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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Macromolecular Substances (3):
Recent article
Macromolecular Substances
Abstract
We introduce a novel method based on genetic algorithms, for the efficient exploration of the multi-body registration search space. The classic scheme of a genetic algorithm was enhanced with new genetic operations, tabu search and parallel computing strategies and validated on a benchmark of synthe...
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PMID: 20056148
PDF is available here.
PDF is available here.
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Abstract
Elucidating the molecular details of qE (energy quenching) induction in higher plants has proven to be a major challenge. Identification of qE mutants has provided initial information on functional elements involved in the qE mechanism; furthermore, investigations on isolated pigment-protein complex...
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PMID: 20298238
PDF is available here.
PDF is available here.
Abstract
We found that MSN-AMF were capable of escaping the acidic endolysosomal vesicles of HeLa cells. Cytotoxicity studies suggested that these nanoparticles are non-toxic to HeLa cells up to a dose level of 50 microg/ml....
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PMID: 20355428
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (337)1-2 2010
Abstract
In the previous studies, MS80 was found to be able to inhibit the pulmonary fibrosis. However, the target of MS80 remains unclear. To determine the target and the antifibrosis mechanisms of MS80, affinity column, MALDITOF-MS/MS, co-immunoprecipitation, and co-localization were used. The results show...
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PMID: 19911254
PDF is available here.
PDF is available here.
Abstract
A novel porphyrin tripod (TPZn(3)) was synthesized via "click chemistry". Three porphyrin moieties of TPZn(3) are geometrically close and linked by a flexible linker. The electron-transfer oxidation of TPZn(3) results in intramolecular pi-dimer formation between porphyrin moieties as indicated by el...
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PMID: 20201539
PDF is available here.
PDF is available here.
Methods in Molecular Biology (627)627 2010
Abstract
This chapter presents an introduction to the kinetic analysis of SPR biosensor data for the determination of affinity and kinetic rate constants of biomolecular interactions between an immobilized and a soluble binding partner. The need to be aware of and critically test the assumptions underlying t...
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PMID: 20217612
PDF is available here.
PDF is available here.
Methods in Molecular Biology (627)627 2010
Abstract
Direct assay of small molecules by SPR in general is troublesome and at least tedious procedures have to be applied. Competition experiments offer an attractive alternative. A small ligand known to bind to the analyte is immobilized on an SPR sensor surface, and the binding of the larger analyte in...
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PMID: 20217616
PDF is available here.
PDF is available here.
Abstract
The supramolecular (HOPD(+))(DB[18]crown-6) cation, in which HOPD(+) and DB[18]crown-6 are o-aminoanilinium and dibenzo[18]crown-6, respectively, was introduced into [Ni(dmit)(2)](-) salts (dmit(2-) = 2-thioxo-1,3-dithiole-4,5-dithiolate). Conformational polymorphs were observed as t...
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PMID: 20029890
PDF is available here.
PDF is available here.
Abstract
The host-guest chemistry between a series of 1-alkyl-3-methyl-imidazolium bromide ([C(n)mim]Br) guests and the macrocyclic host molecule cucurbit[6]uril (CB[6]) in an aqueous system is systematically studied in neutral aqueous media. Both 1D and 2D NMR experiments in conjunction with...
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PMID: 20143372
PDF is available here.
PDF is available here.
Abstract
Abstract
The structure and composition of the oocyst wall are primary factors determining the survival and hydrologic transport of Cryptosporidium parvum oocysts outside the host. Microscopic and biochemical analyses of whole oocysts and purified oocyst walls were undertaken to better understand the inactiva...
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PMID: 20097810
PDF is available here.
PDF is available here.
Abstract
Two novel complexes, namely, [Pd(pdc)(2)].(dmp).6H(2)O (1) and [Pd(pdc)(2)K(H(2)O)(5).3H(2)O]n (2) [H(2)pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesized and characterized as pH-dependent products. Gel electrophoresis assay demonstrated the ability of the co...
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PMID: 20015578
PDF is available here.
PDF is available here.
Journal of Molecular Biology (396)3 2010
Abstract
We report that the SAM is not static but that the SAM core complex can associate with different partner proteins to form two large SAM complexes with different functions in the biogenesis of alpha-helical Tom proteins. We found that a subcomplex of TOM, Tom5-Tom40, associates with the SAM core compl...
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PMID: 20026336
PDF is available here.
PDF is available here.
Abstract
We employed a biochemical approach to isolate AGO-containing miRNPs from human H4 tumor cells by co-immunoprecipitation (co-IP) with a previously described anti-AGO antibody. Co-immunoprecipitated (co-IPed) RNAs were subjected to downstream Affymetrix Human Gene 1.0 ST microarray analysis. During ri...
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PMID: 20042474
PDF is available here.
PDF is available here.
Abstract
We present a cryo-electron microscopy study of the process of accommodation. The structure suggests how tmRNA and SmpB move into the ribosome decoding site after the release of EF-Tu.GDP. While two SmpB molecules are bound per ribosome in a preaccommodated state, our results show that during accommo...
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PMID: 20038631
PDF is available here.
PDF is available here.
Trends in Biotechnology (28)2 2010
Abstract
We focus on physiological, chemical and physical aspects of forisomes and discuss their potential as biomimetic devices.
2009 Elsevier Ltd. All rights reserved....
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PMID: 20004992
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We generated recombinant murine hepatitis coronaviruses that express tagged versions of the nonstructural protein nsp2. We demonstrated by using immunofluorescence assays and electron microscopy that this protein is recruited to the DMV-anchored RTCs, for which its C terminus is essential. Live-cell...
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PMID: 20007278
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We evaluated the HSV-1 DNA-containing complexes at 5 h after (lytic) infection by biochemical fractionations. Nuclear HSV-1 DNA did not fractionate as protein-free HSV-1 DNA but as DNA in cellular nucleosomes. Moreover, MCN released HSV-1 DNA in complexes that fractionate as cellular mono- and dinuc...
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PMID: 20007274
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We analyzed the 2.9-A structure of the VSV N protein bound to RNA (T. J. Green, X. Zhang, G. W. Wertz, and M. Luo, Science 313:357-360, 2006) and identified amino acid residues with the potential to interact with RNA via hydrogen bonds. The contributions of these interactions to N protein function w...
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PMID: 20007268
PDF is available here.
PDF is available here.
Abstract
We report the 1.65 A resolution structure of the DNA-recognition component gp1 of the Shigella bacteriophage Sf6 genome-packaging machine. The structure reveals a ring-like octamer formed by interweaved protein monomers with a highly extended fold, embracing a tunnel through which DNA may be translo...
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PMID: 20133842
PDF is available here.
PDF is available here.
Abstract
The success of early drug-discovery programs depends on the adequate combination of complementary and orthogonal technologies allowing hit/lead compounds to be optimized and improve therapeutic activity. Among the available biophysical methods, native MS recently emerged as an effici...
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PMID: 21426045
PDF is available here.
PDF is available here.
Abstract
In inflammatory bowel disease (IBD), aberrant activation of innate and adaptive immune responses enhances mucosal permeability through mechanisms not completely understood. To examine the role of epithelial nuclear factor (NF-kappaB) in IBD-induced enhanced permeability, epithelial-specific IkappaBal...
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PMID: 20008138
PDF is available here.
PDF is available here.
Abstract
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences ()128 2010
Abstract
We provide a brief description of the ab initio FMO method and demonstrate recent applications to the biomacromolecules....
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PMID: 21381393
PDF is available here.
PDF is available here.
Abstract
To gain a deeper understanding of the physicochemical phenomenon of self-assembled nanoparticles of different generations and ratios of poly (amidoamine) dendrimer (PAMAM) dendrimer and a short-stranded DNA (antisense oligonucleotide), multiple methods were used to characterize these nanoparticles i...
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PMID: 20517481
PDF is available here.
PDF is available here.