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Phospholipids (2):
Recent article
Phospholipids
Abstract
Type 2 diabetes mellitus (T2DM) and its attendant complications, such as diabetic nephropathy (DN), impose a significant societal and economic burden. The investigation of discovering potential biomarkers for T2DM and DN will facilitate the prediction and prevention of diabetes. Phos...
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PMID: 21872008
PDF is available here.
PDF is available here.
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Abstract
Morphofunctional and biochemical properties of erythrocyte membrane were investigated in early postnatal ontogenesis in rats in norm and after prenatal immobilization stress. The transient decrease of erythrocyte membranes stability was revealed in the control rats. The ability to er...
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PMID: 21961297
PDF is available here.
PDF is available here.
Abstract
Erythrocyte phospholipids and lipid fatty acid composition was investigated at different stages of exposure to high-caloric diet in male Wistar rats. The revealed modification of erythrocyte lipids shows specific features of membrane response to stress factors of alimentary nature, i...
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PMID: 21961296
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
This Review is focused on the growing interest brought to phosphorus-containing organic materials for applications in the biomedical field, mainly because of their properties such as biocompatibility, hemocompatibility, and protein adsorption resistance. It mainly describes relevant...
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PMID: 21553908
PDF is available here.
PDF is available here.
Abstract
A general toxicity of basic drugs is related to phospholipidosis in tissues. Therefore, it is essential to predict the tissue distribution of basic drugs to facilitate an initial estimate of that toxicity. The objective of the present study was to further assess the original prediction method that c...
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PMID: 21034759
PDF is available here.
PDF is available here.
Ugeskrift for laeger (173)2 2011
Abstract
OBJECTIVE: To draw attention to the use of intravenous lipids in the treatment of cardiac arrests caused by overdosage of lipophilic drugs. Case reports and animal studies have shown beneficial use of lipids in severe intoxication. The literature is reviewed. CONCLUSION: Lipids have a place in the t...
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PMID: 21219843
PDF is available here.
PDF is available here.
Abstract
Pseudomonas aeruginosa produces a quorum sensing molecule termed the Pseudomonas Quinolone Signal (2-heptyl-3-hydroxy-4-quinolone; PQS) that regulates an array of genes involved in virulence. This chapter addresses four related techniques useful for detecting and quantifying PQS. First, extraction o...
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PMID: 21031314
PDF is available here.
PDF is available here.
Abstract
Stable, insoluble Langmuir monolayer films composed of Staphylococcus aureus-specific lytic bacteriophage were formed at an air-water interface and characterized. The phage monolayer was very strong, withstanding a surface pressure of ∼40 mN/m at 20 °C. The surface pressure-area (Π-A) isotherm p...
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PMID: 20843668
PDF is available here.
PDF is available here.
Abstract
The dietary deficiency of docosahexaenoic acid (DHA) is associated with a variety of human diseases, such as brain disorders and infertility. Because of the capacity to convert DHA precursors, such as α-linolenic acid, to DHA is very limited in the human tissues and the brain, it ha...
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PMID: 20863272
PDF is available here.
PDF is available here.
Trends in Cell Biology (20)11 2010
Abstract
Recent evidence suggests that the major pathways mediating cell cholesterol homeostasis respond to a common signal: active membrane cholesterol. Active cholesterol is the fraction that exceeds the complexing capacity of the polar bilayer lipids. Increments in plasma membrane cholesterol exceeding th...
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PMID: 20843692
PDF is available here.
PDF is available here.
Waste Management (30)11 2010
Abstract
This study investigates changes in waste microbial community composition and biomass during in situ aeration in laboratory-scale columns over 32 weeks. Microbial profiles were assessed in solid and leachate samples in relation to physical-chemical parameters using phospholipid ester linked fatty aci...
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PMID: 20483579
PDF is available here.
PDF is available here.
Hämostaseologie (30 Suppl 1) 2010
Abstract
We found significantly lower levels of PAR1-receptors and higher levels of CD42b in newborn platelets as compared to adult platelets. Levels of Integrin αIIbβ3 in newborn platelets were comparable to adult platelets. Conclusion: A lower content of PAR1-receptors explains very well the hyposensitiv...
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PMID: 21042671
PDF is available here.
PDF is available here.
Abstract
We have used phagocytosis as a paradigm of signal transduction, taking advantage of the generous size of phagosomes and of their comparatively leisurely rate of formation. Aided by the design of specific probes, we demonstrated a highly localized and elegantly choreographed sequence of changes in th...
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PMID: 20739621
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We observed that cholesterol abnormally accumulates in the endolysosomal membrane of LSD cells, thereby reducing the ability of lysosomes to efficiently fuse with endocytic and autophagic vesicles. Furthermore, we discovered that soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) re...
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PMID: 20871593
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)42 2010
Abstract
We studied a range of synthetic peptides: specifically those equating to the N1 (residues 23-110) and N2 (23-89) fragments derived from constitutive processing of PrP(C) and including those representing arbitrarily defined component domains of the N terminus of mouse prion protein. Utilizing more ph...
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PMID: 20679345
PDF is available here.
PDF is available here.
Abstract
We used the fat-1 mouse model, a transgenic animal capable of synthesizing n-3 PUFA from n-6 PUFA, to examine this relationship. Fat-1 mice exhibited a approximately 20-fold decrease in the n-6/n-3 ratio in skeletal muscle, and plasma glucose and the area under the glucose curve were significantly (...
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PMID: 20962926
PDF is available here.
PDF is available here.
Molecular BioSystems (6)10 2010
Abstract
We review the background and the development of the new methodology. Results obtained with photocrosslinking in purified mitochondrial membranes from the yeast Saccharomyces cerevisiae are summarized and future perspectives discussed....
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PMID: 20544074
PDF is available here.
PDF is available here.
Biomedical Materials (5)5 2010
Abstract
We synthesized a water-insoluble phospholipid polymer bearing a phenylboronic acid moiety (PMBV), which induces cell adhesion through a specific interaction with the glycoprotein, fibronectin. Surface plasmon resonance analysis revealed that fibronectin was adsorbed on the PMBV surface. When fibrobl...
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PMID: 20876952
PDF is available here.
PDF is available here.
Abstract
I (ID03-0561(T)) showed low relatedness to the other strains studied. The three strains in group II (ID03-0784(T), ID03-0808 and ID03-0809) formed a group with high relatedness (98-100 %) and showed low relatedness to the other strains studied. The two strains in group III (ID03-0810(T) and ID03-0...
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PMID: 19933586
PDF is available here.
PDF is available here.
Abstract
A Gram-negative, motile, non-spore-forming bacterial strain, designated MJ07(T), was isolated from a farm soil and was characterized to determine its taxonomic position by using a polyphasic approach. Comparative 16S rRNA gene sequence analysis showed that strain MJ07(T) belongs to the family Alcali...
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PMID: 19933592
PDF is available here.
PDF is available here.
Abstract
A haloalkaliphilic archaeon, strain JX313(T), was isolated from a saline-alkaline soil from Daqing, Heilongjiang Province, China. Its morphological, physiological and biochemical features and 16S rRNA gene sequence were determined. Colonies of the strain were orange-red and cells were non-motile coc...
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PMID: 19915113
PDF is available here.
PDF is available here.
Abstract
A polyphasic taxonomic study of a halotolerant bacterium, isolated from sandy rhizospheric soil in Sarbandar, Persian Gulf, Iran, revealed that strain HM6(T) represents a novel species within the genus Nocardiopsis. Results of the 16S rRNA gene sequence comparison revealed that strain HM6(T) cluster...
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PMID: 19933587
PDF is available here.
PDF is available here.
Abstract
Three strains of Gram-negative, rod-shaped, non-spore-forming bacteria (M 2040(T), M 1973 and M 1878-SK2), isolated from milk of camels at a camel-milk production farm in the United Arab Emirates, were investigated for their taxonomic allocation. On the basis of 16S rRNA gene sequence similarities,...
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PMID: 19933583
PDF is available here.
PDF is available here.
Abstract
A Gram-positive, endospore-forming, rod-shaped bacterium, strain PD-A10(T), was isolated from salted crab (poo-khem) in Thailand and subjected to a taxonomic study. Phenotypic and chemotaxonomic characteristics, including phylogenetic analyses, showed that the novel strain was a member of the genus...
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PMID: 19933584
PDF is available here.
PDF is available here.
Abstract
A bacterial strain, SPC26(T), was isolated from a sediment sample of the Southern Ocean off Antarctica. The strain was Gram-staining- and catalase-positive and contained lysine and alanine in the cell-wall peptidoglycan. The major cellular fatty acids were anteiso-C₁₅:₀ (54.92 %), iso-C₁...
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PMID: 19783612
PDF is available here.
PDF is available here.
Abstract
These results suggested that strain VN05A0561(T) represents a novel species of the genus Pseudonocardia, for which the name Pseudonocardia babensis sp. nov. is proposed. The type strain is VN05A0561(T) (=VTCC-A-1757(T)=NBRC 105793(T))....
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PMID: 19933589
PDF is available here.
PDF is available here.
Abstract
A novel Gram-negative, rod-shaped, non-motile bacterium, designated strain LW7(T), was isolated from a water sample collected at a depth of 4.5 m from Lonar Lake in Buldhana district, Maharastra, India. The cell suspension was dark-reddish orange due to the presence of carotenoids. The fatty acids w...
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PMID: 19933591
PDF is available here.
PDF is available here.
Abstract
A xylanolytic bacterium, strain S1-3(T), was isolated from soil collected in Nan province, Thailand. It was characterized taxonomically based on phenotypic characteristics and 16S rRNA gene sequence comparison. The strain was a Gram-stain-positive, facultatively anaerobic, spore-forming, rod-shaped...
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PMID: 19915111
PDF is available here.
PDF is available here.
Abstract
A Gram-positive, coccoid, non-endospore-forming actinobacterium (strain 12-Be-011(T)) was isolated from indoor wall material. Based on 16S rRNA gene sequence comparisons, strain 12-Be-011(T) was clearly shown to belong to the genus Microlunatus and was most closely related to Microlunatus panaciterr...
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PMID: 19946055
PDF is available here.
PDF is available here.
Abstract
Strain KIT 00200-70066-1(T) was isolated from the sputum of a patient with pulmonary disease. Cells of the strain were Gram-variable, facultatively anaerobic, motile, spore-forming rods and formed colourless to white colonies on tryptic soy agar at 30 °C and pH 7. The pathogenicity of...
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PMID: 19946060
PDF is available here.
PDF is available here.
Abstract
A halophilic archaeon, strain RO1-6(T), was isolated from a marine solar saltern in eastern China. Cells of strain RO1-6(T) were pleomorphic and motile and stained Gram-negative. Strain RO1-6(T) grew well on complex medium and colonies were red-pigmented. It was able to grow at 20-50°C (optimum 37...
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PMID: 19946053
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
We believe that metabonomic approach is helpful to further understanding and clinical diagnosis of traditional Chinese medicine (TCM) induced nephrotoxicity.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20678537
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Our present study also showed that supplementation of the synbiotic reduced the concentration of saturated fatty acids (SFA), increased unsaturated fatty acids (UFA), and increased the ratio of UFA:SFA over 12 wk, whereas the control showed inconspicuous changes. The alteration of RBC membrane was a...
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PMID: 20854987
PDF is available here.
PDF is available here.
Journal of Chromatography A (1217)44 2010
Abstract
The use of liposomes as coating materials in capillary electrophoresis has recently emerged as an important and popular research area. There are three preparation methods that are commonly used for coating capillaries with liposomes, namely physical adsorption, avidin-biotin binding and covalent cou...
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PMID: 20870242
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
Abstract
We hypothesized that the insulin-sensitive phenotype associated with Jnk deletion originates from loss of JNK function in skeletal muscle. Short hairpin RNA (shRNA)-mediated gene silencing was used to identify the functions of JNK subtypes in regulating energy metabolism and metabolic responses to e...
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PMID: 20094041
PDF is available here.
PDF is available here.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia (82)3 2010
Abstract
To evaluate the detection rate of prostate cancer (PCa) at initial and repeat biopsy in patients submitted to Sonovue targeted biopsy vs extended or saturation prostate biopsy (SPBx).
From November 2007 to April 2008 60 patients aged 64 years (median) underwent extended TRUS-guided transperineal pro...
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PMID: 21121433
PDF is available here.
PDF is available here.
Abstract
In this article, a hydrophobic (beclomethasone dipropionate; BDP) and a hydrophilic (cytarabine; Ara-C) drugs have been encapsulated in liposomes in order to be administered via the pulmonary route. For this aim, a liposome preparation method, which is easy to scale up, the ethanol injection method,...
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PMID: 19899957
PDF is available here.
PDF is available here.
Pediatric Research (68)3 2010
Abstract
We conclude that improvements in lung mechanics, gas exchange, and changes in CBF are comparable for a porcine-derived and peptide-containing synthetic surfactant, despite instilled volumes differing by 2-fold. Intrapulmonary distribution of surfactant is more uniform after a larger volume is instil...
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PMID: 20531255
PDF is available here.
PDF is available here.
Abstract
We examine the molecular basis of complement activation by PEG-PL engineered nanomedicines and carbon nanotubes and discuss the challenges ahead.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20388529
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Our data indicate that coagulation acceleration can be attributed neither to platelet activation and nor to activation of a clotting factor. When TFPI (tissue factor pathway inhibitor) was absent, no effect on lag time was observed and the anticoagulant activity of TFPI was decreased in the presence...
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PMID: 20589323
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
We hypothesised that factor Xa (FXa) inhibitors would interfere more gradually with this feedback activation loop than thrombin inhibitors, thereby achieving a better balance between haemostasis and prevention of thrombosis. In this study, we compared the effects of TAK-442, a novel FXa inhibitor, v...
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PMID: 20664909
PDF is available here.
PDF is available here.
Abstract
We sought to determine the relationship between the duration of transport and respiratory performance in the rat model.
Four groups of Sprague-Dawley rat pups (10-12 pups/groups) were exposed to simulated medical transport on postnatal day of life 11 or 12. Each group was exposed to an average impul...
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PMID: 20629492
PDF is available here.
PDF is available here.
EMBO Journal (29)17 2010
Abstract
We show that Ups protein import is mediated by another IMS protein, Mdm35p. In vitro import assays show that import of Ups proteins requires Mdm35p. Loss of Mdm35p led to a decrease in steady state levels of Ups proteins in mitochondria. In addition, mdm35Delta cells displayed a similar phenotype to...
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PMID: 20622808
PDF is available here.
PDF is available here.
Atherosclerosis (212)1 2010
Abstract
Abstract
We collected 50 microl cerebrospinal fluid from 17 first-episode schizophrenia patients and 10 healthy controls.
Their proteins were separated by two-dimensional gel electrophoresis without using any depletion method and identified by mass spectrometry.
Approximately 550 spots were detected, six of...
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PMID: 20446881
PDF is available here.
PDF is available here.
Abstract
Aqueous dispersions of fluorescent semiconducting polymer nanospheres (SPNs) have been synthesised by two methods; miniemulsion and micellar encapsulation. The colloidal and optical stability of SPNs synthesised by these two methods has been compared in order to assess the potential of these fluores...
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PMID: 20585697
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)8 2010
Abstract
Phospholipids become increasingly important as formulation excipients and as active ingredients per se. The present article summarizes particular features of commonly used phospholipids and their application spectrum within oral drug formulation and elucidates current strategies to improve bioavaila...
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PMID: 20411409
PDF is available here.
PDF is available here.
Abstract
Voluntary wheel running increased cholesterol turnover in healthy mice owing to an increased fecal bile acid excretion and a decreased intestinal cholesterol absorption. Enhanced cholesterol turnover may contribute to the established reduction of cardiovascular risk induced by regular exercise....
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PMID: 20139791
PDF is available here.
PDF is available here.
Clinical Nutrition (29)4 2010
Abstract
We determined the number of viable cells, apoptosis and cell cycle distribution of HT-29 cells after exposure to one of three lipid emulsions. Cell cycle distribution was also assessed after treatment with lipid emulsions and FU.
The lipid emulsion containing FO induced a significant growth inhibito...
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PMID: 19945772
PDF is available here.
PDF is available here.
Clinical Nutrition (29)4 2010
Abstract
Extensive loss of adipose tissue is a key feature of cancer cachexia. Advanced cancer patients also exhibit low plasma phospholipids. It is not known whether these processes coincide across the cancer trajectory nor has their relationship with survival been defined. Changes in adipose tissue mass an...
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PMID: 19959263
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
We demonstrate that nucleocapsid surface protein P8 is the single nucleocapsid component interacting with the cytoplasmic membrane. This interaction takes place between P8 and phospholipid. Based on this and previous studies, we propose a model where the periplasmic nucleocapsid interacts with the p...
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PMID: 20427561
PDF is available here.
PDF is available here.
Abstract
Species differences in microsomal binding were evaluated for 43 drug molecules in human, monkey, dog and rat liver microsomes, using a fixed concentration of microsomal protein. The dataset included 32 named drugs and 11 proprietary compounds encompassing a broad spectrum of physicoc...
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PMID: 20229604
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
We used cryoelectron microscopy to characterize structural changes induced in lipid vesicles by exposure to endophilin. The vesicles convert rapidly to coated tubules whose morphology reflects the local concentration of endophilin. Their diameters and curvature resemble those of synaptic vesicles in...
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PMID: 20484046
PDF is available here.
PDF is available here.
Abstract
Extensively impaired surfactant trafficking and secretion underlie lysosomal and endoplasmic reticulum stress with apoptosis of AECII in HPSIP, thereby causing the development of HPSIP....
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PMID: 20378731
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We hypothesized that dissemination of liver oxidative stress proceeds through release of biologically active oxidized lipids to the circulation. We searched for these by tandem mass spectrometry in plasma of rats fed a Lieber-DeCarli ethanol diet or in patients with established alcoholic liver infla...
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PMID: 20460374
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We showed that stearoyl-CoA desaturase 1 (SCD1) knockdown increased the amount of saturated fatty acids and decreased that of monounsaturated fatty acids in phospholipids without affecting the amount or the composition of free fatty acid and induced unfolded protein response (UPR), evidenced by incr...
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PMID: 20489212
PDF is available here.
PDF is available here.
Abstract
Milk fat biomarkers were associated with a lower risk of developing a first MI, especially in women. This was partly confirmed in analysis of fermented milk and cheese intake. Components of metabolic syndrome were observed as potential intermediates for the risk relations....
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PMID: 20484449
PDF is available here.
PDF is available here.
Abstract
Higher phospholipid proportions of oleic, alpha-linolenic, and docosahexaenoic acids showed inverse associations with IMT at specific carotid segments in subjects with primary dyslipidemia. High intakes of healthy fats might explain, in part, the Spanish paradox of low IHD rates in the face of a hig...
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PMID: 20463042
PDF is available here.
PDF is available here.