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Abstract
The fraction of nitric oxide in exhaled gas (FE(NO)) is reduced by 30-70% after exposure to partial pressures of oxygen (Po2) of 200-240 kPa for 90 min. The purpose of this study was to partition FE(NO) into its flow-independent alveolar and bronchial components. A reduced bronchial...
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PMID: 21961398
PDF is available here.
PDF is available here.
Abstract
We consider a trial of oral medications (glycopyrrolate 1-2 mg once or twice daily preferred to clonidine 0.1 mg twice daily) as second-line therapy due to the low cost, convenience, and emerging literature supporting their excellent safety and reasonable efficacy. Iontophoresis is considered th...
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PMID: 21714579
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids.
We analyzed a small number of statistically powerful variants selected on the basis of a family-based screening algorithm from among 534,290...
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PMID: 21991891
PDF is available here.
PDF is available here.
Abstract
Copper complex with Curtis macrocyclic tetramine is offered as reagent for extraction-photometric determination of nonsteroidal anti-inflammatory drugs (NSAIDs), belonging to the class of aromatic carboxylic acids. The studies indicate that this method is suitable for quantitative determination of NS...
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PMID: 21928706
PDF is available here.
PDF is available here.
Abstract
The present investigation is an attempt to evaluate the effect of Bergenia ciliata extract on kidney of ethylene glycol induced urolithiasis in adult female Wistar rats. The hydro-alcoholic extract of Bergenia ciliata/standard drug cystone were administrated simultaneously at a dose of 150 and 300 mg...
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PMID: 21928716
PDF is available here.
PDF is available here.
Abstract
We state that the in vitro bovine corneal epithelial primary culture model is useful for ocular studies....
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PMID: 21928720
PDF is available here.
PDF is available here.
Abstract
In order to evaluate the efficacy of an antibacterial therapy, three basic PK/PD indexes were defined: the ratio between the maximum drug concentration obtained after a single dose and minimum inhibitory concentration MIC (CMAX/MIC), the ratio between the area under the curve of dependence between th...
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PMID: 21928725
PDF is available here.
PDF is available here.
Abstract
The purpose of this research was to develop oro-dispersible tablets of metformin by direct compression method using super disintegrants approach, effervescent approach and sublimation approach. Powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausne...
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PMID: 21928717
PDF is available here.
PDF is available here.
Abstract
Hepatic venous outflow tract obstruction (HVOTO) comprises of constellation of disorders causing obstruction of hepatic venous outflow or suprahepatic inferior vena cava (IVC) or both and leading to increased hepatic sinusoidal pressure and portal hypertension. Clinical presentation in HVOTO includes...
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PMID: 21922850
PDF is available here.
PDF is available here.
Abstract
MMW Fortschritte der Medizin (153)36 2011
Abstract
Poultry Science (90)9 2011
Abstract
Central composite design (CCD; 5 levels and 4 factors), response surface methodology (RSM), and artificial neural network-genetic algorithm (ANN-GA) were used to evaluate the response of broiler chicks [ADG and feed conversion ratio (FCR)] to dietary standardized ileal digestible protein (dP), lysine...
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PMID: 21844277
PDF is available here.
PDF is available here.
Abstract
To examine the relationship between drusen counts and drusen area in eyes with age-related macular degeneration, and to correlate drusen areas between fellow eyes.
Digital images from 378 patients (756 eyes) were analyzed using a validated drusen detection algorithm....
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PMID: 21899243
PDF is available here.
PDF is available here.
Abstract
PET/MRI is an emerging dual-modality imaging technology that requires new approaches to PET attenuation correction (AC). We assessed 2 algorithms for whole-body MRI-based AC (MRAC): a basic MR image segmentation algorithm and a method based on atlas registration and pattern recognition (AT&PR).
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PMID: 21828115
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to compare the effectiveness of a hand-held preoperative compact imager (POCI) camera with conventional lymphoscintigraphy using a γ-camera for sentinel lymph node (SLN) detection in breast cancer.
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PMID: 21849400
PDF is available here.
PDF is available here.
Abstract
I study were to evaluate radiation dosimetry, biodistribution, human safety, tolerability, and early elimination of (18)F activity in urine after injection of a single dose of the tracer at rest in healthy subjects....
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PMID: 21849402
PDF is available here.
PDF is available here.
Annals of Surgery (254)3 2011
Abstract
We conducted an analysis from our prospective database of 466 adults' ReLT between February 1984 and September 2010. Mean follow-up was 3 years. Each independent predictor for allograft failure was assigned risk score (RS) points of 1 or 2, proportional to the corresponding parameter estimate under...
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PMID: 21817890
PDF is available here.
PDF is available here.
Abstract
We examined the effect of a graphical indication of the magnitude of Trigg's Tracking Variable, a simple statistically based trend detection algorithm, on the accuracy and latency of the detection of changes in a micro-simulation. Ten anaesthetists each viewed 20 simulations with four variables disp...
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PMID: 21970133
PDF is available here.
PDF is available here.
Abstract
Linear, quadratic, and artificial neural network (ANN)-based metamodels were developed for predicting the extent of anthrax spore inactivation by chlorine dioxide in a ventilated three-dimensional space over time from computational fluid dynamics model (CFD) simulation data. Dimensio...
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PMID: 22010381
PDF is available here.
PDF is available here.
Abstract
Mandibular defect occurs more frequently in recent years, and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic flaws. Tissue engineering, which is a hot research field of biomedical engineering, provides a new direction fo...
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PMID: 21887853
PDF is available here.
PDF is available here.
Proteomics (11)18 2011
Abstract
We present a simple, time- and cost-efficient approach to tackle the proteome of prokaryotic organisms. To obtain large data sets of complex biological experiments high-throughput and time- and cost-efficient methods still have to be developed and refined. In this study, we combined well-approved te...
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PMID: 21751368
PDF is available here.
PDF is available here.
British Journal of Cancer (105)5 2011
Abstract
Therapeutic options for patients with advanced hepatocellular carcinoma (HCC) are limited. There is emerging evidence that the growth of cancer cells may be altered by very low levels of electromagnetic fields modulated at specific frequencies.
A single-group, open-la...
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PMID: 21829195
PDF is available here.
PDF is available here.
Abstract
We screened 240 sera from 64 patients with primary breast cancer. This unique longitudinal sample material was collected from each patient between 0 and 36 mo after the primary operation. The velocity for each serum protein was determined by comparing the samples collected at the primary operation a...
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PMID: 21844363
PDF is available here.
PDF is available here.
Abstract
We present a data mining approach that enables the identification of alternative analog series with different core structures, corresponding substitution patterns, and comparable potency progression. Scaffolds can be exchanged between these series and new analogs suggested that incorporate preferred...
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PMID: 21774471
PDF is available here.
PDF is available here.
Abstract
We present an extension of the activity cliff concept by introducing "activity ridges" that are formed by overlapping "combinatorial" activity cliffs between participating compounds, giving rise to ridge-like structures in activity landscapes. Activity ridges are rich in SAR information. In a system...
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PMID: 21761918
PDF is available here.
PDF is available here.
Abstract
A large-scale similarity search investigation has been carried out on 266 well-defined compound activity classes extracted from the ChEMBL database. The analysis was performed using two widely applied two-dimensional (2D) fingerprints that mark opposite ends of the current performanc...
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PMID: 21728295
PDF is available here.
PDF is available here.
Abstract
We sought to develop an appropriate method to examine large sets of GPCR ligand information for both screening collection enhancement and hit expansion. To this end, we have implemented a modified version of BDACCS that removes highly correlated descriptors (rBDACCS). To test the hypothesis that a s...
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PMID: 21761904
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)33 2011
Abstract
Osteoporotic fractures are associated with excess mortality. Effective treatment options are available, which reduce the risk of vertebral and non-vertebral fractures, but the identification of patients with high fracture risk is problematic. Low bone mineral density (BMD)--the basis for the diagnosi...
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PMID: 21824857
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)33 2011
Abstract
Osteoporosis affects approximately 9% of the population in Hungary resulting in about 100 000 osteoporotic fractures annually. Thirty-five percent of patients with hip fractures due to osteoporosis will die within 1 year. Direct costs of osteoporosis exceed 25 billion forints per year. Apparently, co...
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PMID: 21824859
PDF is available here.
PDF is available here.
Nihon Naika Gakkai Zasshi (100)8 2011
Abstract
Abstract
We shall address. We shall point out the confusions about the conventional identity in the min-plus algebra and present an analytical expression of the asymptotic identity that may not cause confusions....
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PMID: 21822446
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)8 2011
Abstract
We limit ourselves to the presentation of the working population of the migrants, because these represent the largest group of all migrants. The specific situation of asylum seekers will also be refrained to where appropriate....
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PMID: 21796592
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)8 2011
Abstract
Adhesions occur with a high incidence after intra-abdominal surgery but can also develop due to infections, radiation or for idiopathic reasons. The formation of adhesions is initiated by tissue damage and is the result of peritoneal tissue repair involving the activation of the inflammatory system a...
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PMID: 21796600
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)8 2011
Abstract
Abdominal pain without any identifiable cause represents a frequent phenomenon in clinical practice and a challenge for the physician. Prior to establishing the diagnosis of non-specific abdominal pain it is crucial to exclude a variety of potential causes. The differential diagnosis is long and incl...
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PMID: 21796597
PDF is available here.
PDF is available here.
Abstract
Constipation is traditionally defined as three or fewer bowel movements per week. Risk factors for constipation include female sex, older age, inactivity, low caloric intake, low-fiber diet, low income, low educational level, and taking a large number of medications. Chronic constipation is classifie...
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PMID: 21842777
PDF is available here.
PDF is available here.
Abstract
Abstract
The Canadian cervical spine rule (CCS) has been found to be an effective tool to determine the need for radiographic evaluation of the cervical spine (c-spine) incorporating both clinical findings and mechanism. Previously, it has been validated only through clinical follow-up or selective use of X-r...
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PMID: 21825938
PDF is available here.
PDF is available here.
Abstract
Abstract
We provided healthy subjects and stroke patients with a virtual task during robot-assisted gait training, which allowed modulating cognitive load by adapting the difficulty level of the task. We quantified the cognitive load of stroke patients by using psychophysiological measurements and performanc...
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PMID: 21827971
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)8 2011
Abstract
We therefore summarise recent efforts to fundamentally improve this situation by decoupling the sampling of the energy landscape from the description of the kinetics of the process. Recent years have seen the emergence of many advanced sampling techniques, which permit efficient characterisation of...
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PMID: 20851219
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)8 2011
Abstract
We review the recent development of these algorithms and models; then list the related software and data sources; and finally discuss the existence problems and perspectives in this field....
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PMID: 21831798
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate the role of nitric oxide (NO) in the mechanisms of arterial distensibility and intravascular pressure stability in normotensive and spontaneously hypertensive rats. The experiments were performed on the anesthetized male Wistar, Wistar-Kyoto (WKY...
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PMID: 21961305
PDF is available here.
PDF is available here.
Abstract
We reviewed the literature to determine if specific disease parameters or medication use could be used to better characterize fracture risk in individuals with rheumatoid arthritis. Although many studies document a correlation between various parameters of disease activity or severity and decreased...
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PMID: 21810523
PDF is available here.
PDF is available here.
Abstract
The worldwide prevalence of smoking has been estimated at about 50% in men, and 10% in women, with larger variations among different populations studied. Smoking has been shown to affect many organ systems resulting in severe morbidity and increased mortality. In addition, smoking has been identified...
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PMID: 21810524
PDF is available here.
PDF is available here.
Abstract
Risk factors for fracture can be purely skeletal, e.g., bone mass, microarchitecture or geometry, or a combination of bone and falls risk related factors such as age and functional status. The remit of this Task Force was to review the evidence and consider if falls should be incorporated into the FR...
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PMID: 21810525
PDF is available here.
PDF is available here.
Abstract
The 2010 Position Development Conference addressed four questions related to the impact of previous fractures on 10-year fracture risk as calculated by FRAX(®). To address these questions, PubMed was searched on the keywords "fracture, epidemiology, osteoporosis." Titles of retrieved articles were r...
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PMID: 21810526
PDF is available here.
PDF is available here.
Abstract
The World Health Organization fracture risk assessment tool, FRAX(®), is an advance in clinical care that can assist in clinical decision-making. However, with increasing clinical utilization, numerous questions have arisen regarding how to best estimate fracture risk in an individual patient. Recog...
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PMID: 21810522
PDF is available here.
PDF is available here.
Abstract
Given the significant impact the use of glucocorticoids can have on fracture risk independent of bone density, their use has been incorporated as one of the clinical risk factors for calculating the 10-year fracture risk in the World Health Organization's Fracture Risk Assessment Tool (FRAX(®)). Lik...
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PMID: 21810527
PDF is available here.
PDF is available here.
Abstract
Scapular winging is a rare disorder often caused by neuromuscular imbalance in the scapulothoracic stabilizer muscles. Lesions of the long thoracic nerve and spinal accessory nerves are the most common cause. Numerous underlying etiologies have been described. Patients report diffuse...
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PMID: 21807913
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate that recording amplitude and noise are relatively independent of microelectrode size, but instead are primarily affected by the selected recording bandwidth, impedance of the electrode-tissue interface and the density and firing rates of neurons surrounding the recording elec...
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PMID: 21775783
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)29-31 2011
Abstract
Abstract
The computation time required for modeling the nonlinear response of an axon to an applied electric field is a significant limitation to optimizing a large number of neural interface design parameters through use of advanced computer algorithms. This paper introduces two methods of p...
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PMID: 21750371
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)7 2011
Abstract
Tuberculosis continuous to be the world's most important infectious disease in addition to malaria and AIDS. One-third of world's population is infected with Mycobacterium tuberculosis. Every tenth of those people will develop active tuberculosis in his or her lifetime. The global tuberculosis incide...
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PMID: 21728155
PDF is available here.
PDF is available here.
Abstract
We have developed an approach that enhances the power of clustering techniques to infer functional and regulatory meaning of protein states in cell signaling networks. We have created a new computational framework for applying clustering to biological data in order to overcome the typical dependence...
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PMID: 21799663
PDF is available here.
PDF is available here.
Abstract
We analyzed the effect of receptor mutant clones on the Dpp profile in quantitative mathematical models representing transport by either RMT or RED. We then, using novel genetic tools, experimentally monitored the actual Dpp gradient in wing discs containing receptor gain-of-function and loss-of-fun...
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PMID: 21814489
PDF is available here.
PDF is available here.
Abstract
We have developed a sparse Bayesian factor analysis model in which the observed expression diversity of among a large set of high-dimensional images is modeled by a small number of hidden common factors. We apply this approach on embryonic expression patterns from a Drosophila RNA in situ image data...
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PMID: 21814502
PDF is available here.
PDF is available here.
Abstract
The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enro...
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PMID: 21818180
PDF is available here.
PDF is available here.
New predictive models of heart failure mortality using time-series measurements and ensemble models.
Abstract
-Significant gains in accuracy of one year mortality prediction in chronic heart failure can be obtained by using logistic regression models that incorporate serial measurements of biomarkers such as cytokine and cytokine receptor levels. Ensemble models capture inherent variability in large patient...
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PMID: 21562057
PDF is available here.
PDF is available here.
Abstract
We characterized key features of the somatic and dendritic firing and quantified their statistics. We used these features to constrain the density of a set of ion channels over the soma and dendritic surface via multi-objective optimization with an evolutionary algorithm, thus generating a set of de...
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PMID: 21829333
PDF is available here.
PDF is available here.