Abstract
The present review of epidemiologic studies of physical activity and genitourinary cancers (prostate, bladder, renal cell, and testicular cancers) suggests a weak inverse relation of physical activity to risk of prostate and renal cell cancer, with average risk decreases of less than 10% comparing h...
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PMID: 21113760
PDF is available here.
Abstract
We discuss common toxicities arising from genitourinary cancer treatments, in particular the adverse effects from androgen deprivation therapy (ADT) for prostate cancer given its well established detrimental effects on physical, physiological, and psychological function, and existing physical activi...
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PMID: 21113766
PDF is available here.
Abstract
Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy accounting for approximately 1% of vulvar cancers. The rarity of this disease has caused difficulties in its characterization. Controversies exist in the literature regarding many aspects of this condition including the prevalence of...
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PMID: 20883922
PDF is available here.
Axel Heidenreich,
Peter Albers,
Johannes Classen,
Markus Graefen,
Jürgen Gschwend,
Jörg Kotzerke,
Susanne Krege,
Jens Lehmann,
Detlef Rohde,
Heinz Schmidberger,
Michael Uder,
Hajo Zeeb and
Association of Urologic Oncology of the German Cancer Society
Abstract
Imaging studies are an integral and important diagnostic modality to stage, to monitor and follow-up patients with metastatic urogenital cancer. The currently available guidelines on diagnosis and treatment of urogenital cancer do not provide the clinician with evidence-based recommendations for dai...
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PMID: 20693823
PDF is available here.
Zhao-dong Han,
Hui-chan He,
Xue-cheng Bi,
Wei-jun Qin,
Qi-shan Dai,
Jun Zou,
Yong-kang Ye,
Yu-xiang Liang,
Guo-hua Zeng,
Gang Zhu,
Zhi-nan Chen and
Wei-de Zhong
Abstract
CD147/EMMPRIN was expressed in neoplastic tissues, but not in normal tissues. Positive expression was shown in 42 of 52 (80.77%) of the patients with renal carcinoma, 41 of 58 (70.69%) of the patients with bladder carcinoma, 67 of 101 (66.34%) of the patients with prostate carcinoma, 16 of 17 (94.12...
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PMID: 19286191
PDF is available here.
Abstract
As part of the diagnosis and treatment of cancer objective biological measures are becoming increasingly important and may help to elicit the individual patient's risk of future outcome. Among theses measures are markers as determinants for the biological potential of the malignant disease, the pred...
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PMID: 20376654
PDF is available here.
Abstract
We focus on lymphotropic nanoparticle enhanced MRI and its application for the staging of genitourinary malignancies....
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PMID: 20084078
PDF is available here.
Abstract
In the United States, disparities in health care delivery and access are apparent between different racial and ethnic groups. Minorities, including African Americans, often suffer disproportionately from disease compared to Caucasians. In the urologic arena, this is apparent in urologic cancer scree...
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PMID: 20191923
PDF is available here.
C Lavogiez,
E Delaporte,
S Darras-Vercambre,
E Martin De Lassalle,
C Castillo,
X Mirabel,
F Laurent,
P Patenotre,
T Gheit,
J C Talmant,
M Beylot-Barry,
V Martinot,
F Piette,
F Aubin and
L Mortier
Abstract
Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoan...
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PMID: 20029163
PDF is available here.
FUTURE I/II Study Group,
Joakim Dillner,
Susanne K Kjaer,
Cosette M Wheeler,
Kristján Sigurdsson,
Ole-Erik Iversen,
Mauricio Hernandez-Avila,
Gonzalo Perez,
Darron R Brown,
Laura A Koutsky,
Eng Hseon Tay,
Patricia García,
Kevin A Ault,
Suzanne M Garland,
Sepp Leodolter,
Sven-Eric Olsson,
Grace W K Tang,
Daron G Ferris,
Jorma Paavonen,
Matti Lehtinen,
Marc Steben,
F Xavier Bosch,
Elmar A Joura,
Slawomir Majewski,
Nubia Muñoz,
Evan R Myers,
Luisa L Villa,
Frank J Taddeo,
Christine Roberts,
Amha Tadesse,
Janine T Bryan,
Roger Maansson,
Shuang Lu,
Scott Vuocolo,
Teresa M Hesley,
Eliav Barr and
Richard Haupt
Abstract
Quadrivalent HPV vaccine provided sustained protection against low grade lesions attributable to vaccine HPV types (6, 11, 16, and 18) and a substantial reduction in the burden of these diseases through 42 months of follow-up. TRIAL REGISTRATIONS: NCT00092521 and NCT00092534....
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PMID: 20647284
PDF is available here.
Abstract
Adenosarcoma like tumor of the seminal vesicle is reported herein. A 35-year-old male presented with mass in the pelvis between bladder and rectum, involving the seminal vesicle and prostate. Mass recurred after enucleation in four years. Histologically, the tumor was multicystic with bland ciliated...
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PMID: 20551553
PDF is available here.
Abstract
As life expectancy of patients infected by Human Immunodeficiency Virus (HIV) has prolonged, they are treated by physicians of different specialities. This article focuses on urologic complications of HIV infection. Urinary tract infections in HIV positive patients are more frequent than in otherwis...
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PMID: 20429346
PDF is available here.
Abstract
Collaborative studies have dramatically improved therapy of genitourinary RMS with a remarkable improvement of survival. However, refractory or relapsed disease is still the most demanding challenge. Advances in our understanding of RMS molecular biology evolve new risk stratification and new therap...
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PMID: 19440152
PDF is available here.
Abstract
These results suggest that endogenous hormones, environmental contaminants that interact with steroid hormone receptors, and alterations in p53 may play a role in urogenital carcinogenesis in California sea lions....
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PMID: 19276047
PDF is available here.
Abstract
We focus on the treatment of the most predominant sites of origin of EPSCC; the gastrointestinal tract, the genitourinary tract, the head and neck region, and small cell carcinoma of unknown primary. Furthermore we review the available data concerning the controversial issue of prophylactic cranial...
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PMID: 19068273
PDF is available here.
Abstract
None of the extended-field-of-view images was diagnostic. However, they did provide valuable additional information and better documentation of the lesions....
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PMID: 19433027
PDF is available here.
Abstract
We have reported that 14% of prostate cancer (PCa) cases are positive for Reg IV by immunohistochemistry. In the present study, we performed immunohistochemical analysis of Reg IV in other major urological cancers, including 101 renal cell carcinoma (RCC), and 95 urothelial carcinoma (UC) of urinary...
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PMID: 19082448
PDF is available here.
Abstract
Bladder cancer incidences were quite high, especially for men, and appear to be increasing. Prostate cancer has lower incidence rates as compared to western countries but the trend is for rise. There might be an underestimate of incidences, owing to an inability to use data from death certificates....
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PMID: 19640197
PDF is available here.
Abstract
We conclude that the routine use of positive oral contrast material is unnecessary for follow-up multidetector CT for general oncology indications.
(c) RSNA, 2009....
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PMID: 19092097
PDF is available here.
Abstract
We describe postradiosurgical treatment outcomes of our consecutive series of 456 patients (220 females, 236 males, mean age; 60.5 years, range 19-86 years) who underwent gamma knife (GK) treatment for brain metastases originating from non-lung cancers, focusing particularly on GK treatment for mult...
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PMID: 18948727
PDF is available here.
Abstract
We retrieved 58 cases of genital pigmented lesions diagnosed at our hospital from 1986 to 2008 to evaluate their clinicopathologic features with especial consideration to those cases with atypical features. Thirty-two cases (55%) were common nevi, 10 (17%) lentigines, 6 (10%) melanomas, 3 (5%) dyspl...
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PMID: 18976416
PDF is available here.
Abstract
Inflammatory myofibroblastic tumor of the genitourinary tract should be considered a neoplasm of uncertain malignant potential, and routine surveillance and close clinical followup are recommended. Aggressive therapy (radical cystectomy, radiation or chemotherapy) is unwarranted given the indolent a...
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PMID: 18707729
PDF is available here.
Abstract
Paraneoplastic syndromes induced by inappropriate-ectopic production of hormones, cytokines and growth factors, therefore not mediated directly by local infiltration or metastatic spread, occur in approximately 10 per cent of patients with malignant disease in initial phase. Subjects with paraneopla...
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PMID: 18947470
PDF is available here.
Abstract
The daily management of urogenital cancers is currently based on prognostic classifications derived from the identification of independent clinical or biological indicators of overall survival. These classifications are used for patient stratification in clinical trials and definition of appropriate...
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PMID: 19004728
PDF is available here.
Abstract
In cancer patients > or =80 years old selected for chemotherapy, both single and multi-agent therapy appeared to be feasible....
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PMID: 18599305
PDF is available here.
Abstract
The endothelin system comprises the three peptide hormones endothelin (ET)-1, -2, -3, their G protein-coupled receptors, endothelin-A-receptor (ET(A)R) and endothelin-B-receptor (ET(B)R), and the enzymes of endothelin biosynthesis and degradation. In the past two decades, an impressive amount of dat...
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PMID: 18759699
PDF is available here.
Abstract
The QOL score was slightly higher in all patients after the completion of radiotherapy than before the start of radiotherapy. In the palliative radiotherapy group, QOL score was significantly improved by treatment. Anxiety and depression were improved after radiotherapy. There was a correlation betw...
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PMID: 18769996
PDF is available here.
Abstract
Patients presenting with symptoms of ureteral obstruction due to advanced malignancy should be informed of the therapeutic options in the context of the poor prognosis. In the meantime research is needed to find methods of urinary diversion and pharmacological intervention for symptomatic relief wit...
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PMID: 18550089
PDF is available here.
Abstract
The most frequent primary site was in the genito-urinary system in eight patients and the most common bones involved were the calcaneus and the talus in six patients each. All patients died after a mean survival of 14.8 (range, 1 to 54) months after diagnosis of metastases. CONCLUSION: Although meta...
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PMID: 18785420
PDF is available here.
Abstract
There was a significantly higher mortality rate for UB-TCC among exposed patients in the area endemic for arseniasis than in those from other non-endemic areas. The arsenic content of artesian-well water might contribute to the increased ratio of female patients with GU-TCC and the unusually high in...
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PMID: 18445081
PDF is available here.
Abstract
We will summarize the current data on the role of the arachidonic acid-prostaglandin pathway in urologic malignancies and explore some of the mechanistic problems with the use of NSAIDs and the potential for inhibiting other points in the pathway....
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PMID: 18588457
PDF is available here.
Abstract
Aging-correlated pathologies are atherosclerosis, arterial hypertension, diabetes mellitus, bacterial infections, and malnutrition. The progressive impairment of renal function is the cause of the drug-induced renal pathologies: direct damage induced by nephrotoxic drugs or indirect damage induced b...
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PMID: 18922292
PDF is available here.
Abstract
I came across in my 15 years of surgical and molecular pathology practice. The study raises several notions. Extracutaneous malignant melanomas are rare but extremely aggressive lesions with a grim outcome. They include ocular, metastatic, anorectal, mucosal, nail beds, conjunctival, vaginal, urogen...
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PMID: 18568775
PDF is available here.
Abstract
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood. This paper is focuses on imaging for diagnosis, staging, and follow-up of noncraniofacial RMS.
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PMID: 18324394
PDF is available here.
Abstract
The present study reveals that the concordant over-expression of Sp1 and VEGF may play a pivotal role in the tumorigenesis and further malignant transduction of EMPD....
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PMID: 18477144
PDF is available here.
Abstract
The WTX gene is now the most common known gene mutation in Wilms' tumor. It acts as a tumor suppressor gene and may play a role in other malignancies. Current clinical trials have incorporated the loss of heterozygosity of 1p and 16q along with age, tumor size, stage, and response to therapy to risk...
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PMID: 18391632
PDF is available here.
Abstract
Some biochemical markers of mucosal toxicity change significantly during treatment. Further studies must investigate the timing of changes of these biochemical markers, their relationship to gastrointestinal physiological change and the radiotherapy dose delivered to the gastrointestinal tract and w...
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PMID: 18315578
PDF is available here.
Abstract
Incidence of cancer may vary within a country and over time because of previous differences in exposure to risk factors or interventions for early detection (screening). This study describes time-space trends of incidence of common cancer sites across the Netherlands during the period 1989-2003 and...
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PMID: 18183593
PDF is available here.
Abstract
We briefly described microRNA biogenesis, function and the principal approaches for studying the function of microRNAs (miRNA) in solid cancers. There are currently hundreds of confirmed miRNAs in humans, and computational predictions suggest that the total count might be more than thousand. The reg...
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PMID: 18296065
PDF is available here.
Abstract
Zoledronic acid is the only bisphosphonate that has demonstrated statistically significant, long-term clinical benefits through the prevention and delay of skeletal-related events in patients with metastatic prostate cancer or renal cell carcinoma....
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PMID: 18061356
PDF is available here.
Linda Titus-Ernstoff,
Rebecca Troisi,
Elizabeth E Hatch,
Marianne Hyer,
Lauren A Wise,
Julie R Palmer,
Raymond Kaufman,
Ervin Adam,
Kenneth Noller,
Arthur L Herbst,
William Strohsnitter,
Bernard F Cole,
Patricia Hartge and
Robert N Hoover
Abstract
Our data do not support an overall increase of cancer risk in the sons or daughters of women exposed prenatally to DES, but the number of ovarian cancer cases was greater than expected. While preliminary, this finding supports continued monitoring of these daughters....
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PMID: 18223485
PDF is available here.
Abstract
Laparoscopic prostatectomy with extended lymphadenectomy can be performed safely, retrieves a higher node count, and yields positive nodes more frequently than a limited lymphadenectomy. Lymphadenectomy remains the best method to stage prostate cancer; further studies are needed, however, to assess...
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PMID: 18303537
PDF is available here.
Abstract
For prostate cancer, the most interesting findings concern ablative therapies for primary and recurrent prostate cancer with substantial functional and oncologic results. Unfortunately, no recent study assessed the long-term oncologic outcomes after laparoscopic radical prostatectomy. It appears tha...
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PMID: 18303542
PDF is available here.
Abstract
To our knowledge, 28 cases of port site metastasis have been reported in the urologic literature. There has been an increased interest in the use of intraperitoneal instillation of various tumoricidals in order to reduce the risk of port site seeding. SUMMARY: The risk of port site metastases remain...
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PMID: 18303541
PDF is available here.