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Oxygen Consumption (2):
Recent article
Oxygen Consumption
Abstract
Our findings suggest that exercise intensity is independently associated with the improvement of insulin sensitivity in abdominally obese men but not women....
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PMID: 21999295
PDF is available here.
PDF is available here.
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Abstract
The elderly constitute an increasingly large segment of the population and of the patients requiring medical attention. Major surgery is associated with a substantial burden of postoperative morbidity and mortality. Advancing age is a particular risk factor for these outcomes. This article reviews th...
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PMID: 21925407
PDF is available here.
PDF is available here.
Abstract
Abstract
We carried out a systematic and detailed physiological characterization of human liver cells in a 3D hollow-fiber bioreactor system continuously run for > 2 weeks. Primary human hepatocytes were maintained viable and functional over the whole period of cultivation. Both general cellular functions, e...
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PMID: 21442764
PDF is available here.
PDF is available here.
Cell Metabolism (14)2 2011
Abstract
The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains largely unknown. Here, stemness factor-mediated nuclear reprogramming reverted mitochondrial networks into cristae-poor structures. Metabolomic footprinting and fingerprinting distinguished der...
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PMID: 21803296
PDF is available here.
PDF is available here.
Abstract
We return to first principles and derive an index of oxygen supply from Fick's classic first law of diffusion. This oxygen supply index (OSI) incorporates both partial pressure and solubility. Our OSI successfully explains published patterns in body size and species across environmental clines linke...
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PMID: 21905423
PDF is available here.
PDF is available here.
Abstract
I or II, with a mean peak Vo(2) of 18 ml/min/kg. According to the age-adjusted reference values, hormonal deficiencies were present in 29% for total testosterone, 39% for estimated free testosterone, 34% for insulin-like growth factor-1, and 61% for dehydroepiandrosterone sulfate. Dehydroepiandroste...
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PMID: 21752346
PDF is available here.
PDF is available here.
Abstract
We developed a fluorescent probe-assisted microscopy protocol enabling to assess the ΔΨ(m)-generating capacity by mitochondria immobilized on a glass surface at the single organelle resolution-level. The advantage of this assay over others is to scale-down the amount of the biological sample requi...
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PMID: 21762790
PDF is available here.
PDF is available here.
Abstract
To date, there are only a few, non-evidence based, cerebroprotective therapeutic strategies for treatment and, accordingly, for prevention of secondary brain injuries following severe closed head trauma. In order to develop new therapy strategies, existing realistic animal models nee...
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PMID: 21739409
PDF is available here.
PDF is available here.
Abstract
We studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts that associate with detubulation, by confocal laser scanning microscopy. First, exercise training in normal rats increased cardiomyocyte volume by 16% (P...
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PMID: 21660947
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
We can conclude that UCP3 affects thymocyte and spleen cell profiles in the fed and fasted states.
Copyright © 2011. Published by Elsevier B.V....
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PMID: 21689632
PDF is available here.
PDF is available here.
Cell Metabolism (13)6 2011
Abstract
We show that heat shock protein beta-1 (HSPB1 or HSP27) is the downstream mediator of this effect. Disruption of the HSPB1 gene in embryonic fibroblasts with wild-type HMGB1 recapitulates the mitochondrial fragmentation, deficits in mitochondrial respiration, and adenosine triphosphate (ATP) synthes...
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PMID: 21641551
PDF is available here.
PDF is available here.
Abstract
The primary attempt in diagnostic and experimental studies of numerous pathological states associated with mitochondrial dysfunction is a precise evaluation of changes in function, content and structure of mitochondrial OXPHOS system. The analysis of rat heart, liver, brain and kidne...
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PMID: 21664301
PDF is available here.
PDF is available here.
Abstract
We characterized the pathophenotypes of dopaminergic neuronal cells that were deficient in PINK1 or DJ-1, genes with mutations linked to familial PD. Both PINK1- and DJ-1-deficient dopaminergic neurons had the increased production of ROS, severe mitochondrial structural damages and complex I deficit...
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PMID: 21664494
PDF is available here.
PDF is available here.
Abstract
A number of diet and exercise programs purport to help promote and maintain weight loss. However, few studies have compared the efficacy of different methods.
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PMID: 21616195
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1810)9 2011
Abstract
Apelin is an endogenous ligand for the G-protein-coupled 7-transmembrane receptor, APJ. The administration of apelin-13, a truncated 13-amino acid apelin peptide, in diet-induced obese mice is reported to result in a decrease in adiposity due to the increase of energy expenditure with an increase in...
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PMID: 21609753
PDF is available here.
PDF is available here.
Aviation, Space, and Environmental Medicine (82)5 Suppl 2011
Abstract
INTRODUCTION, FACILITIES, AND METHODS: Decompression sickness (DCS) occurring in hypobaric environments related to aviation or spaceflight was a major focus of research at Brooks AFB/City-Base, TX, throughout the period 1960-2010. Multiple hypobaric chambers and extensive support facilities were buil...
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PMID: 21614886
PDF is available here.
PDF is available here.
Abstract
Two weeks of dietary intervention (≈4.3% weight loss) reduced hepatic triglycerides by ≈42% in subjects with NAFLD; however, reductions were significantly greater with dietary carbohydrate restriction than with calorie restriction. This may have been due, in part, to enhanced hepatic and whole-b...
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PMID: 21367948
PDF is available here.
PDF is available here.
Abstract
We sought to analyze the serial exercise data from patients with Tetralogy of Fallot to quantify the changes in their exercise capacity over time and to identify associations with clinical and cardiac magnetic resonance imaging variables. The data from cardiopulmonary exercise tests (CPXs) from 2002...
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PMID: 21529748
PDF is available here.
PDF is available here.
Biological psychology (87)1 2011
Abstract
The purpose of this study was to examine the effects of concurrent physical and mental challenge on stress hormones and indicators of vascular function in firefighters. Twelve professional firefighters exercised at 60% VO(2max) while participating in a computerized Fire Strategies an...
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PMID: 21382435
PDF is available here.
PDF is available here.
Abstract
Abstract
Volume overload of the pulmonary circulation in patients with atrial septal defect (ASD)-type secundum causes pulmonary vascular disease over a long period of time. This study aimed at (1) evaluating pulmonary vascular resistance (PVR) and (2) investigating the relation between PVR and exercise capac...
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PMID: 21357444
PDF is available here.
PDF is available here.
Abstract
We demonstrate that haploinsufficiency for the O(2)-regulated HIF-2α subunit results in augmented carotid body sensitivity to hypoxia, irregular breathing, apneas, hypertension, and elevated plasma norepinephrine levels in adult Hif-2α(+/-) mice. These dysregulated autonomic responses were associa...
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PMID: 21288809
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)11 2011
Abstract
We investigated whether the decrease in respirasome organization reported by us previously in cardiac mitochondria in HF is due to changes in the phospholipids of the mitochondrial inner membrane or modifications of the subunits of the electron transport chain (ETC) complexes. The contents of the ma...
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PMID: 21320465
PDF is available here.
PDF is available here.
Abstract
Patients with dilated cardiomyopathy and implantable cardioverter-defibrillator (ICD) are a high-risk group for arrhythmias. They regularly undergo cardiopulmonary exercise testing (CPET) to assess cardiac reserve and to guide clinical decisions or therapeutic adjustments. Data from previous studies...
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PMID: 21553612
PDF is available here.
PDF is available here.
Journal of Physiology (589)Pt 3 2011
Abstract
Abstract
Nutrient medium for cultivation of Bacillus subtilis IMV V-7023 was optimized by the method of the orthogonal Latin rectangles. Optimum concentrations were investigated in the medium of carbon source (15.0 g/l of molasses), nitrogen (2.0 g/l of corn extract) and content of phosphorus-containing inorg...
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PMID: 21598654
PDF is available here.
PDF is available here.
Abstract
We show that two AOX-utilising mutants, grisea and PaCox17::ble, are able to compensate partially for lowered OXPHOS efficiency resulting from AOX-dependent respiration by increasing mitochondrial content. At the physiological level this is demonstrated by an elevated oxygen consumption and increase...
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PMID: 21305036
PDF is available here.
PDF is available here.
Abstract
We have developed a protocol to expand the application of the XF24 Analyzer to include isolated mitochondria. Acquisition of optimal rates requires assay conditions that are unexpectedly distinct from those of conventional polarography. The optimized conditions, derived from experiments with isolate...
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PMID: 21799747
PDF is available here.
PDF is available here.
Abstract
Physical activity has been shown to be effective in the treatment of conditions, such as fibromyalgia and depression. Although these conditions are associated with irritable bowel syndrome (IBS), no study has assessed the effect of physical activity on gastrointestinal (GI) symptoms in IBS. The aim w...
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PMID: 21206488
PDF is available here.
PDF is available here.
Abstract
Our results clearly indicate that cell-specific oxygen consumption parameters have to be considered in the design of biotechnological devices intended to support kidney function by cell-supported renal replacement therapy. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011....
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PMID: 21312373
PDF is available here.
PDF is available here.
Abstract
We examined mitochondrial function in patients with genetic defects in insulin receptor (INSR) signaling. We found that phosphocreatine recovery after exercise, a measure of skeletal muscle mitochondrial function in vivo, was significantly slowed in patients with INSR mutations compared with that in...
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PMID: 21555852
PDF is available here.
PDF is available here.
Abstract
We recently showed that cardiac lipid content is reduced after 12 weeks of physical activity training in healthy overweight subjects. The beneficial effect of exercise training on cardiovascular risk is well established and the decrease in cardiac lipid content with exercise training in healthy over...
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PMID: 21615922
PDF is available here.
PDF is available here.
Postepy biochemii (57)1 2011
Abstract
A short CV of Britton Chance, an outstanding American biophysicist and biochemists, who has passed away in November 2010, is presented. Chance invented and applied in biochemical research fast recording of difference spectra during chemical reactions. Due to this technique he discove...
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PMID: 21735815
PDF is available here.
PDF is available here.
Abstract
In cerebral ischemia, measurement of cerebral blood flow (CBF) alone is not a sensitive or specific predictor of tissue survival. Measurements of oxygen metabolism, which are directly related to cellular energy metabolism, are better predictors of tissue survival and the best of these is the "oxygen...
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PMID: 21445790
PDF is available here.
PDF is available here.
Abstract
Our previous mathematical model for coupled NO and O(2) transport around an arteriole, modified to include superoxide generation from dysfunctional endothelium, was developed further to include nitrite reductase activity in blood and tissue. Steady-state radial and axial NO and pO(2) profiles in the...
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PMID: 21445797
PDF is available here.
PDF is available here.
Abstract
We can conclude that both sEMG and NIRS give complementary information concerning muscle fatigue....
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PMID: 21445809
PDF is available here.
PDF is available here.
Critical Care Medicine (39)1 2011
Abstract
We explored whether using an integrated monitoring system that continuously amalgamates single noninvasive monitoring parameters (heart rate, respiratory rate, blood pressure, and peripheral oxygen saturation) into AN instability index value (INDEX) correlated with our single-parameter cardiorespira...
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PMID: 20935559
PDF is available here.
PDF is available here.
Critical Care Medicine (39)1 2011
Abstract
The vasopressor effect of arginine vasopressin, a mixed V1a/V2 receptor (V1aR/V2R) agonist, is mediated through the V1aR. Because V2R stimulation may aggravate sepsis-induced vasodilation, fluid accumulation, and microvascular thrombosis, a higher V1aR vs. V2R selectivity might be advantageous. The...
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PMID: 20890184
PDF is available here.
PDF is available here.
Abstract
Recently it has been shown that artistic speech therapy (AST) has effects on heart rate variability. The aim of this pilot study was to investigate whether AST also affects hemodynamics and tissue oxygenation in the brain and skeletal muscle measured by near infrared spectrophotometry(NIRS). The resu...
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PMID: 21445765
PDF is available here.
PDF is available here.
Cardiology in the Young (20)6 2010
Abstract
β-blockers improve the prognosis of patients with cardiac failure due to left ventricular systolic dysfunction. The aim of this study was to assess the efficacy of β-blockers in patients with dysfunctional systemic right ventricle.
Fourteen patients with systemic right ventricle following a Mustar...
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PMID: 20519056
PDF is available here.
PDF is available here.
Cardiology in the Young (20)6 2010
Abstract
We sought to assess the impact of increasing altitude on functional capacity in patients with Fontan palliation.
A retrospective review of 22 patients at low altitude (1602 metres) and 119 patients at sea level with Fontan circulation, as well as age-, gender-, and altitude-matched controls, underwe...
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PMID: 20849678
PDF is available here.
PDF is available here.
Obesity Facts (3)6 2010
Abstract
We compared skeletal muscle mitochondrial respiration in obese subjects to normal-weight reference groups with various degrees of physical activity.
Muscle biopsies were taken from the vastus lateralis muscle of 9 healthy obese subjects (BMI 40 ± 3). Mitochondria were isolated and a...
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PMID: 21196791
PDF is available here.
PDF is available here.
Obesity Facts (3)6 2010
Abstract
We compared skeletal muscle mitochondrial respiration in obese subjects to normal-weight reference groups with various degrees of physical activity.
Muscle biopsies were taken from the vastus lateralis muscle of 9 healthy obese subjects (BMI 40 ± 3). Mitochondria were isolated and a...
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PMID: 21196791
PDF is available here.
PDF is available here.
Abstract
Following various types of plastic surgery, such as adipose grafting and flap elevation, adipose tissue undergoes ischemia, leading to hypoxia and nutrient depletion. However, few studies have examined ischemic and/or hypoxic changes in adipose tissue.
The authors established surgically induced isch...
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PMID: 21124131
PDF is available here.
PDF is available here.
Abstract
Our findings indicated that peripheral adaptations after ULLS could relate to the change in aerobic exercise capacity during one-legged exercise. Our results also suggest that intensive interval training prevents ULLS-induced deconditioning of both aerobic exercise capacity and skeletal muscle volum...
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PMID: 21197852
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)12 2010
Abstract
Dietary fish oil modulates skeletal muscle membrane fatty acid composition. Similar changes in heart membrane composition modulate myocardial oxygen consumption and enhance mechanical performance. The rat in vivo autologous perfused hindlimb was used to investigate the influence of membrane composit...
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PMID: 20691135
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
We studied the effects of 10 cm H2O of positive end-expiratory pressure (PEEP) and PEEP followed by a recruitment maneuver (PEEP+RM) on end-expiratory lung volume (EELV), oxygenation and respiratory mechanics in patients undergoing laparoscopic surgery.
Sixty consecutive adult patients (30 obese, 30...
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PMID: 21068660
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
We found gene expression of the oxygen-sensing pathway, heme oxygenase 2, and the K channels TASK (TWIK-related acid sensitive K channel)-1 and BK (large-conductance potassium channel). In addition, we show the expression of critical receptor subunits such as γ-aminobutyric acid A (α2, β3, and γ...
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PMID: 20980909
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
We present an overview of this field of research with emphasis on relevance in anesthesiology and intensive care....
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PMID: 21045638
PDF is available here.
PDF is available here.
Abstract
Abstract
Although hypothermic selective cerebral perfusion (SCP) is widely used for cerebral protection during aortic surgery, little is known about the ideal pump-flow management during this procedure. This study explored cerebral hemodynamics and metabolism at two different flow rates.
Fourteen pigs (33 to...
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PMID: 21095348
PDF is available here.
PDF is available here.
Abstract
Gold(I) complexes such as auranofin have been used for decades to treat symptoms of rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer drugs. The enzyme thioredoxin reductase (TrxR) is considered as the most relevant molecular target for these species. The her...
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PMID: 21082862
PDF is available here.
PDF is available here.
Abstract
We examined the effect of combined exercise training on the levels of IFN-γ, IL-4 and IL-17 in the plasma and the supernatant of peripheral blood lymphocytes in women with multiple sclerosis. Expanded Disability Status Scale (EDSS), VO(2)max, muscle strength, and balance tests were obtained at base...
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PMID: 20797460
PDF is available here.
PDF is available here.
FEMS Yeast Research (10)7 2010
Abstract
We identified 177 ORFs and 56 proteins among those most expressed during the process, thus highlighting cell stress response, mitochondrial and carbohydrate metabolism as the most represented functional categories. A direct correlation between mRNA changes and protein abundance was observed for seve...
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PMID: 20738407
PDF is available here.
PDF is available here.
Pediatric Research (68)5 2010
Abstract
We conclude that even stable ELBW infants undergo evident transitional changes in cerebral oxygenation and perfusion in the early postnatal period, which may reflect changes in cardiac function and cardiac output....
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PMID: 20657347
PDF is available here.
PDF is available here.
Abstract
2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along...
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PMID: 21155394
PDF is available here.
PDF is available here.
Abstract
The existence of a general influence of exercise on the incidence of decompression sickness (DCS) has been known for more than a half-century. However, quantification of the effect has not been done for several reasons, including isolation of exercise as the only variable. The DCS database at Brooks...
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PMID: 21043293
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)9 2010
Abstract
Two types of relatively high-protein diets, with a normal or low proportion of carbohydrates, have been shown effective for weight loss. The objective was to assess the significance of the presence or absence of carbohydrates and the proportion of fat in high-protein diets for affecting appetite sup...
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PMID: 20565999
PDF is available here.
PDF is available here.
Abstract
The ingestion of CHO solutions has been shown to increase CHO oxidation and improve endurance performance. However, most studies have investigated CHO in solution, and sporting practice includes ingestion of CHO in solid (e.g., energy bars) as well as in liquid form. It remains unknown whether CHO i...
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PMID: 20404762
PDF is available here.
PDF is available here.