the two closely related pheromonal components Bombykol and Bombykal. The selectivity is quantified by the binding free-energy difference, obtained either by the thermodynamic integration...
|
PMID: 19025731
PDF is available here.
Abstract
We thoroughly characterize the mixed monolayers with a variety of techniques to understand the optimal density and distribution of the disaccharide for antibody capture. This work reinforces the importance of controlling the density of ligands at the interface for optimized surface based bioassays....
|
PMID: 19360960
PDF is available here.
Abstract
We investigated the inhibitory effects of 6-shogaol and a related compound, 6-gingerol, on the induction of nitric oxide synthase (NOS) and cyclooxygenase-2 (COX-2) in murine RAW 264.7 cells activated with LPS. Western blotting and reverse transcription-PCR analyses demonstrated that 6-shogaol signi...
|
PMID: 18683823
PDF is available here.
Abstract
Poly(phenylene ethynylene)s bearing a high density of branched amphiphilic side-chains self-assemble at the air-water interface and in water-potassium dodecanoate-decanol lyotropic liquid crystals.
|
PMID: 18985219
PDF is available here.
Abstract
Stimuli-sensitive drug delivery systems (DDSs) have attracted considerable attention in medical and pharmaceutical fields; thermosensitive DDS dealing with poly(N-isopropylacrylamide) (poly(NIPA)) have been widely studied. Novel NIPA emulsion gels, i.e., NIPA hydrogels containing distributed oil (ol...
|
PMID: 18790619
PDF is available here.
Abstract
Ginger rhizome (Zingiber officinale) has been used for centuries to treat dementia in South Asia. This study was undertaken to possibly justify its use. A 70% aqueous/methanolic extract of dried ginger (Zo.Cr) was used. Zo.Cr tested positive for the presence of terpenoids, flavonoids, secondary amin...
|
PMID: 18812031
PDF is available here.