Abstract
Mortality increases when extubations fail. Although predictors of extubation failure have been evaluated, physicians' reasoning to extubate a patient has received minimal attention. We hypothesized that the accuracy and reliability of physicians' extubation decisions are low.
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PMID: 21310114
PDF is available here.
Abstract
The purpose of the present investigation was to observe the ergogenic potential of 0.3 g·kg-1 of sodium bicarbonate (NaHCO3) in competitive, nonelite swimmers using a repeated swim sprint design that eliminated the technical component of turning. Six male (181.2 ± 7.2 cm; 80.3 ± 11.9 kg; 50.8 ±...
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PMID: 20881504
PDF is available here.
Abstract
To report on severe acid-base disturbance in a child with symptomatic epilepsy treated with sulthiame.
A 9.5-year-old boy with chronic generalized tonic-clonic seizures was treated with carbamazepine and valproic acid. Because of poor seizure control, sulthiame was added to the treatment. Two months...
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PMID: 20930598
PDF is available here.
Abstract
The onset of paresis or paralysis and postsurgical mortality varied as a function of cross-clamp time and core temperature that was maintained during the period of cross-clamp. Using optimal surgical parameters (7.5-min cross-clamp duration at 33°C core temperature), the onset of paralysis is delay...
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PMID: 20808212
PDF is available here.
Abstract
Manipulation of the extracellular and/or intracellular pH of tumors may have considerable potential in cancer therapy. The extracellular space of most tumors is mildly acidic, owing to exuberant production of lactic acid. Aerobic glycolysis - attributable largely to chronic activation of hypoxia-ind...
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PMID: 21155627
PDF is available here.
Abstract
We present the case of a patient with profound metabolic acidosis with raised anion gap, due to pyroglutamic acid in the setting of malnutrition and chronic ingestion of acetaminophen....
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PMID: 20925168
PDF is available here.
Abstract
These results suggest that DMI of cows fed diets rich in rapidly degraded starch and low DCAD was limited to maintain the blood pH in a physiological range. Increasing DCAD allowed the cows to increase DMI because of the ability of positive DCAD to maintain blood acid-base status. A localized rumen...
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PMID: 20723694
PDF is available here.
Abstract
Acid-base disturbances may cause a variety of symptoms, multi-organ failure and compromised immune defense. The aim of this paper is to provide an overview of acid-base disturbances in intensive-care patients.
The article is based on a non-systematic search in Pub Med, a textbook on intensive care a...
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PMID: 20706308
PDF is available here.
Abstract
Serum glucose was as discriminating as BD or LAC in differentiating minor from major injury. An initial glucose >/=11.1 mMol/L had a low sensitivity (15%) but a high specificity (94%) for major injury....
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PMID: 20665990
PDF is available here.
Abstract
Dextrans are rarely used because of their negative effects on coagulation and potential for anaphylactic reactions. Gelatin and albumin have little effect on hemostasis, but the disadvantages of gelatin include its high anaphylactoid potential and limited beneficial volume effect. Tetrastarches have...
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PMID: 20386439
PDF is available here.
Abstract
OBJECTIVE-To compare the effects of IV administration of isotonic (1.3%) and hypertonic (8.4%) sodium bicarbonate (NaHCO(3)) solutions on acid-base status in dehydrated calves with strong ion (metabolic) acidosis. DESIGN-Randomized controlled clinical trial. ANIMALS-50 calves with diarrhea and sever...
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PMID: 20470072
PDF is available here.
Abstract
This study aimed to investigate the oxygen uptake and metabolic responses during a 400-m run reproducing the pacing strategy used in competition. A portable gas analyser was used to measure the oxygen uptake (VO2) of ten specifically trained runners racing on an outdoor track. The tests included (1)...
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PMID: 20063105
PDF is available here.
Abstract
The acid-base parameters and buffer systems of blood of different qualifying groups of sportsmen in physiological condition and at physical work were studied. It is shown that initial differences of the acid-basic condition and buffer capacity of integral blood of sportsmen of high qualifying group...
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PMID: 20583577
PDF is available here.
Abstract
The classic "infection stone" struvite is formed as a result of metabolic activity of urease-positive bacteria from alkaline urine with pH-values above 7.5. Due to improved infection diagnostics and antibiotic therapy, the occurrence of infection-related urinary stones in the western industrialized...
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PMID: 20449779
PDF is available here.
Abstract
Contrary to the widely held view that the only response to hypoxemia is a decrease in haemoglobin oxygen affinity, it was shown that under extreme hypoxemic conditions, an increased haemoglobin oxygen affinity improves the oxygenation of tissues. It was also shown that the dominance of hemoglobin wi...
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PMID: 20491333
PDF is available here.
Brett M Macey,
Matthew J Jenny,
Heidi R Williams,
Lindy K Thibodeaux,
Marion Beal,
Jonas S Almeida,
Charles Cunningham,
Annalaura Mancia,
Gregory W Warr,
Erin J Burge,
A Fred Holland,
Paul S Gross,
Sonomi Hikima,
Karen G Burnett,
Louis Burnett and
Robert W Chapman
Abstract
We used a combination of linear and artificial neural network (ANN) modelling to detect and explore interactions among low-dose mixtures of these heavy metals and their impacts on fundamental physiological processes in tissues of the Eastern oyster, Crassostrea virginica. Animals were exposed to Cd...
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PMID: 19958840
PDF is available here.
Abstract
We present the maternal and fetal considerations in anesthesia for intracranial hemorrhage....
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PMID: 20229751
PDF is available here.
Abstract
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether pH-stat or alpha-stat is the best technique to follow in patients undergoing deep hypothermic circulatory arrest. Altogether 206 papers were found using the rep...
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PMID: 19914925
PDF is available here.
Abstract
We present a 19-month-old boy with a history of asthma who presented to the pediatric emergency department with noisy breathing and tachypnea partially responsive to albuterol. He was discharged to routine care at home. His parents brought him back the next day for persistent respiratory distress de...
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PMID: 20145505
PDF is available here.
Abstract
I collagen (C-telopeptide) excretion by 19% when compared with an alkali (base-forming) diet. Cross-sectional studies have shown that there is a correlation between the nutritional acid load and bone health measured by bone ultrasound or dual-energy X-ray absorptiometry. Few studies have been undert...
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PMID: 19954569
PDF is available here.
Abstract
Out of 208 newborn children, 105 children were excluded in accordance with the above criteria, thus the remaining 103 newborn children were included. We demonstrated that lactate and CO2 in arterial umbilical cord blood was higher than in venous umbilical cord blood; furthermore, that O2 and pH in a...
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PMID: 20122330
PDF is available here.
Abstract
The article presents assessment of the state of non-specific resistance of an organism by determination of SH-S-S coefficient relation (K(SU-S-S)) of blood and a spinal liquid in the first days of the disease and their change under influence of different medical products. Features of change of K(SU-...
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PMID: 20614513
PDF is available here.
Abstract
Research of influence of the probiotic drugs BPS-44 and BPS-L on the state of the antioxidation system by means of experiments on young animals of cattle. The authors have established that the effective functioning of antioxidation system of cattles' blood (a decrease of the products of lipids' pero...
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PMID: 20364712
PDF is available here.
Abstract
FHR characteristics in different foetal behavioural states offer the opportunity to design a new index, the WAS index, which shows close (p<<10(-4)) correlations with all variables of the foetal ABB. Thus, the pH value in cord blood can be predicted within clinically reasonable limits. The qualitati...
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PMID: 20155661
PDF is available here.
Abstract
The issue of the acid-base balance (ABB) parameters and their disorders in pets is rarely raised and analysed, though it affects almost 30% of veterinary clinics patients. Traditionally, ABB is described by the Henderson-Hasselbach equation, where blood pH is the resultant of HCO3- and pCO2 concentr...
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PMID: 21033575
PDF is available here.
Abstract
We examined the possibility of facilitated excretion of uric acid by change in urine pH by managing food materials.
Within the framework of the Japanese government's health promotion program, we made recipes which consist of protein-rich and less vegetable-fruit food materials for H+-load (acid diet...
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PMID: 20955624
PDF is available here.
Abstract
INTRODUCTION: Flufenoxuron is a recently introduced insecticide. The compound is known to exert its insecticidal activity by inhibiting chitin synthesis in insects. However, its toxic effects on humans are unknown. CASE REPORT: A 72-year-old woman was brought to the emergency department by ambulance...
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PMID: 20070176
PDF is available here.
Abstract
The different methods for anticoagulation of the extracorporeal circuit for renal replacement therapy (RRT) vary in safety profile, bleeding being the most important side effect. Avoiding severe bleeding is a key aim of RRT prescription. The present paper is a clinical review comparing regional anti...
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PMID: 20427976
PDF is available here.
Abstract
We cloned the sAC ortholog from the dogfish, a shark that regulates blood A/B by absorbing and secreting protons (H(+)) and HCO(3)(-) at its gills. Similar to mammalian sAC, dogfish soluble adenylyl cyclase (dfsAC) is activated by HCO(3)(-) and can be inhibited by two structurally and mechanisticall...
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PMID: 20018667
PDF is available here.
Abstract
Twelve BD patients were included in the study. The time interval between P1 and P2 was 16.08 +/- 8.54 hours (range, 6-32). The number of patients with vasopressor support was 9/12 at P1 and 0/12 at P2, oxygenation disturbances 1/12 in P1 and 0/12 in P2, renal dysfunction 9/12 in P1 and 2/12 in P2, l...
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PMID: 20172302
PDF is available here.
Abstract
We can detect the determining influence of strong electrolytes (Na+, K+ and Cl-) and weak acids (proteins, Pi) on the physiological and pathological acid-base status of the animals....
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PMID: 20329648
PDF is available here.
Abstract
The rate of H(2)O(2) release in EBC increased during exhausting exercise (external load: 300 Watt) by a factor of 2, whereas the pH and the bicarbonate concentration of the EBC, equilibrated with 5% CO(2) at 37 degrees C were not significantly altered. It has to be proven by further experiments whet...
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PMID: 20156744
PDF is available here.
Abstract
Since the topic of the role of the kidneys in the regulation of acid-base balance was last reviewed from a teaching perspective (Koeppen BM. Renal regulation of acid-base balance. Adv Physiol Educ 20: 132-141, 1998), our understanding of the specific membrane transporters involved in H(+), HCO(3)(-)...
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PMID: 19948674
PDF is available here.
Abstract
There were significant relationships between the urinary excretion of urea and magnesium and calcium before the intervention. Comparing before and after intervention, the change in urinary excretion of urea was related to a change in urinary excretion of calcium and magnesium. There was a significan...
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PMID: 20228004
PDF is available here.
Abstract
We identified Na(+)/H(+) exchange, Na(+)-HCO(3)(-) cotransport and anion exchange at the basolateral side of the cells as being involved in intracellular pH regulation and vectorial HCO(3)(-) secretion. This cell line offers a good model for further studies to understand the molecular mechanisms of...
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PMID: 20388965
PDF is available here.
Abstract
The strong ion gap is a derived parameter used to quantify clinically significant but unmeasured charged species in human plasma. In the general population the strong ion gap has a mean value of approximately 0.0 mEq/l, but at present no reference range exists. This severely limits its clinical appl...
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PMID: 20014606
PDF is available here.
Abstract
I collagen. The HCLF group had an 11 (sem 4) % increase (P = 0.003) in N-terminal propeptide, type I procollagen, which could indicate an increased rate of bone turnover. The fall in urinary Ca with the lower-Na lower-acid load diet is likely to have long-term beneficial effects on bone. As bone res...
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PMID: 19445819
PDF is available here.
Abstract
Patients with severe sepsis and septic shock exhibit a complex metabolic acidosis at intensive care unit admission, caused predominantly by hyperchloremic acidosis,which was more pronounced in nonsurvivors. Acidosis resolution in survivors was attributable to a decrease in strong ion gap and lactate...
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PMID: 19885998
PDF is available here.
Abstract
We tested the hypothesis that a cardiopulmonary bypass prime with lactate would be associated with less acidosis than a prime with only chloride anions because of differences in the measured strong-ion-difference. We randomised 20 patients to a 1500 ml bypass prime with either a chloride-only soluti...
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PMID: 19775041
PDF is available here.
Abstract
During normal kidney function, there are routinely wide swings in proximal tubule fluid flow and proportional changes in Na(+) reabsorption across tubule epithelial cells. This "glomerulotubular balance" occurs in the absence of any substantial change in cell volume, and is thus a challenge to coord...
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PMID: 19280266
PDF is available here.
Abstract
Urine pH was dependent on 4 independent variables (urine SID, [NH(4)(+)], PCO(2), and [PO(4)]) and 3 constants. The simplified electroneutrality equation for bovine urine was pH approximately {pK(1)' - log(10)(S PCO(2))} + log(10)([K(+)] + [Na(+)] + [Mg(2+)] + [Ca(2+)] + [NH(4)(+)] - [Cl(-)] - [SO(4...
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PMID: 19566478
PDF is available here.
Abstract
We also sought to evaluate the effects of hypercapnia on the lung and associated changes induced by acid aspiration. We used Spague-Dawley rats anesthetized with intraperitioneal pentobarbital (40 mg/kg). Gastric acid particles were prepared from the stomach contents of rats at necropsy. The rats we...
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PMID: 19777797
PDF is available here.
Abstract
We review here the evidence for defective organellar acidification in CF. Significant technical and conceptual concerns are discussed regarding the validity of data showing too high/low organellar pH in CF cells, and rigorous measurements of organellar pH in CF cells are reviewed that fail to suppor...
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PMID: 19329540
PDF is available here.
Abstract
We conclude that exposure to 12% O2 promotes the chemotactic, phagocytic and oxidative burst activities of PMNs, possibly by increasing lipid peroxidation and decreasing antioxidative capacity. However, this hypoxic effect on PMN bactericidal activity is ameliorated by pretreatment with vitamin E....
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PMID: 19053944
PDF is available here.
Abstract
The aim of the present study was to evaluate a method for calculating arterial values of pH, carbon dioxide tension (P(CO(2))) and oxygen tension (P(O(2))) from peripheral venous values. In total, 40 patients were studied. Arterial and peripheral venous blood were sampled at a department of respirat...
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PMID: 19129271
PDF is available here.
Abstract
We compared haemodilution acid-base effects of 4% albumin, 3.5% polygeline, 4% succinylated gelatin (all weak acid colloids, strong ion difference 12 mEq/l, 17.6 mEq/l and 34 mEq/l respectively), 6% hetastarch (non-weak acid colloid, strong ion difference zero) and 0.9% saline (crystalloid, strong i...
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PMID: 19499860
PDF is available here.
Abstract
We aimed to: (1) quantify and compare blood acid-base disturbances associated with longline capture in five carcharhinid species; (2) examine the extent to which these disturbances correspond with reported at-vessel mortality rates; and (3) investigate how interspecific differences in the physiologi...
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PMID: 18846381
PDF is available here.
Abstract
Plasma bicarbonate concentration increased more rapidly in calves administered bicarbonate-containing ORT solutions, whereas the rate of systemic alkalinization, as assessed via blood pH, did not differ consistently among treatments. The 300 mmol/L ORT solutions were emptied at a significantly slowe...
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PMID: 19335244
PDF is available here.
Abstract
Systemic and microvascular hemodynamic responses to hemorrhagic shock volume resuscitation with hypertonic saline followed by infusion of polymerized bovine hemoglobin (PBH) at different concentrations were studied in the hamster window chamber model to determine the role of plasma oxygen-carrying c...
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PMID: 18636045
PDF is available here.
Abstract
Research aims to find out best medical therapy in treatment of critical patients. The treatment of the critical patients by a combination of the skin surface plasma radiation, external electrical pacing and i.v. infusion of adequate dozes of nitroglycerine in comparison with traditional methods of t...
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PMID: 19359713
PDF is available here.