Abstract
We test our hypothesis that the Hypocretin system is regulated by TNF-α. Prepro-Hypocretin and Hypocretin receptor 2 (HcrtR2) can be detected at a very low level in rat B35 neuroblastoma cells. In response to TNF-α, Prepro-Hypocretin mRNA and protein levels are down-regulated, and also HcrtR2 prot...
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PMID: 21094253
PDF is available here.
Abstract
The neuropeptides hypocretin-1 and -2 (orexin A and B) are critical in the regulation of arousal and maintenance of wakefulness. Understanding the role of the hypocretin system in sleep/wake regulation has come from narcolepsy-cataplexy research. Deficiency of hypocretin results in l...
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PMID: 21170610
PDF is available here.
Abstract
Sleep disorders are common in hemodialysis patients. They can affect their quality of life. The purpose of this study was to evaluate the effects of aerobic training on sleep quality, inflammatory status, and serum leptin levels in hemodialysis patients.
Twenty-eight...
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PMID: 21368391
PDF is available here.
Abstract
Sleep disorders are common in hemodialysis patients. They can affect their quality of life. The purpose of this study was to evaluate the effects of aerobic training on sleep quality, inflammatory status, and serum leptin levels in hemodialysis patients.
Twenty-eight...
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PMID: 21368391
PDF is available here.
Abstract
Monitoring patients' sleep patterns and providing them with educational sessions has proved beneficial in one mental health unit.
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PMID: 21329128
PDF is available here.
Abstract
We can distinguish: the male sex, race, overweight and obesity, thyroid hypofunction, age and alcohol abuse. Obstructive sleep apnea results in the absence (apnea) or reduction (hypopnea) of airflow lasting at least 10 s despite normal respiratory exertion. The apnea and hypopnea result in decreased...
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PMID: 21190150
PDF is available here.
Abstract
The metabolic syndrome (MetS) is a serious risk factor for cardiovascular disease and type 2 diabetes, both of which are highly prevalent in patients with schizophrenia. Unhealthy lifestyle and antipsychotic medication are well known causes of MetS. Pharmacological as well as non-pharmacological int...
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PMID: 21129316
PDF is available here.
Abstract
We initially examine the critical evidence supporting or refuting such proposed associations. In addition, the potential reciprocal roles of obesity and obstructive sleep apnea in the facilitation of their pathophysiology are also reviewed, along with their amplificatory effects on their respective...
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PMID: 21302856
PDF is available here.
Abstract
While nonpharmacologic strategies can help patients understand and accept the diagnosis of fibromyalgia, pharmacologic therapy can provide important additional symptom relief and improvement in functioning. Pharmacologic therapy must be individualized based on a comprehensive evaluation of the patie...
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PMID: 21190634
PDF is available here.
Abstract
Sleep apnea, hypertension, atherosclerosis, and obesity are features of metabolic syndrome associated with decreased restorative sleep and increased pain. These traits are relevant for anesthesiology because they confer increased risks of a negative anesthetic outcome. This study tested the one-tail...
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PMID: 20938334
PDF is available here.
Abstract
Burnout denotes an occupational health concept of emotional and physical exhaustion, depersonalization und decreased personal accomplishment. Prevalence rates range from 10% to 50%, depending from profession, assessment tools and population. Generally, both women and men are equally affected by burn...
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PMID: 21043015
PDF is available here.
Abstract
The aim of this cross-sectional study was to describe menopausal symptoms in Iranian women in Tabriz, north-west Islamic Republic of Iran. A total of 200 women aged 45-55 years completed a Farsi version of the Greene climacteric scale. The mean total Greene scores for 20 items (1 item was excluded)...
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PMID: 21218741
PDF is available here.
Abstract
to evaluate the frequency of sleep problems and daytime tiredness among adolescents with inflammatory bowel disease (IBD) in comparison with their healthy peers.
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PMID: 21102990
PDF is available here.
Abstract
Nocturnal sleep disturbances, including insomnia and recurrent nightmares, represent common distressing sleep complaints that might have important prognostic and therapeutic implications in psychiatric patients. The present study aimed at investigating nocturnal sleep disturbances in relation to the...
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PMID: 21114949
PDF is available here.
Abstract
Sleep disruption has been linked to numerous neural regulatory problems and problems with social emotional and behavioral functioning, and researchers have shown that sleep disruption is prominent in children with symptoms of attention-deficit hyperactivity disorder. These issues are germane to fost...
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PMID: 20814340
PDF is available here.
Abstract
We hypothesized that most of the data involved in the findings would be statistically interconnected and interdependent, indicating biological consistency for this diagnosis. Prospectively obtained data on scalp and sleep electroencephalography (EEG), clinical neurologic soft signs, the dexamethason...
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PMID: 20858567
PDF is available here.
Abstract
Recent publications suggest that fatigue and sleep disturbance are problems in patients with chronic liver disease and in liver transplant recipients.
To characterize the severity and nature of fatigue and sleep quality before and after liver transplantation, to exami...
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PMID: 20929106
PDF is available here.
Abstract
We attempt to update readers on novel developments in the FMS over the last 2 years. We include a discussion of the various pharmacological classes of medications which appear to be of promising potential in this area, including sodium oxybate, dopamine agonists, naltrexone, novel anticonvulsive med...
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PMID: 20486862
PDF is available here.
Abstract
Parkinson's disease (PD) is a debilitating neurodegenerative disorder affecting 1.5% of all above 55 years of age. Sleep related complaints are commonly reported in patients with PD and may form an important determinant of their quality of life. Interactions among genetic and environmental factors m...
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PMID: 20541773
PDF is available here.
Abstract
We have assessed 265 consecutive PD patients by asking them to rank their three most troublesome symptoms in the last 6 months, so to gain further insight from the impact of illness on patients' quality of life. Patients were divided into early (<6 years) and late PD groups (>/=6 years) from symptom...
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PMID: 20629164
PDF is available here.
Abstract
Dramatic advances have been made in the treatment of motor dysfunction in both the early and late phases of Parkinson disease. Effective therapies for the nonmotor symptoms of this disease, however, remain a major unmet clinical need. A recent study has highlighted the dearth of clinical trials for...
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PMID: 20689560
PDF is available here.
Abstract
In the current study, sleep actigraphy and parent-report measures were used to investigate differences in sleeping behavior among four groups of 3- to 7-year-olds (N = 79): children in regular foster care (n = 15); children receiving a therapeutic intervention in foster care (n = 17); low income com...
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PMID: 20221849
PDF is available here.
Abstract
We examined hypocretin levels in dementia with Lewy bodies and Alzheimer's disease cases and correlated these with sleep habits and clinical characteristics. Although limited hypocretin alterations were observed in Alzheimer's disease, we show reduced neocortical hypocretin immunoreactivity in demen...
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PMID: 20531237
PDF is available here.
Abstract
Several studies have reported diverging trends in the prevalence of asthma and wheeze. The aim of this study was to investigate the clinical expression of childhood asthma in 1996 and 2006 by studying asthma morbidity, treatment, and environmental exposures in school children with physician-diagnose...
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PMID: 20408972
PDF is available here.
Abstract
There were 71 nondipper patients (mean age 44.3+/-5.3 years, 33 male/38 female) and 62 dipper hypertensive patients (mean age 43.3+/-6.3 years, 27 male/35 female). The PSQI scores, globally, were significantly higher in the nondippers compared with the dippers. It was noticed that all the components...
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PMID: 20639701
PDF is available here.
Abstract
This investigation assessed the extent to which various health factors are associated with difficulties initiating and maintaining sleep (DIMS) and nightmares among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans reporting a trauma (combat, noncombat, or a trauma before service...
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PMID: 20731260
PDF is available here.
Abstract
The aim of this study was to develop a fully automatic sleep scoring algorithm on the basis of a reproduction of new international sleep scoring criteria from the American Academy of Sleep Medicine. A biomedical signal processing algorithm was developed, allowing for automatic sleep depth quantifica...
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PMID: 20634706
PDF is available here.
Abstract
Sleep in older adults with Alzheimer's disease can often be extremely fragmented, thus disturbing normal sleep-wake rhythms. This poor-quality sleep is challenging for caregivers and frequently results in admitting older adults to long-term care institutions. Many variables, such as genes, medicatio...
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PMID: 20804113
PDF is available here.
Abstract
Among patients with multiple sclerosis (MS), fatigue is the most commonly reported symptom, and one of the most debilitating. Despite its high prevalence and significant impact, fatigue is still poorly understood and often under-emphasized because of its complexity and subjective nature. In recent ye...
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PMID: 20815187
PDF is available here.
Abstract
Nocturnal urinary problems are of great concern for individuals with urinary diversion, especially those with an orthotopic neobladder. Regular disruption of sleep decreases quality of life.
Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. Al...
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PMID: 20478603
PDF is available here.
Abstract
We performed a comprehensive search (from January 1980-December 2008, all age groups, any language, any population) of 9 databases: MEDLINE, EMBASE, CINAHL, Current Contents, PsycINFO, ACP Journal Club, CCTR, CDSR, and DARE. Controlled vocabulary supplemented with keywords was used to define the con...
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PMID: 20458101
PDF is available here.
Abstract
We further monitored the occurrence of restless legs syndrome and sleep attacks (SAs). Motor disability was evaluated by PD diary and by Unified Parkinson Disease Rating Scale part 3 on medication (ON) and after medication withdrawal (OFF). In 8 patients with marked subjective sleep disturbance, pol...
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PMID: 20661025
PDF is available here.
Abstract
The data support the feasibility of CES. Further testing in larger samples is needed to examine the efficacy of CES for symptom management of multiple, concurrent symptoms and to further develop the biobehavioral framework. IMPLICATIONS FOR NURSING: Interventions that are effective at minimizing mor...
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PMID: 20591807
PDF is available here.
Abstract
Sleep for women, including those older than 50 years, appears to be impaired across chemotherapy treatment, although replication of findings is very limited. IMPLICATIONS FOR NURSING: Future research should investigate sleep in specific age and minority groups, include daytime sleep and sleepiness,...
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PMID: 20591805
PDF is available here.
Abstract
Abnormal sleep accompanies many psychiatric conditions, but has long been recognized as a particularly conspicuous feature of affective disorders. More than a mere epiphenomenon, the powerful link between sleep and mood regulation is most dramatically demonstrated by the high efficacy of sleep depri...
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PMID: 20704768
PDF is available here.
Abstract
Although the precise function of sleep is unknown, decades of research strongly implicate that sleep has a vital role in central nervous system (CNS) restoration, memory consolidation, and affect regulation. Slow-wave sleep (SWS) and rapid eye movement (REM) sleep have been of significant interest t...
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PMID: 20704767
PDF is available here.
Abstract
Very little is known about the prevalence of morning work and its relationship with sleep and fatigue. The present study obtained data from a representative sample of the Swedish population (N = 5489) to address this limitation in the literature. The results show that 15% of the population commenced...
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PMID: 20636210
PDF is available here.
Abstract
To investigate the sleep features in the patients with irritable bowel syndrome (IBS) and compare the sleep quality between those IBS patients who were with and without anxiety and depression.
Pittsburgh sleep quality index questionnaire (PSQI), self-rating anxiety scale (SAS) and self-rating depres...
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PMID: 20979769
PDF is available here.
Abstract
The importance of sleep on health has only been recently recognized, and the general public and the medical community are not yet fully knowledgeable about this issue. The great majority of sleep research has been performed in whites of European descent and to a lesser extent in African Americans, ma...
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PMID: 20614856
PDF is available here.
Abstract
Seventy-six participants completed the questionnaire during both conferences, and 55 adults were followed-up at 1 and 3 months; 58% (n = 43) were aged over 60, and women represented 65% (n = 48) of the participants; 63% (n = 46) reported insomnia, out of which 89% complained of chronic insomnia (26%...
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PMID: 20623917
PDF is available here.
Abstract
Sleep problems are common in persons with dementing illnesses and among the most stressful patient behaviors for caregivers. Although studies have shown differences in sleep across ethnic groups, little information is available on ethnic differences among persons with dementia. The purpose of this s...
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PMID: 20572423
PDF is available here.
Abstract
The rule of diagnostic parsimony--otherwise known as "Ockham's Razor"--teaches students of medicine to find a single unifying diagnosis to explain a given patient's symptoms. While this approach has merits in some settings, a more comprehensive approach is often needed for patients with chronic, non...
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PMID: 20572425
PDF is available here.
Abstract
The objective of the present study is to analyze the effect of stress on sleep quality in a group of adolescents.
Two high schools in Alfenas, southern Minas Gerais State, Brazil, were chosen to participate in the study. The sample consisted of both genders (n=160) with 65.63% females. The age range...
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PMID: 20563434
PDF is available here.
Abstract
We discuss possible mechanisms, including cardiovascular disease, obesity, physiologic stress, immunity, and socioeconomic status. We put forth a social-ecological framework to explore five possible pathways for the relationship between sleep duration and mortality, and we conclude with a four-point...
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PMID: 19932976
PDF is available here.
Abstract
This review provides a guide to the primary care physician for diagnosing and managing depression. To identify relevant articles, a PubMed search (ending date parameter, October 15, 2009) was conducted using the keywords depression, antidepressants, side effects, adverse effects, weight gain, sexual...
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PMID: 20431115
PDF is available here.
Abstract
Current evidence suggests that various long-acting opioid analgesics simultaneously achieve pain control and improve sleep. However, the complex interaction between reduced pain and improved sleep requires further study.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 19136144
PDF is available here.
Abstract
Our study's results indicated that sleep hygiene practice was significantly associated with sleep quality. Appropriate measures and sleep hygiene education need to be emphasised among university students in order to increase their awareness on the importance of adopting healthy sleep hygiene practic...
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PMID: 20519753
PDF is available here.
Abstract
The prevalence of asthma was determined in a random sample of schoolchildren in Ahvaz city, southwest Islamic Republic of Iran, based on the International Study of Asthma and Allergy in Childhood (ISAAC) protocol. The prevalence of ever wheeze and current wheeze was 11.1% and 7.4% among 1410 childre...
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PMID: 20799594
PDF is available here.
Abstract
Several sleep-related factors, such as sleep duration, insomnia-related symptoms, and fatigue, are associated with measured and self-reported mobility outcomes....
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PMID: 20159778
PDF is available here.
Abstract
The extracellular parasite Trypanosoma brucei causes human African trypanosomiasis (HAT), also known as sleeping sickness. Trypanosomes are transmitted by tsetse flies and HAT occurs in foci in sub-Saharan Africa. The disease, which is invariably lethal if untreated, evolves in a first hemo-lymphati...
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PMID: 19995590
PDF is available here.
Abstract
Uncontrolled asthma impacted functioning and sleep of children to a significantly greater degree than well-controlled asthma. Proper treatment and disease management to improve symptom control can reduce this impact on the lives of children....
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PMID: 20536279
PDF is available here.
Abstract
BACKGROUND: Behavioural and functional activity monitoring has a long history in sleep research. The term "Actigraphy" refers to methods using computerized wristwatch-size devices (generally placed on the wrist, but also on the ankle or trunk) to record the movement it undergoes. Collected data are...
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PMID: 20527649
PDF is available here.