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Brain Chemistry (0):
Recent article
Brain Chemistry
Proteomics (11)16 2011
Abstract
The HUPO Brain Proteome Project (HUPO BPP) held its 14th workshop during the HUPO 9th Annual World Congress in Sydney, Australia. The principal aim of this project is to discover prognostic and diagnostic biomarkers associated with neurodegenerative diseases and brain aging, with the...
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PMID: 21796782
PDF is available here.
PDF is available here.
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Abstract
Micellar electrokinetic capillary chromatographic (MEKC) with photodiode-array detection was applied to determine temozolomide (TMZ) in human serum and brain tumor. The limit of quantitation (LOQ) was 0.096μg/mL using 325nm as detection wavelength. The method made possible that the...
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PMID: 21727050
PDF is available here.
PDF is available here.
Abstract
We present a stable-isotope labeled choline analog, [1,1,2,2-D(4) ,2-(13) C]choline chloride, that is suitable for this purpose. In this analog, the (13) C position showed 24% polarization in the liquid state, following DNP hyperpolarization. This nucleus also showed a long T(1) (35 s) at 11.8 T a...
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PMID: 21698772
PDF is available here.
PDF is available here.
Abstract
We describe the synthesis and characterization of JM6, a small-molecule prodrug inhibitor of kynurenine 3-monooxygenase (KMO). Chronic oral administration of JM6 inhibits KMO in the blood, increasing kynurenic acid levels and reducing extracellular glutamate in the brain. In a transgenic mouse model...
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PMID: 21640374
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Preparative electrophoresis is a protein fractionation approach useful for the enrichment of low-abundance gene products. Preparative electrophoresis is usually performed in the PrepCell apparatus. Proteins are separated according to their size in a cylindrical gel in the presence of an ionic deterg...
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PMID: 18369871
PDF is available here.
PDF is available here.
médecine/sciences (27)4 2011
Abstract
Abstract
We focus on the antidepressant effects of oral administration of GABA-rich Monascus-fermented product in depression animal model (forced swimming test, FST) by Sprague-Dawley rats, and try to find its possible mechanism in the brain monoamine system. GABA and the Monascus-fermented product (MFP) sig...
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PMID: 21375324
PDF is available here.
PDF is available here.
Abstract
We circumvented light-scattering ambiguity inherent to deep-tissue multifocal two-photon microscopy. We demonstrate calcium imaging at multiple axial planes in the intact mouse brain to monitor network activity of ensembles of cortical neurons in three spatial dimensions....
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PMID: 21217749
PDF is available here.
PDF is available here.
Abstract
The PCr was significantly increased in mouse HD brain extracts as compared to nontransgenic littermates. We also found an approximately 27% decrease in CK activity in both cytosolic and mitochondrial fractions of R6/2 and N171-82Q mice, and an approximately 25% decrease in the mitochondria from HdhQ...
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PMID: 21124007
PDF is available here.
PDF is available here.
BMC Medicine (9)1 2011
Abstract
Cerebral microdialysis (MD) is used to monitor local brain chemistry of patients with traumatic brain injury (TBI). Despite an extensive literature on cerebral MD in the clinical setting, it remains unclear how individual levels of real-time MD data are to be interpreted. Intracrania...
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PMID: 21366904
PDF is available here.
PDF is available here.
Abstract
The effect of lipid nanocomplexes loaded with acetylsalicylic acid (aspirin) on platelet aggregation in vitro was investigated. The antithrombotic effect of aspirin in complex with liposomes prepared from pig brain glycosphingolipids is not only significantly higher compared to control, but also acco...
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PMID: 21809695
PDF is available here.
PDF is available here.
Abstract
Inhibition of the oxidation of fatty acids methyl esters by oregano essential oil was studied using capillary gas chromatography. A mixture of fatty acids which contained saturated, mono-, di-, and polyunsaturated acids with 16-24 carbon atoms was extracted from mice brain. Changes in the composition...
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PMID: 21950127
PDF is available here.
PDF is available here.
Anesthesiology (114)1 2011
Abstract
Anesthesiology (114)1 2011
Abstract
The current study was designed to determine the relation between preoperative cerebral oxygen saturation (Sco2), variables of cardiopulmonary function, mortality, and morbidity in a heterogeneous cohort of cardiac surgery patients.
In this study, 1,178 consecutive patients scheduled for on-pump surg...
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PMID: 21178669
PDF is available here.
PDF is available here.
Brain research (1359) 2010
Abstract
We examined the neuroprotective effect of CsA on hypoxia-ischemia (HI)-induced brain injury in newborn rats. Seven-day-old Sprague-Dawley rat pups were subjected to 2h of 8% oxygen following a unilateral carotid artery ligation. With a single dose of CsA treatment (20mg/kg, intraperitoneal) given im...
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PMID: 20735992
PDF is available here.
PDF is available here.
Abstract
We anticipate that WAX/WCX microcolumns are promising for the integration of protein separation and tryptic digestion aiming at high-throughput proteome study....
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PMID: 20886523
PDF is available here.
PDF is available here.
NeuroImage (53)2 2010
Abstract
Optimisation and comparison of the performance of three different methods for calculating three-dimensional susceptibility maps of the whole brain from gradient-echo (phase and modulus) image data acquired at 7 T is described. The methods studied are a multiple-orientation method in which image data...
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PMID: 20615474
PDF is available here.
PDF is available here.
Abstract
To unveil the mechanism of sleep-improving effect of lyophilized powder of Sini powder on drosophila.
Drosophila melanogaster whose strain were wild Canton S, unmated, were collected daring 12 h after their emergencing, then they were anaesthetized by small flow of CO2 and divided into different tub...
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PMID: 21246833
PDF is available here.
PDF is available here.
Journal of Neurotrauma (27)10 2010
Abstract
We developed an animal model incorporating a lead ball implanted in the brain, or a glass ball as a control, and analyzed histological and biochemical changes in the brain for 28 days after surgery. The concentration of lead in the brain increased with time after implantation of the lead ball, while...
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PMID: 20698761
PDF is available here.
PDF is available here.
Journal of Physiology (588)Pt 19 2010
Abstract
Abstract
We have reported the occurrence of phosphatidyl-D-serine (D-PS) in the rat cerebrum. Here, we describe the tissue distribution of D-PS in the rat. The D/D+L ratio of D-PS in the cerebrum was 0.9%, while no detectable amount of D-PS was detected in the cerebellum. D-PS was also found in the heart, sp...
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PMID: 20834140
PDF is available here.
PDF is available here.
Journal of Proteomics (73)10 2010
Abstract
MALDI mass spectrometry is able to acquire protein profiles directly from tissue that can describe the levels of hundreds of distinct proteins. MALDI imaging MS can simultaneously reveal how each of these proteins varies in heterogeneous tissues. Numerous studies have now demonstrate...
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PMID: 20510389
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of chronic intermittent ethanol vapor exposure on behaviors in the forced swim test (FST) and neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) levels in specific brain regions. Adult male Wistar rats were subjected to intermittent ethanol vapor (14 h on/10 h...
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PMID: 20705420
PDF is available here.
PDF is available here.
Abstract
No pathogenic prions were found in any of the 1142 tested specimens. One specimen revealed weak positivity at initial screening; however, repeated examination of the specimen and other specimens from different locations in the brain of the same donor did not confirm the presence of pathogenic prions...
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PMID: 20520532
PDF is available here.
PDF is available here.
Brain research (1349) 2010
Abstract
Although the etiology of autism is unclear, disruptions of the dopaminergic and serotonergic systems have been associated with the disorder. Based on behavioral differences observed in the BALB/c strain of mice in comparison to other strains, notably, C57BL/6J mice, it has been suggested that the BA...
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PMID: 20599834
PDF is available here.
PDF is available here.
Abstract
We evaluate the theoretical potential of a novel method of drug delivery, discrete controlled release (DCR), to control effective neurotrophin concentration gradients in an isotropic region of neocortex. We do so by constructing computational models of neurotrophin concentration profiles resulting f...
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PMID: 20644248
PDF is available here.
PDF is available here.
Neuroreport (21)11 2010
Abstract
We examined hypocretin levels in dementia with Lewy bodies and Alzheimer's disease cases and correlated these with sleep habits and clinical characteristics. Although limited hypocretin alterations were observed in Alzheimer's disease, we show reduced neocortical hypocretin immunoreactivity in demen...
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PMID: 20531237
PDF is available here.
PDF is available here.
Abstract
Our results show that central fatigue due to hyperthermia and increased body heating rate induced by central Ang II AT1 receptor blockade in exercising rats is related with higher 5-HT content in the preoptic area and hypothalamus as well as with decreased levels of this neurotransmitter in the hipp...
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PMID: 20068491
PDF is available here.
PDF is available here.
Hormones and Behavior (58)3 2010
Abstract
During an agonistic encounter test, dominant male greater long-tailed hamsters (Tscheskia triton) initiated attacks sooner and displayed higher levels of aggression and flank marking behavior than their subordinate counterparts. Accordingly, subordinate males exhibited more defensive behavior than d...
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PMID: 20471386
PDF is available here.
PDF is available here.
Abstract
We propose that long-term oestrogen deficiency may result in abnormal distribution and localization of brain oestrogen receptors, brain mitochondrial dysfunction, septohippocampal cholinergic degeneration and reactive gliosis. These multiple pathogenic factors may account for the lack of any benefic...
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PMID: 20456422
PDF is available here.
PDF is available here.
Abstract
BMS-690514, a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3, is currently under investigation as an oral agent for the treatment of solid tumors. In vitro and in vivo studies were cond...
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PMID: 20166197
PDF is available here.
PDF is available here.
Abstract
We have shown that masking the carboxyl group of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 1) as an esterase-labile acetoxymethyl ester yields 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 2). Nitroxide 2 can cross the blood-brain barrier and is then hy...
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PMID: 20201101
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1801)8 2010
Abstract
We have revealed three marked changes of lipids in brain samples of subjects with mild cognitive impairment of Alzheimer's disease including sulfatides, ceramides, and plasmalogens. Further studies using MDMS-SL lead us to the identification of the potential biochemical mechanisms responsible for th...
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PMID: 20117236
PDF is available here.
PDF is available here.
Abstract
Quantitation of isoprostanes such as 8-iso-PGF(2alpha) and 8,12-iso-iPF(2alpha)-VI in biological fluids has been proposed as a reliable test of oxidant stress and inflammation in a variety of disorders. This paper presents a liquid chromatography method with tandem mass spectrometry detection for the...
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PMID: 20643588
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)7 2010
Abstract
The ischemic brain lesions induced in rats by temporary occlusion of the bilateral common carotid arteries and restoration of blood flow to an ischemic brain region is associated with generation of reactive oxygen species with consequent reperfusion injury.
The present study investigated the neuropr...
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PMID: 20645783
PDF is available here.
PDF is available here.
Neurological Research (32)6 2010
Abstract
The neurological examination scores mildly increased in trauma groups 48 hours after the induction of trauma. Meloxicam treatment improved the altered neurological status. The trauma caused a significant increase in brain water content that was partially reversed by meloxicam. Meloxicam also reduced...
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PMID: 19660237
PDF is available here.
PDF is available here.
Abstract
We found that larval recovery showed progressive increase over the course of infection. Furthermore, the infected mice displayed increased expression of pro-inflammatory cytokines and iNOS, as well as significant disturbances in neurotransmitter profile. Astrocytic activation, evidenced by enhanced...
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PMID: 20302888
PDF is available here.
PDF is available here.
Abstract
We performed an in-depth analysis of phosphorylation sites in mouse brain. To maximize the number of detected phosphorylation sites, we fractionated proteins by size exclusion chromatography (SEC) or separated tryptic peptides on an anion exchanger (SAX) prior or after the TiO(2)-based phosphopeptid...
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PMID: 20415495
PDF is available here.
PDF is available here.
Abstract
We tested this possibility by examining the consequences of selectively modulating CNS NA levels on the development of clinical signs in experimental autoimmune encephalomyelitis (EAE). In mice immunized with myelin oligodendrocyte glycoprotein peptide to develop a chronic disease, pretreatment to s...
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PMID: 19957206
PDF is available here.
PDF is available here.
Abstract
Ventricular pacing leads to a significant decrease in arterial blood pressure and central venous saturation accompanied by an immediate and significant decrease in TOI (63.3% +/- 7.6% to 61.5% +/- 8.4% [P < 0.05]) and HbD (0.51 +/- 1.8 micromol.l(-1) to -2.9 +/- 4.7 micromol.l(-1) [P < 0.05]). CONCL...
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PMID: 20412455
PDF is available here.
PDF is available here.
Glycobiology (20)6 2010
Abstract
We describe a simple and efficient method for mapping the distribution and localization of all sialylated sphingoglycolipids present in coronal mouse brain sections using a conventional axial matrix-assisted laser desorption/ionization time of flight. A single scan of a histological tissue section g...
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PMID: 20190299
PDF is available here.
PDF is available here.
Neurosurgery (66)6 2010
Abstract
Previous studies of spontaneous subarachnoid hemorrhage (SAH) have shown that global cerebral edema on the first computed tomography scan is associated with a more severe initial injury and is an independent predictor of poor outcome. Effects of secondary ischemic events also influence outcome after...
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PMID: 20495425
PDF is available here.
PDF is available here.
Abstract
We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA...
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PMID: 20066485
PDF is available here.
PDF is available here.
Abstract
We observed that DHEA could be metabolized to 7alpha-OH DHEA and 7beta-OH DHEA in mitochondria but the formation of 7alpha-OH DHEA and 7beta-OH DHEA demonstrated different enzymatic kinetic properties. Adding NADPH, an essential cofactor, to mitochondria incubation mixtures increased only the format...
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PMID: 20153344
PDF is available here.
PDF is available here.
Abstract
We investigated whether sub-chronic administration of the second-generation antipsychotic clozapine and the first-generation antipsychotic haloperidol alters brain membrane lipid composition in male Sprague-Dawley rats. The relationship between brain membrane lipid composition and plasma cholesterol...
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PMID: 20227455
PDF is available here.
PDF is available here.
Journal of Physiology (588)Pt 11 2010
Abstract
We observed no signs of muscular fatigue in the elbow flexors and all control MVCs were similar to resting values. Exhaustive exercise provoked cerebral deoxygenation, metabolic changes and indices of fatigue similar to those observed during exercise in hypoxia indicating that reduced cerebral oxyge...
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PMID: 20403976
PDF is available here.
PDF is available here.
Abstract
Lysophosphatidic acid (LPA) is a lipid mediator with multiple biological functions. A highly selective and sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) method was developed for the determination of LPAs (16:0 LPA, 18:0 LPA, 18:1 LPA, 20:4 LPA) in rat brain cryosections. After...
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PMID: 20381434
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
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PMID: 20142434
PDF is available here.
PDF is available here.
Abstract
We describe the recombinant production of the human Y(1) receptor from inclusion bodies of E. coli cultures. The in vitro refolding was carried out in the presence of lipids from bovine brain extracts. Y(1) receptors in brain lipids compete for cellular receptors in competitive binding experiments....
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PMID: 19689227
PDF is available here.
PDF is available here.
Abstract
A long-term high lard diet increased offspring serum TC and LDL-C levels and affected the brain's fatty acid composition, and memory and learning ability. The polyunsaturated fatty acid content of the brain may be correlated with serum cholesterol levels....
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PMID: 20015474
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)6 2010
Abstract
We investigated, in a multimodal high-resolution magnetic resonance imaging (MRI) genetic study, whether reduced hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with MD and healthy subjects...
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PMID: 20147891
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)6 2010
Abstract
We conducted a systems-based genetic association analysis in a sample of 472 treatment-seeking smokers of European ancestry after 8 weeks of transdermal nicotine therapy for smoking cessation. The genotyping panel included 169 single-nucleotide polymorphisms (SNPs) in 7 nicotinic acetylcholine recep...
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PMID: 20147892
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)6 2010
Abstract
We assessed the putative pro-attentional effects of the selective alpha4beta2(*) nicotinic acetylcholine receptor (nAChR) agonist S 38232 in comparison with the non-selective agonist nicotine. Neither drug benefited SAT performance. However, in interaction with the increased task demands implemented...
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PMID: 20147893
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)6 2010
Abstract
We addressed this question by using global gene expression profiling in an animal model of PTSD, stress-enhanced fear learning (SEFL). A total of 15 footshocks were used to induce SEFL and the volatile anesthetic isoflurane was used to suppress the behavioral effects of stress. Gene expression in la...
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PMID: 20147889
PDF is available here.
PDF is available here.
Abstract
Kisspeptins are neuropeptides which activate the hypothalamo-pituitary gonadal axis and are considered to play important physiological roles in the reproduction. Kisspeptins have also been reported to stimulate the aldosterone secretion from the adrenal cortex. However, the expression of kisspeptins...
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PMID: 19898965
PDF is available here.
PDF is available here.
Abstract
Environmental tobacco smoke (ETS) has been linked to deleterious health effects, particularly pulmonary and cardiac disease; yet, the general public considers ETS benign to brain function in adults. In contrast, epidemiological data have suggested that ETS impacts the brain and potentially modulates...
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PMID: 19960371
PDF is available here.
PDF is available here.
Neurochemical Research (35)5 2010
Abstract
Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic acid (22:6n-3; DHA) levels can be potentiate...
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PMID: 20177777
PDF is available here.
PDF is available here.
Neurochemical Research (35)5 2010
Abstract
A variety of drug treatment regimens have been proposed to model the dysphoric state observed during methamphetamine (METH) withdrawal in rats, but little has been established in experiments using mice. In male ICR mice, a fixed-dose injection regimen of METH (1.0 or 2.5 mg/kg, i.p., twice daily for...
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PMID: 20148307
PDF is available here.
PDF is available here.
Abstract
We document here our visualization of chalcedony using a Leica TCS - SP2 confocal laser scanning microscope. Sections of human brain were collected after autopsy from elderly patients. The autofluorescent character of chalcedony allowed us to obtain three-dimensional images of the crystals and matur...
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PMID: 19742355
PDF is available here.
PDF is available here.
Forensic Science International (197)1-3 2010
Abstract
During a routine truck-tank washing operation, five healthy workers were found motionless inside an empty tanker. Four of them died inside the tanker while the fifth died the following day in hospital. Since the true nature of the fatal compound(s) were not known, a rigorous environmental and toxico...
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PMID: 20079984
PDF is available here.
PDF is available here.