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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Depressive Disorder, Major (0):
Recent article
Depressive Disorder, Major
Abstract
Major depressive disorder, the most common psychiatric illness, is often chronic and a major cause of disability. Many patients with major depressive episodes who have an underlying but unrecognized bipolar disorder receive pharmacologic treatment with ineffective regimens that do no...
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PMID: 21810644
PDF is available here.
PDF is available here.
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Abstract
We detected no increased risk for perinatal events with fluoxetine therapy compared to the short half-life antidepressants.
clinicaltrials.gov Identifier: NCT00279370.
© Copyright 2011 Physicians Postgraduate Press, Inc....
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PMID: 21824458
PDF is available here.
PDF is available here.
Abstract
We present data from a genome-wide association study revealing a neuron-specific neutral amino acid transporter (SLC6A15) as a susceptibility gene for MD. Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in the hippo...
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PMID: 21521612
PDF is available here.
PDF is available here.
Journal of Affective Disorders (130)1-2 2011
Abstract
To examine the comparative effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behaviour Therapy (CBT) as treatments for non-melancholic depression.
Participants who met criteria for a current episode of major depressive disorder were randomly as...
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PMID: 21093925
PDF is available here.
PDF is available here.
Abstract
Electroconvulsive therapy is used to treat patients with severe or resistant depression. Troponin elevations are associated with an adverse prognosis, and it is well known that central nervous system insults can cause biochemical evidence of cardiac injury. No study previously has studied this with e...
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PMID: 21396506
PDF is available here.
PDF is available here.
Journal of Trauma (69)6 2010
Abstract
We examined prevalence rates of both posttraumatic stress disorder (PTSD) and major depression at 6 and 12 months in a sample of 677 individuals experiencing different types of trauma who were representative of physical trauma survivors hospitalized in Los Angeles County trauma centers. Demographic...
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PMID: 20693915
PDF is available here.
PDF is available here.
Abstract
The lifetime prevalence of depression, anxiety, and stress among adolescents and young adults around the world is currently estimated to range from 5% to 70%, with an Indian study reporting no depression among college going adolescents. This cross-sectional study was conducted to determine prevalenc...
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PMID: 21135643
PDF is available here.
PDF is available here.
Abstract
In response to high levels of comorbidity and symptom overlap between posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and other disorders, much attention has been devoted to the role of specific and nonspecific symptoms among the disorders. The present study investigated the o...
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PMID: 21135640
PDF is available here.
PDF is available here.
Abstract
Several neuropsychiatric symptoms observed in elders with cognitive impairment no dementia (CIND) can be part of a major depressive episode (MDE) or a "subthreshold" depressive episode. Certain neuropsychiatric symptoms of CIND are essential symptoms of MDE (e.g. dysphoria, anhedonia), while other a...
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PMID: 20836912
PDF is available here.
PDF is available here.
Abstract
I psychiatric disorders were assessed with the Structured Clinical Interview for DSM-IV, and Axis II PDs were assessed with the Diagnostic Interview for DSM-IV Personality Disorders. The course of MDD was assessed with the Longitudinal Interval Follow-up Evaluation at 6 and 12 months and then yearly...
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PMID: 20584514
PDF is available here.
PDF is available here.
Abstract
The heterogeneity of depression in the current classification system remains a point of discussion in the psychiatric field, despite previous efforts to subclassify depressive disorders. Data-driven techniques may help to come to a more empirically based classification. This study aimed to identify...
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PMID: 20673552
PDF is available here.
PDF is available here.
Abstract
We examined the effects of a single dose of ketamine on suicidal ideation in subjects with treatment-resistant major depressive disorder (MDD).
Thirty-three subjects with DSM-IV-diagnosed MDD received a single open-label infusion of ketamine (0.5 mg/kg) and were rated at baseline and at 40, 80, 120,...
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PMID: 20673547
PDF is available here.
PDF is available here.
Abstract
I and Axis II comorbid disorders. However, individuals with CMDD received higher rates of all treatment modalities than individuals with dysthymic disorder.
Individuals with CMDD and dysthymic disorder share many sociodemographic correlates, comorbidity patterns, risk factors, and course. Individual...
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PMID: 21190638
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)44 2010
Abstract
MMW Fortschritte der Medizin (152)44 2010
Abstract
Medical Care (48)11 2010
Abstract
The FDA suicidality warning was associated with an overall decrease in antidepressant treatment for youth with a clinician-reported diagnosis of depression, but not for those with MDD. Also, following the warning, psychotherapy without medication increased....
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PMID: 20856141
PDF is available here.
PDF is available here.
Abstract
We sought to examine the prevalence of FRS in a representative sample of first episode psychosis patients and compare those with and without FRS clinically and in terms of duration of untreated illness. Information was gathered from 158 consecutive cases of first episode psychosis presenting in a de...
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PMID: 21048473
PDF is available here.
PDF is available here.
Abstract
Major depressive disorder (MDD) and bipolar disorder are chronic relapsing-remitting illnesses whose effects on mood, behavior, and thinking exact a heavy toll on patients' physical and mental health and on their capacity for satisfying relationships and employment. In the inpatient setting, these a...
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PMID: 20951273
PDF is available here.
PDF is available here.
Abstract
We conclude that veterans' war service and mental health sequelae including post-traumatic stress disorder are associated with higher rates of mental disorder in their female partners 3 decades after the war....
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PMID: 21048477
PDF is available here.
PDF is available here.
Abstract
Numerous studies have documented high rates of functional impairment in patients with schizophrenia and bipolar disorder. However, this impairment appears early in the course of the illness. The purpose of the present study was to validate the Functioning Assessment Short Test (FAST) by comparing it...
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PMID: 21048476
PDF is available here.
PDF is available here.
Abstract
We examined the diagnostic specificity of interpersonal problems (IP) in generalized anxiety disorder (GAD). We expected generally higher interpersonal distress, and specifically higher levels of nonassertive, exploitable, overly nurturant, and intrusive behavior in n = 58 patients with Diagnostic a...
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PMID: 21048478
PDF is available here.
PDF is available here.
Psicothema (22)4 2010
Abstract
These results highlight that, though many Spanish parents use CP as a disciplinary strategy, it appears to be related to negative outcomes for children regardless the parental context in which it is used....
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PMID: 21044474
PDF is available here.
PDF is available here.
Abstract
We use data from a nationally representative survey to test whether the relationship of stigma with contact remains after taking into account the effects of genetic beliefs and other background characteristics. Contact was defined as a history of psychiatric hospitalization among respondents themsel...
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PMID: 19823756
PDF is available here.
PDF is available here.
Therapeutische Umschau (67)11 2010
Abstract
Since a variety of psychiatric as well as somatic conditions may present with depressive symptoms, careful diagnostic evaluation is warranted. The following article summarizes the most important aspects and provides a clinical guideline for the diagnostic process.
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PMID: 21043014
PDF is available here.
PDF is available here.
Abstract
Herbal preparations for depression are often preferred over pharmaceutical drugs because they are available without prescription and because they are commonly assumed to be safe. St. John's wort (SJW) is one of the best-known and best-selling herbal therapies for depression. Meta-analyses of randomi...
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PMID: 21053786
PDF is available here.
PDF is available here.
Abstract
More prevalent in women than men, clinical depression affects approximately 15 million American adults in a given year. Psychopharmaceutical therapy accompanied by psychotherapy and wellness interventions (e.g., nutrition, exercise, counseling) is effective in 80% of diagnosed cases. A lesser known...
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PMID: 20669869
PDF is available here.
PDF is available here.
Abstract
The development of geriatric psychopharmacology was built on advances in geriatric psychiatry nosology and clinical pharmacology and on increased investment in aging research by the National Institute of Mental Health and by academic institutions. Application of the US Food and Drug Administration's...
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PMID: 21114947
PDF is available here.
PDF is available here.
Abstract
We explored the possibility of using baseline features and early symptom change to predict which patients will and which patients will not respond to treatment.
Participants were 2,280 outpatients enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study who had complete...
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PMID: 21114950
PDF is available here.
PDF is available here.
Abstract
Because of strict inclusion and exclusion criteria, results drawn from placebo-controlled randomized antidepressant efficacy trials may not be transferable to real-world patients.
This study was performed from March 2000 to September 2005 as a prospective, multicenter follow-up. Patients were recrui...
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PMID: 20816028
PDF is available here.
PDF is available here.
Abstract
Although the goal of treatment for major depressive disorder is full remission, for most patients, remission is the exception rather than the rule. Carefully choosing medications with synergistic mechanisms of action at treatment initiation may increase rates of response and remission and decrease t...
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PMID: 21114944
PDF is available here.
PDF is available here.
Psychiatry Research (184)1 2010
Abstract
We aimed to describe the impact of WMLs on white matter pathways in MD using diffusion tensor imaging (DTI) and magnetization transfer imaging. As a novel approach, we used DTI tractography to assess pathways intersected by WMLs. We examined 22 patients with late-onset MD and 22 age- and gender-matc...
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PMID: 20832255
PDF is available here.
PDF is available here.
Perceptual and Motor Skills (111)2 2010
Abstract
Cardiac patients with depression have shown altered autonomic nervous system functioning, expressed as reduced heart rate variability. This may be associated with poorer physical fitness and less physical activity among depressed patients. These relationships were explored among patients enrolled in...
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PMID: 21162459
PDF is available here.
PDF is available here.
Abstract
In a randomized clinical trial with 111 families of parents with a history of major depressive disorder (86% mothers, 14% fathers; 86% Caucasian, 5% African-American, 3% Hispanic, 1% American Indian or Alaska Native, 4% mixed ethnicity), changes in adolescents' (mean age = 11 years; 42% female, 58%...
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PMID: 20873898
PDF is available here.
PDF is available here.
Psychological Medicine (40)10 2010
Abstract
Psychological Medicine (40)10 2010
Abstract
We provide a test of the stress sensitization hypothesis in a national sample.
We investigated whether the association between past-year stressful life events and the 12-month prevalence of major depression, post-traumatic stress disorder (PTSD), other anxiety disorders, and perceived stress varies...
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PMID: 20018126
PDF is available here.
PDF is available here.
Psychological Medicine (40)10 2010
Abstract
Depressed patients show impaired performance following negative feedback; the probability of committing an error is increased immediately after an error. This deficit is assumed to be highly specific and to represent a trait marker of major depressive disorder (MDD). Inconsistencies in currently ava...
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PMID: 20047704
PDF is available here.
PDF is available here.
Psychological Medicine (40)10 2010
Abstract
These results challenge the equivalence assumption for the symptomatic criteria for MD and suggest a more than expected degree of 'covert' heterogeneity among these criteria. Part of this heterogeneity is captured by the distinction between cognitive versus neurovegetative symptoms, with cognitive s...
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PMID: 20059797
PDF is available here.
PDF is available here.
Psychological Medicine (40)10 2010
Abstract
Severity is an important characteristic of major depression (MD) and an 'episode specifier' in DSM-IV classifying depressive episodes as 'mild', 'moderate' or 'severe'. These severity subtypes rely on three different measures of severity: number of criteria symptoms, severity of the symptoms and deg...
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PMID: 20056021
PDF is available here.
PDF is available here.
Psychological Reports (107)2 2010
Abstract
For individuals with mental illness, others' perceptions of mental illness often limit integration into communities. Perceptions of mental illness manifest as social stigma in the form of social distance and may depend on individuals' attributions of the origins of mental illness. 180 university stu...
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PMID: 21117481
PDF is available here.
PDF is available here.
Psychiatry Research (183)3 2010
Abstract
It is poorly understood how stressors modulate neurobiological mechanisms that may contribute to the heterogeneity of major depressive disorder (MDD). Unmedicated patients diagnosed with MDD (n=15) and individually matched healthy controls (n=15) completed stress questionnaires and were studied with...
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PMID: 20685091
PDF is available here.
PDF is available here.
Journal of Clinical Psychiatry (71)suppl 1 2010
Abstract
Depression is often a chronic illness that requires a methodical, long-term approach to manage it optimally. A single antidepressant trial is often insufficient for patients to achieve remission. Remission rates for selective serotonin reuptake inhibitors are about 30% to 35%. Using successive treat...
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PMID: 20977870
PDF is available here.
PDF is available here.
Journal of Clinical Psychiatry (71)suppl 1 2010
Abstract
The probability of achieving and sustaining symptomatic remission in major depressive disorder (MDD) with first-line pharmacotherapy is approximately 30%. Ample documentation shows that the maximal therapeutic effect obtained with antidepressant pharmacotherapy is approximately 4 to 6 weeks, perhaps...
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PMID: 20977871
PDF is available here.
PDF is available here.
Journal of Clinical Psychiatry (71)suppl 1 2010
Abstract
A majority of patients with major depression do not remit or adequately respond to initial antidepressant therapy. When response is insufficient, a diagnosis of depression and any comorbidities should be confirmed, treatment adherence should be established, and antidepressant dosages should be optim...
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PMID: 20977872
PDF is available here.
PDF is available here.
Journal of Clinical Psychiatry (71)suppl 1 2010
Abstract
Primary care clinicians need to move beyond first-line therapy for major depression. While initial treatment is ineffective in about two-thirds of patients, patients who have not responded to such initial treatments can be managed effectively. The severity of depression is as high in primary care as...
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PMID: 20977873
PDF is available here.
PDF is available here.
Abstract
This article provides an overview of several parts of a doctoral thesis on medicine information for patients with a major depression at hospital discharge. A review of the international literature showed that medicine information can increase knowledge and adherence. Inpatients would like to receive...
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PMID: 21090383
PDF is available here.
PDF is available here.
Abstract
I AND postpartum depression', 'bipolar II AND postpartum depression', 'postpartum hypomania', and 'postpartum hypomania AND screening', was carried out. The reference lists of articles identified were also searched to select other relevant publications.
Brief hypomanic symptoms occur in the early pu...
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PMID: 19837461
PDF is available here.
PDF is available here.
Abstract
This systematic review examines the economic and human costs of depression and the potential savings associated with improvement in patient adherence to treatment with antidepressants through the use of enhanced-care programs. A MEDLINE search was conducted for papers published on the health economi...
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PMID: 20715299
PDF is available here.
PDF is available here.
Abstract
We examine the impact of heterogeneity in course of MDD on labor market outcomes....
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PMID: 21051796
PDF is available here.
PDF is available here.
Abstract
Psychiatry Research (178)3 2010
Abstract
The clinical utility of the DSM-IV eating disorder (ED) diagnostic criteria among practicing clinicians has not been formally evaluated, despite the considerable diagnostic challenges these disorders present. This study evaluated inter-rater reliability between research and clinical diagnoses, ident...
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PMID: 20591498
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)15 2010
Abstract
Painful physical symptoms (PPS) may present as a component of major depressive disorder (MDD). Their effect in Chinese patients has not been investigated. This analysis reports the changes in disease severity, treatment patterns, quality of life and outcomes in a Chinese cohort according to the pres...
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PMID: 20819543
PDF is available here.
PDF is available here.
Abstract
The present study explored longitudinal evidence for prodromal symptoms of depression episodes. A model based on previous findings of the relations between prodromal and residual symptoms was described and used to generate hypotheses tested in this study. Data were analyzed from 160 participants fro...
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PMID: 20677835
PDF is available here.
PDF is available here.
Abstract
Resting frontal electroencephalographic (EEG) asymmetry has been hypothesized as a marker of risk for major depressive disorder (MDD), but the extant literature is based predominately on female samples. Resting frontal asymmetry was assessed on 4 occasions within a 2-week period in 306 individuals a...
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PMID: 20677839
PDF is available here.
PDF is available here.
Abstract
We take a fully relational approach to criticism by testing an actor-partner interdependence model (Kenny, Kashy, & Cook, 2006). Patient intended criticism was especially strongly associated with depressive symptoms for wives, whereas patient perceived criticism was especially negatively related to...
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PMID: 20677844
PDF is available here.
PDF is available here.
Abstract
We conducted a randomized controlled trial with 183 older adults with SMI (58% schizophrenia spectrum) age 50 and older at 3 sites who were assigned to HOPES or treatment as usual with blinded follow-up assessments at baseline and 1- and 2-year follow-up.
Retention in the HOPES program was high (80%...
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PMID: 20658812
PDF is available here.
PDF is available here.
Abstract
To examine the relationship between psychiatric disorders and sexual behaviors among adolescents receiving mental health treatment. Adolescents in mental health treatment have been found to have higher rates of HIV risk behavior than their peers, but data concerning the relationship between psychopa...
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PMID: 20658815
PDF is available here.
PDF is available here.
Abstract
We sought to investigate the relationship between the probability of receiving placebo and the likelihood of prematurely discontinuing treatment. Medline/Pubmed publication databases were searched for RCT in MDD. A meta-regression established that the likelihood of receiving placebo did not predict...
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PMID: 20219330
PDF is available here.
PDF is available here.
Abstract
We tested two phenotypes: response rate and remission rate. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for genotypes Met/Met versus Val/Val, Val/Met versus Val/Val, Met/Met versus Val/Met, Val/Met+Met/Met versus Val/Val, Met/...
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PMID: 20167454
PDF is available here.
PDF is available here.
Abstract
We test if off-line motor memory consolidation is impaired in MD. 50 medicated patients with an acute episode of MD, 50 normal controls and 12 patients with a remitted episode of MD were assessed using a sequential finger tapping task before and after a night of sleep. Although depressed patients an...
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PMID: 20199853
PDF is available here.
PDF is available here.
Neuropsychobiology (62)3 2010
Abstract
We examined the effects of cerebrovascular changes on the course of geriatric depressive symptoms, dementia rates, and mortality over a follow-up period of approximately 10 years.
Participants were 84 patients with major depression (age of onset over 50 years); patients suffering from strokes, neuro...
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PMID: 20664230
PDF is available here.
PDF is available here.