Abstract
Parkinson's disease is a hypokinetic movement disorder with cardinal motor features of bradykinesia, resting tremor and rigidity. However, non-motor symptoms, such as cognitive, neuropsychiatric, sleep, autonomic and sensory disturbances are gaining increasing attention. These non-motor symptoms may...
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PMID: 19711119
PDF is available here.
Abstract
We found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochem...
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PMID: 18992722
PDF is available here.
Abstract
Diffuse slowing of the EEG is considered one of the hallmarks of an encephalopathic process and is commonly reported in psychiatric patients. The EEG may be helpful in the diagnostic evaluation of patients with a difficult-to-assess mental status....
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PMID: 19439160
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Abstract
Median age of patients was 23 years (range 5-76 years); 91 were women. All patients presented with psychiatric symptoms or memory problems; 76 had seizures, 88 unresponsiveness (decreased consciousness), 86 dyskinesias, 69 autonomic instability, and 66 hypoventilation. 58 (59%) of 98 patients for wh...
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PMID: 18851928
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Abstract
Tumour location, size and radiographic characteristics varied in each patient. Clinical presentations comprised focal neurological deficits as well as epileptic seizures, persistent headache, mental changes and psycho-organic syndromes. One patient underwent delayed ventriculo-peritoneal shunting af...
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PMID: 19020796
PDF is available here.
Abstract
Testamentary incapacity for medical reasons was established in 47% of the testators, while a strong, statistically significant relationship between a diagnostic category and testamentary incapacity was established among the testators suffering from an organic mental disorder (Chi-square=133.256, p=0...
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PMID: 19011589
PDF is available here.
Abstract
We review the evidence for a sexually dimorphic influence of COMT upon psychiatric phenotypes, and discuss its potential basis. We conclude that despite the evidence being incomplete, and lacking a unifying explanation, there are accumulating and in places compelling data showing that COMT different...
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PMID: 17805313
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Abstract
The COMT gene functional polymorphism val(158)met is one of the most intensively studied variants in psychiatric genetics. Due to small effect size and various methodological issues, its role in various psychiatric disorders and behavioral traits has still not been unequivocally established. In this...
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PMID: 18923401
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Abstract
We appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding "normal" adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the i...
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PMID: 19005040
PDF is available here.
Abstract
We therefore hypothesized that SK3 channels affect 5-HT and DA neurotransmission and associated behaviors. To explore this, we used doxycycline-induced conditional SK3-deficient (T/T) mice. In microdialysis, T/T mice had elevated baseline levels of striatal extracellular DA and the metabolites dihyd...
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PMID: 18616612
PDF is available here.
Abstract
The review of CADASIL literature suggests the need for a more structured approach to the investigation of these disturbances that are highly prevalent and may greatly impact quality of life in these patients....
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PMID: 18384453
PDF is available here.
Abstract
We characterized various behaviors and learning and memory in a mouse model in which major aspects of mesial temporal lobe epilepsy can be reproduced. In this model, a single unilateral injection of kainate into the dorsal hippocampus induces a nonconvulsive status epilepticus, followed by developme...
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PMID: 18585709
PDF is available here.
Abstract
We describe recent findings on the role and mechanisms of epigenetic codes in the brain, and discuss their implication in synaptic plasticity, cognitive functions and psychiatric disorders. We provide examples of transgenerational inheritance of epigenetic marks that affect simple morphological trai...
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PMID: 18353453
PDF is available here.
Abstract
Our investigations of brain-behavior relationships and their impact on psychosocial functioning have attempted to expand upon and chart a somewhat different (subtypal) course for this area of study. One clearly evident conclusion of these efforts is that neuropsychology is a psychosocial science. So...
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PMID: 18608661
PDF is available here.
Abstract
We extensively reviewed the literature of all the cases of organic catatonia in children and adolescents from January 1969 to June 2007. We screened socio-demographic characteristics, organic diagnosis, clinical characteristics and treatment. We found 38 cases of children and adolescents with catato...
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PMID: 18417262
PDF is available here.
Abstract
Learning from one's mistakes is the best learning tool in medicine and this applies as well to epilepsy. This article is a compilation of some of the frequent mistakes that are made in the evaluation and management of patients with epilepsy. It encompasses errors in the clinical diagnosis that resul...
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PMID: 18777483
PDF is available here.
Abstract
We report that the Nr-CAM deletion had no impact on four of the learning tasks (fear conditioning, spatial water maze, Lashley maze and odor discrimination). However, Nr-CAM null mice exhibited impaired performance on a task that required animals to suppress movement (passive avoidance). Although Nr...
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PMID: 18081712
PDF is available here.
Abstract
We report that the Nr-CAM deletion had no impact on four of the learning tasks (fear conditioning, spatial water maze, Lashley maze and odor discrimination). However, Nr-CAM null mice exhibited impaired performance on a task that required animals to suppress movement (passive avoidance). Although Nr...
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PMID: 18081712
PDF is available here.
Abstract
We report a 52-year-old male who presented with a neuropsychiatric disorder and cognitive decline. Despite treatment the patient developed optic atrophy, parkinsonism and dementia and died. The autopsy revealed a nonspecific brain and cerebellar atrophy.Under microscopic examination, lipid crystal c...
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PMID: 18458861
PDF is available here.
Abstract
The evidence to date suggests that if screening with structural neuroimaging was implemented in all patients presenting with psychotic symptoms, little would be found to affect clinical management in addition to that suspected by a full clinical history and neurological examination. From an economic...
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PMID: 18462577
PDF is available here.
Abstract
Analysis of variance indicated no statistically significant differences between ziprasidone and placebo in the CGI-BPD. Nor were significant differences observed between groups in depressive, anxiety, psychotic, or impulsive symptoms. The mean daily dose of ziprasidone was 84.1 mg/day (SD = 54.8; ra...
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PMID: 18251623
PDF is available here.
Abstract
The purpose of the present paper was to describe the circumstances and phenomenology of patients who remove or pierce their eyes or orbits during psychotic illness. In particular, the aim was to determine if patients in their first-episode psychosis (FEP) carry an increased risk of self-inflicted ey...
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PMID: 18247192
PDF is available here.
Abstract
"Executive functions" is an umbrella term for functions such as planning, working memory, inhibition, mental flexibility, as well as the initiation and monitoring of action. The impairment of executive functions in various clinical groups is a topic of much debate, as are recent attempts to formulat...
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PMID: 18096360
PDF is available here.
Abstract
We are at a very early stage of our understanding of DISC1 biology, it is an important time to review what has already been achieved and to discuss its impact. DISC1 biology has enabled the identification of new therapeutic targets in the form of DISC1 binding partners and other molecules found with...
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PMID: 18055216
PDF is available here.
Abstract
We describe a case of a woman who had DD-PT and UIA. The patient in her fifties, a typist with elementary school education, presented to the psychiatrist with the symptoms of irritability, insomnia, suspiciousness and paranoid ideas lasting for about a year. She showed clear symptoms of a delusional...
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PMID: 18365502
PDF is available here.
Abstract
Withdrawal of penicillamine from zinc sulphate/penicillamine maintenance therapy for patients with Wilson's disease was effective, safe and economic, for almost all patients. This retrospective study reiterates that zinc sulphate may be used as a preferred mode of treatment for patients with Wilson'...
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PMID: 17765927
PDF is available here.
Abstract
We evaluated anxiety, locomotor behavior, startle, spatial learning and memory with mice at 2, 4, 6 and 8 months of age. In automated open-field test, IDUA(-/-) mice showed hypoactivity as early as 2 months of age and altered anxiety starting from 6 months of age during the initial exploratory phase...
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PMID: 18022143
PDF is available here.
Abstract
We recently performed a quantitative trait loci (QTL) analysis as a preliminary step in identifying genes that contribute to natural variation in hippocampal Fe, Cu, and Zn content. We used ICP-MS to measure the concentrations of these metals in 120-day-old mice from 30 strains of the BXD/TY panel....
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PMID: 18189309
PDF is available here.
Abstract
There is still place for BACI and BACA in modern neurosurgery for mental disorders, at least in the short term for those who do not want to commit to lifelong device programming and maintenance....
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PMID: 18590381
PDF is available here.
Abstract
In spite of recent developments in the pharmacotherapy of depressive disorders, the delay until clinical improvement can be achieved, and the considerable rate of nonresponse and nonremission, are major problems which remain unresolved. Electroconvulsive therapy (ECT) is a nonpharmacologic biologica...
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PMID: 18472488
PDF is available here.
Abstract
Anticonvulsant drugs are widely used in psychiatric indications. These include mainly alcohol and benzodiazepine withdrawal syndromes, panic and anxiety disorders, dementia, schizophrenia, affective disorders, bipolar affective disorders in particular, and, to some extent, personality disorders. A f...
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PMID: 18472486
PDF is available here.
Abstract
We report a 53-year-old female patient who presented a sudden dramatic memory disorder following coronary and cerebral angiography. The patient was disoriented and kept repeating the same questions about time and place. Transient global amnesia was ultimately diagnosed using the Hodges and Warlow cr...
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PMID: 18634251
PDF is available here.
Abstract
Sotos syndrome, or cerebral gigantism, is a rare genetic syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial gestalt and learning difficulties. It is caused by mutations or deletions of the NSD-1 gene. Most cases are sporadic. Apart from a number of physical...
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PMID: 18381056
PDF is available here.
Pasquale Striano,
Antonio Gambardella,
Antonietta Coppola,
Carlo Di Bonaventura,
Giorgia Bovo,
Erica Diani,
Francesca Boaretto,
Gabriella Egeo,
Clotilde Ciampa,
Angelo Labate,
Stefania Testoni,
Daniela Passarelli,
Ida Manna,
Caterina Sferro,
Umberto Aguglia,
Ferdinando Caranci,
Anna Teresa Giallonardo,
Salvatore Striano,
Carlo Nobile and
Roberto Michelucci
Abstract
INTRODUCTION : Familial mesial temporal lobe epilepsy (FMTLE) is characterized by prominent psychic and autonomic seizures, often without hippocampal sclerosis (HS) or a previous history of febrile seizures (FS), and good prognosis. The genetics of this condition is largely unknown.We present the el...
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PMID: 18004642
PDF is available here.
Abstract
Commitments increased from 40.2 to 46.5 (16%) per 100,000 inhabitants. Controlling for population changes in age and sex, relatively large increases were found in patients over 50 years (25-40% increase), in patients with dementia (59%), 'other organic mental disorders' (40%) and substance abuse (36...
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PMID: 18667238
PDF is available here.
Abstract
INTRODUCTION: Traumatic brain injuries have major socio-economic importance due to their frequency, high mortality and serious consequences. According to their nature the consequences of these injuries may be classified as neurological, psychiatric and esthetic. Various lesions of brain structures c...
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PMID: 19203063
PDF is available here.
Abstract
We present for the first time a pediatric case of acquired chronic hepatocerebral degeneration secondary to endstage biliary disease. The pediatric phenotype of acquired chronic hepatocerebral degeneration is presented, and the differential diagnosis in regard to Wilson's disease and management alte...
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PMID: 18054700
PDF is available here.
Abstract
Our study suggests that in acute stroke patients with DS, there is a direct involvement of the serotonergic system, regardless the degree of disability and the site of the lesion....
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PMID: 18028189
PDF is available here.
Abstract
BACKGROUND: The rate of depression and other psychiatric disorders is greater in multiple sclerosis (MS) than in other chronic conditions or neurologic diseases. This means that clinical neurologists seeing MS patients will frequently be engaged in the diagnosis and treatment of psychiatric distress...
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PMID: 18090712
PDF is available here.
Abstract
We tested different forms of activity-dependent neuronal and behavioral plasticity in knockout mice for the dopamine transporter (DAT-KO), which constitute a unique genetic model of constitutive hyperdopaminergia. We report that DAT-KO mice exhibit slightly increased long-term potentiation and sever...
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PMID: 17342172
PDF is available here.
Abstract
The MRS study revealed that MMSE, CDT, and SRT scores were positively related to N-acetyl-aspartate (NAA)/creatine(Cr) and negatively related to myoinositol (mI)/Cr in the posterior cingulate gyrus, but not in the anterior cingulate gyrus. On the other hand, the scores obtained in two categories of...
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PMID: 17540407
PDF is available here.
Abstract
Unchecked aggression and violence exact a significant toll on human societies. Aggression is an umbrella term for behaviours that are intended to inflict harm. These behaviours evolved as adaptations to deal with competition, but when expressed out of context, they can have destructi...
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PMID: 17585306
PDF is available here.
Abstract
A significant difference was found between QEEGs in SVD subgroups with mild and moderate dementia (p<0.05), but there was no significant difference between visual EEGs. A significant correlation between QEEG parameters such as alpha/slow wave ratio or mean wave frequency and mental impairment (accor...
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PMID: 17337009
PDF is available here.
Abstract
Clinicians should select 1 primary tool based on (1) the population receiving care; (2) an awareness of the effects of educational level, race, and age on scoring; and (3) consideration of adding 1 or 2 other tools for special situations as needed....
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PMID: 17551132
PDF is available here.
Abstract
Animal models are extremely useful tools in defining pathogenesis and treatment of human disease. For many years researchers believed that structural damage to the brain of neuropsychiatric (NP) patients lead to abnormal mental function, but this possibility was not extensively explored until recent...
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PMID: 17223198
PDF is available here.
Abstract
Studies of the brain basis of decision-making and economic behavior are providing a new perspective on the organization and functions of human prefrontal cortex. This line of inquiry has focused particularly on the ventral and medial portions of prefrontal cortex, arguably the most enigmatic regions...
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PMID: 17389302
PDF is available here.
Abstract
Our data show the relevance of parenthood and associated therapeutic issues....
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PMID: 17106841
PDF is available here.
Abstract
We analyzed (18)F-dopa PET data from 11 members of kindreds with familial progressive supranuclear palsy (PSP) to characterize their cerebral dopaminergic dysfunction. Three clinically-affected PSP patients showed reduced (18)F-dopa uptake in the striatum, orbitofrontal cortex and amygdala. One asym...
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PMID: 16897607
PDF is available here.