PMID: 21178559

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PMID: 21178535

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We defined initially inappropriate antibiotic therapy as occurring when the patient either was not administered an antibiotic within 24 hrs of sepsis onset or was treated with an antibiotic to which the culprit pathogen was resistant in vitro. The cohort included 760 subjects (mean age 59.3 ± 16.3... | PMID: 20890186

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Tuberculosis is still a major global health problem. Nowadays nucleic acid amplification tests which are recommended by the World Health Organization (WHO) become popular methods for the rapid detection of Mycobacterium tuberculosis complex (MTC). Recently introduced commercial Xpert MTB/RIF (Cepheid... | PMID: 21341158

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We thus hypothesized that fatty acid composition of Legionella's membrane might influence the sensitivity of the bacteria to warnericin RK. Relationship between sensitivity to the peptide and fatty acid composition was then followed in various conditions. Cells in stationary phase, which were alread... | PMID: 21182824

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PMID: 21287729

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PMID: 21287727

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We demonstrate that the resistance enzyme ANT(4') from Staphylococcus aureus is highly substrate and cosubstrate promiscuous. We show that deoxy-ribonucleotide triphosphates (dNTPs) are better cosubstrates than NTPs. We demonstrate that the position of the triphosphate group (5' and not 3') on the r... | PMID: 21040710

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Microbiological surveillance data is of crucial importance in appropriate management of patients with infectious diseases. The current study was conducted to study the microbiological surveillance data along with antibiotic sensitivity patterns for isolates collected at a single tertiary care center... | PMID: 21563612

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We conclude that L. rhamnosus PRSF-L477 can safely be administrated to healthy subjects at a daily dose of 1 × 10¹¹ cfu.... | PMID: 20691131

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Coxiella burnetii, an obligate intracellular Gram-negative bacterium, is the etiological agent of Q fever. This work takes advantage of a hypersensitive Escherichia coli genetic system to identify genes involved in resistance to nitrosative stress imposed by reactive nitrogen intermediates. Among th... | PMID: 20705129

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Reports detailing bacteremia caused by Chryseobacterium indologenes remain limited, with most cases reported in Taiwan. The clinical significance of C. indologenes has not been fully established. This retrospective study investigated the clinical features and antimicrobial susceptibi... | PMID: 21195977

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We report a metagenomic analysis of a healthy human plaque sample using a combination of second-generation sequencing platforms. A total of 860 million base pairs of non-human sequences were generated. Various analysis tools revealed the presence of 12 well-characterized phyla, members of the TM-7 a... | PMID: 21040513

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We retrospectively reviewed the medical charts of adult patients with a diagnosis of spinal TB. Only those with positive culture results and/or characteristic pathologic findings were enrolled. Demographic data, clinical manifestations and susceptibility to anti-TB drugs were reviewed and analyzed.... | PMID: 21195972

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Recent outbreaks involving multidrug-resistant bacteria have prompted governments to alter the regulations governing antibiotic sales. By combining the new regulations with calls for new drug development and dispensing regimes, can antibiotic resistance be managed? | PMID: 21125698

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We report the successful control of an outbreak caused by imipenem-resistant VIM-1-producing Klebsiella pneumoniae (IR-Kp) in France. This outbreak occurred in a care centre for abdominal surgery that includes a 15-bed liver intensive care unit and performs more than 130 liver transplantations per y... | PMID: 21144428

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The emergence and global spread of carbapenemase-producing Enterobacteriaceae is of great concern to health services worldwide. These bacteria are often resistant to all beta-lactam antibiotics and frequently co-resistant to most other antibiotics, leaving very few treatment options. The epidemiolog... | PMID: 21144429

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PMID: 21141616

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PMID: 21141615

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We show that the Streptococcus thermophilus CRISPR1/Cas system can also naturally acquire spacers from a self-replicating plasmid containing an antibiotic-resistance gene, leading to plasmid loss. Acquired spacers that match antibiotic-resistance genes provide a novel means to naturally select bacte... | PMID: 21048762

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PMID: 21033278

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To investigate the bacterial distribution and resistance to antibiotics in culture-positive urine, and to provide reference for rational use of antibiotics in clinical practice. Distribution and antibiotic resistance to pathogens in 658 culture-positive patients from... | PMID: 21131743

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Routine childhood vaccination has affected frequency and bacteriology of acute otitis media (AOM) and acute bacterial rhinosinusitis (ABRS). Routine influenza vaccination moderately reduces AOM, and the Haemophilus influenzae type b vaccine likely had a minor role in AOM and ABRS. Th... | PMID: 20737301

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The objective of this cross-sectional study was to compare the prevalence of Salmonella and antimicrobial-resistant Salmonella, as well as investigate the distribution of this pathogen in organic and conventional broiler poultry farms. Fecal (n = 420), feed (n = 140), and drinking wa... | PMID: 20617937

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