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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Macromolecular Substances (3):
Recent article
Macromolecular Substances
FEBS Journal (278)19 2011
Abstract
Chromatin remodelling is the ATP-dependent change in nucleosome organisation driven by Snf2 family ATPases. The biochemistry of this process depends on the behaviours of ATP-dependent motor proteins and their dynamic nucleosome substrates, which brings significant technical and conce...
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PMID: 21810178
PDF is available here.
PDF is available here.
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Xenobiotica (41)5 2011
Abstract
Trace fluorescent labeling, typically less than 1%, can be a powerful aid in macromolecule crystallization. Precipitation concentrates a solute, and crystals are the most densely packed solid form. The more densely packed the fluorescing material, the brighter the emission from it; thus, fluorescenc...
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PMID: 18542877
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Microfluidic technologies enable a relatively new approach to macromolecular crystallization, but offer several significant advantages over more traditional techniques. Microfluidic devices provide significant savings in the amount of material required to complete a set of experiments, although rece...
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PMID: 18542878
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Drug delivery by inhalation is routine for the treatment of local pulmonary conditions like asthma, cystic fibrosis, and chronic obstructive pulmonary disease. Only recently, though, has the inhalation route been considered for administering drugs for systemic diseases. The pulmonary route is attrac...
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PMID: 19085124
PDF is available here.
PDF is available here.
médecine/sciences (27)4 2011
Abstract
We raise here a few questions regarding the possible role of time as a key determinant of the metabolic energy budget, that impacts living cells from the organisation of macromolecular assemblies up to the morphogenesis and stabilisation of tissues....
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PMID: 21524409
PDF is available here.
PDF is available here.
Abstract
We study self-avoiding random walks in an environment where sites are excluded randomly, in two and three dimensions. For a single polymer chain, we study the statistics of the time averaged monomer density and show that these are well described by multifractal statistics. This is true even far from...
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PMID: 21517516
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that the Arg-Phe dipeptide dramatically accelerates the aggregation of a model protein, α-lactalbumin, to generate morphologically different structures. TEM revealed transformation of spherical particles observed in the control samples into branched chains of fibril-like nanost...
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PMID: 21365787
PDF is available here.
PDF is available here.
Nano Letters (11)2 2011
Abstract
Convenient and inexpensive methods to pattern the facets of optical fibers with metallic nanostructures would enable many applications. This communication reports a method to generate and transfer arrays of metallic nanostructures to the cleaved facets of optical fibers. The process...
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PMID: 21188998
PDF is available here.
PDF is available here.
Abstract
Noninvasive monitoring of matrix development in tissue-engineered cartilage constructs would permit ongoing assessment with the ability to modify culture conditions during development to optimize tissue characteristics. In this study, chondrocytes seeded in a collagen hydrogel were e...
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PMID: 20807015
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (131)2 2011
Abstract
We urgently need to gather information on the properties and biological effects of nanomaterials, and to establish appropriate standard safety evaluation methods. We are therefore analyzing the association of nanomaterial interactions with macromolecules (proteins, DNA etc.) and biodistribution usin...
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PMID: 21297363
PDF is available here.
PDF is available here.
Abstract
Gel-filtration chromatography is a popular and versatile technique that permits the effective separation of proteins and other biological molecules in high yield. Here, the basis of the method is described and typical matrix types are contrasted. The selection of suitable operating conditions and ap...
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PMID: 20978958
PDF is available here.
PDF is available here.
Abstract
Over the past three decades nuclear magnetic resonance spectroscopy has been developed into a mature technique for the characterization of interactions of small molecule ligands with their corresponding protein and nucleic acid receptors. In fact, a significant number of industrial a...
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PMID: 20809889
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
A novel chemiluminescent (CL) technique for the rapid determination of proteins on a membrane is described. The method utilizes an interaction between luminol-labeled alginic acid macromolecule and proteins. The synthesis of the macromolecular probe consists of the oxidation of alginic acid with NaI...
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PMID: 20865196
PDF is available here.
PDF is available here.
Abstract
We examined possible mechanism(s) responsible for the great reduction in diffusion constants of macromolecules in vivo from that at infinite dilution. In an Escherichia coli cytoplasm model comprised of 15 different macromolecule types at physiological concentrations, BD simulations of molecular-sha...
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PMID: 20937902
PDF is available here.
PDF is available here.
Abstract
We investigated the ritonavir binding reaction by kinetic and equilibrium analysis, elucidated how the drug affects redox properties of the hemoprotein, and determined the 2.0 Å X-ray structure of the CYP3A4-ritonavir complex. Our results show that ritonavir is a type II ligand that perfectly fits...
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PMID: 20937904
PDF is available here.
PDF is available here.
Abstract
Through the stoichiometric 2 : 1 coordination of Zn(2+) with 4-amino-N-(2-methylquinolin-8-yl)benzenesulfonamide-modified per-methyl-beta-cyclodextrin (MQAS-PMCD) and the strong inclusion complexation of permethyl-beta-cyclodextrin cavity with meso-tetrakis-(4-sulfonatophenyl)-porphyrin (TSPP), an e...
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PMID: 20657925
PDF is available here.
PDF is available here.
Chemical Society Reviews (39)9 2010
Abstract
We discuss very recent advances in these areas. Three areas are covered: (i) molecular networks based on peptides and their interactions including (bio-) catalytically driven systems; (ii) supramolecular functionality, both in the context of biological and nanotechnology applications; (iii) approach...
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PMID: 20676412
PDF is available here.
PDF is available here.
Abstract
We present some evidence that the isoheight lines in the ballistic deposition (BD), Eden and restricted solid-on-solid (RSOS) models have conformally invariant properties all in the same universality class as the self-avoiding random walk (SAW), equivalently SLE_{8/3}. This leads to the conclusion t...
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PMID: 20866762
PDF is available here.
PDF is available here.
Abstract
We first explain the principles of the method and then describe the application of TCCD to a range of biomedical problems and how this method may be developed further in the future to try to monitor biological processes in live cells....
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PMID: 20658976
PDF is available here.
PDF is available here.
Abstract
We really able to understand about complex formation and can any of this information provide a useful tool to aid drug development? Correlations between thermodynamic data and structural detail have been investigated, allowing insight into ways in which these can be used to understand protein-ligand...
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PMID: 20658972
PDF is available here.
PDF is available here.
Biomedical Materials (5)4 2010
Abstract
We report that polyacrylic acid (PAA) can act as an efficient agent to modulate nano-CaP formation. The dimension of the resultant sphere-like nanoparticles (5-60 nm) can readily be regulated by changing PAA concentrations (75-200 microg ml(-1)). In contrast to other additives, PAA is a water-solubl...
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PMID: 20603529
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)8 2010
Abstract
We review recent developments in optical biolabeling and bio-imaging involving upconversion nanoparticles, simultaneously bringing to the forefront the desirable characteristics, strengths and weaknesses of these luminescent nanomaterials....
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PMID: 20485777
PDF is available here.
PDF is available here.
Abstract
Journal of Molecular Biology (400)4 2010
Abstract
We introduce the concept of His-tagged adaptor molecules, which eliminate the need for the target protein or complex to be His-tagged. The use of His-tagged protein A as adaptor molecule allows Affinity Grids to be used for the preparation of virtually any protein or complex provided that a specific...
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PMID: 20562026
PDF is available here.
PDF is available here.
Abstract
We introduce here multiplex nonlinear optical imaging as a powerful tool for studying the molecular organization and its transformation in cellular processes, with the specific example of apoptosis. Apoptosis is a process of self-initiated cell death, critically important for physiological regulatio...
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PMID: 20615987
PDF is available here.
PDF is available here.
Biological Chemistry (391)7 2010
Abstract
Small-angle scattering (SAS) of X-rays and neutrons reveals low-resolution structures of biological macromolecules in solution. With the recent experimental and methodological advances, SAS became a unique tool for characterising biological systems. The method covers an extremely broad range of mole...
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PMID: 20482320
PDF is available here.
PDF is available here.
Abstract
We describe a fast and efficient method for the isolation of the ERalpha receptosome for proteomics analysis. Using immobilized estrogen response element on a Sepharose column in combination with two-dimensional electrophoresis and MALDI-TOF MS, significant amounts of proteins could be isolated and...
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PMID: 20348541
PDF is available here.
PDF is available here.
Abstract
We studied the function of lipid rafts in generation and signaling of T-cell receptor microclusters (TCR-MCs) and central supramolecular activation clusters (cSMACs) at immunological synapse (IS). It has been suggested that lipid raft accumulation creates a platform for recruitment of signaling mole...
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PMID: 20498282
PDF is available here.
PDF is available here.
Journal of Molecular Biology (399)4 2010
Abstract
We have characterized the enzyme by means of X-ray crystallography. Structures of Mth212 wild-type or mutant proteins either alone or in complex with DNA substrates and products have been determined to a resolution of up to 1.2 A, suggesting key residues for the uridine endonuclease activity. The in...
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PMID: 20434457
PDF is available here.
PDF is available here.
Journal of Molecular Biology (399)4 2010
Abstract
Aminoacyl-tRNA (aa-tRNA), in a ternary complex with elongation factor-Tu and GTP, enters the aminoacyl (A) site of the ribosome via a multi-step, mRNA codon-dependent mechanism. This process gives rise to the preferential selection of cognate aa-tRNAs for each mRNA codon and, consequently, the fidel...
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PMID: 20434456
PDF is available here.
PDF is available here.
Abstract
We report crystallographic and biophysical data that demonstrate a previously unidentified direct interaction of MD-1 with LPS. The crystal structure of chicken MD-1 (cMD-1) at 2.0 A resolution exhibits a beta-cup-like fold, similar to MD-2, that encloses a hydrophobic cavity between the two beta-sh...
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PMID: 20534476
PDF is available here.
PDF is available here.
Abstract
We show that the reaction also requires the flexible domain of the active center, the trigger loop (TL). We show that the invariant histidine (beta' His1242) of the TL is essential for hydrolysis/proofreading and participates in the reaction in two distinct ways: by positioning the 3' end nucleotide...
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PMID: 20534498
PDF is available here.
PDF is available here.
Abstract
Assessing the environmental transport and fate of manufactured nanoparticles (NPs) and potential exposure risks requires models for predicting attachment of NPs coated with organic macromolecules in porous media. The objective of this study was to determine the properties of coated nanoparticles tha...
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PMID: 20465214
PDF is available here.
PDF is available here.
Biochemistry (Washington) (49)23 2010
Abstract
We report here two X-ray structures of the chicken smooth muscle tropomyosin overlap complex. A novel approach was used to stabilize the C-terminal and N-terminal fragments. Globular domains from both the human DNA ligase binding protein XRCC4 and bacteriophage varphi29 scaffolding protein Gp7 were...
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PMID: 20465283
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe a method to correct the errors induced by viscous drag on the cantilever in macromolecular manipulation experiments using the atomic force microscope. The cantilever experiences a viscous drag force in these experiments because of its motion relative to the surrounding liquid. This visco...
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PMID: 20590242
PDF is available here.
PDF is available here.
Chemical Communications (46)20 2010
Abstract
We have developed a facile strategy to fabricate a large-scale, orderly-patterned honeycomb structure by using supramolecular self-assembly of a low mass organic molecule.
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PMID: 20458395
PDF is available here.
PDF is available here.
Chemical Communications (46)20 2010
Abstract
A novel class of chiral coordination polymer organogels, with multi-stimuli responsive properties and suitable for use as catalysts in 1,3-dipolar Huisgen cycloaddition reaction, are reported.
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PMID: 20582353
PDF is available here.
PDF is available here.
Abstract
In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials....
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PMID: 20163978
PDF is available here.
PDF is available here.
Journal of Virological Methods (166)1-2 2010
Abstract
Tobacco mosaic virus (TMV) derivatives are explored currently extensively with regard to nanotechnological applications. Since certain technically desired TMV mutants may not be accessible from plants, the utility of the fission yeast Schizosaccharomyces pombe for heterologous production of TMV coat...
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PMID: 20219539
PDF is available here.
PDF is available here.
Abstract
We screened a short hairpin library targeting members of the deubiquitination enzyme family and identified the X-linked deubiquitination enzyme USP26 as a novel regulator of AR signaling. USP26 is a nuclear protein that binds to AR via three important nuclear receptor interaction motifs, and modulat...
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PMID: 20501646
PDF is available here.
PDF is available here.
Abstract
We report the 3.4 A resolution crystal structure of a minimal UPF3b-EJC assembly, consisting of the interacting domains of five proteins (UPF3b, MAGO, Y14, eIF4AIII, and Barentsz) together with RNA and adenylyl-imidodiphosphate. Human UPF3b binds with the C-terminal domain stretched over a composite...
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PMID: 20479275
PDF is available here.
PDF is available here.
Abstract
We report the crystal structures of the human CFI(m)25 homodimer in complex with UGUAAA and UUGUAU RNA sequences. CFI(m)25 is the first Nudix protein to be reported to bind RNA in a sequence-specific manner. The UGUA sequence contributes to binding specificity through an intramolecular G:A Watson-Cr...
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PMID: 20479262
PDF is available here.
PDF is available here.
Chemical Reviews (110)5 2010
Abstract
Chemical Reviews (110)5 2010
Abstract
Abstract
We used cryo-electron microscopy to visualize the ClpA-ATPgammaS hexamer, in the context of ClpAP complexes. Two segments lining the axial channel show anomalously low density, indicating that these motifs, which have been implicated in substrate translocation, are mobile. We infer that ATP hydrolys...
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PMID: 20462489
PDF is available here.
PDF is available here.
Human Vaccines (6)5 2010
Abstract
We demonstrate that truncation of the nuclear targeting and DNA binding signals at the C-terminus of the HPV-16 and HPV-18 L1 proteins prevented intranuclear formation of the VLPs in the host cells and led to cytoplasmic localization of the L1 proteins as shown by in situ immunogold detection and el...
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PMID: 20953154
PDF is available here.
PDF is available here.
Chemical Communications (46)16 2010
Abstract
SBA-15-Fe(terpy)(2+) complex efficiently catalyzed oxidative C-C cross-coupling reactions of tertiary amines with carbon nucleophiles in high product yields. The supported terpyridine ligand can be recycled by filtration.
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PMID: 20369167
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
We use scanning tunneling microscopy to investigate the influence of molecular ratio on the self-assembly of PTCDA-melamine structures on Au(111)-(22 x complex square root of 3). Our observations reveal that three different chiral supramolecular networks having a PTCDA:melamine ratio of 3:2, 1:2, 1:...
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PMID: 20348601
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
Size-based separations technologies will inevitably benefit from advances in nanotechnology. Direct-write nanofabrication provides a useful mechanism for depositing/etching nanoscale elements in environments otherwise inaccessible to conventional nanofabrication techniques. Here, electron beam induc...
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PMID: 20351412
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
These results help explain the observed inhomogeneity of the characterized ternary chalcogenide growth products at various growth substrate locations....
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PMID: 20351405
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
We successfully obtained a distinct type of image contrast mode which does not exhibit hydroxyl (OH) impurity defects that mostly appear in common nc-AFM images. We named the obtained distinct type of image contrast as the 'hidden mode'. The assignments of surface atomic rows in this contrast mode a...
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PMID: 20348596
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
We fabricated Bi nanowire interconnections between two pre-patterned electrodes using a combination of on-film formation of nanowires (OFF-ON) and self-assembly. Bi nanowires were found to grow laterally from a multilayer structure with a Cr (or SiO(2)) overlayer on top of a Bi thin film through the...
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PMID: 20348595
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
InGaP nanowires (NWs) were grown by the Au-assisted method in a gas source molecular beam epitaxy system. The dependence of InGaP composition, morphology and stacking fault density was studied with respect to group III and V impingement rate and size of the Au particle. Compositional analysis showed...
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PMID: 20348594
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
We also observe, after studying the properties of thermally treated samples, that the Au-Fe alloy is stabilized, not by surface effects, but by the combination of the out-of-equilibrium nature of the ion implantation technique and by changes in the properties due to size effects....
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PMID: 20348591
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
We report a simple and efficient electrochemical process that combines galvanic reaction and electron-beam lithography to selectively synthesize gold nanoparticles that are consequently used for the growth of ordered GaAs nanowire arrays with pre-defined diameter and position. Size and density contr...
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PMID: 20351413
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
Porous metal (Pd and Co) and semiconductor (ZnO) nanowires, porous metal (Pt and Ni) nanotubes, and unique multiple Pt nanowires are prepared from a novel nanoconfined surfactant templated electrodeposition approach. More specifically, the overall diameter of nanowires or nanotubes is defined by the...
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PMID: 20351410
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
These results suggest that Joule heating might be a general way to transform or anneal nanowires, pointing to applications such as metal nanowire fabrication, novel memory elements based on material transformation, or in situ improvement of field emitters....
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PMID: 20351407
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
Novel tin-oxide (SnO(2))-coated single-walled carbon nanotube (SWNT) bundles supporting platinum (Pt) electrocatalysts for ethanol oxidation were developed for direct ethanol fuel cells. SnO(2)-coated SWNT (SnO(2)-SWNT) bundles were synthesized by a simple chemical-solution route. SnO(2)-SWNT bundle...
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PMID: 20351403
PDF is available here.
PDF is available here.
Nanotechnology (21)16 2010
Abstract
A method for inscribing surface relief gratings in azopolymer thin films via proximity field nanopatterning is reported. Azopolymers prepared by ring opening metathesis polymerization were cast as thin films and brought into conformal contact with transparent polydimethylsiloxane phase masks. Irradi...
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PMID: 20348592
PDF is available here.
PDF is available here.